Contribution of astrocytes to neuropathology of neurodegenerative diseases

[1]  Stephen A. Goutman,et al.  Amyotrophic lateral sclerosis , 2022, Nature Reviews Disease Primers.

[2]  S. Elkabes,et al.  Role of astroglial toll-like receptors (TLRs) in central nervous system infections, injury and neurodegenerative diseases , 2020, Brain, Behavior, and Immunity.

[3]  H. Cao,et al.  Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease , 2020, Proceedings of the National Academy of Sciences.

[4]  C. Webber,et al.  A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders , 2020, Nature Communications.

[5]  K. Suk,et al.  Microglia Gone Awry: Linking Immunometabolism to Neurodegeneration , 2020, Frontiers in Cellular Neuroscience.

[6]  C. Troakes,et al.  The Increased Densities, But Different Distributions, of Both C3 and S100A10 Immunopositive Astrocyte-Like Cells in Alzheimer’s Disease Brains Suggest Possible Roles for Both A1 and A2 Astrocytes in the Disease Pathogenesis , 2020, Brain sciences.

[7]  M. Izrael,et al.  Rising Stars: Astrocytes as a Therapeutic Target for ALS Disease , 2020, Frontiers in Neuroscience.

[8]  Jie Zhang,et al.  A1 reactive astrocytes and a loss of TREM2 are associated with an early stage of pathology in a mouse model of cerebral amyloid angiopathy , 2020, Journal of Neuroinflammation.

[9]  S. Carmichael,et al.  Glia in neurodegeneration: Drivers of disease or along for the ride? , 2020, Neurobiology of Disease.

[10]  D. Foguel,et al.  Astrocyte glutamate transporters are increased in an early sporadic model of synucleinopathy , 2020, Neurochemistry International.

[11]  Jamie L. Marshall,et al.  Disease-associated astrocytes in Alzheimer’s disease and aging , 2020, Nature Neuroscience.

[12]  K. Fukuchi,et al.  TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease , 2020, Frontiers in Immunology.

[13]  G. Kovacs Astroglia and Tau: New Perspectives , 2020, Frontiers in Aging Neuroscience.

[14]  P. Andrés‐Benito,et al.  White matter alterations in Alzheimer’s disease without concomitant pathologies , 2020, Neuropathology and applied neurobiology.

[15]  R. Zorec,et al.  Astrocytes with TDP-43 inclusions exhibit reduced noradrenergic cAMP and Ca2+ signaling and dysregulated cell metabolism , 2020, Scientific Reports.

[16]  C. Ponting,et al.  Edinburgh Research Explorer Identification of region-specific astrocyte subtypes at single cell resolution , 2022 .

[17]  T. G. Belgard,et al.  No Longer Underappreciated: The Emerging Concept of Astrocyte Heterogeneity in Neuroscience , 2020, Brain sciences.

[18]  C. Behrends,et al.  Glia-specific autophagy dysfunction in ALS. , 2020, Seminars in cell & developmental biology.

[19]  I. Ferrer,et al.  Relevance of host tau in tau seeding and spreading in tauopathies , 2020, Brain pathology.

[20]  Craig D. Hughes,et al.  Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death , 2020, Communications Biology.

[21]  M. Okun,et al.  Diagnosis and Treatment of Parkinson Disease: A Review. , 2020, JAMA.

[22]  A. Singleton,et al.  Genetics of Parkinson's disease: An introspection of its journey towards precision medicine , 2020, Neurobiology of Disease.

[23]  Ki Duk Park,et al.  Aberrant Tonic Inhibition of Dopaminergic Neuronal Activity Causes Motor Symptoms in Animal Models of Parkinson’s Disease , 2020, Current Biology.

[24]  Vijay Kumar,et al.  Therapeutic Advances for Huntington’s Disease , 2020, Brain sciences.

[25]  Shang Gao,et al.  Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS , 2019, Nature Medicine.

[26]  K. Cheung,et al.  A small molecule transcription factor EB activator ameliorates beta‐amyloid precursor protein and Tau pathology in Alzheimer's disease models , 2019, Aging cell.

[27]  S. Wilton,et al.  ALS Genetics, Mechanisms, and Therapeutics: Where Are We Now? , 2019, Front. Neurosci..

[28]  J. Ringman,et al.  Cognitive symptoms of Alzheimer’s disease: clinical management and prevention , 2019, BMJ.

[29]  H. Kawamata,et al.  Glial mitochondrial function and dysfunction in health and neurodegeneration , 2019, Molecular and Cellular Neuroscience.

[30]  C. Escartin,et al.  Questions and (some) answers on reactive astrocytes , 2019, Glia.

[31]  Sonja W. Scholz,et al.  Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies , 2019, The Lancet Neurology.

[32]  M. Lasaga,et al.  Unraveling the β-amyloid clearance by astrocytes: Involvement of metabotropic glutamate receptor 3, sAPPα, and class-A scavenger receptor , 2019, Neurochemistry International.

[33]  E. Feldman,et al.  Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity , 2019, EBioMedicine.

[34]  James Hawrot,et al.  Modeling cell-autonomous motor neuron phenotypes in ALS using iPSCs , 2019, Neurobiology of Disease.

[35]  M. Papa,et al.  Regional brain susceptibility to neurodegeneration: what is the role of glial cells? , 2019, Neural regeneration research.

[36]  M. Heneka,et al.  Inflammasome‐mediated innate immunity in Alzheimer's disease , 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[37]  L. Buée,et al.  NLRP3 inflammasome activation drives tau pathology , 2019, Nature.

[38]  O. Hardiman,et al.  Lifetime Risk and Heritability of Amyotrophic Lateral Sclerosis. , 2019, JAMA neurology.

