Choice behavior of hippocampectomized rats in the radial arm maze

Rats with hippocampal lesions (n = 16), sham-operated controls (n = 5), and unoperated controls (n = 8) were trained on place and cue tasks in an elevated radial arm maze. Hippocampallesioned rats had impaired working memory and impaired cognitive-map formation. The behavior of the hippocampals in choosing arms was different from that of the controls even immediately after training began. The hippocampals were not able to rapidly perceive the spatial requirements of the task and did not show the inherent stereotyped behavior employed by controls. Nonetheless, the hippocampals showed that they could learn problem-solving behavior as training progresses.

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