Mutations in the p53 Tumor Suppressor Gene and Early Onset Breast Cancer

Among breast cancer patients p53 gene mutation is associated with a poor prognosis. Young women with breast cancer are more likely than older women to have a poor prognosis, but whether p53 gene mutation plays a role in breast cancer in young women is not clear. This study identified 199 breast cancer patients and tested the hypothesis that p53 gene mutation was associated with early onset breast cancer. Patients with p53 gene mutations were 3-times more likely to have an early onset breast cancer (age

[1]  A. Levine,et al.  P53 is a tumor suppressor gene , 2004, Cell.

[2]  R. Elledge,et al.  The p53 tumor suppressor gene in breast cancer , 2004, Breast Cancer Research and Treatment.

[3]  W. El-Deiry,et al.  DNA replication blockade impairs p53-transactivation. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[4]  C. Deng,et al.  Roles of BRCA1 and its interacting proteins , 2000, BioEssays : news and reviews in molecular, cellular and developmental biology.

[5]  C Béroud,et al.  p53 Website and analysis of p53 gene mutations in human cancer: Forging a link between epidemiology and carcinogenesis , 2000, Human mutation.

[6]  M. Hollstein,et al.  p53 and human cancer: the first ten thousand mutations. , 2000, Advances in cancer research.

[7]  D. Page,et al.  The p53 tumor suppressor gene in ductal carcinoma in situ of the breast. , 2000, The American journal of pathology.

[8]  K. Isselbacher,et al.  Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. , 1999, Science.

[9]  P. May,et al.  Twenty years of p53 research: structural and functional aspects of the p53 protein , 1999, Oncogene.

[10]  M. Pincus,et al.  Conformational and Molecular Basis for Induction of Apoptosis by a p53 C-terminal Peptide in Human Cancer Cells* , 1999, The Journal of Biological Chemistry.

[11]  E. Berns,et al.  Is TP53 dysfunction required for BRCA1-associated carcinogenesis? , 1999, Molecular and Cellular Endocrinology.

[12]  C Caldas,et al.  Somatic mutations in the p53 gene and prognosis in breast cancer: a meta-analysis , 1999, British Journal of Cancer.

[13]  B. Ponder,et al.  Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2. , 1999, Molecular cell.

[14]  M. Kubbutat,et al.  Regulation of Mdm2-Directed Degradation by the C Terminus of p53 , 1998, Molecular and Cellular Biology.

[15]  M. Higashiyama,et al.  Mutations in exon 7 and 8 of p53 as poor prognostic factors in patients with non-small cell lung cancer , 1998, Oncogene.

[16]  D. Haber,et al.  Hereditary breast cancer. , 1998, Annual review of medicine.

[17]  Bert Vogelstein,et al.  Gatekeepers and caretakers , 1997, Nature.

[18]  A. Levine.  p53, the Cellular Gatekeeper for Growth and Division , 1997, Cell.

[19]  M. Nadji,et al.  Detection of p53 Gene Abnormality by Sequence Analysis of Archival Paraffin Tissue: A Comparison with Fresh‐frozen Specimens , 1996, Diagnostic molecular pathology : the American journal of surgical pathology, part B.

[20]  R. Walker,et al.  Breast carcinomas occurring in young women (< 35 years) are different. , 1996, British Journal of Cancer.

[21]  J. Rodriguez-Sierra,et al.  Younger women with breast carcinoma have a poorer prognosis than older women , 1996, Cancer.

[22]  J. Foekens,et al.  TP53 and MYC gene alterations independently predict poor prognosis in breast cancer patients , 1996, Genes, chromosomes & cancer.

[23]  V. Velculescu,et al.  Biological and clinical importance of the p53 tumor suppressor gene. , 1996, Clinical chemistry.

[24]  Sheila Seal,et al.  BRCA2 mutations in primary breast and ovarian cancers , 1996, Nature Genetics.

[25]  M. Skolnick,et al.  Low incidence of BRCA2 mutations in breast carcinoma and other cancers , 1996, Nature Genetics.