[39]  C. Williams-Gray,et al.  Toll-like receptors and their therapeutic potential in Parkinson’s disease and α-synucleinopathies , 2019, Brain, Behavior, and Immunity.

[40]  Benjamin R. Kummer,et al.  Associations between cerebrovascular risk factors and parkinson disease , 2019, Annals of neurology.

[41]  E. Huang,et al.  Astrocytic Tau Deposition Is Frequent in Typical and Atypical Alzheimer Disease Presentations. , 2019, Journal of neuropathology and experimental neurology.

[42]  D. D. Di Monte,et al.  Oxidative stress in vagal neurons promotes parkinsonian pathology and intercellular α-synuclein transfer. , 2019, The Journal of clinical investigation.

[43]  G. Dorn,et al.  Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration , 2019, Nature Neuroscience.

[44]  Jingli Cai,et al.  Subregional differences in astrocytes underlie selective neurodegeneration or protection in Parkinson's disease models in culture , 2019, Glia.

[45]  M. Aschner,et al.  Astrocytic Oxidative/Nitrosative Stress Contributes to Parkinson’s Disease Pathogenesis: The Dual Role of Reactive Astrocytes , 2019, Antioxidants.

[46]  J. Goldberg,et al.  α-Synuclein 2.0 — Moving towards Cell Type Specific Pathophysiology , 2019, Neuroscience.

[47]  R. Barker,et al.  Genetic analysis of Mendelian mutations in a large UK population-based Parkinson’s disease study , 2019, Brain : a journal of neurology.

[48]  J. Hodges,et al.  Neuroinflammation in frontotemporal dementia , 2019, Nature Reviews Neurology.

[49]  K. Freude,et al.  Cell Type Specific Expression of Toll-Like Receptors in Human Brains and Implications in Alzheimer's Disease , 2019, BioMed research international.

[50]  V. Kumar,et al.  Toll-like receptors in the pathogenesis of neuroinflammation , 2019, Journal of Neuroimmunology.

[51]  D. Binder,et al.  Post-translational Regulation of GLT-1 in Neurological Diseases and Its Potential as an Effective Therapeutic Target , 2019, Front. Mol. Neurosci..

[52]  B. Khakh,et al.  The Emerging Nature of Astrocyte Diversity. , 2019, Annual review of neuroscience.

[53]  Sean P. Palecek,et al.  Regionally specified human pluripotent stem cell-derived astrocytes exhibit different molecular signatures and functional properties , 2019, Development.

[54]  T. Dawson,et al.  The A1 astrocyte paradigm: New avenues for pharmacological intervention in neurodegeneration , 2019, Movement disorders : official journal of the Movement Disorder Society.

[55]  D. Foguel,et al.  α‐synuclein oligomers enhance astrocyte‐induced synapse formation through TGF‐β1 signaling in a Parkinson's disease model , 2019, Journal of neurochemistry.

[56]  E. Joe,et al.  A Parkinson's disease gene, DJ-1, regulates anti-inflammatory roles of astrocytes through prostaglandin D2 synthase expression , 2019, Neurobiology of Disease.

[57]  Huaxi Xu,et al.  Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment. , 2019, The Journal of clinical investigation.

[58]  Yang Hong,et al.  The neuroprotection of progesterone against Aβ-induced NLRP3-Caspase-1 inflammasome activation via enhancing autophagy in astrocytes. , 2019, International immunopharmacology.

[59]  Marie-Laure Arotcarena,et al.  Autophagy in Synucleinopathy: The Overwhelmed and Defective Machinery , 2019, Cells.

[60]  M. Tremblay,et al.  Inflammatory mechanisms in neurodegeneration , 2019, Journal of neurochemistry.

[61]  A. Fukuda,et al.  Diverse Actions of Astrocytes in GABAergic Signaling , 2019, International journal of molecular sciences.

[62]  I. Ferrer,et al.  Involvement of Oligodendrocytes in Tau Seeding and Spreading in Tauopathies , 2019, Front. Aging Neurosci..

[63]  S. Leng,et al.  Interferon-γ Potentiates α-Synuclein-induced Neurotoxicity Linked to Toll-like Receptors 2 and 3 and Tumor Necrosis Factor-α in Murine Astrocytes , 2019, Molecular Neurobiology.

[64]  C. Webber,et al.  RNA sequencing reveals MMP2 and TGFB1 downregulation in LRRK2 G2019S Parkinson's iPSC-derived astrocytes , 2019, Neurobiology of Disease.

[65]  J. Ávila,et al.  Extracellular Monomeric Tau Is Internalized by Astrocytes , 2019, Front. Neurosci..

[66]  J. Kessler,et al.  Neuronal apolipoprotein E4 increases cell death and phosphorylated tau release in alzheimer disease , 2019, Annals of neurology.

[67]  J. Ting,et al.  The NLRP3 inflammasome: molecular activation and regulation to therapeutics , 2019, Nature Reviews Immunology.

[68]  G. van Loo,et al.  Inflammasomes in neuroinflammatory and neurodegenerative diseases , 2019, EMBO molecular medicine.

[69]  P. Lewczuk,et al.  Advantages and disadvantages of the use of the CSF Amyloid β (Aβ) 42/40 ratio in the diagnosis of Alzheimer’s Disease , 2019, Alzheimer's Research & Therapy.

[70]  Jia-Da Li,et al.  The Roles of Post-translational Modifications on α-Synuclein in the Pathogenesis of Parkinson’s Diseases , 2019, Front. Neurosci..

[71]  Jennifer L. Agustus,et al.  Frontotemporal Dementia: A Clinical Review , 2019, Seminars in Neurology.

