The cellular organization of gene expression.

[1]  Gail Sudlow,et al.  Interphase Cell Cycle Dynamics of a Late-Replicating, Heterochromatic Homogeneously Staining Region: Precise Choreography of Condensation/Decondensation and Nuclear Positioning , 1998, The Journal of cell biology.

[2]  L. Cantley,et al.  SRPK2: A Differentially Expressed SR Protein-specific Kinase Involved in Mediating the Interaction and Localization of Pre-mRNA Splicing Factors in Mammalian Cells , 1998, The Journal of cell biology.

[3]  A. Krainer,et al.  A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm. , 1998, Genes & development.

[4]  Angus I. Lamond,et al.  Spatial Organization of Large-Scale Chromatin Domains in the Nucleus: A Magnified View of Single Chromosome Territories , 1997, The Journal of cell biology.

[5]  D. Bentley,et al.  5'-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II. , 1997, Genes & development.

[6]  E. Cho,et al.  mRNA capping enzyme is recruited to the transcription complex by phosphorylation of the RNA polymerase II carboxy-terminal domain. , 1997, Genes & development.

[7]  M. Garcia-Blanco,et al.  Both phosphorylation and dephosphorylation of ASF/SF2 are required for pre-mRNA splicing in vitro. , 1997, RNA.

[8]  A. Murray,et al.  Interphase chromosomes undergo constrained diffusional motion in living cells , 1997, Current Biology.

[9]  D. Reinberg,et al.  Mammalian capping enzyme complements mutant Saccharomyces cerevisiae lacking mRNA guanylyltransferase and selectively binds the elongating form of RNA polymerase II. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[10]  J. Corden,et al.  A CTD function linking transcription to splicing. , 1997, Trends in biochemical sciences.

[11]  J. Manley,et al.  Mechanism and regulation of mRNA polyadenylation. , 1997, Genes & development.

[12]  P. Fortes,et al.  Participation of the nuclear cap binding complex in pre-mRNA 3' processing. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[13]  M. Carmo-Fonseca,et al.  The spatial distribution of human immunoglobulin genes within the nucleus: evidence for gene topography independent of cell type and transcriptional activity , 1997, Human Genetics.

[14]  R. van Driel,et al.  Nuclear distribution of transcription factors in relation to sites of transcription and RNA polymerase II. , 1997, Journal of cell science.

[15]  A. Krainer,et al.  Role of the Modular Domains of SR Proteins in Subnuclear Localization and Alternative Splicing Specificity , 1997, The Journal of cell biology.

[16]  P. Jordan,et al.  The cdk7-cyclin H-MAT1 complex associated with TFIIH is localized in coiled bodies. , 1997, Molecular biology of the cell.

[17]  Daniel Axelrod,et al.  Chromatin Dynamics in Interphase Nuclei and Its Implications for Nuclear Structure , 1997, The Journal of cell biology.

[18]  Michael R. Green,et al.  Targeting of U2AF65 to Sites of Active Splicing in the Nucleus , 1997, The Journal of cell biology.

[19]  C. Will,et al.  Protein functions in pre-mRNA splicing. , 1997, Current opinion in cell biology.

[20]  I. Stagljar,et al.  A Novel SR-Related Protein Specifically Interacts with the Carboxy-Terminal Domain (CTD) of RNA Polymerase through a Conserved Interaction Domain , 1997, Biological chemistry.

[21]  J. Greenblatt,et al.  RNA polymerase II holoenzyme and transcriptional regulation. , 1997, Current opinion in cell biology.

[22]  G. Dreyfuss,et al.  Nuclear export of proteins and RNAs. , 1997, Current opinion in cell biology.

[23]  I. Stagljar,et al.  A serine/arginine-rich nuclear matrix cyclophilin interacts with the C-terminal domain of RNA polymerase II. , 1997, Nucleic acids research.

[24]  Tom Misteli,et al.  The dynamics of a pre-mRNA splicing factor in living cells , 1997, Nature.

