Iterated profile searches with PSI-BLAST--a tool for discovery in protein databases.

We thank the developers of PSI-BLAST, who include D. J. Lipman, T. L. Madden, W. Miller, A. A. Schaffer, J. Zhang and Z. Zhang. We also thank L. Aravind for his collaboration on the application of PSI-BLAST to the detection of subtle relationships among proteins.

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