GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence

[1]  T. Spector,et al.  Heritability of Raynaud's phenomenon and vascular responsiveness to cold: a study of adult female twins. , 2007, Arthritis and rheumatism.

[2]  R. Coggeshall,et al.  Blocking Caspase Activity Prevents Transsynaptic Neuronal Apoptosis and the Loss of Inhibition in Lamina II of the Dorsal Horn after Peripheral Nerve Injury , 2005, The Journal of Neuroscience.

[3]  Roger B. Fillingim,et al.  Cluster analysis of multiple experimental pain modalities , 2005, Pain.

[4]  S. Snyder,et al.  S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding , 2005, Nature Cell Biology.

[5]  S. McMahon,et al.  Role of the Immune system in chronic pain , 2005, Nature Reviews Neuroscience.

[6]  D. Singer,et al.  Long-Term Outcomes of Surgical and Nonsurgical Management of Lumbar Spinal Stenosis: 8 to 10 Year Results from the Maine Lumbar Spine Study , 2005, Spine.

[7]  D. Singer,et al.  Long-Term Outcomes of Surgical and Nonsurgical Management of Sciatica Secondary to a Lumbar Disc Herniation: 10 Year Results from the Maine Lumbar Spine Study , 2005, Spine.

[8]  S. Bressman,et al.  High mutation rate in dopa-responsive dystonia: Detection with comprehensive GCHI screening , 2005, Neurology.

[9]  M. Tsuda,et al.  Neuropathic pain and spinal microglia: a big problem from molecules in ‘small’ glia , 2005, Trends in Neurosciences.

[10]  J. Rosenberg,et al.  From acute to chronic pain after laparoscopic cholecystectomy: A prospective follow-up analysis , 2005, Scandinavian journal of gastroenterology.

[11]  W. Maixner,et al.  Genetic basis for individual variations in pain perception and the development of a chronic pain condition. , 2005, Human molecular genetics.

[12]  J. Boorman,et al.  Voltage-gated sodium channels and pain pathways. , 2004, Journal of neurobiology.

[13]  S. Gross,et al.  The Mechanism of Potent GTP Cyclohydrolase I Inhibition by 2,4-Diamino-6-hydroxypyrimidine , 2004, Journal of Biological Chemistry.

[14]  Tim D Spector,et al.  Structural, psychological, and genetic influences on low back and neck pain: a study of adult female twins. , 2004, Arthritis and rheumatism.

[15]  F. Hofmann,et al.  Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[16]  C. Woolf,et al.  Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn , 2003, Molecular and Cellular Neuroscience.

[17]  K. Hsu,et al.  cGMP/protein kinase G-dependent potentiation of glutamatergic transmission induced by nitric oxide in immature rat rostral ventrolateral medulla neurons in vitro. , 2003, Molecular pharmacology.

[18]  Philip S. Portoghese,et al.  Antidepressant-Like Effects of κ-Opioid Receptor Antagonists in the Forced Swim Test in Rats , 2003, Journal of Pharmacology and Experimental Therapeutics.

[19]  Elissa J. Chesler,et al.  The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[20]  Joshua A. Bueller,et al.  COMT val158met Genotype Affects µ-Opioid Neurotransmitter Responses to a Pain Stressor , 2003, Science.

[21]  Andreas Bracher,et al.  Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I. , 2003, Journal of molecular biology.

[22]  Michael Costigan,et al.  Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury. , 2002, BMC Neuroscience.

[23]  M. Ueffing,et al.  Glial cell line‐derived neurotrophic factor up‐regulates GTP‐cyclohydrolase I activity and tetrahydrobiopterin levels in primary dopaminergic neurones , 2002, Journal of neurochemistry.

[24]  Hiroshi Baba,et al.  Partial Peripheral Nerve Injury Promotes a Selective Loss of GABAergic Inhibition in the Superficial Dorsal Horn of the Spinal Cord , 2002, The Journal of Neuroscience.

[25]  G. Gebhart,et al.  Chronic pain and medullary descending facilitation , 2002, Trends in Neurosciences.

[26]  Peter H. Westfall,et al.  Testing Association of Statistically Inferred Haplotypes with Discrete and Continuous Traits in Samples of Unrelated Individuals , 2002, Human Heredity.

[27]  T. Hakoshima,et al.  Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[28]  M. Shimoji,et al.  Characterization of GTP cyclohydrolase I gene expression in the human neuroblastoma SKN‐BE(2)M17: enhanced transcription in response to cAMP is conferred by the proximal promoter , 2001, Journal of neurochemistry.

