Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies
暂无分享,去创建一个
[1] B. Fischer. Lessons Learned. , 2016, Schizophrenia bulletin.
[2] F. Tiberg,et al. Octreotide s.c. depot provides sustained octreotide bioavailability and similar IGF-1 suppression to octreotide LAR in healthy volunteers , 2015, British journal of clinical pharmacology.
[3] George A. Calin,et al. RNAi Therapies: Drugging the Undruggable , 2014, Science Translational Medicine.
[4] Gang Zheng,et al. Investigating the impact of nanoparticle size on active and passive tumor targeting efficiency. , 2014, ACS nano.
[5] E. Takai,et al. Arginine and lysine reduce the high viscosity of serum albumin solutions for pharmaceutical injection. , 2014, Journal of bioscience and bioengineering.
[6] F. Tiberg,et al. Octreotide fluid crystal provides sustained octreotide bioavailability and similar IGF1 suppression to that of octreotide LAR (Sandostatin LAR): randomized, open-label, Phase I, repeat-dose study in healthy volunteers , 2014 .
[7] Norman J Wagner,et al. Observation of small cluster formation in concentrated monoclonal antibody solutions and its implications to solution viscosity. , 2014, Biophysical journal.
[8] David J Brayden,et al. The role of citric acid in oral peptide and protein formulations: relationship between calcium chelation and proteolysis inhibition. , 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
[9] M. Álvarez,et al. Estudio observacional de infusión subcutánea continua de insulina a lo largo de 7 años en el tratamiento de la diabetes mellitus tipo 1 , 2014 .
[10] Tim R. Dargaville,et al. Controlling microencapsulation and release of micronized proteins using poly(ethylene glycol) and electrospraying. , 2014, European journal of pharmaceutics and biopharmaceutics.
[11] Panagiota Papargyri,et al. An observational 7-year study of continuous subcutaneous insulin infusion for the treatment of type 1 diabetes mellitus. , 2014, Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion.
[12] Jonathan M. Brunger,et al. Scaffold-mediated lentiviral transduction for functional tissue engineering of cartilage , 2014, Proceedings of the National Academy of Sciences.
[13] M. R. Sherman,et al. Selectivity of binding of PEGs and PEG-like oligomers to anti-PEG antibodies induced by methoxyPEG-proteins. , 2014, Molecular Immunology.
[14] Xiaoyang Xu,et al. Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. , 2014, Advanced drug delivery reviews.
[15] John Hardy,et al. Antiamyloid therapy for Alzheimer's disease--are we on the right road? , 2014, The New England journal of medicine.
[16] S. Mitragotri,et al. Topical delivery of hyaluronic acid into skin using SPACE-peptide carriers. , 2014, Journal of controlled release : official journal of the Controlled Release Society.
[17] Anirvan Ghosh,et al. Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle , 2014, Neuron.
[18] Chun-Xia Zhao,et al. Nanoparticle vaccines. , 2014, Vaccine.
[19] H. Gram,et al. Pharmacokinetics, biocompatibility and bioavailability of a controlled release monoclonal antibody formulation. , 2013, Journal of controlled release : official journal of the Controlled Release Society.
[20] S. Mitragotri,et al. Mucoadhesive intestinal devices for oral delivery of salmon calcitonin. , 2013, Journal of controlled release : official journal of the Controlled Release Society.
[21] D. Holtzman,et al. Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo , 2013, Neuron.
[22] J. Lachowicz,et al. Abstract P6-11-05: ANG4043, a brain-penetrant anti-HER2 mAb increases survival in mice bearing intracranial BT-474 breast tumor cells , 2013 .
[23] J. Dumont,et al. Phase 3 study of recombinant factor IX Fc fusion protein in hemophilia B. , 2013, The New England journal of medicine.
[24] S. Mitragotri,et al. A permeation enhancer for increasing transport of therapeutic macromolecules across the intestine. , 2013, Journal of controlled release : official journal of the Controlled Release Society.
[25] Leslie R Evans,et al. Albumin as a versatile platform for drug half-life extension. , 2013, Biochimica et biophysica acta.
[26] R. Komotar,et al. The role of Gliadel wafers in the treatment of high-grade gliomas , 2013, Expert review of anticancer therapy.
