Use of genomic data in risk assessment case study: I. Evaluation of the dibutyl phthalate male reproductive development toxicity data set.

[1]  R. Chapin,et al.  Reproductive toxicity of di-n-butylphthalate in a continuous breeding protocol in Sprague-Dawley rats. , 1997, Environmental health perspectives.

[2]  P. Foster,et al.  Male reproductive tract malformations in rats following gestational and lactational exposure to Di(n-butyl) phthalate: an antiandrogenic mechanism? , 1998, Toxicological sciences : an official journal of the Society of Toxicology.

[3]  A. Saillenfait,et al.  Assessment of the Developmental Toxicity, Metabolism, and Placental Transfer of Di-n-butyl Phthalate Administered to Pregnant Rats , 1998 .

[4]  M. Ema,et al.  Further evaluation of developmental toxicity of di-n-butyl phthalate following administration during late pregnancy in rats. , 1998, Toxicology letters.

[5]  L. Gray,et al.  Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p′-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproduc , 1999, Toxicology and industrial health.

[6]  P. Foster,et al.  Disruption of androgen-regulated male reproductive development by di(n-butyl) phthalate during late gestation in rats is different from flutamide. , 1999, Toxicology and applied pharmacology.

[7]  M. Ema,et al.  Critical period for adverse effects on development of reproductive system in male offspring of rats given di-n-butyl phthalate during late pregnancy. , 2000, Toxicology letters.

[8]  P. Foster,et al.  Dose-dependent alterations in androgen-regulated male reproductive development in rats exposed to Di(n-butyl) phthalate during late gestation. , 2000, Toxicological sciences : an official journal of the Society of Toxicology.

[9]  M. Ema,et al.  Adverse effects on development of the reproductive system in male offspring of rats given monobutyl phthalate, a metabolite of dibutyl phthalate, during late pregnancy. , 2001, Reproductive toxicology.

[10]  P. Foster,et al.  Altered gene profiles in fetal rat testes after in utero exposure to di(n-butyl) phthalate. , 2001, Toxicological sciences : an official journal of the Society of Toxicology.

[11]  T. Colborn,et al.  Hypospadias and endocrine disruption: is there a connection? , 2001, Environmental health perspectives.

[12]  N. Skakkebaek,et al.  Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects , 2001, Human reproduction.

[13]  Paul M D Foster,et al.  Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di(n-butyl) phthalate. , 2002, Reproductive toxicology.

[14]  P. Foster,et al.  Pathogenesis of Male Reproductive Tract Lesions from Gestation Through Adulthood Following in Utero Exposure to Di(n-butyl) Phthalate , 2003, Toxicologic pathology.

[15]  L Earl Gray,et al.  Effects of dibutyl phthalate in male rabbits following in utero, adolescent, or postpubertal exposure. , 2003, Toxicological sciences : an official journal of the Society of Toxicology.

[16]  R. Sharpe,et al.  Human 'testicular dysgenesis syndrome': a possible model using in-utero exposure of the rat to dibutyl phthalate. , 2003, Human reproduction.

[17]  P. Foster,et al.  Quantitative changes in gene expression in fetal rat testes following exposure to di(n-butyl) phthalate. , 2003, Toxicological sciences : an official journal of the Society of Toxicology.

[18]  M. Hirose,et al.  Diverse developmental toxicity of di-n-butyl phthalate in both sexes of rat offspring after maternal exposure during the period from late gestation through lactation. , 2004, Toxicology.

[19]  Yunhui Zhang,et al.  Reproductive and developmental toxicity in F1 Sprague-Dawley male rats exposed to di-n-butyl phthalate in utero and during lactation and determination of its NOAEL. , 2004, Reproductive toxicology.

[20]  T. Klonisch,et al.  Molecular and genetic regulation of testis descent and external genitalia development. , 2004, Developmental biology.

[21]  W. Krol,et al.  Pharmacokinetics of dibutylphthalate in pregnant rats. , 2004, Toxicological sciences : an official journal of the Society of Toxicology.

[22]  P. Foster,et al.  Dose-dependent alterations in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di (n-butyl) phthalate. , 2004, Toxicological sciences : an official journal of the Society of Toxicology.

[23]  G. Held,et al.  Phthalate ester-induced gubernacular lesions are associated with reduced insl3 gene expression in the fetal rat testis. , 2004, Toxicology letters.

[24]  K. Gaido,et al.  Di(n-butyl) phthalate impairs cholesterol transport and steroidogenesis in the fetal rat testis through a rapid and reversible mechanism. , 2004, Endocrinology.

[25]  P. Foster,et al.  Male Reproductive Tract Lesions at 6, 12, and 18 Months of Age Following in Utero Exposure to Di(n-butyl) Phthalate , 2004, Toxicologic pathology.