[25]  M. Roth,et al.  Distribution of pre-mRNA splicing factors at sites of RNA polymerase II transcription. , 1997, Genes & development.

[26]  A. Krainer,et al.  RNA splicing specificity determined by the coordinated action of RNA recognition motifs in SR proteins. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[27]  T. Misteli,et al.  Protein phosphorylation and the nuclear organization of pre-mRNA splicing. , 1997, Trends in cell biology.

[28]  S. Berget,et al.  Dynamic relocation of transcription and splicing factors dependent upon transcriptional activity , 1997, The EMBO journal.

[29]  A. Klingenhoff,et al.  Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue. , 1997, Nucleic acids research.

[30]  J. Manley,et al.  Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: creation of an SRp40-specific splicing enhancer. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[31]  P. Scherer,et al.  Syndet is a novel SNAP-25 related protein expressed in many tissues. , 1997, Journal of cell science.

[32]  A. Raap,et al.  Splicing factors associate with nuclear HCMV-IE transcripts after transcriptional activation of the gene, but dissociate upon transcription inhibition: evidence for a dynamic organization of splicing factors. , 1997, Journal of cell science.

[33]  J. Manley,et al.  Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing. , 1997, Genes & development.

[34]  M. Wickens,et al.  The C-terminal domain of RNA polymerase II couples mRNA processing to transcription , 1997, Nature.

[35]  L. Du,et al.  A Functional Interaction between the Carboxy-Terminal Domain of RNA Polymerase II and Pre-mRNA Splicing , 1997, The Journal of cell biology.

[36]  D. Bregman,et al.  Splicing Factors Associate with Hyperphosphorylated RNA Polymerase II in the Absence of Pre-mRNA , 1997, The Journal of cell biology.

[37]  D. Spector,et al.  Nuclear organization and gene expression. , 1996, Experimental cell research.

[38]  A S Belmont,et al.  In vivo localization of DNA sequences and visualization of large-scale chromatin organization using lac operator/repressor recognition , 1996, The Journal of cell biology.

[39]  O. Bensaude,et al.  The nuclear matrix protein p255 is a highly phosphorylated form of RNA polymerase II largest subunit which associates with spliceosomes. , 1996, Nucleic acids research.

[40]  A Benner,et al.  Active and inactive genes localize preferentially in the periphery of chromosome territories , 1996, The Journal of cell biology.

[41]  T. Misteli,et al.  Serine/threonine phosphatase 1 modulates the subnuclear distribution of pre-mRNA splicing factors. , 1996, Molecular biology of the cell.

[42]  M. Dahmus Reversible Phosphorylation of the C-terminal Domain of RNA Polymerase II* , 1996, The Journal of Biological Chemistry.

[43]  P. Sharp,et al.  A hyperphosphorylated form of the large subunit of RNA polymerase II is associated with splicing complexes and the nuclear matrix. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[44]  A. Yuryev,et al.  The C-terminal domain of the largest subunit of RNA polymerase II interacts with a novel set of serine/arginine-rich proteins. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[45]  J. Manley,et al.  SR proteins and splicing control. , 1996, Genes & development.

[46]  E. Manders,et al.  The RNA 3′ cleavage factors CstF 64 kDa and CPSF 100 kDa are concentrated in nuclear domains closely associated with coiled bodies and newly synthesized RNA. , 1996, The EMBO journal.

[47]  D. Jackson,et al.  Active RNA polymerases are localized within discrete transcription "factories' in human nuclei. , 1996, Journal of cell science.

[48]  L. Wieslander,et al.  Demonstration of a dynamic, transcription-dependent organization of pre- mRNA splicing factors in polytene nuclei , 1996, The Journal of cell biology.

[49]  J. LaSalle,et al.  Homologous Association of Oppositely Imprinted Chromosomal Domains , 1996, Science.

[50]  J. Tazi,et al.  Specific phosphorylation of SR proteins by mammalian DNA topoisomerase I , 1996, Nature.

