Objectives: The objective of the study is to incorporate the nanostructured silver vanadate (AgVO3) decorated with silver nanoparticles at endodontic sealers AH Plus, Sealapex, Sealer 26, and Endofill, at concentrations of 2.5%, 5%, and 10%, and to evaluate physical-chemical properties. Materials and Methods: The study was to evaluate the radiopacity using digital radiography (n = 5), the tooth color change in 48 incisors (n = 3) for 7, 30, 90, and 180 days in a spectrophotometer, and the topographic distribution in a confocal laser (n = 5). The radiopacity was analyzed by Kruskal–Wallis test and the permutation (α = 0.05) and the color and topographical distribution by descriptive statistical analysis. Results: The AgVO3 had no effect on the radiopacity of Endofill and Sealapex (P > 0.05) and at 2.5% concentrations increased the radiopacity of Sealer 26 and AH Plus (P < 0.05). The Endofill 10% showed less color change, and the major changes were the modified groups in 180 days. The AgVO3 showed a circular topographic distribution in areas of the sealers. Conclusion: It was found that the addition of AgVO3 did not affect the radiopacity of Endofill and Sealapex however, increased the radipacity of Sealer 26 and AH Plus. For modified groups, the greatest color change was promoted after 180 days, except for Endofill with 10%. Topographic distribution of nanomaterial affected the color change of theevaluated sealers.