Hypothalamic AMP-activated protein kinase as a mediator of whole body energy balance

[1]  R. Parakhia,et al.  Metformin Activates AMP Kinase through Inhibition of AMP Deaminase , 2010, The Journal of Biological Chemistry.

[2]  Yung‐Chieh Tsai,et al.  The role of hypothalamic AMP-activated protein kinase in ovariectomy-induced obesity in rats , 2010, Menopause.

[3]  G. Rutter,et al.  Hypothalamic Nutrient Sensing Activates a Forebrain-Hindbrain Neuronal Circuit to Regulate Glucose Production In Vivo , 2010, Diabetes.

[4]  David Carling,et al.  Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation , 2010, Science.

[5]  J. Baik,et al.  Hypothalamic Angptl4/Fiaf Is a Novel Regulator of Food Intake and Body Weight , 2010, Diabetes.

[6]  Ricardo Lage,et al.  Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance , 2010, Nature Medicine.

[7]  G. Rutter,et al.  Hypothalamic AMP-Activated Protein Kinase Regulates Glucose Production , 2010, Diabetes.

[8]  M. J. Vazquez,et al.  Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[9]  Jun-ping Wen,et al.  Globular adiponectin regulates energy homeostasis through AMP-activated protein kinase–acetyl-CoA carboxylase (AMPK/ACC) pathway in the hypothalamus , 2010, Molecular and Cellular Biochemistry.

[10]  B. Viollet,et al.  Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. , 2010, The Journal of clinical investigation.

[11]  T. Horvath,et al.  Uncoupling protein-2 decreases the lipogenic actions of ghrelin. , 2010, Endocrinology.

[12]  M. Tena-Sempere,et al.  Cross-talk between orexins (hypocretins) and the neuroendocrine axes (hypothalamic–pituitary axes) , 2010, Frontiers in Neuroendocrinology.

[13]  K. da Boit,et al.  Influence of Ghrelin and Growth Hormone Deficiency on AMP‐Activated Protein Kinase and Hypothalamic Lipid Metabolism , 2010, Journal of neuroendocrinology.

[14]  C. Vaslet,et al.  Hypothalamic Sirt1 Regulates Food Intake in a Rodent Model System , 2009, PloS one.

[15]  W. D. van Marken Lichtenbelt,et al.  Cold-activated brown adipose tissue in healthy men. , 2009, The New England journal of medicine.

[16]  J. Orava,et al.  Functional brown adipose tissue in healthy adults. , 2009, The New England journal of medicine.

[17]  A. Hevener,et al.  AMPK β1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance* , 2009, The Journal of Biological Chemistry.

[18]  Robert E. Lewis,et al.  KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity. , 2009, Cell metabolism.

[19]  S. Imran,et al.  Resistin differentially modulates neuropeptide gene expression and AMP-activated protein kinase activity in N-1 hypothalamic neurons , 2009, Brain Research.

[20]  S. Sangiao-Alvarellos,et al.  Central ghrelin regulates peripheral lipid metabolism in a growth hormone-independent fashion. , 2009, Endocrinology.

[21]  M. Lane,et al.  Central lactate metabolism suppresses food intake via the hypothalamic AMP kinase/malonyl-CoA signaling pathway. , 2009, Biochemical and biophysical research communications.

[22]  F. Haj,et al.  Neuronal Protein Tyrosine Phosphatase 1B Deficiency Results in Inhibition of Hypothalamic AMPK and Isoform-Specific Activation of AMPK in Peripheral Tissues , 2009, Molecular and Cellular Biology.

[23]  R. Sherwin,et al.  Hypothalamic AMP-activated protein kinase activation with AICAR amplifies counterregulatory responses to hypoglycemia in a rodent model of type 1 diabetes. , 2009, American journal of physiology. Regulatory, integrative and comparative physiology.

[24]  B. Viollet,et al.  Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio. , 2009, Free radical biology & medicine.

[25]  M. Lane,et al.  Effect of glucose and fructose on food intake via malonyl-CoA signaling in the brain. , 2009, Biochemical and biophysical research communications.

