Gene therapy clinical trials worldwide to 2007—an update

To date, over 1340 gene therapy clinical trials have been completed, are ongoing or have been approved worldwide. In 1997 we set up a database to bring together global information on gene therapy clinical trials as comprehensively as possible. The data are compiled and regularly updated from official agency sources, published literature, conference presentations and posters and from information kindly provided by investigators or trial sponsors themselves.

[1]  S. Rosenberg,et al.  T Lymphocyte-Directed Gene Therapy for ADA− SCID: Initial Trial Results After 4 Years , 1995, Science.

[2]  One of three successfully treated CGD patients in a Swiss‐German gene therapy trial died due to his underlying disease , 2006, The journal of gene medicine.

[3]  K. Cichutek,et al.  Is it going to be SIN? , 2006, The journal of gene medicine.

[4]  Christof von Kalle,et al.  A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency. , 2003, The New England journal of medicine.

[5]  Zhao-hui Peng,et al.  Current status of gendicine in China: recombinant human Ad-p53 agent for treatment of cancers. , 2005, Human gene therapy.

[6]  Yang Du,et al.  Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1 , 2006, Nature Medicine.

[7]  K. Cornetta,et al.  Gene transfer into humans--immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction. , 1990, The New England journal of medicine.

[8]  Adam Bagg,et al.  Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer. , 2003, Molecular genetics and metabolism.

[9]  F. Deist,et al.  Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. , 2000, Science.

[10]  Anastasia Khvorova,et al.  Induction of the interferon response by siRNA is cell type- and duplex length-dependent. , 2006, RNA.

[11]  Jerry M. Guo,et al.  Chinese gene therapy. Splicing out the West? , 2006, Science.

[12]  A. Fire,et al.  Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans , 1998, Nature.

[13]  S. Woo,et al.  Complete and persistent phenotypic correction of phenylketonuria in mice by site-specific genome integration of murine phenylalanine hydroxylase cDNA , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[14]  Cameron S. Osborne,et al.  LMO2-Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1 , 2003, Science.

[15]  B. Gansbacher.  Report of a second serious adverse event in a clinical trial of gene therapy for X‐linked severe combined immune deficiency (X‐SCID) , 2003, The journal of gene medicine.

[16]  J. Kaiser,et al.  As Gelsinger Case Ends, Gene Therapy Suffers Another Blow , 2005, Science.

[17]  A. Hotz-Wagenblatt,et al.  Insertion of retroviral vectors in NOD/SCID repopulating human peripheral blood progenitor cells occurs preferentially in the vicinity of transcription start regions and in introns. , 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

[18]  Christine Kinnon,et al.  Mutations in TNFRSF13B Encoding TACI Are Associated With Common Variable Immunodeficiency in Humans , 2006, Pediatrics.

[19]  S. Rosenberg,et al.  Cancer Regression in Patients After Transfer of Genetically Engineered Lymphocytes , 2006, Science.

[20]  A. Fischer,et al.  Treatment of an infant with X-linked severe combined immunodeficiency ( SCID-X 1 ) by gene therapy in Australia , 2000 .

[21]  Kathryn L. Parsley,et al.  Successful reconstitution of immunity in ADA-SCID by stem cell gene therapy following cessation of PEG-ADA and use of mild preconditioning. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

[22]  J. Wixon,et al.  Gene therapy clinical trials worldwide 1989–2004—an overview , 2004, The journal of gene medicine.

[23]  B. Gänsbacher.  Policy statement on the social, ethical and public awareness issues in gene therapy , 2002, The journal of gene medicine.

[24]  Jerry M. Guo,et al.  Splicing Out the West? , 2006, Science.

[25]  B. Gansbacher.  Policy statement on the social, ethical and public awareness issues in gene therapy. , 2002 .