[27] A. Chilkoti,et al. A depot-forming glucagon-like peptide-1 fusion protein reduces blood glucose for five days with a single injection. , 2013, Journal of controlled release : official journal of the Controlled Release Society.
[28] R. Langer,et al. Transepithelial Transport of Fc-Targeted Nanoparticles by the Neonatal Fc Receptor for Oral Delivery , 2013, Science Translational Medicine.
[29] David Goldstein,et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. , 2013, The New England journal of medicine.
[30] A. Mikos,et al. Effect of temporally patterned TNF-α delivery on in vitro osteogenic differentiation of mesenchymal stem cells cultured on biodegradable polymer scaffolds , 2013, Journal of biomaterials science. Polymer edition.
[31] S. Jon,et al. Oral delivery of an anti-diabetic peptide drug via conjugation and complexation with low molecular weight chitosan. , 2013, Journal of controlled release : official journal of the Controlled Release Society.
[32] D. Spector,et al. Receptor-mediated delivery of engineered nucleases for genome modification , 2013, Nucleic acids research.
[33] L. Vassilev,et al. Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy , 2013, Proceedings of the National Academy of Sciences.
[34] F. Sonntag,et al. A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture. , 2013, Lab on a chip.
[35] R. Haag,et al. Surfactant free preparation of biodegradable dendritic polyglycerol nanogels by inverse nanoprecipitation for encapsulation and release of pharmaceutical biomacromolecules. , 2013, Journal of controlled release : official journal of the Controlled Release Society.
[36] K. Scearce-Levie,et al. A Therapeutic Antibody Targeting Bace1 Inhibits Amyloid-beta Production in Vivo , 2013 .
[37] T. Patapoff,et al. Trehalose limits BSA aggregation in spray-dried formulations at high temperatures: implications in preparing polymer implants for long-term protein delivery. , 2013, Journal of pharmaceutical sciences.
[38] G. Coukos,et al. Chemoimmunotherapy Using Pegylated Liposomal Doxorubicin and Interleukin-18 in Recurrent Ovarian Cancer: A Phase I Dose-Escalation Study , 2013, Cancer Immunology Research.
[39] P. Wertz,et al. Current Understanding of Skin Biology Pertinent to Skin Penetration: Skin Biochemistry , 2013, Skin Pharmacology and Physiology.
[40] S. Mitragotri. Engineering Approaches to Transdermal Drug Delivery: A Tribute to Contributions of Prof. Robert Langer , 2013, Skin Pharmacology and Physiology.
[41] K. Scearce-Levie,et al. Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier , 2013, Science Translational Medicine.
[42] W. Pardridge,et al. Pharmacokinetics and brain uptake in the rhesus monkey of a fusion protein of arylsulfatase a and a monoclonal antibody against the human insulin receptor , 2013, Biotechnology and bioengineering.
[43] S. S. Matthews,et al. Impact of site-specific PEGylation on the conformational stability and folding rate of the Pin WW domain depends strongly on PEG oligomer length. , 2013, Bioconjugate chemistry.
[44] T. Bailey,et al. A Long-Acting Human Growth Hormone With Delayed Clearance (VRS-317): Results of a Double-Blind, Placebo-Controlled, Single Ascending Dose Study in Growth Hormone–Deficient Adults , 2013, The Journal of clinical endocrinology and metabolism.
[45] E. Arbit,et al. Glucose-Reducing Effect of the ORMD-0801 Oral Insulin Preparation in Patients with Uncontrolled Type 1 Diabetes: A Pilot Study , 2013, PloS one.
[46] C. Harrison. Deal watch: Chiasma and Roche partner in oral peptide drug delivery , 2013, Nature reviews. Drug discovery.
[47] S. Schulte. Innovative coagulation factors: albumin fusion technology and recombinant single-chain factor VIII. , 2013, Thrombosis research.
[48] G. Pasut,et al. Conjugation of hyaluronan to proteins. , 2013, Carbohydrate polymers.
[49] A. Göpferich,et al. Protein-polyanion interactions for the controlled release of monoclonal antibodies. , 2013, Biomacromolecules.
[50] W. Banks,et al. Conjugates of superoxide dismutase 1 with amphiphilic poly(2-oxazoline) block copolymers for enhanced brain delivery: synthesis, characterization and evaluation in vitro and in vivo. , 2013, Molecular pharmaceutics.
