MEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis.
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H. Aburatani | S. Tsutsumi | R. Delwel | P. Valk | Takuro Nakamura | T. Kuwata | R. Goitsuka | Takashi Yokoyama | A. Couzinet | M. Nakatake
[1] K. Igarashi,et al. Ewing's sarcoma precursors are highly enriched in embryonic osteochondrogenic progenitors. , 2014, The Journal of clinical investigation.
[2] T. Kume,et al. Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation , 2014, Nature.
[3] H. Nakauchi,et al. Homeodomain Transcription Factor Meis1 Is a Critical Regulator of Adult Bone Marrow Hematopoiesis , 2014, PloS one.
[4] Fátima Sánchez-Cabo,et al. Analysis of the DNA-binding profile and function of TALE homeoproteins reveals their specialization and specific interactions with Hox genes/proteins. , 2013, Cell reports.
[5] R. Morgan,et al. The role of HOX genes in normal hematopoiesis and acute leukemia , 2013, Leukemia.
[6] C. Scheiermann,et al. Mesenchymal stem cell: keystone of the hematopoietic stem cell niche and a stepping-stone for regenerative medicine. , 2013, Annual review of immunology.
[7] N. Copeland,et al. Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress. , 2012, Blood.
[8] Chengcheng Zhang,et al. Meis1 regulates the metabolic phenotype and oxidant defense of hematopoietic stem cells. , 2012, Blood.
[9] Bas J. Wouters,et al. C/EBPγ deregulation results in differentiation arrest in acute myeloid leukemia. , 2012, The Journal of clinical investigation.
[10] R. Slany,et al. The homeodomain region controls the phenotype of HOX-induced murine leukemia. , 2012, Blood.
[11] Lina A. Thoren,et al. HemaExplorer: a database of mRNA expression profiles in normal and malignant haematopoiesis , 2012, Nucleic Acids Res..
[12] F. Reyal,et al. Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression. , 2012, Cancer research.
[13] Alejo E. Rodriguez-Fraticelli,et al. Synaptotagmin-Like Proteins Control Formation of a Single Apical Membrane Domain in Epithelial Cells , 2012, Nature Cell Biology.
[14] T. Suda,et al. Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration. , 2012, Blood.
[15] A. Fischer,et al. Terminal transport of lytic granules to the immune synapse is mediated by the kinesin-1/Slp3/Rab27a complex. , 2012, Blood.
[16] W. Kiosses,et al. Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase–activating protein Gem-interacting protein , 2012, Molecular biology of the cell.
[17] A. Bretscher,et al. EPI64 interacts with Slp1/JFC1 to coordinate Rab8a and Arf6 membrane trafficking , 2012, Molecular biology of the cell.
[18] A. Hero,et al. Identification and characterization of Hoxa9 binding sites in hematopoietic cells. , 2012, Blood.
[19] Lei Ding,et al. Endothelial and perivascular cells maintain haematopoietic stem cells , 2011, Nature.
[20] P. Aplan,et al. NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights. , 2011, Blood.
[21] L. Bullinger,et al. High BRE expression predicts favorable outcome in adult acute myeloid leukemia, in particular among MLL-AF9-positive patients. , 2011, Blood.
[22] Nicola K. Wilson,et al. Cell of origin in AML: susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complex. , 2011, Cancer cell.
[23] S. Alahari,et al. Integrin-mediated function of Rab GTPases in cancer progression , 2010, Molecular Cancer.
[24] Cheng Cheng Zhang,et al. The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche. , 2010, Cell stem cell.
[25] Kevin S. Smith,et al. GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis. , 2010, Cancer cell.
[26] Takahiro Ito,et al. Regulation of myeloid leukemia by the cell fate determinant Musashi , 2010, Nature.
[27] N. Hacohen,et al. Synaptotagmin-mediated vesicle fusion regulates cell migration , 2010, Nature Immunology.
[28] C. Bach,et al. Leukemogenic transformation by HOXA cluster genes. , 2010, Blood.
[29] H. Aburatani,et al. Function of EWS-POU5F1 in sarcomagenesis and tumor cell maintenance. , 2010, The American journal of pathology.
[30] M. Cleary,et al. A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription. , 2010, Cancer cell.
[31] A. Smolenski,et al. Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets. , 2009, Blood.
[32] D. Scadden,et al. The leukemic stem cell niche: current concepts and therapeutic opportunities. , 2009, Blood.
[33] Huiqing Shen,et al. Transcriptional Activation by MEIS1A in Response to Protein Kinase A Signaling Requires the Transducers of Regulated CREB Family of CREB Co-activators , 2009, The Journal of Biological Chemistry.
