Mechanism in Autoimmune Disease Overexpression of CD40: A Novel Genetically Driven Target Tissue

Mehdi Keddache, Weijia Zhang and Yaron TomerErlinda Concepcion, Eric Smith, Eric Jacobson, Rauf Latif, Amanda K. Huber, Fred D. Finkelman, Cheuk Wun Li,http://www.jimmunol.org/content/189/6/3043doi: 10.4049/jimmunol.1200311August 2012;J Immunol€2012; 189:3043-3053; Prepublished online 10MaterialSupplementary1.DC1.htmlhttp://www.jimmunol.org/content/suppl/2012/08/10/jimmunol.120031Referenceshttp://www.jimmunol.org/content/189/6/3043.full#ref-list-1This article cites 46 articles, 11 of which you can access for free at: Subscriptionshttp://jimmunol.org/subscriptionsInformation about subscribing to The Journal of Immunology is online at: Permissionshttp://www.aai.org/ji/copyright.htmlSubmit copyright permission requests at: Email Alertshttp://jimmunol.org/cgi/alerts/etocReceive free email-alerts when new articles cite this article. Sign up at:

[1]  M. Taniyama,et al.  Association of a C/T single-nucleotide polymorphism in the 5' untranslated region of the CD40 gene with Graves' disease in Japanese. , 2006, Thyroid : official journal of the American Thyroid Association.

[2]  Robert W. Williams,et al.  Probing the genetic basis for thyrotropin receptor antibodies and hyperthyroidism in immunized CXB recombinant inbred mice. , 2006, Endocrinology.

[3]  Luis Rodrigo,et al.  CD40: Novel Association with Crohn's Disease and Replication in Multiple Sclerosis Susceptibility , 2010, PloS one.

[4]  Masanori Aikawa,et al.  TRAF-1, -2, -3, -5, and -6 Are Induced in Atherosclerotic Plaques and Differentially Mediate Proinflammatory Functions of CD40L in Endothelial Cells , 2007, Arteriosclerosis, thrombosis, and vascular biology.

[5]  M. Béné,et al.  Coexpression of CD40 and class II antigen HLA-DR in Graves' disease thyroid epithelial cells. , 1997, Clinical immunology and immunopathology.

[6]  Michelino Di Rosa,et al.  Vitamin D3: a helpful immuno‐modulator , 2011, Immunology.

[7]  Barbara Jarzab,et al.  Association of CD40 gene polymorphism (C-1T) with susceptibility and phenotype of Graves' disease. , 2005, Thyroid : official journal of the American Thyroid Association.

[8]  Yuko Hamada,et al.  In situ Expression of CD40 and CD40 Ligand in Psoriasis , 2004, Dermatology.

[9]  Taiji Oashi,et al.  A Graves' disease-associated Kozak sequence single-nucleotide polymorphism enhances the efficiency of CD40 gene translation: a case for translational pathophysiology. , 2005, Endocrinology.

[10]  Pablo Moscato,et al.  Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20 , 2009, Nature Genetics.

[11]  A Muraguchi,et al.  The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells , 1988, The Journal of experimental medicine.

[12]  E. Ponomarev,et al.  CD40 Expression by Microglial Cells Is Required for Their Completion of a Two-Step Activation Process during Central Nervous System Autoimmune Inflammation1 , 2006, The Journal of Immunology.

[13]  M. Hewison.  Vitamin D and innate and adaptive immunity. , 2011, Vitamins and hormones.

[14]  G. Davı̀,et al.  Increased soluble CD40 ligand levels in cystic fibrosis , 2004, Journal of thrombosis and haemostasis : JTH.

[15]  Yuji Nagayama,et al.  The thyrotropin receptor autoantigen in Graves disease is the culprit as well as the victim. , 2003, The Journal of clinical investigation.

[16]  D. Sciaky,et al.  CD40 expression in human thyroid tissue: evidence for involvement of multiple cell types in autoimmune and neoplastic diseases. , 1999, Thyroid : official journal of the American Thyroid Association.

[17]  Fiona Crawford,et al.  CD40 is expressed and functional on neuronal cells , 2002, The EMBO journal.

[18]  J. Banchereau,et al.  The functional CD40 antigen of fibroblasts may contribute to the proliferation of rheumatoid synovium , 1996, Clinical and experimental immunology.

[19]  D. Klein,et al.  A functional CD40 receptor is expressed in pancreatic beta cells , 2005, Diabetologia.

[20]  Jack P Antel,et al.  CD40 engagement stimulates IL-12 p70 production by human microglial cells: basis for Th1 polarization in the CNS , 2000, Journal of Neuroimmunology.

[21]  Cees van Kooten,et al.  The CD40-CD40L pathway contributes to the proinflammatory function of intestinal epithelial cells in inflammatory bowel disease. , 2010, The American journal of pathology.