[51] Krishnendu Roy,et al. Micro and Nanoparticle‐Based Delivery Systems for Vaccine Immunotherapy: An Immunological and Materials Perspective , 2013, Advanced healthcare materials.
[52] Laurent Ducry,et al. Antibody-Drug Conjugates , 2013, Methods in Molecular Biology.
[53] Arianna Menciassi,et al. Wearable and implantable pancreas substitutes , 2013, Journal of Artificial Organs.
[54] Andrew Taberner,et al. Needle-free jet injection using real-time controlled linear Lorentz-force actuators. , 2012, Medical engineering & physics.
[55] H. Zisser,et al. Technosphere insulin effectively controls postprandial glycemia in patients with type 2 diabetes mellitus. , 2012, Diabetes technology & therapeutics.
[56] Richard A Flavell,et al. Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy. , 2012, Nature materials.
[57] M. Morfini,et al. Safety and pharmacokinetics of a novel recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) in hemophilia B patients. , 2012, Blood.
[58] Elizabeth Nance,et al. A Dense Poly(Ethylene Glycol) Coating Improves Penetration of Large Polymeric Nanoparticles Within Brain Tissue , 2012, Science Translational Medicine.
[59] Masakazu Hirose,et al. Quality of Life and Technology: Impact on Children and Families With Diabetes , 2012, Current Diabetes Reports.
[60] N. Binkley,et al. A phase 3 trial of the efficacy and safety of oral recombinant calcitonin: The oral calcitonin in postmenopausal osteoporosis (ORACAL) trial , 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[61] Paolo De Coppi,et al. Production and Implantation of Renal Extracellular Matrix Scaffolds From Porcine Kidneys as a Platform for Renal Bioengineering Investigations , 2012, Annals of surgery.
[62] Francesco M Veronese,et al. State of the art in PEGylation: the great versatility achieved after forty years of research. , 2012, Journal of controlled release : official journal of the Controlled Release Society.
[63] C. Mirkin,et al. Topical delivery of siRNA-based spherical nucleic acid nanoparticle conjugates for gene regulation , 2012, Proceedings of the National Academy of Sciences.
[64] Yun Yen,et al. Preclinical study of the cyclodextrin-polymer conjugate of camptothecin CRLX101 for the treatment of gastric cancer. , 2012, Nanomedicine : nanotechnology, biology, and medicine.
[65] J. Iqbal,et al. In vivo evaluation of an oral drug delivery system for peptides based on S-protected thiolated chitosan. , 2012, Journal of controlled release : official journal of the Controlled Release Society.
[66] Z. Su,et al. A novel sustained-release formulation of recombinant human growth hormone and its pharmacokinetic, pharmacodynamic and safety profiles. , 2012, Molecular pharmaceutics.
[67] Y. Barenholz. Doxil®--the first FDA-approved nano-drug: lessons learned. , 2012, Journal of controlled release : official journal of the Controlled Release Society.
[68] W. Stemmer,et al. A Novel Long-Acting Human Growth Hormone Fusion Protein (VRS-317): Enhanced In Vivo Potency and Half-Life , 2012, Journal of pharmaceutical sciences.
[69] Yanan Tan,et al. Hypoglycemic activity and oral bioavailability of insulin-loaded liposomes containing bile salts in rats: the effect of cholate type, particle size and administered dose. , 2012, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
[70] Evripidis Gavathiotis,et al. A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers. , 2012, The Journal of clinical investigation.
[71] M. Rathbone,et al. Recent developments in buccal and sublingual delivery systems , 2012, Expert opinion on drug delivery.
[72] Mark E. Davis,et al. Systemic delivery of siRNA nanoparticles targeting RRM2 suppresses head and neck tumor growth. , 2012, Journal of controlled release : official journal of the Controlled Release Society.
[73] P. Uzor,et al. Transdermal Drug Delivery , 2012 .
[74] Robert Langer,et al. Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile , 2012, Science Translational Medicine.
[75] R. Reid,et al. Predictable and tunable half-life extension of therapeutic agents by controlled chemical release from macromolecular conjugates , 2012, Proceedings of the National Academy of Sciences.
