Vitamin D 25-hydroxylase - Four decades of searching, are we there yet?

[1]  P. Kraft,et al.  Genetic predictors of 25-hydroxyvitamin D levels and risk of multiple sclerosis , 2011, Journal of Neurology.

[2]  G. Strapazzon,et al.  Bone mineral density and testicular failure: evidence for a role of vitamin D 25-hydroxylase in human testis. , 2011, The Journal of clinical endocrinology and metabolism.

[3]  Daniel L. Koller,et al.  Common genetic determinants of vitamin D insufficiency: a genome-wide association study , 2010, The Lancet.

[4]  H. Leffers,et al.  Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract. , 2010, Human reproduction.

[5]  K. Kang,et al.  Age-related changes in hepatic expression and activity of cytochrome P450 in male rats , 2010, Archives of Toxicology.

[6]  Z. Dvořák,et al.  Intestinal cell-specific vitamin D receptor (VDR)-mediated transcriptional regulation of CYP3A4 gene. , 2010, Biochemical pharmacology.

[7]  K. Gyllensten,et al.  Regulation of Human Vitamin D3 25-Hydroxylases in Dermal Fibroblasts and Prostate Cancer LNCaP Cells , 2009, Molecular Pharmacology.

[8]  J. Dressman,et al.  Cytochrome P450-mediated metabolism in the human gut wall. , 2009, The Journal of pharmacy and pharmacology.

[9]  C. Thangavel,et al.  Sex-dependent expression of CYP2C11 in spleen, thymus and bone marrow regulated by growth hormone. , 2007, Biochemical pharmacology.

[10]  K. Badenhoop,et al.  CYP2R1 (vitamin D 25‐hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans , 2007, Diabetes/metabolism research and reviews.

[11]  P. Beaune,et al.  Reverse transcriptase-PCR quantification of mRNA levels from cytochrome (CYP)1, CYP2 and CYP3 families in 22 different human tissues , 2007, Pharmacogenetics and genomics.

[12]  M. Holick Vitamin D deficiency. , 2007, The New England journal of medicine.

[13]  M. Norlin,et al.  Enzymes in the conversion of cholesterol into bile acids. , 2007, Current molecular medicine.

[14]  Hee-Won Park,et al.  Structural analysis of CYP2R1 in complex with vitamin D3. , 2007, Journal of molecular biology.

[15]  Keiko Yamamoto,et al.  Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases , 2006, Steroids.

[16]  J. Liao,et al.  Cytochrome P450 epoxygenase CYP2J2 and the risk of coronary artery disease. , 2006, Trends in cardiovascular medicine.

[17]  R. Mehta,et al.  Hepatic activation and inactivation of clinically-relevant vitamin D analogs and prodrugs. , 2006, Anticancer research.

[18]  W. L. Nelson,et al.  Intestinal and Hepatic CYP3A4 Catalyze Hydroxylation of 1α,25-Dihydroxyvitamin D3: Implications for Drug-Induced Osteomalacia , 2006, Molecular Pharmacology.

[19]  M. Haussler,et al.  Molecular and functional comparison of 1,25‐dihydroxyvitamin D3 and the novel vitamin D receptor ligand, lithocholic acid, in activating transcription of cytochrome P450 3A4 , 2005 .

[20]  J. Schenkman,et al.  Expression patterns of mouse and human CYP orthologs (families 1-4) during development and in different adult tissues. , 2005, Archives of biochemistry and biophysics.

[21]  N. Bell,et al.  Characterization of recombinant CYP2C11: a vitamin D 25-hydroxylase and 24-hydroxylase. , 2005, American journal of physiology. Endocrinology and metabolism.

[22]  J. Halpert,et al.  CYP3A4 is a vitamin D-24- and 25-hydroxylase: analysis of structure function by site-directed mutagenesis. , 2005, The Journal of clinical endocrinology and metabolism.

[23]  K. Inouye,et al.  Metabolism of vitamin D by human microsomal CYP2R1. , 2004, Biochemical and biophysical research communications.

[24]  H. Ide,et al.  Identification of a Novel Rat Microsomal Vitamin D3 25-Hydroxylase* , 2004, Journal of Biological Chemistry.

[25]  Jeffrey B. Cheng,et al.  Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[26]  D. Grant,et al.  Distribution of Soluble Epoxide Hydrolase and of Cytochrome P450 2C8, 2C9, and 2J2 in Human Tissues , 2004, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[27]  M. Moghadasian Cerebrotendinous xanthomatosis: clinical course, genotypes and metabolic backgrounds. , 2004, Clinical and investigative medicine. Medecine clinique et experimentale.

