Antimalarial drug quality: Methods to detect suspect drugs

Malaria is a major public health problem in the endemic countries of Africa, Asia and Latin America. Poor quality antimalarials are of major, but neglected, concern in the control of Plasmodium falciparum malaria. They cause treatment failure and economic loss, and engender drug resistance and loss of confidence in health systems. The emergence of resistance to the artemisinin derivatives in Asia bodes ill for malaria control in Africa, and strenuous efforts are needed to improve the quality of the world’s supply of antimalarials. This article reviews the problem and discusses methods available to determine the quality of antimalarials.

[1]  M. Rowland,et al.  Epidemic of Plasmodium falciparum Malaria Involving Substandard Antimalarial Drugs, Pakistan, 2003 , 2009, Emerging infectious diseases.

[2]  H. Kaur,et al.  Simple Field Assays to Check Quality of Current Artemisinin-Based Antimalarial Combination Formulations , 2009, PloS one.

[3]  K. Silamut,et al.  Artemisinin resistance in Plasmodium falciparum malaria. , 2009, The New England journal of medicine.

[4]  Christina Y Hampton,et al.  A stratified random survey of the proportion of poor quality oral artesunate sold at medicine outlets in the Lao PDR – implications for therapeutic failure and drug resistance , 2009, Malaria Journal.

[5]  P. Newton,et al.  Guidelines for Field Surveys of the Quality of Medicines: A Proposal , 2009, PLoS medicine.

[6]  O. Onwujekwe,et al.  Quality of anti-malarial drugs provided by public and private healthcare providers in south-east Nigeria , 2009, Malaria Journal.

[7]  S. P. Kachur,et al.  A Nationwide Survey of the Quality of Antimalarials in Retail Outlets in Tanzania , 2008, PloS one.

[8]  C. Ricci,et al.  Assessment of hand-held Raman instrumentation for in situ screening for potentially counterfeit artesunate antimalarial tablets by FT-Raman spectroscopy and direct ionization mass spectrometry. , 2008, Analytica chimica acta.

[9]  Thomas Layloff,et al.  The use of Minilabs to improve the testing capacity of regulatory authorities in resource limited settings: Tanzanian experience. , 2008, Health policy.

[10]  C. Mace,et al.  Substandard medicines in resource‐poor settings: a problem that can no longer be ignored , 2008, Tropical medicine & international health : TM & IH.

[11]  A. Attaran,et al.  Antimalarial Drug Quality in the Most Severely Malarious Parts of Africa – A Six Country Study , 2008, PloS one.

[12]  G. Lewison,et al.  Malaria research, 1980-2004, and the burden of disease. , 2008, Acta tropica.

[13]  Christina Y Hampton,et al.  A Collaborative Epidemiological Investigation into the Criminal Fake Artesunate Trade in South East Asia , 2008, PLoS medicine.

[14]  P. Newton,et al.  Corrigendum to "Use of refractometry and colorimetry as field methods to rapidly assess antimalarial drug quality" [J. Pharm. Biomed. Anal. , 2007 .

[15]  L. Valvo,et al.  Medicines informal market in Congo, Burundi and Angola: counterfeit and sub-standard antimalarials , 2007, Malaria Journal.

[16]  Henry Nettey,et al.  Use of refractometry and colorimetry as field methods to rapidly assess antimalarial drug quality. , 2007, Journal of pharmaceutical and biomedical analysis.

[17]  J. Plaizier-Vercammen,et al.  Quality control of active ingredients in artemisinin‐derivative antimalarials within Kenya and DR Congo , 2006, Tropical medicine & international health : TM & IH.

[18]  K. A. Hall,et al.  Characterization of counterfeit artesunate antimalarial tablets from southeast Asia. , 2006, The American journal of tropical medicine and hygiene.

[19]  Paul N Newton,et al.  Counterfeit anti-infective drugs. , 2006, The Lancet. Infectious diseases.

[20]  P. Newton,et al.  Manslaughter by Fake Artesunate in Asia—Will Africa Be Next? , 2006, PLoS medicine.

[21]  R. Snow,et al.  The quality of sulphadoxine‐pyrimethamine and amodiaquine products in the Kenyan retail sector , 2005, Journal of clinical pharmacy and therapeutics.

[22]  R. Snow,et al.  Brands, costs and registration status of antimalarial drugs in the Kenyan retail sector , 2005, Malaria Journal.

[23]  R. Cody,et al.  Versatile new ion source for the analysis of materials in open air under ambient conditions. , 2005, Analytical chemistry.

[24]  R. Cooks,et al.  Mass Spectrometry Sampling Under Ambient Conditions with Desorption Electrospray Ionization , 2004, Science.

[25]  B. Sharp,et al.  Intercontinental Spread of Pyrimethamine-Resistant Malaria , 2004, Science.

[26]  R. D. Jee,et al.  Application of near-infrared spectroscopy to the determination of the sites of manufacture of proprietary products. , 2004, Journal of pharmaceutical and biomedical analysis.

[27]  L. Basco,et al.  Molecular epidemiology of malaria in Cameroon. XIX. Quality of antimalarial drugs used for self-medication. , 2004, The American journal of tropical medicine and hygiene.

[28]  G. Tomson,et al.  Evaluation of the quality of amodiaquine and sulphadoxine/pyrimethamine tablets sold by private wholesale pharmacies in Dar Es Salaam Tanzania , 2003, Journal of clinical pharmacy and therapeutics.

[29]  M. Green,et al.  Authentication of artemether, artesunate and dihydroartemisinin antimalarial tablets using a simple colorimetric method , 2001, Tropical medicine & international health : TM & IH.

[30]  Stephane Proux,et al.  Fake artesunate in southeast Asia , 2001, The Lancet.

[31]  M. Green,et al.  A colorimetric field method to assess the authenticity of drugs sold as the antimalarial artesunate. , 2000, Journal of pharmaceutical and biomedical analysis.

[32]  P. Byass,et al.  Mortality and morbidity from malaria among children in a rural area of The Gambia, West Africa. , 1987, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[33]  J. Commey,et al.  SERUM CHLOROQUINE LEVELS IN CHILDREN BEFORE TREATMENT FOR MALARIA , 1984, The Lancet.

[34]  Jianjun Liu,et al.  Competing Interests: The authors , 2006 .

[35]  J. Breman,et al.  The ears of the hippopotamus: manifestations, determinants, and estimates of the malaria burden. , 2001, The American journal of tropical medicine and hygiene.

[36]  J. Roberts,et al.  Consumption of chloroquine phosphate provided for treatment of malaria by volunteer village health workers in Saradidi, Kenya. , 1987, Annals of tropical medicine and parasitology.

[37]  M. Simons,et al.  Letter: Levamisole and lymphocyte responsiveness. , 1975, Lancet.