DEHYDRATION OF THREONINE ESTERS DURING TOSYLATION

Tosylation of N-α-protected threonine methyl-and benzyl esters was investigated. Depending on the protecting groups, the composition of the reaction mixtures showed different ratio between O-tosyl-and dehydrothreonine derivatives. The latter was formed exclusively in case of N-α-Fmoc-threonine benzyl ester.

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