[76] H. Shepard,et al. Effective targeting of the tumor microenvironment for cancer therapy. , 2012, Anticancer research.
[77] R. Kontermann,et al. Therapeutic Proteins: Strategies to Modulate Their Plasma Half-Lives , 2012 .
[78] Theodore W Randolph,et al. Protein instability and immunogenicity: roadblocks to clinical application of injectable protein delivery systems for sustained release. , 2012, Journal of pharmaceutical sciences.
[79] Seeram Ramakrishna,et al. Advances in polymeric systems for tissue engineering and biomedical applications. , 2012, Macromolecular bioscience.
[80] Robert Langer,et al. First-in-Human Testing of a Wirelessly Controlled Drug Delivery Microchip , 2012, Science Translational Medicine.
[81] Y. Kwak,et al. The effect of SonoPrep® on EMLA® cream application for pain relief prior to intravenous cannulation , 2012, European Journal of Pediatrics.
[82] M. R. Sherman,et al. Role of the Methoxy Group in Immune Responses to mPEG-Protein Conjugates , 2012, Bioconjugate chemistry.
[83] T. Hey,et al. Half‐Life Extension through HESylation® , 2012 .
[84] A. Fischman,et al. CNS Penetration of Intrathecal-Lumbar Idursulfase in the Monkey, Dog and Mouse: Implications for Neurological Outcomes of Lysosomal Storage Disorder , 2012, PloS one.
[85] Ulrik B. Nielsen,et al. Antitumor Activity of a Novel Bispecific Antibody That Targets the ErbB2/ErbB3 Oncogenic Unit and Inhibits Heregulin-Induced Activation of ErbB3 , 2012, Molecular Cancer Therapeutics.
[86] J. Andersen,et al. Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor , 2012, Nature Communications.
[87] W. V. Osdol,et al. In Situ Forming Systems (Depots) , 2012 .
[88] Yoshio Kato,et al. targeted gene knockout by direct delivery of zinc-finger nuclease proteins , 2012 .
[89] D. Burgess,et al. Long Acting Injections and Implants , 2012, Advances in Delivery Science and Technology.
[90] P Schaepelynck,et al. Advances in pump technology: insulin patch pumps, combined pumps and glucose sensors, and implanted pumps. , 2011, Diabetes & metabolism.
[91] M. Trautmann,et al. Encapsulation of exenatide in poly-(D,L-lactide-co-glycolide) microspheres produced an investigational long-acting once-weekly formulation for type 2 diabetes. , 2011, Diabetes technology & therapeutics.
[92] S. Mitragotri,et al. Delivery of siRNA and other macromolecules into skin and cells using a peptide enhancer , 2011, Proceedings of the National Academy of Sciences.
[93] P. Davies,et al. Passive Immunization with Anti-Tau Antibodies in Two Transgenic Models , 2011, The Journal of Biological Chemistry.
[94] Cindi M Morshead,et al. Controlled epi-cortical delivery of epidermal growth factor for the stimulation of endogenous neural stem cell proliferation in stroke-injured brain. , 2011, Biomaterials.
[95] Tina N. Davis,et al. A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo. , 2011, Chemistry & biology.
[96] R. Murthy,et al. Opsonization, Biodistribution, Cellular Uptake and Apoptosis Study of PEGylated PBCA Nanoparticle as Potential Drug Delivery Carrier , 2011, Pharmaceutical Research.
[97] C. Tack,et al. Improved Pharmacokinetic and Pharmacodynamic Profile of Rapid-Acting Insulin Using Needle-Free Jet Injection Technology , 2011, Diabetes Care.
[98] W. Luk,et al. Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target , 2011, Science Translational Medicine.
[99] K. Scearce-Levie,et al. A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-β Production in Vivo , 2011, Science Translational Medicine.
[100] E. Masliah,et al. Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease , 2011, PloS one.
[101] M. Wood,et al. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes , 2011, Nature Biotechnology.
[102] Jason A. Burdick,et al. Hyaluronic Acid Hydrogels for Biomedical Applications , 2011, Advanced materials.
[103] A. Klibanov,et al. Hydrophobic salts markedly diminish viscosity of concentrated protein solutions , 2011, Biotechnology and bioengineering.
