Reticulons promote formation of ER-derived double-membrane vesicles that facilitate SARS-CoV-2 replication

SARS-CoV-2 is the etiologic agent of COVID-19. Understanding how SARS-CoV-2 exploits host factors to replicate its genome is of great importance. Here, the authors demonstrate that two ER membrane proteins, RTN3 and RTN4, are hijacked by SARS-CoV-2 to help promote the formation of virally induced double-membrane vesicles that are critical for efficient viral genome replication.

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