[28]  B. Hollis,et al.  CYP3A4 is a Human Microsomal Vitamin D 25‐Hydroxylase , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[29]  Jeffrey B. Cheng,et al.  De-orphanization of Cytochrome P450 2R1 , 2003, Journal of Biological Chemistry.

[30]  D. Lewis,et al.  Functional interaction of cytochrome P450 with its redox partners: a critical assessment and update of the topology of predicted contact regions. , 2003, Journal of inorganic biochemistry.

[31]  K. Bodin,et al.  Metabolism of 25-hydroxyvitamin D3 by microsomal and mitochondrial vitamin D3 25-hydroxylases (CYP2D25 and CYP27A1): a novel reaction by CYP27A1. , 2003, Biochimica et biophysica acta.

[32]  E. Delvin,et al.  Calcitriol regulates the expression of the genes encoding the three key vitamin D3 hydroxylases and the drug‐metabolizing enzyme CYP3A4 in the human fetal intestine , 2003, Clinical endocrinology.

[33]  M. Haussler,et al.  Liganded VDR induces CYP3A4 in small intestinal and colon cancer cells via DR3 and ER6 vitamin D responsive elements. , 2002, Biochemical and biophysical research communications.

[34]  J. Pascussi,et al.  Expression of CYP3A4, CYP2B6, andCYP2C9 Is Regulated by the Vitamin D Receptor Pathway in Primary Human Hepatocytes* , 2002, The Journal of Biological Chemistry.

[35]  M. Norlin,et al.  Kidney microsomal 25- and 1alpha-hydroxylase in vitamin D metabolism: catalytic properties, molecular cloning, cellular localization and expression during development. , 2002, Biochimica et biophysica acta.

[36]  E. Schuetz,et al.  Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3. , 2001, Molecular pharmacology.

[37]  M. Ingelman-Sundberg,et al.  The importance of residues in substrate recognition site 3 for the catalytic function of CYP2D25 (vitamin D 25-hydroxylase). , 2001, Biochemical and biophysical research communications.

[38]  L. Valiquette,et al.  Expression of CYP27A, a gene encoding a vitamin D‐25 hydroxylase in human liver and kidney , 2001, Clinical endocrinology.

[39]  D. Russell,et al.  Disruption of the Sterol 27-Hydroxylase Gene in Mice Results in Hepatomegaly and Hypertriglyceridemia , 2000, The Journal of Biological Chemistry.

[40]  K. Wikvall,et al.  Porcine microsomal vitamin D(3) 25-hydroxylase (CYP2D25). Catalytic properties, tissue distribution, and comparison with human CYP2D6. , 2000, The Journal of biological chemistry.

[41]  K. Inouye,et al.  Metabolism of vitamin D3 by human CYP27A1. , 2000 .

[42]  T. Chang,et al.  Effect of androgen administration during puberty on hepatic CYP2C11, CYP3A, and CYP2A1 expression in adult female rats. , 1998, Drug metabolism and disposition: the biological fate of chemicals.

[43]  N. Maeda,et al.  Markedly Reduced Bile Acid Synthesis but Maintained Levels of Cholesterol and Vitamin D Metabolites in Mice with Disrupted Sterol 27-Hydroxylase Gene* , 1998, The Journal of Biological Chemistry.

[44]  T. Bergman,et al.  Cloning, structure, and expression of a cDNA encoding vitamin D3 25-hydroxylase. , 1997, Biochemical and biophysical research communications.

[45]  D. Flint,et al.  Hormonal regulation of microsomal cytochrome P450 2C11 in rat liver and kidney. , 1997, The Journal of pharmacology and experimental therapeutics.

[46]  W. Miller,et al.  Cloning of human 25-hydroxyvitamin D-1 alpha-hydroxylase and mutations causing vitamin D-dependent rickets type 1. , 1997, Molecular endocrinology.

[47]  H. DeLuca,et al.  Cloning and expression of rat 25-hydroxyvitamin D3-1α-hydroxylase cDNA , 1997 .

[48]  H. DeLuca,et al.  Molecular Cloning of cDNA and Genomic DNA for Human 25-hydroxyvitamin D31α-hydroxylase , 1997 .

[49]  F. Glorieux,et al.  The 25‐Hydroxyvitamin D 1‐Alpha‐Hydroxylase Gene Maps to the Pseudovitamin D‐Deficiency Rickets (PDDR) Disease Locus , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[50]  S. Kato,et al.  25-Hydroxyvitamin D3 1α-Hydroxylase and Vitamin D Synthesis , 1997 .

[51]  M. Waterman,et al.  Expression, purification, and enzymatic properties of recombinant human cytochrome P450c27 (CYP27). , 1997, Archives of biochemistry and biophysics.