[72]  F. Gomes,et al.  Astrocyte Heterogeneity: Impact to Brain Aging and Disease , 2019, Front. Aging Neurosci..

[73]  V. Romanov,et al.  Protein misfolding and aggregation in neurodegenerative diseases: a review of pathogeneses, novel detection strategies, and potential therapeutics , 2019, Reviews in the neurosciences.

[74]  W. Ray,et al.  The Role of APOE4 in Disrupting the Homeostatic Functions of Astrocytes and Microglia in Aging and Alzheimer’s Disease , 2019, Front. Aging Neurosci..

[75]  I. Dewachter,et al.  Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo , 2019, Acta Neuropathologica.

[76]  A. Spada,et al.  TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunities , 2019, Neurobiology of Disease.

[77]  L. Ferraiuolo,et al.  Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS , 2019, EBioMedicine.

[78]  M. Turner,et al.  Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis , 2019, Brain : a journal of neurology.

[79]  Andrea Volterra,et al.  Astrocyte function from information processing to cognition and cognitive impairment , 2019, Nature Neuroscience.

[80]  Paul M. Levine,et al.  α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson’s disease , 2019, Proceedings of the National Academy of Sciences.

[81]  A. Consiglio,et al.  Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease , 2019, Stem cell reports.

[82]  A. Halle,et al.  Inhibition of Stat3‐mediated astrogliosis ameliorates pathology in an Alzheimer's disease model , 2019, EMBO molecular medicine.

[83]  T. Deierborg,et al.  Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response , 2018, Front. Cell. Neurosci..

[84]  Y. Hsu,et al.  Insights into GABAAergic system alteration in Huntington's disease , 2018, Royal Society Open Biology.

[85]  R. Baloh,et al.  Inflammation in ALS/FTD pathogenesis , 2018, Acta Neuropathologica.

[86]  I. Ferrer,et al.  Aging‐related tau astrogliopathy (ARTAG): not only tau phosphorylation in astrocytes , 2018, Brain pathology.

[87]  A. Alonso,et al.  Hyperphosphorylation of Tau Associates With Changes in Its Function Beyond Microtubule Stability , 2018, Front. Cell. Neurosci..

[88]  D. Holtzman,et al.  Intercellular Spread of Protein Aggregates in Neurodegenerative Disease. , 2018, Annual review of cell and developmental biology.

[89]  A. Velasco,et al.  Endocytosis and Transcytosis of Amyloid-β Peptides by Astrocytes: A Possible Mechanism for Amyloid-β Clearance in Alzheimer's Disease. , 2018, Journal of Alzheimer's disease : JAD.

[90]  E. Newcombe,et al.  Inflammation: the link between comorbidities, genetics, and Alzheimer’s disease , 2018, Journal of Neuroinflammation.

[91]  Souvarish Sarkar,et al.  Prokineticin‐2 promotes chemotaxis and alternative A2 reactivity of astrocytes , 2018, Glia.

[92]  A. Isaacs,et al.  C9orf72-mediated ALS and FTD: multiple pathways to disease , 2018, Nature Reviews Neurology.

[93]  S. Hickman,et al.  Microglia in neurodegeneration , 2018, Nature Neuroscience.

[94]  J. Dunys,et al.  Are N- and C-terminally truncated Aβ species key pathological triggers in Alzheimer's disease? , 2018, The Journal of Biological Chemistry.

[95]  C. Soto,et al.  Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases , 2018, Nature Neuroscience.

[96]  T. Dawson,et al.  Animal models of neurodegenerative diseases , 2018, Nature Neuroscience.

[97]  D. Bryder,et al.  Rapid and efficient induction of functional astrocytes from human pluripotent stem cells , 2018, Nature Methods.

[98]  Zhandong Liu,et al.  TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading , 2018, The Journal of experimental medicine.

[99]  E. Masliah,et al.  Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation , 2018, Molecular Neurodegeneration.

[100]  Robert H. Brown,et al.  Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis , 2018, Proceedings of the National Academy of Sciences.

[101]  D. Bennett,et al.  Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer’s pathology , 2018, The Journal of clinical investigation.

[102]  Sarah F. McComish,et al.  Generation of defined neural populations from pluripotent stem cells , 2018, Philosophical Transactions of the Royal Society B: Biological Sciences.

[103]  D. Hinkle,et al.  Astrocyte-specific DJ-1 overexpression protects against rotenone-induced neurotoxicity in a rat model of Parkinson's disease , 2018, Neurobiology of Disease.

[104]  H. Braak,et al.  Spreading of Tau Pathology in Sporadic Alzheimer’s Disease Along Cortico-cortical Top-Down Connections , 2018, Cerebral cortex.

[105]  R. Rao,et al.  Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH , 2018, Proceedings of the National Academy of Sciences.

[106]  T. Ciossek,et al.  Increased Oxidative Stress Exacerbates &agr;-Synuclein Aggregation In Vivo , 2018, Journal of neuropathology and experimental neurology.

[107]  Stéphanie Morin,et al.  GAT-3 Dysfunction Generates Tonic Inhibition in External Globus Pallidus Neurons in Parkinsonian Rodents. , 2018, Cell reports.

[108]  J. Cleary,et al.  All in the Family: Repeats and ALS/FTD , 2018, Trends in Neurosciences.

[109]  N. J. Allen,et al.  Astrocytes, neurons, synapses: a tripartite view on cortical circuit development , 2018, Neural Development.

[110]  Z. Mari,et al.  Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease , 2018, Nature Medicine.

[111]  I. Ferrer,et al.  Glutamate Transporter GLT1 Expression in Alzheimer Disease and Dementia With Lewy Bodies , 2018, Front. Aging Neurosci..

