Interleukin-6 stimulation of growth of prostate cancer in vitro and in vivo through activation of the androgen receptor.
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Dietmar Fuchs | Hannes Steiner | D. Fuchs | J. Bektic | A. Hobisch | Z. Culig | Patrizia L Moser | Jasmin Bektic | H. Neuwirt | H. Steiner | Zoran Culig | Alfred Hobisch | Kamilla Malinowska | Hannes Neuwirt | Ilaria T Cavarretta | Hermann Dietrich | H. Dietrich | P. Moser | I. Cavarretta | K. Malinowska
[1] J. Eastham,et al. Androgen receptor mutations in prostate cancer. , 2000, Cancer research.
[2] C. Tepper,et al. Inappropriate activation of the androgen receptor by nonsteroids: involvement of the Src kinase pathway and its therapeutic implications. , 2006, Cancer research.
[3] H. Klocker,et al. Interleukin-6 regulates prostate-specific protein expression in prostate carcinoma cells by activation of the androgen receptor. , 1998, Cancer research.
[4] C. Huggins,et al. Studies on prostatic cancer: I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. 1941. , 2002, The Journal of urology.
[5] Jing-Jy Cheng,et al. Herbal remedy magnolol suppresses IL‐6‐induced STAT3 activation and gene expression in endothelial cells , 2006, British journal of pharmacology.
[6] A. Papatsoris,et al. The power and promise of “rewiring” the mitogen-activated protein kinase network in prostate cancer therapeutics , 2007, Molecular Cancer Therapeutics.
[7] G. Wang,et al. Identification of genes targeted by the androgen and PKA signaling pathways in prostate cancer cells , 2006, Oncogene.
[8] G Bartsch,et al. Epidermal growth factor (EGF) receptor blockade inhibits the action of EGF, insulin-like growth factor I, and a protein kinase A activator on the mitogen-activated protein kinase pathway in prostate cancer cell lines. , 1999, Cancer research.
[9] J. Bektic,et al. Regulation of growth of prostate cancer cells selected in the presence of interleukin‐6 by the anti‐interleukin‐6 antibody CNTO 328 , 2006, The Prostate.
[10] D. Fuchs,et al. The antiapoptotic effect of IL-6 autocrine loop in a cellular model of advanced prostate cancer is mediated by Mcl-1 , 2007, Oncogene.
[11] M. Oya,et al. STAT3, but not ERKs, mediates the IL-6-induced proliferation of renal cancer cells, ACHN and 769P. , 2002, Kidney international.
[12] J. Simons,et al. Characterization of the role of IL‐6 in the progression of prostate cancer , 1999, The Prostate.
[13] B. Bonavida,et al. Interleukin-6 induces G1 arrest through induction of p27(Kip1), a cyclin-dependent kinase inhibitor, and neuron-like morphology in LNCaP prostate tumor cells. , 1999, Biochemical and biophysical research communications.
[14] O. Franco,et al. Mitogen‐activated protein kinase pathway is involved in androgen‐independent PSA gene expression in LNCaP cells , 2003, The Prostate.
[15] D. Tindall,et al. p300 mediates androgen-independent transactivation of the androgen receptor by interleukin 6. , 2002, Cancer research.
[16] F. Fauvel-Lafève,et al. Stromal cells from human benign prostate hyperplasia produce a growth‐inhibitory factor for LNCaP prostate cancer cells, identified as interleukin‐6 , 1996, International journal of cancer.
[17] P. Sehgal,et al. Induction of β 2-interferon by tumor necrosis factor: A homeostatic mechanism in the control of cell proliferation , 1986, Cell.
[18] D. Fuchs,et al. Interleukin‐6 and oncostatin M stimulation of proliferation of prostate cancer 22Rv1 cells through the signaling pathways of p38 mitogen‐activated protein kinase and phosphatidylinositol 3‐kinase , 2005, The Prostate.
[19] E. Bissonette,et al. Constitutive activation of the Ras/mitogen-activated protein kinase signaling pathway promotes androgen hypersensitivity in LNCaP prostate cancer cells. , 2003, Cancer research.
[20] M. M. Bradford. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.
[21] E. Keller,et al. Inhibition of NFkappaB activity through maintenance of IkappaBalpha levels contributes to dihydrotestosterone-mediated repression of the interleukin-6 promoter. , 1996, The Journal of biological chemistry.