[104] A. Hoffman,et al. Efficient Intracellular Delivery of a Pro-Apoptotic Peptide With A pH-Responsive Carrier. , 2011, Reactive & functional polymers.
[105] M. Prausnitz,et al. Microneedle Vaccination with Stabilized Recombinant Influenza Virus Hemagglutinin Induces Improved Protective Immunity , 2011, Clinical and Vaccine Immunology.
[106] C. Duvall,et al. Intracellular delivery of a protein antigen with an endosomal-releasing polymer enhances CD8 T-cell production and prophylactic vaccine efficacy. , 2010, Bioconjugate chemistry.
[107] Sandeep Yadav,et al. Factors affecting the viscosity in high concentration solutions of different monoclonal antibodies. , 2010, Journal of pharmaceutical sciences.
[108] R. Luxenhofer,et al. Protein modification with amphiphilic block copoly(2-oxazoline)s as a new platform for enhanced cellular delivery. , 2010, Molecular pharmaceutics.
[109] C. Davis,et al. Microneedle Delivery of H5N1 Influenza Virus-Like Particles to the Skin Induces Long-Lasting B- and T-Cell Responses in Mice , 2010, Clinical and Vaccine Immunology.
[110] V. Koul,et al. Investigation on the synergistic effect of a combination of chemical enhancers and modulated iontophoresis for transdermal delivery of insulin , 2010, Drug development and industrial pharmacy.
[111] David R. Liu,et al. Potent Delivery of Functional Proteins into Mammalian Cells in Vitro and in Vivo Using a Supercharged Protein , 2010, ACS chemical biology.
[112] S. Mitragotri,et al. Ultrasound-Enhanced Drug Transport and Distribution in the Brain , 2010, AAPS PharmSciTech.
[113] Soong Ho Um,et al. Therapeutic cell engineering using surface-conjugated synthetic nanoparticles , 2010, Nature Medicine.
[114] Erkki Ruoslahti,et al. Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs , 2010, Science.
[115] Charles Tator,et al. Poly(ethylene glycol) modification enhances penetration of fibroblast growth factor 2 to injured spinal cord tissue from an intrathecal delivery system. , 2010, Journal of controlled release : official journal of the Controlled Release Society.
[116] D. Benoit,et al. Intracellular delivery of a proapoptotic peptide via conjugation to a RAFT synthesized endosomolytic polymer. , 2010, Molecular pharmaceutics.
[117] W. Banks,et al. Transport across the Blood-Brain Barrier of Pluronic Leptin , 2010, Journal of Pharmacology and Experimental Therapeutics.
[118] JaneR . Taylor,et al. The behavioral and biochemical effects of BDNF containing polymers implanted in the hippocampus of rats , 2010, Brain Research.
[119] Mark E. Davis,et al. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles , 2010, Nature.
[120] M. Karsdal,et al. The effect of oral salmon calcitonin delivered with 5-CNAC on bone and cartilage degradation in osteoarthritic patients: a 14-day randomized study. , 2010, Osteoarthritis and cartilage.
[121] P. Raskin,et al. Review of clinical trials: update on oral insulin spray formulation , 2010 .
[122] J. Desjarlais,et al. Enhanced antibody half-life improves in vivo activity , 2010, Nature Biotechnology.
[123] Tetsu Kobayashi,et al. Importance of Neonatal FcR in Regulating the Serum Half-Life of Therapeutic Proteins Containing the Fc Domain of Human IgG1: A Comparative Study of the Affinity of Monoclonal Antibodies and Fc-Fusion Proteins to Human Neonatal FcR , 2010, The Journal of Immunology.
[124] Matthew H. M. Lim,et al. Perfused multiwell plate for 3D liver tissue engineering. , 2010, Lab on a chip.
[125] Raymond E. Moellering,et al. Direct inhibition of the NOTCH transcription factor complex , 2010, Nature.
[126] Martin Körber,et al. Improved Lysozyme Stability and Release Properties of Poly(lactide-co-glycolide) Implants Prepared by Hot-Melt Extrusion , 2010, Pharmaceutical Research.
[127] David J Brayden,et al. Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic. , 2009, Advanced drug delivery reviews.
[128] Willem P C Stemmer,et al. A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner , 2009, Nature Biotechnology.