[52]  K. Tomer,et al.  Molecular Cloning, Expression, and Functional Significance of a Cytochrome P450 Highly Expressed in Rat Heart Myocytes* , 1997, The Journal of Biological Chemistry.

[53]  K. Tomer,et al.  Molecular Cloning and Expression of CYP2J2, a Human Cytochrome P450 Arachidonic Acid Epoxygenase Highly Expressed in Heart (*) , 1996, The Journal of Biological Chemistry.

[54]  Eva Axén Purification from pig kidney of a microsomal cytochrome P450 catalyzing 1α‐hydroxylation of 25‐hydroxyvitamin D3 , 1995, FEBS letters.

[55]  E. Axén,et al.  Effects on CYP27 mRNA Expression in Rat Kidney and Liver by 1α,25-Dihydroxyvitamin D3, a Suppressor of Renal 25-Hydroxyvitamin D3 1α-Hydroxylase Activity , 1995 .

[56]  E. Axén,et al.  Liver mitochondrial cytochrome P450 CYP27 and recombinant-expressed human CYP27 catalyze 1 alpha-hydroxylation of 25-hydroxyvitamin D3. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[57]  T. Bergman,et al.  Microsomal 25-hydroxylation of vitamin D2 and vitamin D3 in pig liver , 1994, The Journal of Steroid Biochemistry and Molecular Biology.

[58]  M. Holick,et al.  A possible genetic defect in 25-hydroxylation as a cause of rickets. , 1994, The Journal of pediatrics.

[59]  G. Jones,et al.  Transfected human liver cytochrome P-450 hydroxylates vitamin D analogs at different side-chain positions. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[60]  T. Bergman,et al.  Purification and characterization of a vitamin D3 25-hydroxylase from pig liver microsomes. , 1992, The Biochemical journal.

[61]  S. Addya,et al.  Characterization of a female-specific hepatic mitochondrial cytochrome P-450 whose steady-state level is modulated by testosterone. , 1991, Biochemistry.

[62]  D. Russell,et al.  Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis. , 1991, The Journal of biological chemistry.

[63]  M. Noshiro,et al.  Expression of rat liver vitamin D3 25‐hydroxylase cDNA in Saccharomyces cerevisiae , 1991, FEBS letters.

[64]  Y. Ohyama,et al.  Multi-functional property of rat liver mitochondrial cytochrome P-450. , 1991, Journal of biochemistry.

[65]  H. Rennert,et al.  A cDNA encoding a rat mitochondrial cytochrome P450 catalyzing both the 26-hydroxylation of cholesterol and 25-hydroxylation of vitamin D3: gonadotropic regulation of the cognate mRNA in ovaries. , 1990, DNA and cell biology.

[66]  T. Bergman,et al.  Characterization of pig kidney microsomal cytochrome P-450 catalysing 25-hydroxylation of vitamin D3 and C27 steroids. , 1990, The Biochemical journal.

[67]  M. Noshiro,et al.  Molecular cloning of cDNA for vitamin D3 25‐hydroxylase from rat liver mitochondria , 1990, FEBS letters.

[68]  H. Jörnvall,et al.  Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme. , 1989, The Journal of biological chemistry.

[69]  Y. Ohyama,et al.  Purification and characterization of 5 beta-cholestane-3 alpha,7 alpha,12 alpha-triol 27-hydroxylase from female rat liver mitochondria. , 1988, The Journal of biological chemistry.

[70]  H. Dahlbäck Characterization of the liver mitochondrial cytochrome P-450 catalyzing the 26-hydroxylation of 5β-cholestane-3α, 7α, 12α-triol , 1988 .

[71]  Y. Ohyama,et al.  Purification and characterization of vitamin D 25-hydroxylase from rat liver mitochondria. , 1988, The Journal of biological chemistry.

[72]  H. Postlind,et al.  Purification of a cytochrome P-450 from pig kidney microsomes catalysing the 25-hydroxylation of vitamin D3. , 1988, The Biochemical journal.

[73]  K. Wikvall,et al.  25-Hydroxylation of vitamin D3 by a cytochrome P-450 from rabbit liver mitochondria. , 1988, The Biochemical journal.

[74]  S. Hayashi,et al.  Sex-related difference in vitamin D3 25-hydroxylase of rat liver microsomes. , 1988, Journal of biochemistry.

[75]  Y. Fujii‐Kuriyama,et al.  Structural analysis and specific expression of microsomal cytochrome P-450(M-1) mRNA in male rat livers. , 1987, The Journal of biological chemistry.

