Chemical library synthesis using convergent approaches.

New strategies are continuously being developed in combinatorial and diversity-oriented synthesis. Convergent design in target-oriented synthesis is commonly employed for construction of complex molecules. In this mini-review, we describe examples of convergent library design and synthesis as well as potential areas for future development.

[1]  Stuart L Schreiber,et al.  Generating Diverse Skeletons of Small Molecules Combinatorially , 2003, Science.

[2]  W. Ryan,et al.  Automated parallel synthesis of chalcone-based screening libraries , 1998 .

[3]  Dale L. Boger,et al.  Convergent Solution-Phase Combinatorial Synthesis with Multiplication of Diversity Through Rigid Biaryl and Diarylacetylene Couplings. , 2000 .

[4]  D. Boger,et al.  Solution-phase combinatorial synthesis: Convergent multiplication of diversity via the olefin metathesis reaction , 1998 .

[5]  Powers,et al.  Convergent automated parallel synthesis. , 1999, Drug discovery today.

[6]  P. Arya,et al.  Toward high-throughput synthesis of complex natural product-like compounds in the genomics and proteomics age. , 2002, Chemistry & biology.

[7]  D. Williams,et al.  Isolation and structure elucidation of Chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp. , 2001, Journal of the American Chemical Society.

[8]  D. Boger,et al.  Cytokine receptor dimerization and activation: prospects for small molecule agonists. , 2001, Bioorganic & medicinal chemistry.

[9]  R. Chott,et al.  Synthesis of highly substituted 5-(trifluoromethyl)ketoimidazoles using a mixed-solid/solution phase motif. , 2000, Biotechnology and bioengineering.

[10]  Stuart L Schreiber,et al.  Convergent diversity-oriented synthesis of small-molecule hybrids. , 2005, Angewandte Chemie.

[11]  M. Kelly-Borges,et al.  8-Hydroxymanzamine A, a beta-carboline alkaloid from a sponge, Pachypellina sp. , 1994, Journal of natural products.

[12]  J. Nielsen,et al.  A convergent solid-phase synthesis of actinomycin analogues--towards implementation of double-combinatorial chemistry. , 1996, Bioorganic & medicinal chemistry.

[13]  C. Kitada,et al.  Application of an automated synthesis suite to parallel solution-phase peptide synthesis. , 2001, Chemical & pharmaceutical bulletin.

[14]  Y. Hui,et al.  New cytotoxic annonaceous acetogenins: Bullatanocin and cis- and trans-Bullatanocinone, from Annona bullata (Annonaceae) , 1993 .

[15]  MULTISTEP CONVERGENT SOLUTION-PHASE COMBINATORIAL SYNTHESIS AND DELETION SYNTHESIS DECONVOLUTION , 1998 .

[16]  D. Boger,et al.  Identification of a novel class of small-molecule antiangiogenic agents through the screening of combinatorial libraries which function by inhibiting the binding and localization of proteinase MMP2 to integrin alpha(V)beta(3). , 2001, Journal of the American Chemical Society.

[17]  Dale L Boger,et al.  Solution-phase combinatorial libraries: modulating cellular signaling by targeting protein-protein or protein-DNA interactions. , 2003, Angewandte Chemie.

[18]  E. Corey,et al.  The Logic of Chemical Synthesis , 1989 .

[19]  Herbert Waldmann,et al.  From protein domains to drug candidates-natural products as guiding principles in the design and synthesis of compound libraries. , 2002, Angewandte Chemie.

[20]  S. Schreiber,et al.  Synthetic strategy toward skeletal diversity via solid-supported, otherwise unstable reactive intermediates. , 2004, Angewandte Chemie.

[21]  Vishwakarma Singh,et al.  Hybrid systems through natural product leads: an approach towards new molecular entities. , 2002, Chemical Society reviews.

[22]  G. Jung,et al.  The Use of Templates in Combinatorial Chemistry for the Solid‐Phase Synthesis of Multiple Core Structure Libraries , 1999 .

[23]  D. Boger,et al.  Erythropoietin mimetics derived from solution phase combinatorial libraries. , 2002, Journal of the American Chemical Society.

[24]  T. O'Brien,et al.  Fragment-based drug discovery. , 2004, Journal of medicinal chemistry.

[25]  J. Panek,et al.  Total Synthesis of Oleandolide , 1999 .

[26]  Dustin J Maly,et al.  Tyrosylprotein sulfotransferase inhibitors generated by combinatorial target-guided ligand assembly. , 2002, Bioorganic & medicinal chemistry letters.

[27]  Y. Hiraku,et al.  Amplification of C1027-induced DNA cleavage and apoptosis by a quinacrine-netropsin hybrid molecule in tumor cell lines. , 2005, Archives of biochemistry and biophysics.

[28]  S. Chandrasekhar,et al.  Natural product hybrids as new leads for drug discovery. , 2003, Angewandte Chemie.

[29]  R. Dolle Comprehensive survey of combinatorial library synthesis: 2000. , 2001, Journal of combinatorial chemistry.

[30]  K. Janda,et al.  Soluble polymer-supported convergent parallel library synthesis. , 2003, Chemical communications.

[31]  Stuart L Schreiber,et al.  A planning strategy for diversity-oriented synthesis. , 2004, Angewandte Chemie.

[32]  D. Boger,et al.  Convergent Solution-Phase Combinatorial Synthesis with Multiplication of Diversity through Rigid Biaryl and Diarylacetylene Couplings , 1999 .

[33]  K. Giuliano,et al.  Synthesis and biological assessment of simplified analogues of the potent microtubule stabilizer (+)-discodermolide. , 2003, Bioorganic & medicinal chemistry.

[34]  Dustin J Maly,et al.  Combinatorial target-guided ligand assembly: identification of potent subtype-selective c-Src inhibitors. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[35]  E B Reilly,et al.  Discovery and SAR of diarylsulfide cyclopropylamide LFA-1/ICAM-1 interaction antagonists. , 2001, Bioorganic & medicinal chemistry letters.

[36]  G. Slobodkin,et al.  Convergent Parallel Synthesis , 1997 .

[37]  W. Ryan,et al.  Solution phase synthesis of a spiro[pyrrolidine-2,3′-oxindole] library via a three component 1,3-dipolar cycloaddition reaction , 1998 .

[38]  Günther Jung,et al.  Combinatorial chemistry : synthesis, analysis, screening , 1999 .

[39]  J. Porco,et al.  Total Synthesis and Stereochemical Assignment of the Salicylate Antitumor Macrolide Lobatamide C1 , 2002 .

[40]  D. Crothers,et al.  Synthesis and a Preliminary DNA Binding Study of Hybrids of the Carbohydrate Domain of Calicheamicin γ 1I and the Aglycone of Daunorubicin: Calichearubicins A and B , 1996 .

[41]  I. Bianchi,et al.  Solid-phase convergent synthesis of a benzimidazolone library via the combination of two smaller arrays of carboxylic acids and secondary amines. , 2004, Journal of combinatorial chemistry.