[26]  P. Foster,et al.  Altered gene expression during rat Wolffian duct development following di(n-butyl) phthalate exposure. , 2005, Toxicological sciences : an official journal of the Society of Toxicology.

[27]  P. Foster,et al.  Critical window of male reproductive tract development in rats following gestational exposure to di-n-butyl phthalate. , 2005, Birth defects research. Part B, Developmental and reproductive toxicology.

[28]  R. Kruse,et al.  Decrease in Anogenital Distance among Male Infants with Prenatal Phthalate Exposure , 2005, Environmental health perspectives.

[29]  P. Foster Mode of Action: Impaired Fetal Leydig Cell Function—Effects on Male Reproductive Development Produced by Certain Phthalate Esters , 2005, Critical reviews in toxicology.

[30]  D. K. Saxena,et al.  Testicular effects of di-n-butyl phthalate (DBP): Biochemical and histopathological alterations , 2005, Archives of Toxicology.

[31]  S. Young,et al.  Gene Expression Profiling Following In Utero Exposure to Phthalate Esters Reveals New Gene Targets in the Etiology of Testicular Dysgenesis1 , 2005, Biology of reproduction.

[32]  S. Young,et al.  Differential Steroidogenic Gene Expression in the Fetal Adrenal Gland Versus the Testis and Rapid and Dynamic Response of the Fetal Testis to Di(n-butyl) Phthalate1 , 2005, Biology of reproduction.

[33]  Kim Boekelheide,et al.  Exposure In Utero to Di(n-Butyl) Phthalate Alters the Vimentin Cytoskeleton of Fetal Rat Sertoli Cells and Disrupts Sertoli Cell-Gonocyte Contact1 , 2005, Biology of reproduction.

[34]  R. Sharpe,et al.  Abnormal Leydig Cell aggregation in the fetal testis of rats exposed to di (n-butyl) phthalate and its possible role in testicular dysgenesis. , 2005, Endocrinology.

[35]  R. Sharpe,et al.  Expression of insulin-like factor 3 protein in the rat testis during fetal and postnatal development and in relation to cryptorchidism induced by in utero exposure to di (n-Butyl) phthalate. , 2005, Endocrinology.

[36]  Jorma Toppari,et al.  Human Breast Milk Contamination with Phthalates and Alterations of Endogenous Reproductive Hormones in Infants Three Months of Age , 2005, Environmental health perspectives.

[37]  A. Calafat,et al.  Altered Semen Quality in Relation to Urinary Concentrations of Phthalate Monoester and Oxidative Metabolites , 2006, Epidemiology.

[38]  R. M. David,et al.  Proposed Mode of Action for In Utero Effects of Some Phthalate Esters on the Developing Male Reproductive Tract , 2006, Toxicologic pathology.

[39]  R. Sharpe,et al.  Acute and long-term effects of in utero exposure of rats to di(n-butyl) phthalate on testicular germ cell development and proliferation. , 2006, Endocrinology.

[40]  Nina Hallmark,et al.  Time-dependent and compartment-specific effects of in utero exposure to Di(n-butyl) phthalate on gene/protein expression in the fetal rat testis as revealed by transcription profiling and laser capture microdissection. , 2007, Toxicological sciences : an official journal of the Society of Toxicology.

[41]  J. Toppari,et al.  Development and descent of the testis in relation to cryptorchidism , 2007, Acta paediatrica.

[42]  Amy D. Kyle,et al.  Meeting Report: Moving Upstream—Evaluating Adverse Upstream End Points for Improved Risk Assessment and Decision-Making , 2008, Environmental health perspectives.

[43]  Shanna H Swan,et al.  Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans. , 2008, Environmental research.

[44]  Lee B. Smith,et al.  Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism. , 2008, The Journal of clinical investigation.

[45]  G P Daston,et al.  Inter-laboratory control data for reproductive endpoints required in the OPPTS 870.3800/OECD 416 reproduction and fertility test. , 2009, Birth defects research. Part B, Developmental and reproductive toxicology.

[46]  Karen Lowrie,et al.  Toxicity testing in the 21st century. , 2009, Risk analysis : an official publication of the Society for Risk Analysis.

[47]  J. Elder,et al.  Cryptorchidism and testicular cancer: separating fact from fiction. , 2009, The Journal of urology.

[48]  Susan Hester,et al.  Utilizing toxicogenomic data to understand chemical mechanism of action in risk assessment. , 2013, Toxicology and applied pharmacology.

[49]  Weihsueh A Chiu,et al.  An approach for integrating toxicogenomic data in risk assessment: the dibutyl phthalate case study. , 2013, Toxicology and applied pharmacology.

[50]  Meric A. Ovacik,et al.  Use of genomic data in risk assessment case study: II. Evaluation of the dibutyl phthalate toxicogenomic data set. , 2013, Toxicology and applied pharmacology.