[26]  E. Palmer,et al.  Identification and importance of brown adipose tissue in adult humans. , 2009, The New England journal of medicine.

[27]  E. Ropelle,et al.  Central Exercise Action Increases the AMPK and mTOR Response to Leptin , 2008, PloS one.

[28]  A. Vidal-Puig,et al.  AMPK: a metabolic gauge regulating whole-body energy homeostasis. , 2008, Trends in molecular medicine.

[29]  S. Woods,et al.  Fatty Acid Synthase Inhibitors Modulate Energy Balance via Mammalian Target of Rapamycin Complex 1 Signaling in the Central Nervous System , 2008, Diabetes.

[30]  M. Lane,et al.  Differential effects of central fructose and glucose on hypothalamic malonyl–CoA and food intake , 2008, Proceedings of the National Academy of Sciences.

[31]  A. Bookout,et al.  Brain SIRT1: Anatomical Distribution and Regulation by Energy Availability , 2008, The Journal of Neuroscience.

[32]  Hyunju Chung,et al.  Acute effects of glucagon-like peptide-1 on hypothalamic neuropeptide and AMP activated kinase expression in fasted rats. , 2008, Endocrine journal.

[33]  A. Saha,et al.  The AMPK-Malonyl-CoA-CPT1 Axis in the Control of Hypothalamic Neuronal Function—Reply , 2008 .

[34]  A. Arduini,et al.  The AMPK-malonyl-CoA-CPT1 axis in the control of hypothalamic neuronal function. , 2008, Cell metabolism.

[35]  N. Ozaki,et al.  Glucocorticoids increase neuropeptide Y and agouti-related peptide gene expression via adenosine monophosphate-activated protein kinase signaling in the arcuate nucleus of rats. , 2008, Endocrinology.

[36]  D. Carling,et al.  The regulation of AMP-activated protein kinase by upstream kinases , 2008, International Journal of Obesity.

[37]  Tamas L. Horvath,et al.  UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals , 2008, Nature.

[38]  S. Woods,et al.  Regulation of food intake through hypothalamic signaling networks involving mTOR. , 2008, Annual review of nutrition.

[39]  S. Woods,et al.  The Role of Hypothalamic Mammalian Target of Rapamycin Complex 1 Signaling in Diet-Induced Obesity , 2008, The Journal of Neuroscience.

[40]  L. Velloso,et al.  Intracerebroventricular injection of citrate inhibits hypothalamic AMPK and modulates feeding behavior and peripheral insulin signaling. , 2008, The Journal of endocrinology.

[41]  L. Velloso,et al.  Citrate diminishes hypothalamic acetyl-CoA carboxylase phosphorylation and modulates satiety signals and hepatic mechanisms involved in glucose homeostasis in rats. , 2008, Life sciences.

[42]  Jiawei Wu,et al.  Downregulation of AMP‐activated protein kinase by Cidea‐mediated ubiquitination and degradation in brown adipose tissue , 2008, The EMBO journal.

[43]  Ricardo Lage,et al.  Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. , 2008, Cell metabolism.

[44]  A. Means,et al.  Hypothalamic CaMKK2 contributes to the regulation of energy balance. , 2008, Cell metabolism.

[45]  S. Sangiao-Alvarellos,et al.  Central resistin regulates hypothalamic and peripheral lipid metabolism in a nutritional-dependent fashion. , 2008, Endocrinology.

[46]  M. Korbonits,et al.  The Orexigenic Effect of Ghrelin Is Mediated through Central Activation of the Endogenous Cannabinoid System , 2008, PloS one.

[47]  M. M. Dias,et al.  A Central Role for Neuronal AMP-Activated Protein Kinase (AMPK) and Mammalian Target of Rapamycin (mTOR) in High-Protein Diet–Induced Weight Loss , 2008, Diabetes.

[48]  Haiying Cheng,et al.  Key Role for AMP-Activated Protein Kinase in the Ventromedial Hypothalamus in Regulating Counterregulatory Hormone Responses to Acute Hypoglycemia , 2008, Diabetes.

