Concepts and characteristics of the ‘COST Reference Microplasma Jet’

Biomedical applications of non-equilibrium atmospheric pressure plasmas have attracted intense interest in the past few years. Many plasma sources of diverse design have been proposed for these applications, but the relationship between source characteristics and application performance is not well-understood, and indeed many sources are poorly characterized. This circumstance is an impediment to progress in application development. A reference source with well-understood and highly reproducible characteristics may be an important tool in this context. Researchers around the world should be able to compare the characteristics of their own sources and also their results with this device. In this paper, we describe such a reference source, developed from the simple and robust micro-scaled atmospheric pressure plasma jet (μ-APPJ) concept. This development occurred under the auspices of COST Action MP1101 'Biomedical Applications of Atmospheric Pressure Plasmas'. Gas contamination and power measurement are shown to be major causes of irreproducible results in earlier source designs. These problems are resolved in the reference source by refinement of the mechanical and electrical design and by specifying an operating protocol. These measures are shown to be absolutely necessary for reproducible operation. They include the integration of current and voltage probes into the jet. The usual combination of matching unit and power supply is replaced by an integrated LC power coupling circuit and a 5 W single frequency generator. The design specification and operating protocol for the reference source are being made freely available.

[1]  Martin Polak,et al.  Low temperature atmospheric pressure plasma sources for microbial decontamination , 2011 .

[2]  D. Joyeux,et al.  Absolute atomic oxygen and nitrogen densities in radio-frequency driven atmospheric pressure cold plasmas: Synchrotron vacuum ultra-violet high-resolution Fourier-transform absorption measurements , 2013 .

[3]  S. Reuter,et al.  Measurement of hydroxyl radical (OH) concentration in an argon RF plasma jet by laser-induced fluorescence , 2013 .

[4]  K. Niemi,et al.  Cold atmospheric pressure plasma jets as sources of singlet delta oxygen for biomedical applications , 2011 .

[5]  T. Gans,et al.  Electron Heating in Dual-Radio-Frequency-Driven Atmospheric-Pressure Plasmas , 2011, IEEE Transactions on Plasma Science.

[6]  Mounir Laroussi,et al.  Arc-Free Atmospheric Pressure Cold Plasma Jets: A Review , 2007 .

[7]  Jaeyoung Park,et al.  The atmospheric-pressure plasma jet: a review and comparison to other plasma sources , 1998 .

[8]  A. Lichtenberg,et al.  Particle-in-cell and global simulations of α to γ transition in atmospheric pressure Penning-dominated capacitive discharges , 2014 .

[9]  H. McCarthy,et al.  Interactions of a non-thermal atmospheric pressure plasma effluent with PC-3 prostate cancer cells , 2014 .

[10]  A. Lichtenberg,et al.  Analytical–numerical global model of atmospheric-pressure radio-frequency capacitive discharges , 2012 .

[11]  Steffen Brinckmann,et al.  Photons and particles emitted from cold atmospheric-pressure plasma inactivate bacteria and biomolecules independently and synergistically , 2013, Journal of The Royal Society Interface.

[12]  Z. Petrović,et al.  Detection of atomic oxygen and nitrogen created in a radio-frequency-driven micro-scale atmospheric pressure plasma jet using mass spectrometry , 2012 .

[13]  M. Laroussi,et al.  Low-Temperature Plasmas for Medicine? , 2009, IEEE Transactions on Plasma Science.

[14]  Gregory Fridman,et al.  Applied Plasma Medicine , 2008 .

[15]  J. Lackmann,et al.  The Role of VUV Radiation in the Inactivation of Bacteria with an Atmospheric Pressure Plasma Jet , 2011, 1105.6260.

[16]  S. Reuter,et al.  Absolute atomic oxygen density distributions in the effluent of a microscale atmospheric pressure plasma jet , 2008 .

[17]  R. Brinkmann,et al.  Spatially resolved simulation of a radio-frequency driven micro-atmospheric pressure plasma jet and its effluent , 2011, 1104.3288.

[18]  N. Braithwaite,et al.  Power coupling and electrical characterization of a radio-frequency micro atmospheric pressure plasma jet , 2014 .

[19]  S. Reuter,et al.  Diagnostic-based modeling on a micro-scale atmospheric-pressure plasma jet , 2010 .

[20]  T. von Woedtke,et al.  Clinical Plasma Medicine: State and Perspectives of in Vivo Application of Cold Atmospheric Plasma , 2014 .

[21]  F. Iza,et al.  Electron heating in radio-frequency capacitively coupled atmospheric-pressure plasmas , 2008 .

[22]  T. von Woedtke,et al.  Plasma Processes and Plasma Sources in Medicine , 2012 .

[23]  M. Turner,et al.  Gas and heat dynamics of a micro-scaled atmospheric pressure plasma reference jet , 2015 .

[24]  Y. Akishev,et al.  Plasma for Bio-Decontamination, Medicine and Food Security , 2012, NATO Science for Peace and Security Series A: Chemistry and Biology.

[25]  Gregor E. Morfill,et al.  Plasma medicine: an introductory review , 2009 .

[26]  S. Reuter,et al.  Spatially resolved diagnostics on a microscale atmospheric pressure plasma jet , 2008 .

[27]  Karl H. Schoenbach,et al.  Microplasmas and applications , 2006 .

[28]  J. Lackmann,et al.  Characterization of Damage to Bacteria and Bio-macromolecules Caused by (V)UV Radiation and Particles Generated by a Microscale Atmospheric Pressure Plasma Jet , 2012 .

[29]  Manfred Stieber,et al.  Non-thermal atmospheric pressure discharges for surface modification , 2005 .

[30]  S. Reuter,et al.  Absolute atomic oxygen density profiles in the discharge core of a microscale atmospheric pressure plasma jet , 2008 .

[31]  R. Leask,et al.  Miniature atmospheric pressure glow discharge torch (APGD-t) for local biomedical applications , 2006 .

[32]  S. McMahon,et al.  Cold atmospheric pressure plasma jet interactions with plasmid DNA , 2011 .

[33]  E. Wagenaars,et al.  Two-photon absorption laser-induced fluorescence measurements of atomic nitrogen in a radio-frequency atmospheric-pressure plasma jet , 2012 .

[34]  V. Schulz-von der Gathen,et al.  Investigations of the spatio-temporal build-up of atomic oxygen inside the micro-scaled atmospheric pressure plasma jet , 2010 .

[35]  Manfred Stieber,et al.  RF Capillary Jet ‐ a Tool for Localized Surface Treatment , 2007 .

[36]  Kurt Becker,et al.  Microplasmas, an emerging field of low-temperature plasma science and technology , 2006 .

[37]  T. von Woedtke,et al.  Atmospheric-pressure plasma sources: Prospective tools for plasma medicine , 2010 .

[38]  Timo Gans,et al.  The role of helium metastable states in radio-frequency driven helium–oxygen atmospheric pressure plasma jets: measurement and numerical simulation , 2011 .

[39]  David B. Graves,et al.  Low temperature plasma biomedicine: A tutorial reviewa) , 2014 .