[112]  V. Baekelandt,et al.  Linking Neuroinflammation and Neurodegeneration in Parkinson's Disease , 2018, Journal of immunology research.

[113]  G. Forloni,et al.  Alzheimer’s Disease, Oligomers, and Inflammation , 2018, Journal of Alzheimer's disease : JAD.

[114]  G. Forloni,et al.  Alpha-synuclein oligomers impair memory through glial cell activation and via Toll-like receptor 2 , 2018, Brain, Behavior, and Immunity.

[115]  M. Suster,et al.  Astroglial DJ-1 over-expression up-regulates proteins involved in redox regulation and is neuroprotective in vivo , 2018, Redox biology.

[116]  Ben A. Barres,et al.  Normal aging induces A1-like astrocyte reactivity , 2018, Proceedings of the National Academy of Sciences.

[117]  Shin-ichi Hisanaga,et al.  Phospho-Tau Bar Code: Analysis of Phosphoisotypes of Tau and Its Application to Tauopathy , 2018, Front. Neurosci..

[118]  F. Kametani,et al.  Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease , 2018, Front. Neurosci..

[119]  K. Krishnamurthy,et al.  Astrocytes expressing ALS‐linked mutant FUS induce motor neuron death through release of tumor necrosis factor‐alpha , 2018, Glia.

[120]  J. Hardy,et al.  Alzheimer's disease , 2018, European journal of neurology.

[121]  M. Mattson,et al.  Deficiency of Toll-like receptors 2, 3 or 4 extends life expectancy in Huntington’s disease mice , 2018, Heliyon.

[122]  Hope D. Anderson,et al.  Astrocyte dysfunction in Alzheimer disease , 2017, Journal of neuroscience research.

[123]  Yue-Ming Li,et al.  The role of astrocytes in amyloid production and Alzheimer's disease , 2017, Open Biology.

[124]  M. Spillantini,et al.  Astrocytes in mouse models of tauopathies acquire early deficits and lose neurosupportive functions , 2017, Acta neuropathologica communications.

[125]  E. Galea,et al.  Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease , 2017, Glia.

[126]  M. Viitanen,et al.  PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease , 2017, Stem cell reports.

[127]  E. Masliah,et al.  ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity , 2017, Nature Communications.

[128]  Nicola J. Allen,et al.  Cell Biology of Astrocyte-Synapse Interactions , 2017, Neuron.

[129]  D. Frenkel,et al.  DJ‐1 deficiency impairs autophagy and reduces alpha‐synuclein phagocytosis by microglia , 2017, Journal of neurochemistry.

[130]  Christopher R. Sibley,et al.  A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models , 2017, Nature Communications.

[131]  Jun Liu,et al.  DJ-1 Inhibits α-Synuclein Aggregation by Regulating Chaperone-Mediated Autophagy , 2017, Front. Aging Neurosci..

[132]  Markus Glatzel,et al.  The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. , 2017, Immunity.

[133]  M. Heneka,et al.  Microglia in Alzheimer's disease. , 2017, The Journal of clinical investigation.

[134]  Z. Cai,et al.  Astrocyte and Alzheimer’s disease , 2017, Journal of Neurology.

[135]  Roy W Jones,et al.  On the path to 2025: understanding the Alzheimer’s disease continuum , 2017, Alzheimer's Research & Therapy.

[136]  I. Landrieu,et al.  Supplementary Materials for Identification of the Tau phosphorylation pattern that drives its aggregation , 2017 .

[137]  Giovanni Coppola,et al.  Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence , 2017, Neuron.

[138]  F. J. Livesey,et al.  Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways , 2018, Cell reports.

[139]  M. Fakhoury Microglia and Astrocytes in Alzheimer's Disease: Implications for Therapy , 2017, Current neuropharmacology.

[140]  C. Zurzolo,et al.  α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading , 2017, Acta Neuropathologica.

[141]  E. H. Howlett,et al.  Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage , 2017, Molecular and Cellular Neuroscience.

[142]  D. Holtzman,et al.  Glial contributions to neurodegeneration in tauopathies , 2017, Molecular Neurodegeneration.

[143]  B. Barres,et al.  Reactive Astrocytes: Production, Function, and Therapeutic Potential. , 2017, Immunity.

[144]  I. Amit,et al.  A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease , 2017, Cell.

[145]  Christopher R. Sibley,et al.  Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS , 2017, Cell reports.

[146]  O. Arancio,et al.  Reduced gliotransmitter release from astrocytes mediates tau‐induced synaptic dysfunction in cultured hippocampal neurons , 2017, Glia.

[147]  H. Lashuel,et al.  Glycation potentiates &agr;-synuclein-associated neurodegeneration in synucleinopathies , 2017, Brain : a journal of neurology.

[148]  U. Armato,et al.  Amyloid β-Exposed Human Astrocytes Overproduce Phospho-Tau and Overrelease It within Exosomes, Effects Suppressed by Calcilytic NPS 2143—Further Implications for Alzheimer's Therapy , 2017, Front. Neurosci..

[149]  Yu-ping Peng,et al.  TGF-β1 Neuroprotection via Inhibition of Microglial Activation in a Rat Model of Parkinson’s Disease , 2017, Journal of Neuroimmune Pharmacology.

[150]  D. Holtzman,et al.  Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition , 2017, Journal of Neuroscience.

[151]  C. B. Ransom,et al.  Modulation of Tonic GABA Currents by Anion Channel and Connexin Hemichannel Antagonists , 2017, Neurochemical Research.

[152]  John L. Robinson,et al.  Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases , 2017, Journal of neuropathology and experimental neurology.

[153]  M. Goedert,et al.  The Synucleinopathies: Twenty Years On , 2017, Journal of Parkinson's disease.