[49]  P. Cohen,et al.  The selectivity of protein kinase inhibitors: a further update. , 2007, The Biochemical journal.

[50]  G. Shulman,et al.  Regulation of hypothalamic malonyl-CoA by central glucose and leptin , 2007, Proceedings of the National Academy of Sciences.

[51]  R. Heath,et al.  Defining the Mechanism of Activation of AMP-activated Protein Kinase by the Small Molecule A-769662, a Member of the Thienopyridone Family* , 2007, Journal of Biological Chemistry.

[52]  M. Birnbaum,et al.  Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake , 2007, Proceedings of the National Academy of Sciences.

[53]  D. Hardie,et al.  AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy , 2007, Nature Reviews Molecular Cell Biology.

[54]  G. Barsh,et al.  AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. , 2007, The Journal of clinical investigation.

[55]  T. Bengtsson,et al.  Unexpected evidence for active brown adipose tissue in adult humans. , 2007, American journal of physiology. Endocrinology and metabolism.

[56]  Kohjiro Ueki,et al.  Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. , 2007, Cell metabolism.

[57]  Qian Gao,et al.  Neurobiology of feeding and energy expenditure. , 2007, Annual review of neuroscience.

[58]  K. Nakao,et al.  Central melanocortin signaling restores skeletal muscle AMP-activated protein kinase phosphorylation in mice fed a high-fat diet. , 2007, Cell metabolism.

[59]  D. Carling,et al.  Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade. , 2007, The Biochemical journal.

[60]  C. Lelliott,et al.  Hypothalamic fatty acid metabolism: A housekeeping pathway that regulates food intake , 2007, BioEssays : news and reviews in molecular, cellular and developmental biology.

[61]  M. J. Vazquez,et al.  Peripheral tissue–brain interactions in the regulation of food intake , 2007, Proceedings of the Nutrition Society.

[62]  David Carling,et al.  Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling. , 2006, Cell metabolism.

[63]  Michael D. Schneider,et al.  A pivotal role for endogenous TGF-β-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway , 2006, Proceedings of the National Academy of Sciences.

[64]  Uwe Riek,et al.  Dissecting the Role of 5′-AMP for Allosteric Stimulation, Activation, and Deactivation of AMP-activated Protein Kinase* , 2006, Journal of Biological Chemistry.

[65]  M. W. Schwartz,et al.  Central nervous system control of food intake and body weight , 2006, Nature.

[66]  M. Febbraio,et al.  Ciliary neurotrophic factor suppresses hypothalamic AMP-kinase signaling in leptin-resistant obese mice. , 2006, Endocrinology.

[67]  B. Kahn,et al.  Diet-induced Obesity Alters AMP Kinase Activity in Hypothalamus and Skeletal Muscle* , 2006, Journal of Biological Chemistry.

[68]  P. Pfluger,et al.  Ghrelin action in the brain controls adipocyte metabolism. , 2006, The Journal of clinical investigation.

[69]  J. Zierath,et al.  AMP-activated protein kinase signaling in metabolic regulation. , 2006, The Journal of clinical investigation.

[70]  G. Rutter,et al.  Expanding role of AMPK in endocrinology , 2006, Trends in Endocrinology & Metabolism.

[71]  R. Sherwin,et al.  Activation of AMP-Activated Protein Kinase Within the Ventromedial Hypothalamus Amplifies Counterregulatory Hormone Responses in Rats With Defective Counterregulation , 2006, Diabetes.

[72]  L. Kifle,et al.  Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. , 2006, Cell metabolism.

[73]  George Thomas,et al.  Hypothalamic mTOR Signaling Regulates Food Intake , 2006, Science.

[74]  C. Lelliott,et al.  Tamoxifen-Induced Anorexia Is Associated With Fatty Acid Synthase Inhibition in the Ventromedial Nucleus of the Hypothalamus and Accumulation of Malonyl-CoA , 2006, Diabetes.

