The free hormone hypothesis. Distinction from the free hormone transport hypothesis.

I. The free hormone transport hypothesis: distinction from the free hormone hypothesis. II. The free hormone hypothesis: importance of the rate-limiting step in tissue uptake. III. Explicit consideration of multiple plasma hormone-binding proteins in transport models. IV. Diffusion barriers in transport models. V. Functions of plasma hormone-binding proteins. VI. Conclusions and areas for future investigation.

[1]  C. Mendel.  The free hormone hypothesis: a physiologically based mathematical model. , 1989, Endocrine reviews.

[2]  R. Weisiger,et al.  Uptake of oleate from albumin solutions by rat liver. Failure to detect catalysis of the dissociation of oleate from albumin by an albumin receptor. , 1987, The Journal of clinical investigation.

[3]  P. Siiteri,et al.  Conservation of free but not total or non-sex-hormone-binding-globulin-bound testosterone in serum from Nagase analbuminemic rats. , 1989, Endocrinology.

[4]  W. Sibbald,et al.  A role for corticosteroid-binding globulin in delivery of cortisol to activated neutrophils. , 1990, The Journal of clinical endocrinology and metabolism.

[5]  S. Pond,et al.  Hepatic uptake of protein-bound ligands: extended sinusoidal perfusion model. , 1991 .

[6]  R. Ekins.  Measurement of free hormones in blood. , 1990, Endocrine reviews.

[7]  C. Mendel.  Rates of dissociation of sex steroid hormones from human sex hormone-binding globulin: A reassessment , 1990, The Journal of Steroid Biochemistry and Molecular Biology.

[8]  R. Weisiger.  Dissociation from albumin: a potentially rate-limiting step in the clearance of substances by the liver. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[9]  P. Siiteri,et al.  Rates of dissociation of steroid and thyroid hormones from human serum albumin , 1990, The Journal of Steroid Biochemistry and Molecular Biology.

[10]  S. Pond,et al.  The Puzzle of Rates of Cellular Uptake of Protein-Bound Ligands , 1988 .

[11]  R. W. Kuhn,et al.  Uptake of cortisol by the perfused rat liver: validity of the free hormone hypothesis applied to cortisol. , 1989, Endocrinology.

[12]  U. Westphal,et al.  Kinetic and equilibrium studies on steroid interaction with human corticosteroid-binding globulin. , 1978, Biochemistry.

[13]  G R Wilkinson,et al.  Plasma binding and transport of diazepam across the blood-brain barrier. No evidence for in vivo enhanced dissociation. , 1989, The Journal of clinical investigation.

[14]  R. Weisiger,et al.  Uptake of 3,5,3'-triiodothyronine by the perfused rat liver: return to the free hormone hypothesis. , 1988, Endocrinology.

[15]  L. Bass,et al.  Physiologically based models and strategic experiments in hepatic pharmacology. , 1988, Biochemical pharmacology.

[16]  R. W. Kuhn,et al.  The serum transport of steroid hormones. , 1982, Recent progress in hormone research.

[17]  R. W. Kuhn,et al.  Uptake of corticosterone by the perfused rat liver. , 1991, Endocrinology.

[18]  C. Divino,et al.  Receptor-mediated uptake and internalization of transthyretin. , 1990, The Journal of biological chemistry.

[19]  C. Longcope,et al.  Steroid dynamics under steady-state conditions. , 1969, Recent progress in hormone research.

[20]  M. S. Khan,et al.  The rat hepatic corticosteroid-binding globulin receptor: distinction from the asialoglycoprotein receptor. , 1990, Endocrinology.

[21]  A. Jones,et al.  Thyroid hormone-binding proteins in plasma facilitate uniform distribution of thyroxine within tissues: a perfused rat liver study. , 1987, Endocrinology.

[22]  C. Goresky,et al.  On the uptake of materials by the intact liver. The transport and net removal of galactose. , 1973, The Journal of clinical investigation.

[23]  M. S. Khan,et al.  The control of the interaction of sex hormone-binding globulin with its receptor by steroid hormones. , 1990, The Journal of biological chemistry.

[24]  R. Weisiger,et al.  Uptake of thyroxine by the perfused rat liver: implications for the free hormone hypothesis. , 1988, The American journal of physiology.

[25]  A N Pettitt,et al.  A Bayesian analysis of capillary heterogeneity in the intact pig liver. , 1983, Biometrics.

[26]  W. Pardridge.  Plasma protein-mediated transport of steroid and thyroid hormones. , 1987, The American journal of physiology.

[27]  R. Weisiger,et al.  Thyroxine uptake by perfused rat liver. No evidence for facilitation by five different thyroxine-binding proteins. , 1990, The Journal of clinical investigation.

[28]  J. Dunn,et al.  Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma. , 1981, The Journal of clinical endocrinology and metabolism.