[51]  D. Agard,et al.  Specific interactions of chromatin with the nuclear envelope: positional determination within the nucleus in Drosophila melanogaster. , 1996, Molecular biology of the cell.

[52]  D C Ward,et al.  Inhibition of RNA polymerase II transcription causes chromatin decondensation, loss of nucleolar structure, and dispersion of chromosomal domains. , 1996, Experimental cell research.

[53]  E. Nikolakaki,et al.  A Nuclear Envelope-associated Kinase Phosphorylates Arginine-Serine Motifs and Modulates Interactions between the Lamin B Receptor and Other Nuclear Proteins (*) , 1996, The Journal of Biological Chemistry.

[54]  T Pawson,et al.  The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution. , 1996, The EMBO journal.

[55]  R. van Driel,et al.  Nuclear domains involved in RNA synthesis, RNA processing, and replication. , 1996, Critical reviews in eukaryotic gene expression.

[56]  T. Maniatis,et al.  An amino acid sequence motif sufficient for subnuclear localization of an arginine/serine-rich splicing factor. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[57]  J. Mcneil,et al.  Nonrandom gene organization: structural arrangements of specific pre- mRNA transcription and splicing with SC-35 domains , 1995, The Journal of cell biology.

[58]  Roland Eils,et al.  Three‐dimensional distribution of centromeric or paracentromeric heterochromatin of chromosomes 1, 7, 15 and 17 in human lymphocyte nuclei studied with light microscopic axial tomography , 1995 .

[59]  Xiang-Dong Fu,et al.  The superfamily of arginine/serine-rich splicing factors. , 1995, RNA.

[60]  S. Shuman,et al.  RNA capping enzyme and DNA ligase: a superfamily of covalent nucleotidyl transferases , 1995, Molecular microbiology.

[61]  D. Bregman,et al.  Transcription-dependent redistribution of the large subunit of RNA polymerase II to discrete nuclear domains , 1995, The Journal of cell biology.

[62]  P. Park,et al.  Organization of centromeric domains in hepatocyte nuclei: rearrangement associated with de novo activation of the vitellogenin gene family in Xenopus laevis. , 1995, Experimental cell research.

[63]  A. Lamond,et al.  Dynamic organization of splicing factors in adenovirus-infected cells , 1995, Journal of virology.

[64]  I. Mattaj,et al.  The influence of 5′ and 3′ end structures on pre-mRNA metabolism , 1995, Journal of Cell Science.

[65]  G. Ast,et al.  Splicing components are excluded from the transcriptionally inactive XY body in male meiotic nuclei. , 1994, Molecular biology of the cell.

[66]  J. E. Mermoud,et al.  Regulation of mammalian spliceosome assembly by a protein phosphorylation mechanism. , 1994, The EMBO journal.

[67]  E. Wahle,et al.  Immunodetection of poly(A) binding protein II in the cell nucleus. , 1994, Experimental cell research.

[68]  J. Keene,et al.  The U1 small nuclear ribonucleoprotein (snRNP) 70K protein is transported independently of U1 snRNP particles via a nuclear localization signal in the RNA-binding domain , 1994, Molecular and cellular biology.

[69]  William Arbuthnot Sir Lane,et al.  A serine kinase regulates intracellular localization of splicing factors in the cell cycle , 1994, Nature.

[70]  A. Krainer,et al.  Mechanisms for selecting 5' splice sites in mammalian pre-mRNA splicing. , 1994, Trends in genetics : TIG.

[71]  S. Fakan,et al.  Perichromatin fibrils are in situ forms of nascent transcripts. , 1994, Trends in cell biology.

[72]  L. Wieslander,et al.  Splicing of Balbiani ring 1 gene pre-mRNA occurs simultaneously with transcription , 1994, Cell.

[73]  Michael R. Green,et al.  Localization of pre-mRNA splicing in mammalian nuclei , 1994, Nature.

