Hybrid mass spectrometers for tandem mass spectrometry

Mass spectrometers that use different types of analyzers for the first and second stages of mass analysis in tandem mass spectrometry (MS/MS) experiments are often referred to as “hybrid” mass spectrometers. The general goal in the design of a hybrid instrument is to combine different performance characteristics offered by various types of analyzers into one mass spectrometer. These performance characteristics may include mass resolving power, the ion kinetic energy for collision-induced dissociation, and speed of analysis. This paper provides a review of the development of hybrid instruments over the last 30 years for analytical applications.

[1]  M. Gross,et al.  Triple analyzer mass spectrometry for high resolution MS/MS studies , 1982 .

[2]  M. Senko,et al.  A two-dimensional quadrupole ion trap mass spectrometer , 2002, Journal of the American Society for Mass Spectrometry.

[3]  R. Cooks,et al.  Direct mass spectrometric mixture analysis by negative chemical ionization/mass-analyzed ion kinetic energy spectrometry , 1978 .

[4]  Scott A. Busby,et al.  Novel linear quadrupole ion trap/FT mass spectrometer: performance characterization and use in the comparative analysis of histone H3 post-translational modifications. , 2004, Journal of proteome research.

[5]  J. Futrell,et al.  Photodissociation of CH3Cl+ and CH3Br+ in a tandem quadrupole mass spectrometer , 1974 .

[6]  A. Makarov,et al.  In-series combination of a magnetic-sector mass spectrometer with a time-of-flight quadratic-field ion mirror , 1998 .

[7]  C. Enke,et al.  Mass spectrometry/mass spectrometry by time-resolved magnetic dispersion , 1983 .

[8]  K. Jennings.  Collision-induced decompositions of aromatic molecular ions , 1968 .

[9]  Liang Li,et al.  Photoinduced dissociation of electrospray-generated ions in an ion trap/time-of-flight mass spectrometer using a pulsed CO2 laser. , 2002, Rapid communications in mass spectrometry : RCM.

[10]  C. Enke,et al.  Beam deflection for temporal encoding in time-of-flight mass spectrometry , 1990, Journal of the American Society for Mass Spectrometry.

[11]  R. Williams,et al.  Quantitative measurement of deamidation in lens betaB2-crystallin and peptides by direct electrospray injection and fragmentation in a Fourier transform mass spectrometer. , 2005, Molecular vision.

[12]  C. Enke,et al.  MS/MS by time-resolved magnetic dispersion mass spectrometry , 1983 .

[13]  H. S. McKown,et al.  Improved Performance of a Tandem Quadrupole/Time-of-Flight Mass Spectrometer , 1987 .

[14]  R. L. Hunter,et al.  Coupling a quadrupole mass spectrometer and a Fourier transform mass spectrometer , 1985 .

[15]  Martin Raymond Green,et al.  A combined magnetic sector–time‐of‐flight mass spectrometer for structural determination studies by tandem mass spectrometry , 1995 .

[16]  R. Cooks,et al.  A hybrid BEQQ mass spectrometer , 1985 .

[17]  V. Wysocki,et al.  Implementation of low-energy surface-induced dissociation (eV SID) and high-energy collision-induced dissociation (keV CID) in a linear sector-TOF hybrid tandem mass spectrometer , 2001 .

[18]  Albert J R Heck,et al.  Improving the performance of a quadrupole time-of-flight instrument for macromolecular mass spectrometry. , 2006, Analytical chemistry.

[19]  Dual linear ion trap/orthogonal acceleration time-of-flight mass spectrometer with improved precursor ion selectivity. , 2005, Rapid communications in mass spectrometry : RCM.

[20]  G. Glish,et al.  High-resolution detection of daughter ions with a hybrid mass spectrometer , 1986 .

[21]  R. Cotter,et al.  A quadrupole ion trap/time-of-flight mass spectrometer with a parabolic reflectron. , 1998, Journal of mass spectrometry : JMS.

[22]  R. Cooks,et al.  Identification of individual steroids in biological matrices by mass-analyzed ion kinetic energy spectrometry. , 1979, Analytical biochemistry.

[23]  R. Cooks,et al.  Charge exchange using a double quadrupole mass spectrometer , 1980 .

[24]  C. Enke,et al.  Complete mass spectrometry/mass spectrometry data field acquisition on the chromatographic time scale by time-resolved ion momentum spectrometry with time-array detection. , 1990, Analytical chemistry.