[26]  C. Harris,et al.  Deletions and insertions in the p53 tumor suppressor gene in human cancers: confirmation of the DNA polymerase slippage/misalignment model. , 1996, Cancer research.

[27]  G M Lenoir,et al.  Hereditary breast cancer: Pathobiology, prognosis, and BRCA1 and BRCA2 gene linkage , 1996, Cancer.

[28]  L Piana,et al.  Age as a prognostic factor in breast cancer: Relationship to pathologic and biologic features , 1995, International journal of cancer.

[29]  V. Chen,et al.  Racial disparity in the association of p53 gene alterations with breast cancer survival. , 1995, Cancer research.

[30]  John Calvin Reed,et al.  Tumor suppressor p53 is a direct transcriptional activator of the human bax gene , 1995, Cell.

[31]  M. Stratton,et al.  Breast cancer susceptibility: a complex disease unravels. , 1995, Trends in genetics : TIG.

[32]  M. Skolnick,et al.  BRCA1 mutations in primary breast and ovarian carcinomas. , 1994, Science.

[33]  Steven E. Bayer,et al.  A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. , 1994, Science.

[34]  D. Schaid,et al.  p53 gene mutations in breast cancers in midwestern US women: null as well as missense-type mutations are associated with poor prognosis. , 1994, Oncogene.

[35]  C. Harris,et al.  Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. , 1994, Cancer research.

[36]  P. Jeffrey,et al.  Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. , 1994, Science.

[37]  D. Neuberg,et al.  Relationship of patient age to pathologic features of the tumor and prognosis for patients with stage I or II breast cancer. , 1994, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[38]  Yi-Song Wang,et al.  WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. , 1994, Cancer research.

[39]  M. Stenmark-Askmalm,et al.  Cellular accumulation of p53 protein: an independent prognostic factor in stage II breast cancer. , 1994, European journal of cancer.

[40]  D. Allred,et al.  Breast cancer outcome and predictors of outcome: are there age differentials? , 1994, Journal of the National Cancer Institute. Monographs.

[41]  R. Mirimanoff,et al.  Clinical implications of the p53 tumor-suppressor gene. , 1994, The New England journal of medicine.

[42]  J. Trent,et al.  WAF1, a potential mediator of p53 tumor suppression , 1993, Cell.

[43]  C. Redmond,et al.  Breast cancer: factors associated with stage at diagnosis in black and white women. Black/White Cancer Survival Study Group. , 1993, Journal of the National Cancer Institute.

[44]  A. Levine,et al.  The p53-mdm-2 autoregulatory feedback loop. , 1993, Genes & development.

[45]  M. Stratton,et al.  Constitutional mutation in exon 8 of the p53 gene in a patient with multiple primary tumours: molecular and immunohistochemical findings. , 1993, Oncogene.

[46]  M. Oren,et al.  mdm2 expression is induced by wild type p53 activity. , 1993, The EMBO journal.

[47]  Bert Vogelstein,et al.  p53 function and dysfunction , 1992, Cell.

[48]  A. Levine,et al.  The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation , 1992, Cell.

[49]  E. Kawasaki,et al.  Accumulation of p53 tumor suppressor gene protein: an independent marker of prognosis in breast cancers. , 1992, Journal of the National Cancer Institute.

[50]  B. Vogelstein,et al.  Inherited p53 gene mutations in breast cancer. , 1992, Cancer research.

[51]  G. Thomas,et al.  p53 from basic research to clinical applications. , 1992, Critical reviews in oncogenesis.

[52]  V. Rotter,et al.  Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis , 1990, Molecular and cellular biology.

[53]  L. Strong,et al.  Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. , 1990, Science.

[54]  J. Jenkins,et al.  The p53 nuclear localisation signal is structurally linked to a p34cdc2 kinase motif. , 1990, Oncogene.

[55]  W. Blattner,et al.  A cancer family syndrome in twenty-four kindreds. , 1988, Cancer research.

[56]  I Persson,et al.  The relation between survival and age at diagnosis in breast cancer. , 1986, The New England journal of medicine.