[22]  G. Rogler,et al.  Inducible CD40 expression mediates NFκB activation and cytokine secretion in human colonic fibroblasts , 2003, Gut.

[23]  Lei Zhang,et al.  Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation. , 2005, Cancer research.

[24]  Tae Yong Kim,et al.  A C/T polymorphism in the 5'-untranslated region of the CD40 gene is associated with Graves' disease in Koreans. , 2003, Thyroid : official journal of the American Thyroid Association.

[25]  Kentaro Yamada,et al.  A C/T polymorphism in the 5' untranslated region of the CD40 gene is associated with later onset of Graves' disease in Japanese. , 2005, Endocrine journal.

[26]  Yuji Nagayama,et al.  Low-dose immunization with adenovirus expressing the thyroid-stimulating hormone receptor A-subunit deviates the antibody response toward that of autoantibodies in human Graves' disease. , 2004, Endocrinology.

[27]  Choon-Sik Park,et al.  Association analysis of CD40 polymorphisms with asthma and the level of serum total IgE. , 2007, American journal of respiratory and critical care medicine.

[28]  T. Behrens,et al.  Delineating the genetic basis of systemic lupus erythematosus. , 2001, Immunity.

[29]  T. Hirano,et al.  Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2). , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[30]  Chun Xing Li,et al.  A CD40 Kozak sequence polymorphism and susceptibility to antibody-mediated autoimmune conditions: the role of CD40 tissue-specific expression , 2007, Genes and Immunity.

[31]  B. Rapoport,et al.  Susceptibility rather than resistance to hyperthyroidism is dominant in a thyrotropin receptor adenovirus-induced animal model of Graves' disease as revealed by BALB/c-C57BL/6 hybrid mice. , 2004, Endocrinology.

[32]  Insoo Kang,et al.  CD40 ligation of rheumatoid synovial fibroblasts regulates RANKL-mediated osteoclastogenesis: evidence of NF-kappaB-dependent, CD40-mediated bone destruction in rheumatoid arthritis. , 2006, Arthritis and rheumatism.

[33]  T. Hirano,et al.  Molecular regulation of B lymphocyte response. , 1988, Annual review of immunology.

[34]  Jing Cui,et al.  Common variants at CD40 and other loci confer risk of rheumatoid arthritis , 2008, Nature Genetics.

[35]  Erlinda Concepcion,et al.  A C/T single-nucleotide polymorphism in the region of the CD40 gene is associated with Graves' disease. , 2002, Thyroid : official journal of the American Thyroid Association.

[36]  Alejandro Aruffo,et al.  CD40 is functionally expressed on human keratinocytes , 1996, European journal of immunology.

[37]  Dagmar Klein,et al.  CD40–CD40 Ligand Interaction Activates Proinflammatory Pathways in Pancreatic Islets , 2006, Diabetes.

[38]  S. Khoury,et al.  Kinetics of expression of costimulatory molecules and their ligands in murine relapsing experimental autoimmune encephalomyelitis in vivo. , 1998, Journal of immunology.

[39]  L Nduwayo,et al.  Fonction et auto-immunité thyroïdienne chez 215 patients séropositifs pour le virus de l'hépatite C , 1998 .

[40]  Daniel Paris,et al.  Ligation of Microglial CD40 Results in p44/42 Mitogen-Activated Protein Kinase-Dependent TNF-α Production That Is Opposed by TGF-β1 and IL-10 , 1999, The Journal of Immunology.

[41]  Y. Shoenfeld,et al.  The Role of CD40–CD154 Interactions in Autoimmunity and the Benefit of Disrupting this Pathway , 2004, Autoimmunity.

[42]  Y. Bacq,et al.  [Thyroid function and autoimmunity in 215 patients seropositive for the hepatitis C virus]. , 1998, Annales d'endocrinologie.

[43]  G. Bishop,et al.  CD40 and autoimmunity: the dark side of a great activator. , 2009, Seminars in immunology.

[44]  L. Boon,et al.  Coculture of human liver macrophages and cholangiocytes leads to CD40‐dependent apoptosis and cytokine secretion , 2007, Hepatology.

[45]  Stefanie Dimmeler,et al.  CD40 and vascular inflammation. , 2004, The Canadian journal of cardiology.

[46]  Masami Niwa,et al.  A Novel Murine Model of Graves’ Hyperthyroidism with Intramuscular Injection of Adenovirus Expressing the Thyrotropin Receptor , 2002, The Journal of Immunology.

[47]  Sung-Hwan Park,et al.  Augmented production of chemokines by the interaction of type II collagen-reactive T cells with rheumatoid synovial fibroblasts. , 2004, Arthritis and rheumatism.