[129] J. Rosenstock,et al. Safety and efficacy of inhaled human insulin (exubera) during discontinuation and readministration of therapy in adults with type 2 diabetes: a 3-year randomized controlled trial. , 2009, Diabetes technology & therapeutics.
[130] A. Daugherty,et al. Proteins and Peptides : Pharmacokinetic, Pharmacodynamic, and Metabolic Outcomes , 2009 .
[131] Seiichi Funamoto,et al. In vivo evaluation of a novel scaffold for artificial corneas prepared by using ultrahigh hydrostatic pressure to decellularize porcine corneas , 2009, Molecular vision.
[132] M. S. Muthu,et al. PLGA nanoparticle formulations of risperidone: preparation and neuropharmacological evaluation. , 2009, Nanomedicine : nanotechnology, biology, and medicine.
[133] Samir Mitragotri,et al. Transcutaneous immunization using common chemicals. , 2009, Journal of controlled release : official journal of the Controlled Release Society.
[134] J. Marvin,et al. Engineering Human IgG1 Affinity to Human Neonatal Fc Receptor: Impact of Affinity Improvement on Pharmacokinetics in Primates , 2009, The Journal of Immunology.
[135] M. Bush,et al. Safety, tolerability, pharmacodynamics and pharmacokinetics of albiglutide, a long‐acting glucagon‐like peptide‐1 mimetic, in healthy subjects , 2009, Diabetes, obesity & metabolism.
[136] Howard C. Zisser,et al. Clinical Update on Optimal Prandial Insulin Dosing Using a Refined Run-to-Run Control Algorithm , 2009, Journal of diabetes science and technology.
[137] Michael S. Goldberg,et al. Development of lipidoid-siRNA formulations for systemic delivery to the liver. , 2009, Molecular therapy : the journal of the American Society of Gene Therapy.
[138] K. Chester,et al. Site-specific polysialylation of an antitumor single-chain Fv fragment. , 2009, Bioconjugate chemistry.
[139] E. Miele,et al. Albumin-bound formulation of paclitaxel (Abraxane® ABI-007) in the treatment of breast cancer , 2009, International journal of nanomedicine.
[140] Samir Mitragotri,et al. Dynamic control of needle-free jet injection. , 2009, Journal of controlled release : official journal of the Controlled Release Society.
[141] N. Smith,et al. Dose comparison of ultrasonic transdermal insulin delivery to subcutaneous insulin injection , 2008, International journal of nanomedicine.
[142] B. Kerwin. Polysorbates 20 and 80 used in the formulation of protein biotherapeutics: structure and degradation pathways. , 2008, Journal of pharmaceutical sciences.
[143] S. Mitragotri,et al. Discovery of synergistic permeation enhancers for oral drug delivery. , 2008, Journal of Controlled Release.
[144] Nicholas A Peppas,et al. Wheat germ agglutinin functionalized complexation hydrogels for oral insulin delivery. , 2008, Biomacromolecules.
[145] G. Hardee,et al. Oral delivery of antisense oligonucleotides in man. , 2008, Journal of pharmaceutical sciences.
[146] M. Castelli,et al. Pharmacokinetics and Pharmacodynamics of Oral Heparin Solid Dosage Form in Healthy Human Subjects , 2007, Journal of clinical pharmacology.
[147] David J Mooney,et al. Spatiotemporal control over growth factor signaling for therapeutic neovascularization. , 2007, Advanced drug delivery reviews.
[148] H Lennernäs,et al. Intestinal permeability and its relevance for absorption and elimination , 2007, Xenobiotica; the fate of foreign compounds in biological systems.
[149] K. Lundstrom,et al. Review on Medusa®:a polymer-based sustained release technology for protein and peptide drugs , 2007, Expert opinion on drug delivery.
[150] Samir Mitragotri,et al. Needle-free delivery of macromolecules across the skin by nanoliter-volume pulsed microjets , 2007, Proceedings of the National Academy of Sciences.
[151] D J Mooney,et al. Spatiotemporal control of vascular endothelial growth factor delivery from injectable hydrogels enhances angiogenesis , 2007, Journal of thrombosis and haemostasis : JTH.
[152] S. Korsmeyer,et al. A stapled BID BH3 helix directly binds and activates BAX. , 2006, Molecular cell.
