Pharmacophore Modeling as an Efficient Tool in the Discovery of Novel Noncompetitive AMPA Receptor Antagonists
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M. Letizia Barreca | Laura De Luca | Alba Chimirri | Rosaria Gitto | Silvana Quartarone | Giovambattista De Sarro | R. Gitto | M. Barreca | A. Chimirri | G. Sarro | L. D. Luca | S. Quartarone
[1] A. Ganong,et al. Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist , 2002, Neuropharmacology.
[2] Andrew Smellie,et al. Poling: Promoting conformational variation , 1995, J. Comput. Chem..
[3] R. B. Carter,et al. Synthesis of 7,8-(methylenedioxy)-1-phenyl-3,5-dihydro-4H-2, 3-benzodiazepin-4-ones as novel and potent noncompetitive AMPA receptor antagonists. , 1998, Journal of Medicinal Chemistry.
[4] G. De Sarro,et al. Synthesis and evaluation of pharmacological and pharmacokinetic properties of 11H-[1,2,4]triazolo[4,5-c][2,3]benzodiazepin-3(2H)-ones. , 2000, Journal of medicinal chemistry.
[5] A. Ganong,et al. Atropisomeric quinazolin-4-one derivatives are potent noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists. , 2001, Bioorganic & medicinal chemistry letters.
[6] C. Valenzuela,et al. Allosteric modulators of the AMPA receptor: novel 6-substituted dihydrophthalazines. , 1999, Bioorganic & Medicinal Chemistry Letters.
[7] M. Rogawski,et al. AMPA receptors in epilepsy and as targets for antiepileptic drugs. , 1999, Advances in neurology.
[8] A. Constanti,et al. 1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists. , 1997, Journal of Medicinal Chemistry.
[9] K. A. Jones,et al. Substituted 1,2-dihydrophthalazines: potent, selective, and noncompetitive inhibitors of the AMPA receptor. , 1996, Journal of Medicinal Chemistry.
[10] R. Gitto,et al. AMPA receptor antagonists , 1999 .
[11] R. Dingledine,et al. The glutamate receptor ion channels. , 1999, Pharmacological reviews.
[12] S. Nikam,et al. AMPA receptor antagonists. , 2001, Current medicinal chemistry.
[13] F. Menniti,et al. Quinazolin-4-one alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists: structure-activity relationship of the C-2 side chain tether. , 2001, Journal of medicinal chemistry.
[14] M. Karplus,et al. CHARMM: A program for macromolecular energy, minimization, and dynamics calculations , 1983 .
[15] P. Krogsgaard‐Larsen,et al. Ligands for glutamate receptors: design and therapeutic prospects. , 2000, Journal of medicinal chemistry.
[16] M. Rogawski,et al. GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses , 1993, Neuron.
[17] I. Tarnawa,et al. Structural analogues of some highly active non-competitive AMPA antagonists. , 2000, Bioorganic & medicinal chemistry letters.
[18] A. Constanti,et al. 3,5-Dihydro-4H-2,3-benzodiazepine-4-thiones: a new class of AMPA receptor antagonists. , 1998, Journal of medicinal chemistry.
[19] G. De Sarro,et al. GYKI 52466 and related 2,3-benzodiazepines as anticonvulsant agents in DBA/2 mice. , 1995, European journal of pharmacology.