[154]  Sarika Singh,et al.  Astrocytes: inexplicable cells in neurodegeneration , 2017, The International journal of neuroscience.

[155]  V. Rasche,et al.  Transient IKK2 activation in astrocytes initiates selective non-cell-autonomous neurodegeneration , 2017, Molecular Neurodegeneration.

[156]  Shaomin Li,et al.  Rapamycin upregulates glutamate transporter and IL-6 expression in astrocytes in a mouse model of Parkinson's disease , 2017, Cell Death & Disease.

[157]  Manoj Kumar,et al.  INGE GRUNDKE-IQBAL AWARD FOR ALZHEIMER’S RESEARCH: NEUROTOXIC REACTIVE ASTROCYTES ARE INDUCED BY ACTIVATED MICROGLIA , 2019, Alzheimer's & Dementia.

[158]  R. J. Kelleher,et al.  Presenilin-1 mutations and Alzheimer’s disease , 2017, Proceedings of the National Academy of Sciences.

[159]  S. Akira,et al.  Toll-Like Receptor Signaling and Its Inducible Proteins , 2016, Microbiology spectrum.

[160]  Yigong Shi,et al.  Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase , 2016, Proceedings of the National Academy of Sciences.

[161]  G. Halliday,et al.  Toll-like receptor 2 is increased in neurons in Parkinson’s disease brain and may contribute to alpha-synuclein pathology , 2016, Acta Neuropathologica.

[162]  A. Ascherio,et al.  The epidemiology of Parkinson's disease: risk factors and prevention , 2016, The Lancet Neurology.

[163]  Robert H Miller,et al.  Contribution of the oligodendrocyte lineage to CNS repair and neurodegenerative pathologies , 2016, Neuropharmacology.

[164]  Akshata A Almad,et al.  Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis , 2016, Glia.

[165]  E. Joe,et al.  DJ-1 deficiency impairs glutamate uptake into astrocytes via the regulation of flotillin-1 and caveolin-1 expression , 2016, Scientific Reports.

[166]  S. Gentleman,et al.  ARTAG in the basal forebrain: widening the constellation of astrocytic tau pathology , 2016, Acta neuropathologica communications.

[167]  K. Fitzgerald,et al.  Inflammasome Complexes: Emerging Mechanisms and Effector Functions , 2016, Cell.

[168]  Timothy H Murphy,et al.  Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models , 2016, Nature Communications.

[169]  I. Dewachter,et al.  Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease , 2016, Journal of Neuroinflammation.

[170]  J. Koh,et al.  Metallothionein-3 modulates the amyloid β endocytosis of astrocytes through its effects on actin polymerization , 2015, Molecular Brain.

[171]  J. Ávila,et al.  Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo. , 2015, Journal of Alzheimer's disease : JAD.

[172]  Stephen F. Carter,et al.  Early astrocytosis in autosomal dominant Alzheimer’s disease measured in vivo by multi-tracer positron emission tomography , 2015, Scientific Reports.

[173]  K. Boylan Familial Amyotrophic Lateral Sclerosis. , 2015, Neurologic clinics.

[174]  Christine Van Broeckhoven,et al.  The genetic landscape of Alzheimer disease: clinical implications and perspectives , 2015, Genetics in Medicine.

[175]  C. Escartin,et al.  Elusive roles for reactive astrocytes in neurodegenerative diseases , 2015, Front. Cell. Neurosci..

[176]  Christian A. Ross,et al.  Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS , 2015, Nature Neuroscience.

[177]  B. Khakh,et al.  Diversity of astrocyte functions and phenotypes in neural circuits , 2015, Nature Neuroscience.

[178]  Christer Halldin,et al.  Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study , 2015, European Journal of Nuclear Medicine and Molecular Imaging.

[179]  O. Garaschuk,et al.  Neuroinflammation in Alzheimer's disease , 2015, The Lancet Neurology.

[180]  G. Forloni,et al.  The Parkinson's Disease-Related Protein DJ-1 Protects Dopaminergic Neurons in vivo and Cultured Cells from Alpha-Synuclein and 6-Hydroxydopamine Toxicity , 2014, Neurodegenerative Diseases.

[181]  Y. Bae,et al.  Glial GABA, synthesized by monoamine oxidase B, mediates tonic inhibition , 2014, The Journal of physiology.

[182]  S. Elkabes,et al.  Toll-like receptors in central nervous system injury and disease: A focus on the spinal cord , 2014, Brain, Behavior, and Immunity.

[183]  M. Hutton,et al.  Astrocytes and neuroinflammation in Alzheimer's disease. , 2014, Biochemical Society transactions.

[184]  Qingli Xiao,et al.  Enhancing Astrocytic Lysosome Biogenesis Facilitates Aβ Clearance and Attenuates Amyloid Plaque Pathogenesis , 2014, The Journal of Neuroscience.

[185]  Yong Jeong,et al.  GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease , 2014, Nature Medicine.

[186]  M. Gearing,et al.  Tonic inhibition in dentate gyrus impairs long-term potentiation and memory in an Alzhiemer’s disease model , 2014, Nature Communications.

[187]  A. Laties,et al.  Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer’s disease-linked presenilin 1 A246E mutation can be reversed with cAMP , 2014, Neuroscience.

[188]  Satoshi O. Suzuki,et al.  Extensive dysregulations of oligodendrocytic and astrocytic connexins are associated with disease progression in an amyotrophic lateral sclerosis mouse model , 2014, Journal of Neuroinflammation.

[189]  Mackenzie W. Mathis,et al.  Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS , 2014, Neuron.

[190]  L. Ferraiuolo,et al.  Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS , 2013, Proceedings of the National Academy of Sciences.