[153] N. Peppas,et al. Is the oral route possible for peptide and protein drug delivery? , 2006, Drug discovery today.
[154] S. Mitragotri,et al. Needle-free liquid jet injections: mechanisms and applications , 2006, Expert review of medical devices.
[155] Randall J Mrsny,et al. Formulation and delivery issues for monoclonal antibody therapeutics. , 2006, Advanced drug delivery reviews.
[156] D. Jacqmin,et al. Pharmacokinetics (PK) and immunologic responses in a phase I/II study of a sustained release formulation of IL-2 in renal cell carcinoma (RCC) patients. , 2006, Journal of Clinical Oncology.
[157] A. G. Ding,et al. Prediction of microclimate pH in poly(lactic-co-glycolic acid) films. , 2006, Journal of the American Chemical Society.
[158] Wenjuan Yang,et al. Transdermal protein delivery by a coadministered peptide identified via phage display , 2006, Nature Biotechnology.
[159] Samir Mitragotri,et al. Role of target geometry in phagocytosis. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[160] B. Silverman,et al. Single- and multiple-dose pharmacokinetics of long-acting injectable naltrexone. , 2006, Alcoholism, clinical and experimental research.
[161] Nicholas A Peppas,et al. Novel oral insulin delivery systems based on complexation polymer hydrogels: single and multiple administration studies in type 1 and 2 diabetic rats. , 2006, Journal of controlled release : official journal of the Controlled Release Society.
[162] G. Verdine. Drugging the "undruggable". , 2006, Harvey lectures.
[163] K. Srivenugopal,et al. RETRACTED: Oral delivery of low-molecular-weight heparin using sodium caprate as absorption enhancer reaches therapeutic levels , 2005, Journal of drug targeting.
[164] Y. Kalia,et al. Effect of Charge and Molecular Weight on Transdermal Peptide Delivery by Iontophoresis , 2005, Pharmaceutical Research.
[165] Steven J Shire,et al. Reversible self-association increases the viscosity of a concentrated monoclonal antibody in aqueous solution. , 2005, Journal of pharmaceutical sciences.
[166] D. Mooney,et al. Bone regeneration in a rat cranial defect with delivery of PEI-condensed plasmid DNA encoding for bone morphogenetic protein-4 (BMP-4) , 2005, Gene Therapy.
[167] F. Ahsan,et al. Tetradecylmaltoside (TDM) enhances in vitro and in vivo intestinal absorption of enoxaparin, a low molecular weight heparin , 2005, Journal of drug targeting.
[168] D. Holdstock. Past, present--and future? , 2005, Medicine, conflict, and survival.
[169] Mark E. Davis,et al. Cyclodextrin-based pharmaceutics: past, present and future , 2004, Nature Reviews Drug Discovery.
[170] Samir Mitragotri,et al. Oral delivery of macromolecules using intestinal patches: applications for insulin delivery. , 2004, Journal of controlled release : official journal of the Controlled Release Society.
[171] A. Margolin,et al. Injectable controlled release formulations incorporating protein crystals. , 2004, Journal of controlled release : official journal of the Controlled Release Society.
[172] Jennifer L Davis,et al. Novel approaches to ocular drug delivery. , 2004, Current opinion in molecular therapeutics.
[173] M. Kermode. Unsafe injections in low-income country health settings: need for injection safety promotion to prevent the spread of blood-borne viruses. , 2004, Health promotion international.
[174] L. Klumb,et al. Poly(Lactide-Co-Glycolide) Microsphere Formulations of Darbepoetin Alfa: Spray Drying Is an Alternative to Encapsulation by Spray-Freeze Drying , 2004, Pharmaceutical Research.
[175] K. J. Brodbeck,et al. Sustained Release of Human Growth Hormone from PLGA Solution Depots , 1999, Pharmaceutical Research.
[176] Robert Langer,et al. Controlled Delivery Systems for Proteins Based on Poly(Lactic/Glycolic Acid) Microspheres , 1991, Pharmaceutical Research.
[177] A. Griesmacher,et al. Salmon calcitonin nasal spray treatment for postmenopausal women after hip fracture with total hip arthroplasty , 2004, Journal of Bone and Mineral Metabolism.
