Particle growth mechanisms in fluidised bed granulation—I: The effect of process variables
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Abstract Two types of product granule have been identified in an experimental study of batch fluidised bed granulation; agglomerates which consist of two or more, and usually several, initial particles; and layered granules, which consist of single primary particles with dried feed material adhering to the surface. Increasing the excess fluidising gas velocity, in the range U-U mf = 0.15-0.525 m s −1 , resulted in decreased particle growth rates and, depending upon the binder material, a change in product morphology from agglomerates to layered granules. Similar changes resulted from increasing the mean size of the starting material. Thus, a mechanism of particle growth is proposed in which the strength of inter-particle bridges and the extent of fluid drag and inertial forces on particles determine the equilibrium granule form and size. However, if the initial particles are porous this mechanism may break down since liquid may enter intra-particle pores and be unavailable for the initial formation of liquid bonds.
[1] W L Davies,et al. Batch production of pharmaceutical granulations in a fluidized bed. I. Effects of process variables on physical properties of final granulation. , 1971, Journal of pharmaceutical sciences.
[2] A. W. Nienow,et al. On atomising a liquid into a gas fluidised bed , 1982 .
[3] J. W. Loeding,et al. THE USE OF FLUIDIZED BEDS FOR THE CONTINUOUS DRYING AND CALCINATION OF DISSOLVED NITRATE SALTS , 1957 .