[191]  Adriano Chiò,et al.  State of play in amyotrophic lateral sclerosis genetics , 2013, Nature Neuroscience.

[192]  A. Dvorzhak,et al.  Reduced tonic inhibition in striatal output neurons from Huntington mice due to loss of astrocytic GABA release through GAT-3 , 2013, Front. Neural Circuits.

[193]  Clemens F. Kaminski,et al.  Extracellular Monomeric Tau Protein Is Sufficient to Initiate the Spread of Tau Protein Pathology* , 2013, The Journal of Biological Chemistry.

[194]  Saikat Ghosh,et al.  The Parkinson's disease-associated H50Q mutation accelerates α-Synuclein aggregation in vitro. , 2013, Biochemistry.

[195]  Xiong-hao Liu,et al.  Expression of ALS‐linked TDP‐43 mutant in astrocytes causes non‐cell‐autonomous motor neuron death in rats , 2013, The EMBO journal.

[196]  Ewout J. N. Groen,et al.  Protein aggregation in amyotrophic lateral sclerosis , 2013, Acta Neuropathologica.

[197]  T. Schäffer,et al.  Oxidative stress-induced posttranslational modifications of alpha-synuclein: Specific modification of alpha-synuclein by 4-hydroxy-2-nonenal increases dopaminergic toxicity , 2013, Molecular and Cellular Neuroscience.

[198]  D. Hinkle,et al.  DJ-1 Expression Modulates Astrocyte-Mediated Protection Against Neuronal Oxidative Stress , 2013, Journal of Molecular Neuroscience.

[199]  S. Finkbeiner,et al.  Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy , 2013, Proceedings of the National Academy of Sciences.

[200]  A. Romano,et al.  Glutamatergic alterations and mitochondrial impairment in a murine model of Alzheimer disease , 2012, Neurobiology of Aging.

[201]  D. A. Bosco,et al.  An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1 , 2012, Proceedings of the National Academy of Sciences.

[202]  Naruhiko Sahara,et al.  Propagation of Tau Pathology in a Model of Early Alzheimer's Disease , 2012, Neuron.

[203]  Ove Almkvist,et al.  Evidence for Astrocytosis in Prodromal Alzheimer Disease Provided by 11C-Deuterium-L-Deprenyl: A Multitracer PET Paradigm Combining 11C-Pittsburgh Compound B and 18F-FDG , 2012, The Journal of Nuclear Medicine.

[204]  R. Vassar,et al.  The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis , 2011, Journal of Neuroinflammation.

[205]  David Heckerman,et al.  A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD , 2011, Neuron.

[206]  Bruce L. Miller,et al.  Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS , 2011, Neuron.

[207]  L. Barbeito,et al.  Phenotypically aberrant astrocytes that promote motoneuron damage in a model of inherited amyotrophic lateral sclerosis , 2011, Proceedings of the National Academy of Sciences.

[208]  C. Lomen‐Hoerth,et al.  Clinical Phenomenology and Neuroimaging Correlates in ALS-FTD , 2011, Journal of Molecular Neuroscience.

[209]  N. Maragakis,et al.  Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo , 2011, Proceedings of the National Academy of Sciences.

[210]  J. Mendell,et al.  Astrocytes from Familial and Sporadic ALS Patients are Toxic to Motor Neurons , 2011, Nature Biotechnology.

[211]  W Noble,et al.  Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture , 2011, Cell Death and Disease.

[212]  M. Duchen,et al.  Beta-amyloid activates PARP causing astrocytic metabolic failure and neuronal death. , 2011, Brain : a journal of neurology.

[213]  S. Akira,et al.  Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. , 2011, Immunity.

[214]  D. Hinkle,et al.  DJ‐1 deficiency in astrocytes selectively enhances mitochondrial Complex I inhibitor‐induced neurotoxicity , 2011, Journal of neurochemistry.

[215]  Anne Corbett,et al.  Alzheimer's disease , 2011, The Lancet.

[216]  R. Vandenberg,et al.  Glutamate transporter variants reduce glutamate uptake in Alzheimer's disease , 2011, Neurobiology of Aging.

[217]  P. Mcgeer,et al.  Astrocytes are GABAergic cells that modulate microglial activity , 2011, Glia.

[218]  I. Mackenzie,et al.  TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia , 2010, The Lancet Neurology.

[219]  Shaun S. Sanders,et al.  Palmitoylation and function of glial glutamate transporter-1 is reduced in the YAC128 mouse model of Huntington disease , 2010, Neurobiology of Disease.

[220]  K. Pahan,et al.  Fibrillar Amyloid-β-Activated Human Astroglia Kill Primary Human Neurons via Neutral Sphingomyelinase: Implications for Alzheimer's Disease , 2010, The Journal of Neuroscience.

[221]  Jeffery N Agar,et al.  Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS , 2010, Nature Neuroscience.

[222]  M. Guillermier,et al.  In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects , 2010, Human molecular genetics.

[223]  H. Cai,et al.  Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice , 2010, Molecular Brain.

[224]  S. Akira,et al.  Pattern Recognition Receptors and Inflammation , 2010, Cell.

[225]  E. Masliah,et al.  Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies* , 2010, The Journal of Biological Chemistry.

[226]  S. Traynelis,et al.  Bestrophin-1 Encodes for the Ca2+-Activated Anion Channel in Hippocampal Astrocytes , 2009, The Journal of Neuroscience.

[227]  Valerio Embrione,et al.  A Gene Network Regulating Lysosomal Biogenesis and Function , 2009, Science.

[228]  Bradley T. Hyman,et al.  Tau pathophysiology in neurodegeneration: a tangled issue , 2009, Trends in Neurosciences.