[22] C. Sawyers,et al. NF-κB Activates Prostate-Specific Antigen Expression and Is Upregulated in Androgen-Independent Prostate Cancer , 2002, Molecular and Cellular Biology.
[23] Taosheng Chen,et al. Elevation of cyclic adenosine 3',5'-monophosphate potentiates activation of mitogen-activated protein kinase by growth factors in LNCaP prostate cancer cells. , 1999, Cancer research.
[24] Martin R. Schneider,et al. Switch from antagonist to agonist of the androgen receptor blocker bicalutamide is associated with prostate tumour progression in a new model system , 1999, British Journal of Cancer.
[25] D. Fuchs,et al. Accelerated in vivo growth of prostate tumors that up-regulate interleukin-6 is associated with reduced retinoblastoma protein expression and activation of the mitogen-activated protein kinase pathway. , 2003, The American journal of pathology.
[26] Jin-Tang Dong. Prevalent mutations in prostate cancer , 2006, Journal of cellular biochemistry.
[27] S. Rudikoff,et al. IL-6 mediated activation of STAT3 bypasses Janus kinases in terminally differentiated B lineage cells , 2002, Oncogene.
[28] A. Dunn,et al. gp130-mediated Signal Transduction in Embryonic Stem Cells Involves Activation of Jak and Ras/Mitogen-activated Protein Kinase Pathways* , 1996, The Journal of Biological Chemistry.
[29] Hideo Araki,et al. Novel mutations of androgen receptor: a possible mechanism of bicalutamide withdrawal syndrome. , 2003, Cancer research.
[30] Georg Bartsch,et al. Interleukin‐6 regulation of prostate cancer cell growth , 2005, Journal of cellular biochemistry.
[31] A. Nel,et al. Recombinant IL-6 activates p42 and p44 mitogen-activated protein kinases in the IL-6 responsive B cell line, AF-10. , 1993, Journal of immunology.
[32] A. J. Garrett,et al. CANCER XENOGRAFTS IN NUDE MICE , 1976, The Lancet.
[33] C. Sawyers,et al. NF-kappa B activates prostate-specific antigen expression and is upregulated in androgen-independent prostate cancer. , 2002, Molecular and cellular biology.
[34] H. Kung,et al. Neuropeptide-Induced Androgen Independence in Prostate Cancer Cells: Roles of Nonreceptor Tyrosine Kinases Etk/Bmx, Src, and Focal Adhesion Kinase , 2001, Molecular and Cellular Biology.
[35] C. Huggins,et al. STUDIES ON PROSTATIC CANCER: II. THE EFFECTS OF CASTRATION ON ADVANCED CARCINOMA OF THE PROSTATE GLAND , 1941 .
[36] D. Peehl,et al. Two mutations identified in the androgen receptor of the new human prostate cancer cell line MDA PCa 2a. , 1999, The Journal of urology.
[37] Mitogenic effect of nerve growth factor (NGF) in LNCaP prostate adenocarcinoma cells: role of the high- and low-affinity NGF receptors. , 2000, Molecular endocrinology.
[38] E. Keller,et al. Anti‐interleukin‐6 monoclonal antibody induces regression of human prostate cancer xenografts in nude mice , 2001, The Prostate.
[39] Brooks Pm,et al. Effect of gonadal steroids on the production of IL-1 and IL-6 by blood mononuclear cells in vitro. , 1993 .
[40] W. Farrar,et al. Interleukin 6 activates androgen receptor-mediated gene expression through a signal transducer and activator of transcription 3-dependent pathway in LNCaP prostate cancer cells. , 2000, Cancer research.
[41] N. Bruchovsky,et al. Activation of the Androgen Receptor N-terminal Domain by Interleukin-6 via MAPK and STAT3 Signal Transduction Pathways* , 2002, The Journal of Biological Chemistry.
[42] M. Morimatsu,et al. Central IL-1 differentially regulates peripheral IL-6 and TNF synthesis , 1998, Cellular and Molecular Life Sciences CMLS.
[43] W. Isaacs,et al. Androgen receptor gene mutations in human prostate cancer. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[44] Z. Hall. Cancer , 1906, The Hospital.
[45] W. Isaacs,et al. ras gene mutations in human prostate cancer. , 1990, Cancer research.
[46] D. Johnston,et al. Establishment of two human prostate cancer cell lines derived from a single bone metastasis. , 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.
[47] H. Scher,et al. Collocation of androgen receptor gene mutations in prostate cancer. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.