[76]  H. Jörnvall,et al.  Sex differences in cytochrome P-450-dependent 25-hydroxylation of C27-steroids and vitamin D3 in rat liver microsomes. , 1986, The Journal of biological chemistry.

[77]  J. I. Pedersen,et al.  Subcellular localization of vitamin D3 25-hydroxylase in human liver. , 1984, The Journal of biological chemistry.

[78]  M. Noshiro,et al.  Purification of cytochrome P-450 catalyzing 25-hydroxylation of vitamin D3 from rat liver microsomes. , 1984, Biochemical and biophysical research communications.

[79]  K. Wikvall Hydroxylations in biosynthesis of bile acids. Isolation of a cytochrome P-450 from rabbit liver mitochondria catalyzing 26-hydroxylation of C27-steroids. , 1984, The Journal of biological chemistry.

[80]  S. Andersson,et al.  25-hydroxylation of C27-steroids and vitamin D3 by a constitutive cytochrome P-450 from rat liver microsomes. , 1983, The Journal of biological chemistry.

[81]  H. DeLuca,et al.  Characteristics of the rat liver microsomal enzyme system converting cholecalciferol into 25-hydroxycholecalciferol. Evidence for the participation of cytochrome p-450. , 1979, The Biochemical journal.

[82]  H. DeLuca,et al.  Incorportion of oxygen-18 into the 25-position of cholecalciferol by hepatic cholecalciferol 25-hydroxylase. , 1978, The Biochemical journal.

[83]  I. Björkhem,et al.  Assay and properties of a mitochondrial 25-hydroxylase active on vitamine D3. , 1978, The Journal of biological chemistry.

[84]  H. DeLuca,et al.  The effect of hepatectomy on the synthesis of 25-hydroxyvitamin D3. , 1976, The Journal of clinical investigation.

[85]  I. Björkhem,et al.  Mitochondrial omega-hydroxylation of cholesterol side chain. , 1974, The Journal of biological chemistry.

[86]  M. Haussler,et al.  Vitamin D 3 -25-hydroxylase: tissue occurrence and apparent lack of regulation. , 1973, Archives of biochemistry and biophysics.

[87]  H. DeLuca,et al.  Isolation and identification of 1,25-dihydroxycholecalciferol. A metabolite of vitamin D active in intestine. , 1971, Biochemistry.

[88]  H. Nowicki,et al.  1,25-Dihydroxycholecalciferol: Identification of the Proposed Active Form of Vitamin D3 in the Intestine , 1971, Science.

[89]  Dudley H. Williams,et al.  Identification of 1,25-Dihydroxycholecalciferol, a New Kidney Hormone controlling Calcium Metabolism , 1971, Nature.

[90]  H. DeLuca,et al.  "Activation" of vitamin D by the liver. , 1969, The Journal of clinical investigation.

[91]  H. DeLuca,et al.  The role of the liver in the metabolism of vitamin D. , 1969, The Journal of clinical investigation.

[92]  H. DeLuca,et al.  25-hydroxycholecalciferol. A biologically active metabolite of vitamin D3. , 1968, Biochemistry.

[93]  S. Imaoka,et al.  Localization of rat cytochrome P450 in various tissues and comparison of arachidonic acid metabolism by rat P450 with that by human P450 orthologs. , 2005, Drug metabolism and pharmacokinetics.

[94]  L. Maltais,et al.  Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. , 2004, Pharmacogenetics.

[95]  C. Theodoropoulos,et al.  High sensitivity of rat hepatic vitamin D3-25 hydroxylase CYP27A to 1,25-dihydroxyvitamin D3 administration. , 2003, American journal of physiology. Endocrinology and metabolism.

[96]  D. Nelson Comparison of P450s from human and fugu: 420 million years of vertebrate P450 evolution. , 2003, Archives of biochemistry and biophysics.

[97]  F. Guengerich,et al.  Cytochrome P-450 3A4: regulation and role in drug metabolism. , 1999, Annual review of pharmacology and toxicology.

[98]  M. Gascon-Barré CHAPTER 4 – The Vitamin D 25-Hydroxylase , 1997 .

[99]  D. Gazit,et al.  Osteoporosis and increased bone fractures in cerebrotendinous xanthomatosis. , 1993, Metabolism: clinical and experimental.

[100]  W. Levin,et al.  Age- and Gender-Related Expression of Rat Liver Cytochrome P450 , 1993 .

[101]  M. Noshiro,et al.  Isolation of a cytochrome P-450 that catalyzes the 25-hydroxylation of vitamin D3 from rat liver microsomes. , 1986, Journal of biochemistry.

[102]  H. DeLuca,et al.  Subcellular location of rat liver calciferol-25-hydroxylase. , 1974, Archives of biochemistry and biophysics.