[29]  N. Blau,et al.  Mutations in the sepiapterin reductase gene cause a novel tetrahydrobiopterin-dependent monoamine-neurotransmitter deficiency without hyperphenylalaninemia. , 2001, American journal of human genetics.

[30]  W D Willis,et al.  Role of Neurotransmitters in Sensitization of Pain Responses , 2001, Annals of the New York Academy of Sciences.

[31]  Jacob Rosenberg,et al.  Characteristics and prediction of early pain after laparoscopic cholecystectomy , 2001, Pain.

[32]  O. Hwang,et al.  Tetrahydrobiopterin is released from and causes preferential death of catecholaminergic cells by oxidative stress. , 2000, Molecular pharmacology.

[33]  C. Woolf,et al.  Spared nerve injury: an animal model of persistent peripheral neuropathic pain , 2000, Pain.

[34]  N. Blau,et al.  Tetrahydrobiopterin biosynthesis, regeneration and functions. , 2000, The Biochemical journal.

[35]  辻野 宏明.  Activating transcription factor 3 (ATF 3) induction by axotomy in sensory and motoneurons : a novel neuronal marker of nerve injury , 2000 .

[36]  G. Kapatos,et al.  Identification and Characterization of Basal and Cyclic AMP Response Elements in the Promoter of the Rat GTP Cyclohydrolase I Gene* , 2000, The Journal of Biological Chemistry.

[37]  Atsushi Tokunaga,et al.  Activating Transcription Factor 3 (ATF3) Induction by Axotomy in Sensory and Motoneurons: A Novel Neuronal Marker of Nerve Injury , 2000, Molecular and Cellular Neuroscience.

[38]  C. Woolf,et al.  Transcriptional and posttranslational plasticity and the generation of inflammatory pain. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[39]  M. Salter,et al.  Src, a molecular switch governing gain control of synaptic transmission mediated by N-methyl-D-aspartate receptors. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[40]  G. Elmer,et al.  Heritability of nociception I: Responses of 11 inbred mouse strains on 12 measures of nociception , 1999, Pain.

[41]  E. Walters,et al.  Cyclic GMP pathway is critical for inducing long–term sensitization of nociceptive sensory neurons , 1999, Nature Neuroscience.

[42]  S. Werner,et al.  Induction of inducible nitric oxide synthase and its corresponding tetrahydrobiopterin-cofactor-synthesizing enzyme GTP-cyclohydrolase I during cutaneous wound repair. , 1998, The Journal of investigative dermatology.

[43]  E. Kremmer,et al.  Phosphorylation of GTP Cyclohydrolase I and Modulation of Its Activity in Rodent Mast Cells , 1998, The Journal of Biological Chemistry.

[44]  S. Gross,et al.  GTP Cyclohydrolase I Inhibition by the Prototypic Inhibitor 2,4-Diamino-6-Hydroxypyrimidine , 1998, The Journal of Biological Chemistry.

[45]  M. Segal,et al.  Nitric oxide-related species inhibit evoked neurotransmission but enhance spontaneous miniature synaptic currents in central neuronal cultures. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[46]  R. Deyo,et al.  The Maine Lumbar Spine Study, Part II: 1‐Year Outcomes of Surgical and Nonsurgical Management of Sciatica , 1996, Spine.

[47]  R. Deyo,et al.  The Maine Lumbar Spine Study, Part I: Background and Concepts , 1996, Spine.

[48]  T. Masaki,et al.  Stimulating effect of 6R-tetrahydrobiopterin on Ca2+ channels in neurons of rat dorsal motor nucleus of the vagus. , 1996, Biochemical and biophysical research communications.

[49]  S. Tsuji,et al.  Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene , 1994, Nature Genetics.

[50]  Y. Watanabe,et al.  Dopamine‐Releasing Action of 6R‐l‐erythro‐Tetrahydrobiopterin: Analysis of Its Action Site Using Sepiapterin , 1994, Journal of neurochemistry.

[51]  Joseph Loscalzo,et al.  A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds , 1993, Nature.

[52]  C. Woolf.  Evidence for a central component of post-injury pain hypersensitivity , 1983, Nature.

[53]  S. Milstien,et al.  Tetrahydro-sepiapterin is an intermediate in tetrahydrobiopterin biosynthesis. , 1983, Biochemical and biophysical research communications.