Relative roles of the different Pax6 domains for pancreatic alpha cell development

[1]  J. Kitz,et al.  The homeodomain of PAX6 is essential for PAX6-dependent activation of the rat glucagon gene promoter: evidence for a PH0-like binding that induces an active conformation. , 2009, Biochimica et biophysica acta.

[2]  J. Philippe,et al.  Pax6 Regulates the Proglucagon Processing Enzyme PC2 and Its Chaperone 7B2 , 2009, Molecular and Cellular Biology.

[3]  S. Saule,et al.  Relationship of Pax6 Activity Levels to the Extent of Eye Development in the Mouse, Mus musculus , 2008, Genetics.

[4]  M. Wheeler,et al.  Transcription factor expression in the developing human fetal endocrine pancreas , 2008, Diabetologia.

[5]  J. Philippe,et al.  Pax-6 and c-Maf Functionally Interact with the α-Cell-specific DNA Element G1 in Vivo to Promote Glucagon Gene Expression* , 2007, Journal of Biological Chemistry.

[6]  J. Ahnfelt-Rønne,et al.  The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice. , 2006, Journal of molecular endocrinology.

[7]  Xueying Gu,et al.  Conditional Expression of Smad7 in Pancreatic β Cells Disrupts TGF-β Signaling and Induces Reversible Diabetes Mellitus , 2006, PLoS biology.

[8]  Peter Nürnberg,et al.  Three novel Pax6 alleles in the mouse leading to the same small-eye phenotype caused by different consequences at target promoters. , 2005, Investigative ophthalmology & visual science.

[9]  O. Madsen,et al.  Genetic determinants of pancreatic epsilon-cell development. , 2005, Developmental biology.

[10]  M. Götz,et al.  Molecular dissection of Pax6 function: the specific roles of the paired domain and homeodomain in brain development , 2004, Development.

[11]  P. Gruss,et al.  Conditional inactivation of Pax6 in the pancreas causes early onset of diabetes. , 2004, Developmental biology.

[12]  O. Madsen,et al.  The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity. , 2004, Developmental biology.

[13]  L. Sussel,et al.  Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[14]  S. Theander,et al.  Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells. , 2004, Endocrinology.

[15]  Ahmed Mansouri,et al.  Opposing actions of Arx and Pax4 in endocrine pancreas development. , 2003, Genes & development.

[16]  H. Peters,et al.  Molecular characterization of Pax6(2Neu) through Pax6(10Neu): an extension of the Pax6 allelic series and the identification of two possible hypomorph alleles in the mouse Mus musculus. , 2001, Genetics.

[17]  S. Saule,et al.  Interaction of Maf Transcription Factors with Pax-6 Results in Synergistic Activation of the Glucagon Promoter* , 2001, The Journal of Biological Chemistry.

[18]  P. Gruss,et al.  Pax genes and the differentiation of hormone-producing endocrine cells in the pancreas , 2000, Mechanisms of Development.

[19]  M. German,et al.  Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. , 1997, Genes & development.

[20]  C. Desplan,et al.  Cooperative interactions between paired domain and homeodomain. , 1996, Development.

[21]  J. Caboche,et al.  Nuclear localization signals, DNA binding, and transactivation properties of quail Pax-6 (Pax-QNR) isoforms. , 1995, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[22]  M. Busslinger,et al.  DNA-binding and transactivation properties of Pax-6: three amino acids in the paired domain are responsible for the different sequence recognition of Pax-6 and BSAP (Pax-5) , 1995, Molecular and cellular biology.

[23]  N. Seidah,et al.  Electron microscopic immunocytochemical evidence for the involvement of the convertases PC1 and PC2 in the processing of proinsulin in pancreatic beta-cells. , 1995, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[24]  G. Saunders,et al.  Mouse Small eye results from mutations in a paired-like homeobox-containing gene , 1991, Nature.

[25]  P. Herrera,et al.  Genes controlling pancreas ontogeny. , 2008, The International journal of developmental biology.

[26]  S. Saule,et al.  Relationship of Pax 6 activity levels to the extent of eye development in the mouse , Mus musculus , 2008 .

[27]  C. Orvain,et al.  Transcription factors in pancreatic development. Animal models. , 2007, Endocrine development.

[28]  P Gruss,et al.  Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas. , 1997, Nature.