mCPP-induced hypophagia in rats is unaffected by the profile of dietary unsaturated fatty acids

The n-3 and n-6 polyunsaturated fatty acids (PUFAs) have been shown to modify central serotonergic parameters relevant to ingestive behavior. Evidence suggests an association between the 5-HT(2C) receptor and fat intake. The present research sought to examine the role of the 5-HT(2C) receptor subtype on food intake when diets with different fatty acid compositions are consumed. The effects of 1-(3-chlorophenyl)piperazine (mCPP) on consumption of both low-fat (Experiment 1) and high-fat diets (Experiment 2) differing in their predominant PUFA profiles were compared in rats. Regardless of the PUFA profile, mCPP induced hypophagia within each experiment. Although the present results lend further support to a large body of evidence demonstrating the ability of mCPP to reduce food intake, they do not support the idea that the essential fatty acid composition of the diet can differentially modulate mCPP-induced hypophagia.

[1]  S. Leibowitz,et al.  Hypothalamic serotonin in the control of meal patterns and macronutrient selection , 1986, Brain Research Bulletin.

[2]  L. Heisler,et al.  Reduction of Fat and Protein Intakes But Not Carbohydrate Intake Following Acute and Chronic Fluoxetine in Female Rats , 1999, Pharmacology Biochemistry and Behavior.

[3]  D. Guilloteau,et al.  Dietary fish oil affects monoaminergic neurotransmission and behavior in rats. , 1998, The Journal of nutrition.

[4]  R. Eglen,et al.  RS-102221: A Novel High Affinity and Selective, 5-HT2C Receptor Antagonist , 1997, Neuropharmacology.

[5]  B. Tabachnick,et al.  Using Multivariate Statistics , 1983 .

[6]  G. Bray,et al.  Chronic d-Fenfluramine Treatment Reduces Fat Intake Independent of Macronutrient Preference , 1998, Pharmacology Biochemistry and Behavior.

[7]  T. Kawada,et al.  The Orosensory Recognition of Long-Chain Fatty Acids in Rats , 1999, Physiology & Behavior.

[8]  G. Kennett,et al.  Potencies of antagonists indicate that 5‐HT1C receptors mediate 1–3(chlorophenyl)piperazine‐induced hypophagia , 1991, British journal of pharmacology.

[9]  K. Simansky,et al.  Behavioral mechanisms for the anorectic action of the serotonin (5-HT) uptake inhibitor sertraline in rats: Comparison with directly acting 5-HT agonists , 1990, Brain Research Bulletin.

[10]  G. Curzon,et al.  Effect of reserpine on behavioural responses to agonists at 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor subtypes , 1999, Neuropharmacology.

[11]  L. Heisler,et al.  Fluoxetine Decreases Fat and Protein Intakes But Not Carbohydrate Intake in Male Rats , 1997, Pharmacology Biochemistry and Behavior.

[12]  J. Halford,et al.  Serotonin, eating behavior, and fat intake. , 1995, Obesity research.

[13]  S. Leibowitz,et al.  Nocturnal patterns of macronutrient intake in freely feeding and food-deprived rats. , 1989, The American journal of physiology.

[14]  S. Garattini,et al.  m-Chlorophenylpiperazine: A central serotonin agonist causing powerful anorexia in rats , 1979, Naunyn-Schmiedeberg's Archives of Pharmacology.

[15]  R. Kanarek,et al.  Differential effects of amphetamine and fenfluramine on dietary self-selection in rats , 1982, Pharmacology Biochemistry and Behavior.

[16]  Gerard P. Smith.  Satiation: From Gut to Brain , 1998 .

[17]  G. Kennett,et al.  5-HT1B agonists induce anorexia at a postsynaptic site. , 1987, European journal of pharmacology.

[18]  L. Tecott,et al.  Reduced satiating effect of d-fenfluramine in serotonin 5-HT2C receptor mutant mice , 1999, Psychopharmacology.

[19]  Peter G. Clifton,et al.  Similarities in the action of Ro 60-0175, a 5-HT2C receptor agonist, and d-fenfluramine on feeding patterns in the rat , 2000, Psychopharmacology.

[20]  G. Bray,et al.  Activation of hypothalamic serotonin receptors reduced intake of dietary fat and protein but not carbohydrate. , 1999, The American journal of physiology.

[21]  R. Kanarek,et al.  Peripheral serotonin administration selectively reduces fat intake in rats , 1988, Pharmacology Biochemistry and Behavior.

[22]  S. Dryden,et al.  Differential effects of the 5-HT 1B 2C receptor agonist mCPP and the 5-HT1A agonist flesinoxan on hypothalamic neuropeptide Y in the rat: Evidence that NPY may mediate serotonin's effects on food intake , 1996, Peptides.

[23]  R. Wurtman,et al.  Drugs that enhance central serotoninergic transmission diminish elective carbohydrate consumption by rats. , 1979, Life sciences.

[24]  K. Simansky,et al.  Serotonergic control of the organization of feeding and satiety , 1995, Behavioural Brain Research.

[25]  D. Middlemiss,et al.  Centrally active 5-HT receptor agonists and antagonists , 1992, Neuroscience & Biobehavioral Reviews.

[26]  P. G. Clifton,et al.  Effects of food deprivation and mCPP treatment on the microstructure of ingestive behaviour of male and female rats , 1993, Journal of psychopharmacology.