[74]  J. Manley,et al.  Functional domains of the human splicing factor ASF/SF2. , 1993, The EMBO journal.

[75]  B. van Steensel,et al.  Fluorescent labeling of nascent RNA reveals transcription by RNA polymerase II in domains scattered throughout the nucleus , 1993, The Journal of cell biology.

[76]  C. Will,et al.  Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors. , 1993, Nucleic acids research.

[77]  M. Yanagida,et al.  Cell cycle-dependent specific positioning and clustering of centromeres and telomeres in fission yeast , 1993, The Journal of cell biology.

[78]  J. Tazi,et al.  Thiophosphorylation of U1-70K protein inhibits pre-mRNA splicing , 1993, Nature.

[79]  G. Dreyfuss,et al.  hnRNP proteins: localization and transport between the nucleus and the cytoplasm. , 1993, Trends in cell biology.

[80]  D. Spector,et al.  In vivo evidence that transcription and splicing are coordinated by a recruiting mechanism , 1993, Cell.

[81]  A. Greenleaf,et al.  Positive patches and negative noodles: linking RNA processing to transcription? , 1993, Trends in biochemical sciences.

[82]  M. Yanagida,et al.  A mitotic role for a novel fission yeast protein kinase dsk1 with cell cycle stage dependent phosphorylation and localization. , 1993, Molecular biology of the cell.

[83]  D. Spector,et al.  Macromolecular domains within the cell nucleus. , 1993, Annual review of cell biology.

[84]  P. Cohen,et al.  Ser/Thr-specific protein phosphatases are required for both catalytic steps of pre-mRNA splicing. , 1992, Nucleic acids research.

[85]  R. Ochs,et al.  Nuclear bodies (NBs): a newly "rediscovered" organelle. , 1992, Experimental cell research.

[86]  M B Roth,et al.  SR proteins: a conserved family of pre-mRNA splicing factors. , 1992, Genes & development.

[87]  D. Spector,et al.  Nascent pre-mRNA transcripts are associated with nuclear regions enriched in splicing factors. , 1991, Genes & development.

[88]  M B Roth,et al.  A conserved family of nuclear phosphoproteins localized to sites of polymerase II transcription , 1991, The Journal of cell biology.

[89]  P. Bingham,et al.  Arginine/serine-rich domains of the su(wa) and tra RNA processing regulators target proteins to a subnuclear compartment implicated in splicing , 1991, Cell.

[90]  M. Bartholdi,et al.  Nuclear distribution of centromeres during the cell cycle of human diploid fibroblasts. , 1991, Journal of cell science.

[91]  M. Green,et al.  Biochemical characterization of U2 snRNP auxiliary factor: an essential pre‐mRNA splicing factor with a novel intranuclear distribution. , 1991, The EMBO journal.

[92]  R. Pepperkok,et al.  Mammalian nuclei contain foci which are highly enriched in components of the pre‐mRNA splicing machinery. , 1991, The EMBO journal.

[93]  J. Manley,et al.  A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro , 1990, Cell.

[94]  Adrian R. Krainer,et al.  The essential pre-mRNA splicing factor SF2 influences 5′ splice site selection by activating proximal sites , 1990, Cell.

[95]  L. Manuelidis,et al.  Movement of the X chromosome in epilepsy. , 1988, Science.

[96]  D. Pinkel,et al.  Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[97]  Y. Osheim,et al.  Splice site selection, rate of splicing, and alternative splicing on nascent transcripts. , 1988, Genes & development.

[98]  L. Manuelidis Different central nervous system cell types display distinct and nonrandom arrangements of satellite DNA sequences. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[99]  A. Monneron,et al.  Fine structural organization of the interphase nucleus in some mammalian cells. , 1969, Journal of ultrastructure research.

[100]  Beck Js Variations in the morphological patterns of "autoimmune" nuclear fluorescence. , 1961 .

[101]  H. Swift Studies on nuclear fine structure. , 1959, Brookhaven symposia in biology.