[34] K. Kaibuchi,et al. Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27. , 2009, Developmental cell.
[35] Baolin Wu,et al. A role for MEIS1 in MLL-fusion gene leukemia. , 2009, Blood.
[36] Bas J. Wouters,et al. Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling , 2009, Haematologica.
[37] S. Itohara,et al. Expression of Rab27B-binding protein Slp1 in pancreatic acinar cells and its involvement in amylase secretion. , 2008, Archives of biochemistry and biophysics.
[38] T. Daniele,et al. Slp1 and Slp2-a Localize to the Plasma Membrane of CTL and Contribute to Secretion from the Immunological Synapse , 2008, Traffic.
[39] Jill P. Mesirov,et al. GSEA-P: a desktop application for Gene Set Enrichment Analysis , 2007, Bioinform..
[40] J. Downing,et al. Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias , 2007, Leukemia.
[41] G. Jin,et al. Trib1 and Evi1 cooperate with Hoxa and Meis1 in myeloid leukemogenesis. , 2007, Blood.
[42] C. Lavau,et al. Flt3 is dispensable to the Hoxa9/Meis1 leukemogenic cooperation. , 2007, Blood.
[43] T. Jacks,et al. Restoration of p53 function leads to tumour regression in vivo , 2007, Nature.
[44] H. Janssen,et al. Synaptotagmin 3 deficiency in T cells impairs recycling of the chemokine receptor CXCR4 and thereby inhibits CXCL12 chemokine-induced migration , 2007, Journal of Cell Science.
[45] T. Nagasawa,et al. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. , 2006, Immunity.
[46] Matthew Meyerson,et al. The Menin Tumor Suppressor Protein Is an Essential Oncogenic Cofactor for MLL-Associated Leukemogenesis , 2005, Cell.
[47] Takuro Nakamura. NUP98 Fusion in Human Leukemia: Dysregulation of the Nuclear Pore and Homeodomain Proteins , 2005, International journal of hematology.
[48] G. Morrone,et al. Enforced Activation of STAT5A Facilitates the Generation of Embryonic Stem–Derived Hematopoietic Stem Cells That Contribute to Hematopoiesis In Vivo , 2004, Stem cells.
[49] N. Copeland,et al. Hematopoietic, angiogenic and eye defects in Meis1 mutant animals , 2004, The EMBO journal.
[50] J. Downing,et al. Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. , 2002, Blood.
[51] K. Calvo,et al. Meis1a suppresses differentiation by G-CSF and promotes proliferation by SCF: Potential mechanisms of cooperativity with Hoxa9 in myeloid leukemia , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[52] U. Thorsteinsdóttir,et al. NUP98–HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice , 2001, The EMBO journal.
[53] J. Mesirov,et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. , 1999, Science.
[54] Unnur Thorsteinsdottir,et al. Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b , 1998, The EMBO journal.
[55] M. Magli,et al. Effects of HOX homeobox genes in blood cell differentiation , 1997, Journal of cellular physiology.
[56] N. Copeland,et al. Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins , 1997, Molecular and cellular biology.
[57] Guy Sauvageau,et al. The Role of HOX Homeobox Genes in Normal and Leukemic Hematopoiesis , 1996, Stem cells.
[58] Takuro Nakamura,et al. Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias , 1996, Nature Genetics.
[59] K. Huebner,et al. Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice , 1995, Molecular and cellular biology.
[60] K. Döhner,et al. Deregulated expression of EVI1 defines a poor prognostic subset of MLL-rearranged acute myeloid leukemias: a study of the German-Austrian Acute Myeloid Leukemia Study Group and the Dutch-Belgian-Swiss HOVON/SAKK Cooperative Group. , 2013, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[61] Ira M. Hall,et al. BEDTools: a flexible suite of utilities for comparing genomic features , 2010, Bioinform..
[62] Cheang Ly Be,et al. Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with (cid:1) 9 (cid:2) 1 and (cid:1) 4 (cid:2) 1 integrins , 2009 .
[63] W. Pear,et al. Tribbles homolog 2 (Trib2) and HoxA9 cooperate to accelerate acute myelogenous leukemia. , 2008, Blood cells, molecules & diseases.
[64] C. Lavau,et al. Flt 3 is dispensable to the Hoxa 9 / Meis 1 leukemogenic cooperation , 2007 .
[65] 杉山 立樹. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches , 2007 .
[66] Mitsunori Fukuda,et al. Versatile role of Rab27 in membrane trafficking: focus on the Rab27 effector families. , 2005, Journal of biochemistry.