[25]  R. Cooks,et al.  Mapping of cocaine and cinnamoylcocaine in whole coca plant tissues by MIKES , 1979 .

[26]  R. Cooks,et al.  Identification of barbiturates by chemical ionization and mass-analyzed ion kinetic energy spectrometry. , 1977, Analytical chemistry.

[27]  J. Beynon,et al.  Design and Performance of a Mass-analyzed Ion Kinetic Energy (MIKE) Spectrometer , 1973 .

[28]  J. Futrell,et al.  Tandem Mass Spectrometer for Study of Ion‐Molecule Reactions , 1966 .

[29]  W. E. Reynolds,et al.  Recent improvements in and analytical applications of advanced ion trap technology , 1984 .

[30]  J. Perlaux,et al.  Modification d'un spectromètre de masse à géométrie inversée et applications à l'étude de processus collisionnels , 2010 .

[31]  R. Cooks,et al.  A sector/ion trap hybrid mass spectrometer of BE/trap configuration , 1990 .

[32]  J. Holland,et al.  Time-of-flight space and energy focusing examined in time-resolved ion momentum spectrometry , 1986 .

[33]  A. Burlingame,et al.  Peptide sequence determination by matrix-assisted laser desorption ionization employing a tandem double focusing magnetic—Orthogonal acceleration time-of-flight mass spectrometer , 1996, Journal of the American Society for Mass Spectrometry.

[34]  N. Nibbering,et al.  Fourier-transform ion cyclotron resonance , 1985 .

[35]  W. Gabryelski,et al.  Photo-induced dissociation of electrospray generated ions in an ion trap/time-of-flight mass spectrometer , 1999 .

[36]  Christoph H Borchers,et al.  Combined top-down and bottom-up proteomics identifies a phosphorylation site in stem-loop-binding proteins that contributes to high-affinity RNA binding. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[37]  G. Glish,et al.  Tandem quadrupole/time-of-flight instrument for mass spectrometry/mass spectrometry , 1984 .

[38]  P. J. Todd,et al.  Collisional activation and metastable ion characteristics. 73. High-resolution tandem mass spectrometer (MS/MS) of increased sensitivity and mass range , 1980 .

[39]  C. Enke,et al.  Design, construction, and evaluation of an integrating transient recorder for data acquisition in capillary gas chromatography/time-of-flight mass spectrometry , 1991 .

[40]  A. Makarov,et al.  Performance evaluation of a hybrid linear ion trap/orbitrap mass spectrometer. , 2006, Analytical chemistry.

[41]  R. Cooks,et al.  Multiple reaction monitoring in mass spectrometry/mass spectrometry for direct analysis of complex mixtures , 1978 .

[42]  J. Hager.  Performance optimization and fringing field modifications of a 24‐mm long RF‐only quadrupole mass spectrometer , 1999 .

[43]  David H. Smith,et al.  THE DESIGN AND PERFORMANCE EVALUATION OF A NEW HIGH-PERFORMANCE MASS-ANALYZED ION KINETIC ENERGY (MIKE) SPECTROMETER , 1980 .

[44]  R. P. Morgan,et al.  The MM-ZAB-2F double-focussing mass spectrometer and mike spectrometer , 1978 .

[45]  Makarov,et al.  Electrostatic axially harmonic orbital trapping: a high-performance technique of mass analysis , 2000, Analytical chemistry.

[46]  Jennifer M. Campbell,et al.  A new linear ion trap time‐of‐flight system with tandem mass spectrometry capabilities , 1998 .

[47]  Electrospray ionization-Fourier transform ion cyclotron mass spectrometry using ion preselection and external accumulation for ultrahigh sensitivity , 2001, Journal of the American Society for Mass Spectrometry.

[48]  F. McLafferty.  Tandem mass spectrometry (MS/MS): a promising new analytical technique for specific component determination in complex mixtures , 1980 .

[49]  A new hybrid electrospray Fourier transform mass spectrometer: design and performance characteristics. , 2006, Rapid communications in mass spectrometry : RCM.

[50]  Y. Hashimoto,et al.  Orthogonal trap time-of-flight mass spectrometer using a collisional damping chamber. , 2005, Rapid communications in mass spectrometry : RCM.