[229]  D. Hinkle,et al.  DJ-1 knock-down in astrocytes impairs astrocyte-mediated neuroprotection against rotenone , 2009, Neurobiology of Disease.

[230]  M. Ehlers,et al.  Pruning and loss of excitatory synapses by the parkin ubiquitin ligase , 2008, Proceedings of the National Academy of Sciences.

[231]  F. Gage,et al.  Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. , 2008, Cell stem cell.

[232]  K. Eggan,et al.  Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation. , 2008, Cell stem cell.

[233]  D. Thal,et al.  Cerebral Small Vessel Disease-Induced Apolipoprotein E Leakage Is Associated With Alzheimer Disease and the Accumulation of Amyloid &bgr;-Protein in Perivascular Astrocytes , 2008, Journal of neuropathology and experimental neurology.

[234]  D. Sengelaub,et al.  Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse , 2008, Neuroscience.

[235]  L. Barbeito,et al.  Mitochondrial Dysfunction in SOD1G93A-Bearing Astrocytes Promotes Motor Neuron Degeneration: Prevention by Mitochondrial-Targeted Antioxidants , 2008, The Journal of Neuroscience.

[236]  D. Gutmann,et al.  Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis , 2008, Nature Neuroscience.

[237]  Jun Fan,et al.  DJ-1 Decreases Bax Expression through Repressing p53 Transcriptional Activity* , 2008, Journal of Biological Chemistry.

[238]  P. Emson,et al.  Glutamate Uptake is Reduced in Prefrontal Cortex in Huntington’s Disease , 2008, Neurochemical Research.

[239]  J. Trojanowski,et al.  Tau-mediated neurodegeneration in Alzheimer's disease and related disorders , 2007, Nature Reviews Neuroscience.

[240]  H. Braak,et al.  Development of α-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson’s disease , 2007, Acta Neuropathologica.

[241]  Hynek Wichterle,et al.  Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons , 2007, Nature Neuroscience.

[242]  Harald Sontheimer,et al.  Anion channels in astrocytes: Biophysics, pharmacology, and function , 2006, Glia.

[243]  D. Cleveland,et al.  ALS: A Disease of Motor Neurons and Their Nonneuronal Neighbors , 2006, Neuron.

[244]  H. Braak,et al.  Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry , 2006, Acta Neuropathologica.

[245]  R. Ravid,et al.  Toll‐like receptor 3 on adult human astrocytes triggers production of neuroprotective mediators , 2006, Glia.

[246]  J. Trojanowski,et al.  Impaired Glutamate Transport in a Mouse Model of Tau Pathology in Astrocytes , 2006, The Journal of Neuroscience.

[247]  Wenbo Zhou,et al.  DJ-1 Up-regulates Glutathione Synthesis during Oxidative Stress and Inhibits A53T α-Synuclein Toxicity* , 2005, Journal of Biological Chemistry.

[248]  Ji-Yeon Shin,et al.  Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity , 2005, The Journal of cell biology.

[249]  T. Klockgether,et al.  Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice , 2005, Journal of Neuroinflammation.

[250]  David S. Park,et al.  Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[251]  Paul H. Axelsen,et al.  The E46K Mutation in α-Synuclein Increases Amyloid Fibril Formation* , 2005, Journal of Biological Chemistry.

[252]  S. Roßner,et al.  Alzheimer's disease β‐secretase BACE1 is not a neuron‐specific enzyme , 2005 .

[253]  T. Giese,et al.  Expression and function of Toll-like receptor 3 in human astrocytes , 2004 .

[254]  Rina Bandopadhyay,et al.  The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease. , 2004, Brain : a journal of neurology.

[255]  M. Duchen,et al.  β-Amyloid Peptides Induce Mitochondrial Dysfunction and Oxidative Stress in Astrocytes and Death of Neurons through Activation of NADPH Oxidase , 2004, The Journal of Neuroscience.

[256]  Minh N. H. Nguyen,et al.  Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice , 2003, Science.

[257]  G. Bishop,et al.  Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice. , 2003, Human molecular genetics.

[258]  M. D'Andrea,et al.  Astrocytes accumulate Aβ42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains , 2003, Brain Research.

[259]  Patrizia Rizzu,et al.  Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism , 2002, Science.

[260]  R. Ravid,et al.  Broad Expression of Toll‐Like Receptors in the Human Central Nervous System , 2002, Journal of neuropathology and experimental neurology.

[261]  K. Lindenberg,et al.  Impaired glutamate transport and glutamate-glutamine cycling: downstream effects of the Huntington mutation. , 2002, Brain : a journal of neurology.

[262]  J. Rothstein,et al.  Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS) , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[263]  Robert H. Brown,et al.  Rats Expressing Human Cytosolic Copper–Zinc Superoxide Dismutase Transgenes with Amyotrophic Lateral Sclerosis: Associated Mutations Develop Motor Neuron Disease , 2001, The Journal of Neuroscience.

[264]  A. Mahal,et al.  Impaired Glutamate Uptake in the R6 Huntington's Disease Transgenic Mice , 2001, Neurobiology of Disease.

[265]  D. Butterfield,et al.  The glial glutamate transporter, GLT‐1, is oxidatively modified by 4‐hydroxy‐2‐nonenal in the Alzheimer's disease brain: the role of Aβ1–42 , 2001, Journal of neurochemistry.

[266]  V. Bigl,et al.  Neuronal and glial β‐secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology , 2001, Journal of neuroscience research.

[267]  D. Selkoe Alzheimer's disease: genes, proteins, and therapy. , 2001, Physiological reviews.