[48] P. Brooks,et al. Effect of gonadal steroids on the production of IL-1 and IL-6 by blood mononuclear cells in vitro. , 1993, Clinical and experimental rheumatology.
[49] Chawnshang Chang,et al. Interleukin-6 differentially regulates androgen receptor transactivation via PI3K-Akt, STAT3, and MAPK, three distinct signal pathways in prostate cancer cells. , 2003, Biochemical and biophysical research communications.
[50] P. Heinrich,et al. Cell Density–Dependent Increase of Constitutive Signal Transducers and Activators of Transcription 3 Activity in Melanoma Cells Is Mediated by Janus Kinases , 2007, Molecular Cancer Research.
[51] Yi Lu,et al. Inhibition of interleukin-6 with CNTO328, an anti-interleukin-6 monoclonal antibody, inhibits conversion of androgen-dependent prostate cancer to an androgen-independent phenotype in orchiectomized mice. , 2006, Cancer research.
[52] L. Koniaris,et al. Interleukin-6 mediates G(0)/G(1) growth arrest in hepatocellular carcinoma through a STAT 3-dependent pathway. , 2008, The Journal of surgical research.
[53] Nicholas Bruchovsky,et al. Ligand-independent Activation of the Androgen Receptor by Interleukin-6 and the Role of Steroid Receptor Coactivator-1 in Prostate Cancer Cells* , 2002, The Journal of Biological Chemistry.
[54] L. Nazareth,et al. Activation of the Human Androgen Receptor through a Protein Kinase A Signaling Pathway* , 1996, The Journal of Biological Chemistry.
[55] Chawnshang Chang,et al. Inhibition of NFκB Activity through Maintenance of IκBα Levels Contributes to Dihydrotestosterone-mediated Repression of the Interleukin-6 Promoter* , 1996, The Journal of Biological Chemistry.
[56] H. Klocker,et al. Prostate cancer cells (LNCaP) generated after long-term interleukin 6 (IL-6) treatment express IL-6 and acquire an IL-6 partially resistant phenotype. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.
[57] P. Johnston,et al. Interleukin-8 signaling promotes androgen-independent proliferation of prostate cancer cells via induction of androgen receptor expression and activation. , 2008, Carcinogenesis.
[58] H. Klocker,et al. Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone. , 1993, Molecular endocrinology.
[59] M. Nakafuku,et al. Differentiation factors, including nerve growth factor, fibroblast growth factor, and interleukin-6, induce an accumulation of an active Ras.GTP complex in rat pheochromocytoma PC12 cells. , 1992, The Journal of biological chemistry.
[60] M. Kuo,et al. Interleukin-6 Inhibits Transforming Growth Factor-β-induced Apoptosis through the Phosphatidylinositol 3-Kinase/Akt and Signal Transducers and Activators of Transcription 3 Pathways* , 1999, The Journal of Biological Chemistry.
[61] B. Wegiel,et al. Interleukin‐6 activates PI3K/Akt pathway and regulates cyclin A1 to promote prostate cancer cell survival , 2007, International journal of cancer.
[62] J. Pinski,et al. Interleukin‐6 inhibits the growth of prostate cancer xenografts in mice by the process of neuroendocrine differentiation , 2004, International journal of cancer.
[63] H. Klocker,et al. Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor and epidermal growth factor. , 1995, European urology.
[64] G. Bartsch,et al. Mechanisms of endocrine therapy-responsive and -unresponsive prostate tumours. , 2005, Endocrine-related cancer.
[65] P. Heinrich,et al. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. , 2003, The Biochemical journal.
[66] H. Broxmeyer,et al. Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor. , 1995, The Journal of clinical investigation.
[67] Noah Craft,et al. A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase , 1999, Nature Medicine.
[68] Y. Horiguchi,et al. Serum interleukin 6 as a prognostic factor in patients with prostate cancer. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.
[69] K. A. Klein,et al. Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice , 1997, Nature Medicine.
[70] T. Chung,et al. STAT3 mediates IL‐6‐induced growth inhibition in the human prostate cancer cell line LNCaP , 2000, The Prostate.
[71] Robert Walgate,et al. Proliferation , 1985, Nature.
[72] G. Bartsch,et al. Suppressor of cytokine signaling-3 antagonizes cAMP effects on proliferation and apoptosis and is expressed in human prostate cancer. , 2006, The American journal of pathology.