[75]  G. Bergström,et al.  Growth hormone receptor deficiency results in blunted ghrelin feeding response, obesity, and hypolipidemia in mice. , 2006, American journal of physiology. Endocrinology and metabolism.

[76]  W. Wahli,et al.  The Fasting-induced Adipose Factor/Angiopoietin-like Protein 4 Is Physically Associated with Lipoproteins and Governs Plasma Lipid Levels and Adiposity* , 2006, Journal of Biological Chemistry.

[77]  B. Lowell,et al.  Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis , 2005, The Journal of comparative neurology.

[78]  B. Lowell,et al.  Mice lacking ghrelin receptors resist the development of diet-induced obesity. , 2005, The Journal of clinical investigation.

[79]  M. Sleeman,et al.  Absence of ghrelin protects against early-onset obesity. , 2005, The Journal of clinical investigation.

[80]  K-U. Lee,et al.  Hypothalamic AMP-activated protein kinase mediates counter-regulatory responses to hypoglycaemia in rats , 2005, Diabetologia.

[81]  D. Hardie,et al.  Cannabinoids and Ghrelin Have Both Central and Peripheral Metabolic and Cardiac Effects via AMP-activated Protein Kinase* , 2005, Journal of Biological Chemistry.

[82]  A. Edelman,et al.  Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. , 2005, Cell metabolism.

[83]  R. Heath,et al.  Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. , 2005, Cell metabolism.

[84]  M. Lane,et al.  Monitoring energy balance: metabolites of fatty acid synthesis as hypothalamic sensors. , 2005, Annual review of biochemistry.

[85]  A. Vidal-Puig,et al.  Gateway to the metabolic syndrome , 2005, Nature Medicine.

[86]  S. Tovar,et al.  Regulation of growth hormone secretagogue receptor gene expression in the arcuate nuclei of the rat by leptin and ghrelin. , 2004, Diabetes.

[87]  R. Sherwin,et al.  Potential role for AMP-activated protein kinase in hypoglycemia sensing in the ventromedial hypothalamus. , 2004, Diabetes.

[88]  B. Monia,et al.  Role of resistin in diet-induced hepatic insulin resistance. , 2004, The Journal of clinical investigation.

[89]  B. Viollet,et al.  Anti-obesity effects of α-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase , 2004, Nature Medicine.

[90]  G. Ronnett,et al.  C75, a Fatty Acid Synthase Inhibitor, Reduces Food Intake via Hypothalamic AMP-activated Protein Kinase* , 2004, Journal of Biological Chemistry.

[91]  M. Birnbaum,et al.  AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus , 2004, Nature.

[92]  D. Carling,et al.  AMP-activated Protein Kinase Plays a Role in the Control of Food Intake* , 2004, Journal of Biological Chemistry.

[93]  R. Huganir,et al.  C75, a Fatty Acid Synthase Inhibitor, Modulates AMP-activated Protein Kinase to Alter Neuronal Energy Metabolism* , 2004, Journal of Biological Chemistry.

[94]  J. Flier.  Obesity Wars Molecular Progress Confronts an Expanding Epidemic , 2004, Cell.

[95]  E. Kraegen,et al.  Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity. , 2003, Endocrinology.

[96]  David Carling,et al.  Supplemental Data LKB 1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade , 2003 .

[97]  J. Goldberg.  How does an axon grow? , 2003, Genes & development.

[98]  J. Friedman.  A War on Obesity, Not the Obese , 2003, Science.

[99]  F. Casanueva,et al.  Agouti-related peptide, neuropeptide Y, and somatostatin-producing neurons are targets for ghrelin actions in the rat hypothalamus. , 2003, Endocrinology.

[100]  M. Prentki,et al.  Coordinate Regulation of Malonyl-CoA Decarboxylase,sn-Glycerol-3-phosphate Acyltransferase, and Acetyl-CoA Carboxylase by AMP-activated Protein Kinase in Rat Tissues in Response to Exercise* , 2002, The Journal of Biological Chemistry.

[101]  David Carling,et al.  The Anti-diabetic Drugs Rosiglitazone and Metformin Stimulate AMP-activated Protein Kinase through Distinct Signaling Pathways* , 2002, The Journal of Biological Chemistry.

