Meningitis patients with pneumonia: correlation between blood parameters and clinical features.

Background: This research aimed to explore the possible relationship between the main experimental parameters and clinical status in meningitis patients with pneumonia infection. Methods: A retrospective analysis of the demographic characteristics, clinical features and laboratory parameters of meningitis patients was performed. Results: D-dimer, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) exhibited good diagnostic ability for meningitis complicated with pneumonia. Additionally, we observed a positive correlation between D-dimer and CRP in cases of meningitis with pneumonia infection. D-dimer, ESR and Streptococcus pneumoniae (S. pneumoniae) were independently associated with meningitis patients with pneumonia infection. Conclusion: D-dimer, CRP, ESR and S. pneumoniae infection may effectively anticipate disease progression and adverse consequences in meningitis patients with pneumonia infection.

[1]  J. Day,et al.  Treatment of Cryptococcal Meningitis: How Have We Got Here and Where are We Going? , 2022, Drugs.

[2]  Katherine L. McPherson,et al.  Inflammatory Markers in Substance Use and Mood Disorders: A Neuroimaging Perspective , 2022, Frontiers in Psychiatry.

[3]  Ling Cao,et al.  D-dimer: The Risk Factor of Children's Severe Mycoplasma Pneumoniae Pneumonia , 2022, Frontiers in Pediatrics.

[4]  Jin-lin Wu,et al.  Value of D-dimer in predicting various clinical outcomes following community-acquired pneumonia: A network meta-analysis , 2022, PloS one.

[5]  Belela Samuel Kotola,et al.  Mathematical model analysis and numerical simulation for codynamics of meningitis and pneumonia infection with intervention , 2022, Scientific Reports.

[6]  N. El-Najjar,et al.  Efficacy of Vancomycin and Meropenem in Central Nervous System Infections in Children and Adults: Current Update , 2022, Antibiotics.

[7]  Xiaoxiang Chen,et al.  Elevated Serum D-Dimer May Reflect the Presence of Gut Inflammation in Spondyloarthritis , 2022, Frontiers in Medicine.

[8]  Ming-wu Li,et al.  The epidemiology of concurrent extrapulmonary tuberculosis in inpatients with extrapulmonary tuberculosis lesions in China: a large-scale observational multi-center investigation. , 2021, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

[9]  D. Denning,et al.  Estimated burden of serious fungal infections in Togo , 2021, Mycoses.

[10]  X. Qin,et al.  D-Dimer Combined With CRP Can Improve the Differential Value of Bacterial Meningitis and Tuberculous Meningitis. , 2021, Laboratory medicine.

[11]  F. Iovino,et al.  Neuronal Damage and Neuroinflammation, a Bridge Between Bacterial Meningitis and Neurodegenerative Diseases , 2021, Frontiers in Cellular Neuroscience.

[12]  M. Marquart.  Pathogenicity and virulence of Streptococcus pneumoniae: Cutting to the chase on proteases , 2021, Virulence.

[13]  S. Katrak.  Central nervous system tuberculosis , 2020, Journal of the Neurological Sciences.

[14]  S. Dutta,et al.  C-reactive protein as a predictor of meningitis in early onset neonatal sepsis: a single unit experience , 2020, Journal of perinatal medicine.

[15]  J. Wojta.  Macrophages and Thrombin—Another Link between Inflammation and Coagulation , 2020, Thrombosis and Haemostasis.

[16]  A. van der Ende,et al.  Community-acquired pneumonia in patients with bacterial meningitis: A prospective nationwide cohort study. , 2020, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[17]  B. Hoen,et al.  Community-acquired bacterial meningitis in adults: in-hospital prognosis, long term disability and determinants of outcome in a multicentre prospective cohort. , 2020, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[18]  K. Prasad,et al.  The current global situation for tuberculous meningitis: epidemiology, diagnostics, treatment and outcomes , 2019, Wellcome open research.

[19]  Getachew Teshome Tilahun,et al.  Optimal Control Analysis of Pneumonia and Meningitis Coinfection , 2019, Comput. Math. Methods Medicine.

[20]  Richard A. Giovane,et al.  Central Nervous System Infections. , 2018, Primary care.

[21]  D. van de Beek,et al.  Update on community-acquired bacterial meningitis: guidance and challenges. , 2017, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[22]  C. Whitney,et al.  Community-acquired bacterial meningitis , 2016, Nature Reviews Disease Primers.

[23]  S. Berg,et al.  Epidemiology of invasive pneumococcal infections: manifestations, incidence and case fatality rate correlated to age, gender and risk factors , 2016, BMC Infectious Diseases.

[24]  Ryan T Novak,et al.  Population-based Surveillance for Bacterial Meningitis in China, September 2006–December 2009 , 2014, Emerging infectious diseases.

[25]  A. Sié,et al.  The Causative Pathogen Determines the Inflammatory Profile in Cerebrospinal Fluid and Outcome in Patients with Bacterial Meningitis , 2013, Mediators of inflammation.

[26]  S. Bourdoulous,et al.  Mechanisms of meningeal invasion by a bacterial extracellular pathogen, the example of Neisseria meningitidis , 2010, Progress in Neurobiology.