[268]  R. Veerhuis,et al.  Costimulatory Effects of Interferon-γ and Interleukin-1β or Tumor Necrosis Factor α on the Synthesis of Aβ1-40 and Aβ1-42 by Human Astrocytes , 2000, Neurobiology of Disease.

[269]  J. Trojanowski,et al.  Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. , 2000, Science.

[270]  N. Shibata,et al.  iNOS and nitrotyrosine immunoreactivity in amyotrophic lateral sclerosis , 2000, Neuroscience Letters.

[271]  E. Masliah,et al.  Abnormal Glutamate Transport Function in Mutant Amyloid Precursor Protein Transgenic Mice , 2000, Experimental Neurology.

[272]  S. Hayashi,et al.  NACP/α-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson’s disease brains , 2000, Acta Neuropathologica.

[273]  T. Komori,et al.  Tau‐positive dial Inclusions in Progressive Supranuclear Palsy, Corticobasal Degeneration and Pick's Disease , 1999, Brain pathology.

[274]  E. Ohama,et al.  Recent advances in research on neuropathological aspects of familial amyotrophic lateral sclerosis with superoxide dismutase 1 gene mutations: neuronal Lewy body-like hyaline inclusions and astrocytic hyaline inclusions. , 1999, Histology and histopathology.

[275]  S. Przedborski,et al.  Inducible Nitric Oxide Synthase Up‐Regulation in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis , 1999, Journal of neurochemistry.

[276]  H. Braak,et al.  Fleecy amyloid deposits in the internal layers of the human entorhinal cortex are comprised of N-terminal truncated fragments of Abeta. , 1999, Journal of neuropathology and experimental neurology.

[277]  Peter T. Lansbury,et al.  Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease , 1998, Nature Medicine.

[278]  R. Crowther,et al.  α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies , 1998 .

[279]  D. Borchelt,et al.  ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions , 1997, Neuron.

[280]  E. Masliah,et al.  Deficient glutamate tranport is associated with neurodegeneration in Alzheimer's disease , 1996 .

[281]  Allan I. Levey,et al.  Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo , 1996, Neuron.

[282]  N. Brecha,et al.  GAT-3, a High-Affinity GABA Plasma Membrane Transporter, Is Localized to Astrocytic Processes, and It Is Not Confined to the Vicinity of GABAergic Synapses in the Cerebral Cortex , 1996, The Journal of Neuroscience.

[283]  A Hirano,et al.  Neuropathology of ALS , 1996, Neurology.

[284]  M. Beal,et al.  Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury , 1996, Nature Genetics.

[285]  A. Levey,et al.  Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis , 1995, Annals of neurology.

[286]  D. Borchelt,et al.  An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria , 1995, Neuron.

[287]  J. Kimura,et al.  Immunocytochemical characterization of glial fibrillary tangles in Alzheimer's disease brain. , 1995, The American journal of pathology.

[288]  P. Kushner,et al.  Reactive astrocytes are widespread in the cortical gray matter of amyotrophic lateral sclerosis , 1994, Journal of neuroscience research.

[289]  Michel Goedert,et al.  Identification of two distinct synucleins from human brain , 1994, FEBS letters.

[290]  J. Haines,et al.  Genetic linkage analysis of familial amyotrophic lateral sclerosis using human chromosome 21 microsatellite DNA markers. , 1994, American journal of medical genetics.

[291]  M. Fukui,et al.  Widespread distribution of tau in the astrocytic elements of glial tumors , 1993, Acta Neuropathologica.

[292]  P. Lansbury,et al.  The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. , 1993, Biochemistry.

[293]  T. Iwaki,et al.  Hydrated autoclave pretreatment enhances tau immunoreactivity in formalin-fixed normal and Alzheimer's disease brain tissues. , 1991, Laboratory investigation; a journal of technical methods and pathology.

[294]  P. Kushner,et al.  Reactive Astrogliosis is Widespread in the Subcortical White Matter of Amyotrophic Lateral Sclerosis Brain , 1991, Journal of neuropathology and experimental neurology.

[295]  K. H. Backus,et al.  γ-Aminobutyric acid opens Cl-channels in cultured astrocytes , 1987, Brain Research.

[296]  M. Kirschner,et al.  A protein factor essential for microtubule assembly. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[297]  A. Verkhratsky,et al.  The Concept of Neuroglia. , 2019, Advances in experimental medicine and biology.

[298]  K. Yamanaka,et al.  The multi-dimensional roles of astrocytes in ALS , 2018, Neuroscience Research.

[299]  M. Nedergaard,et al.  Physiology of Astroglia. , 2018, Physiological reviews.

[300]  S. Cajal,et al.  DREAM-Dependent Activation of Astrocytes in Amyotrophic Lateral Sclerosis , 2017, Molecular Neurobiology.

[301]  C. L. Lau,et al.  SOD1 Mutations Causing Familial Amyotrophic Lateral Sclerosis Induce Toxicity in Astrocytes: Evidence for Bystander Effects in a Continuum of Astrogliosis , 2017, Neurochemical Research.

[302]  F. Biagioni,et al.  Neurons other than motor neurons in motor neuron disease. , 2017, Histology and histopathology.

[303]  Reisa A. Sperling,et al.  Alzheimer's disease , 2015, Nature Reviews Disease Primers.

[304]  P Riederer,et al.  Alterations in expression of glutamatergic transporters and receptors in sporadic Alzheimer's disease. , 2007, Journal of Alzheimer's disease : JAD.

[305]  H. Braak,et al.  Neuropathological stageing of Alzheimer-related changes , 2004, Acta Neuropathologica.

[306]  H. Braak,et al.  Amyloid β-protein (Aβ)-containing astrocytes are located preferentially near N-terminal-truncated Aβ deposits in the human entorhinal cortex , 2000, Acta Neuropathologica.