[102]  Young-Bum Kim,et al.  Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase , 2002, Nature.

[103]  G. Frost,et al.  Ghrelin enhances appetite and increases food intake in humans. , 2001, The Journal of clinical endocrinology and metabolism.

[104]  R. Batterham,et al.  Ghrelin causes hyperphagia and obesity in rats. , 2001, Diabetes.

[105]  J. Kamegai,et al.  Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats. , 2001, Diabetes.

[106]  Margaret S. Wu,et al.  Role of AMP-activated protein kinase in mechanism of metformin action. , 2001, The Journal of clinical investigation.

[107]  B. Wisse,et al.  A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. , 2001, Diabetes.

[108]  M. Tschöp,et al.  Post-prandial decrease of circulating human ghrelin levels , 2001, Journal of endocrinological investigation.

[109]  M. Nakazato,et al.  A role for ghrelin in the central regulation of feeding , 2001, Nature.

[110]  K. Nakao,et al.  Ghrelin strongly stimulates growth hormone release in humans. , 2000, The Journal of clinical endocrinology and metabolism.

[111]  F. Casanueva,et al.  Ghrelin-induced growth hormone secretion in humans. , 2000, European journal of endocrinology.

[112]  S. Bloom,et al.  The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. , 2000, Endocrinology.

[113]  M. Tschöp,et al.  Ghrelin induces adiposity in rodents , 2000, Nature.

[114]  K. Kangawa,et al.  Ghrelin stimulates gastric acid secretion and motility in rats. , 2000, Biochemical and biophysical research communications.

[115]  M. Prentki,et al.  Activation of Malonyl-CoA Decarboxylase in Rat Skeletal Muscle by Contraction and the AMP-activated Protein Kinase Activator 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside* , 2000, The Journal of Biological Chemistry.

[116]  S. Woods,et al.  Central nervous system control of food intake , 2000, Nature.

[117]  M. Nakazato,et al.  Ghrelin is a growth-hormone-releasing acylated peptide from stomach , 1999, Nature.

[118]  P. Gorden,et al.  Thyroid hormone induced brown adipose tissue and amelioration of diabetes in a patient with extreme insulin resistance. , 2010, The Journal of clinical endocrinology and metabolism.

[119]  M. Taouis,et al.  Adiponectin receptors are expressed in hypothalamus and colocalized with proopiomelanocortin and neuropeptide Y in rodent arcuate neurons. , 2009, The Journal of endocrinology.

[120]  清水 裕史.  Glucocorticoids increase neuropeptide Y and agouti-related peptide gene expression via adenosine monophosphate-activated protein kinase signaling in the arcuate nucleus of rats , 2009 .

[121]  S. Schinner.  AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity , 2009 .

[122]  S. Woods,et al.  Effects of a fixed meal pattern on ghrelin secretion: evidence for a learned response independent of nutrient status. , 2006, Endocrinology.

[123]  D. Hardie,et al.  AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. , 2005, Cell metabolism.

[124]  G. Biolo,et al.  Ghrelin regulates mitochondrial-lipid metabolism gene expression and tissue fat distribution in liver and skeletal muscle. , 2005, American journal of physiology. Endocrinology and metabolism.

[125]  J. Park,et al.  Enhanced hypothalamic AMP-activated protein kinase activity contributes to hyperphagia in diabetic rats. , 2005, Diabetes.

[126]  Roy J Martin,et al.  Role of neuronal energy status in the regulation of adenosine 5'-monophosphate-activated protein kinase, orexigenic neuropeptides expression, and feeding behavior. , 2005, Endocrinology.

[127]  S. O’Rahilly,et al.  Monogenic obesity in humans. , 2005, Annual review of medicine.

[128]  David Carling,et al.  The AMP-activated protein kinase cascade--a unifying system for energy control. , 2004, Trends in biochemical sciences.

[129]  B. Viollet,et al.  The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity. , 2003, The Journal of clinical investigation.