[51]  R G Cooks,et al.  Alkaloids in Whole Plant Material: Direct Analysis by Kinetic Energy Spectrometry , 1978, Science.

[52]  Heewon Lee,et al.  Mass‐selective analysis of ions in time‐of‐flight mass spectrometry using an ion‐trap storage device , 1994 .

[53]  R. Cooks,et al.  Mixture analysis by mass-analyzed ion kinetic energy spectrometry , 1976 .

[54]  R. Cooks,et al.  Direct analysis of mixtures by double quadrupole mass spectrometry , 1980 .

[55]  R. Cooks,et al.  A new “hybrid” sector/quadrupole mass spectrometer for mass spectrometry/mass spectrometry , 1982 .

[56]  P. H. Hemberger,et al.  Functional group screening of complex mixtures with a double quadrupole mass spectrometer , 1980 .

[57]  Bruce Hewitt Newcome,et al.  Mass Spectrometry on the Chromatographic Time Scale: Realistic Expectations , 1983 .

[58]  J. Holland,et al.  Post-sector beam deflection in time-resolved ion momentum spectrometry (trims) , 1988 .

[59]  L. K. Bertram,et al.  Design and performance of a hybrid mass spectrometer of QEB geometry , 1986 .

[60]  R. Cooks,et al.  Angle-resolved mass spectrometry , 1979 .

[61]  James W. Hager,et al.  A new linear ion trap mass spectrometer , 2002 .

[62]  R. Cooks,et al.  A double quadrupole for mass spectrometry/mass spectrometry , 1980 .

[63]  R. Cooks,et al.  A tandem quadrupole-ion trap mass spectrometer , 1991 .

[64]  J. Yates,et al.  Tandem quadrupole Fourier-transform mass spectrometry of oligopeptides and small proteins. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[65]  Rachel L Martin,et al.  Analysis of high mass peptides using a novel matrix-assisted laser desorption/ionisation quadrupole ion trap time-of-flight mass spectrometer. , 2003, Rapid communications in mass spectrometry : RCM.

[66]  R. L. Hunter,et al.  Tandem-quadrupole Fourier transform mass spectrometry of oligopeptides , 1985 .

[67]  F. McLafferty,et al.  Separation/identification system for complex mixtures using mass separation and mass spectral characterization , 1978 .

[68]  Christie G. Enke,et al.  Selected Ion Fragmentation with a Tandem Quadrupole Mass Spectrometer. , 1978 .

[69]  Alexander Makarov,et al.  Dynamic range of mass accuracy in LTQ orbitrap hybrid mass spectrometer , 2006, Journal of the American Society for Mass Spectrometry.

[70]  R. Cooks,et al.  Direct Analysis of Mixtures by Mass Spectrometry , 1978 .

[71]  R. Cooks,et al.  Angle resolved mass spectrometry with a reversed geometry spectrometer , 1980 .

[72]  J. D. Morrison,et al.  A mass spectrometer for the study of laser-induced photodissociation of ions , 1978 .

[73]  R. Cooks,et al.  SELECTED FRAGMENT SCANS OF MASS SPECTROMETERS IN DIRECT MIXTURE ANALYSIS , 1979 .

[74]  A. Marshall,et al.  Fourier Transform Ion Cyclotron Resonance Spectroscopy , 1974 .

[75]  D. Lubman,et al.  An ion trap storage/time-of-flight mass spectrometer , 1992 .

[76]  Jay P. Charlebois,et al.  Construction of a hybrid quadrupole/fourier transform ion cyclotron resonance mass spectrometer for versatile MS/MS above 10 kDa , 2004, Journal of the American Society for Mass Spectrometry.

[77]  W. Goux,et al.  Relative quantification of tau-related peptides using guanidino-labeling derivatization (GLaD) with online-LC on a hybrid ion trap (IT) time-of-flight (ToF) mass spectrometer , 2007, Journal of the American Society for Mass Spectrometry.

[78]  J. Watson,et al.  New time‐of‐flight mass spectrometer for improved mass resolution, versatility, and mass spectrometry/mass spectrometry studies , 1986 .

[79]  P. H. Hemberger,et al.  Ion structure determinations and ion—molecule reactions by double quadrupole mass spectrometry , 1980 .

[80]  J. Beynon,et al.  Scanning of sector mass spectrometers to observe the fragmentations of metastable ions , 1977 .