[178] Robert Langer,et al. Multi-pulse drug delivery from a resorbable polymeric microchip device , 2003, Nature materials.
[179] Jagdish Singh,et al. Electronically facilitated transdermal delivery of human parathyroid hormone (1-34). , 2003, International journal of pharmaceutics.
[180] J. Egrie,et al. Darbepoetin alfa has a longer circulating half-life and greater in vivo potency than recombinant human erythropoietin. , 2003, Experimental hematology.
[181] A. Minton,et al. Effect of dextran on protein stability and conformation attributed to macromolecular crowding. , 2003, Journal of molecular biology.
[182] L. Illum. Nasal drug delivery--possibilities, problems and solutions. , 2003, Journal of controlled release : official journal of the Controlled Release Society.
[183] G. Hardee,et al. Effect of sodium caprate on the intestinal absorption of two modified antisense oligonucleotides in pigs. , 2002, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[184] J. Cleland,et al. Sustained delivery of human growth hormone from a novel gel system: SABER. , 2002, Biomaterials.
[185] Robert Langer,et al. Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[186] S. Yalkowsky,et al. Review on the systemic delivery of insulin via the ocular route. , 2002, International journal of pharmaceutics.
[187] N. Shibata,et al. Gastrointestinal mucoadhesive patch system (GI-MAPS) for oral administration of G-CSF, a model protein. , 2002, Biomaterials.
[188] E. Mini,et al. Clinical Pharmacokinetics of Depot Leuprorelin , 2002, Clinical pharmacokinetics.
[189] F. Newman,et al. Safety and immunogenicity of varying dosages of trivalent inactivated influenza vaccine administered by needle-free jet injectors. , 2001, Vaccine.
[190] J. Mestecky,et al. Biodegradable block copolymers for delivery of proteins and water-insoluble drugs. , 2001, Journal of controlled release : official journal of the Controlled Release Society.
[191] J. Rothbard,et al. Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation , 2000, Nature Medicine.
[192] R. Motter,et al. Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease , 2000, Nature Medicine.
[193] H. Ravivarapu,et al. Sustained suppression of pituitary-gonadal axis with an injectable, in situ forming implant of leuprolide acetate. , 2000, Journal of pharmaceutical sciences.
[194] C. Baird,et al. The pilot study. , 2000, Orthopedic nursing.
[195] S. Schwendeman,et al. Stabilization of proteins encapsulated in injectable poly (lactide-co-glycolide) , 2000, Nature Biotechnology.
[196] T. Park,et al. Microencapsulation of human growth hormone within biodegradable polyester microspheres: protein aggregation stability and incomplete release mechanism. , 1999, Biotechnology and bioengineering.
[197] B. Chang,et al. Hydrogen bonding between sugar and protein is responsible for inhibition of dehydration-induced protein unfolding. , 1999, Archives of biochemistry and biophysics.
[198] Scott D. Putney,et al. Improving protein therapeutics with sustained-release formulations , 1998, Nature Biotechnology.
[199] N Lotan,et al. Large porous particles for pulmonary drug delivery. , 1997, Science.
[200] R. Ranganathan,et al. Structural and Functional Analysis of the Mitotic Rotamase Pin1 Suggests Substrate Recognition Is Phosphorylation Dependent , 1997, Cell.
[201] R. Gupta,et al. Stabilization of tetanus and diphtheria toxoids against moisture-induced aggregation. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[202] S. Mitragotri,et al. Ultrasound-mediated transdermal protein delivery , 1995, Science.
[203] R. Langer,et al. Controlled release of polypeptides from polyanhydrides. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[204] J L Cleland,et al. The development of stable protein formulations: a close look at protein aggregation, deamidation, and oxidation. , 1993, Critical reviews in therapeutic drug carrier systems.
[205] K. Whaley,et al. Macromolecules released from polymers: diffusion into unstirred fluids. , 1990, Biomaterials.
[206] E. Thompson,et al. Laboratory Investigation of Cerebrospinal Fluid Proteins , 1990, Annals of clinical biochemistry.
[207] T. Y. Tsang. Mechanisms and Applications , 1989 .
[208] R. Langer,et al. Polymers for the sustained release of proteins and other macromolecules , 1976, Nature.