Human somatosensory evoked potential dipoles: how accurate are the localizations?

In contrast to studies describing human magnetoencephalographic fields, the literature on human electrophysiologic dipoles has paid relatively little attention to the spatial variability of dipole solutions. Based on studies of six normal subjects repeated on three different days, it was found that electrophysiologic dipoles calculated from scalp somatosensory evoked potentials had a variability similar to that reported for magnetoencephalography. The localization accuracy of the technique has yet to be demonstrated for natural neurophysiologic dipoles. Improvements in models and registration with MRI, and confirmation from independent techniques will likely lead to improvements in accuracy.

[1]  T. Yoshimoto,et al.  Neuromagnetic evidence of pre- and post-central cortical sources of somatosensory evoked responses. , 1996, Electroencephalography and clinical neurophysiology.

[2]  G. Glover,et al.  Characterization of spatial distortion in magnetic resonance imaging and its implications for stereotactic surgery. , 1994, Neurosurgery.

[3]  B.N. Cuffin,et al.  Effects of head shape on EEGs and MEGs , 1990, IEEE Transactions on Biomedical Engineering.

[4]  Christoph Baumgartner,et al.  Investigation of multiple simultaneously active brain sources in the electroencephalogram , 1989, Journal of Neuroscience Methods.

[5]  T Musha,et al.  Effects of cavities on EEG dipole localization and their relations with surface electrode positions. , 1989, International journal of bio-medical computing.

[6]  W W Sutherling,et al.  Spatiotemporal modeling of cerebral evoked magnetic fields to median nerve stimulation. , 1991, Electroencephalography and clinical neurophysiology.

[7]  A S Gevins,et al.  Neurocognitive Networks of the Human Brain a , 1991, Annals of the New York Academy of Sciences.

[8]  J. Kaas,et al.  Multiple representations of the body within the primary somatosensory cortex of primates. , 1979, Science.

[9]  H Uchida,et al.  Identification of pre- and postcentral gyri on CT and MR images on the basis of the medullary pattern of cerebral white matter. , 1991, Radiology.

[10]  J. Mazziotta,et al.  Imaging techniques for cortical functional localization. , 1992, Clinical neurosurgery.

[11]  V L Towle,et al.  Locating VEP equivalent dipoles in magnetic resonance images. , 1995, The International journal of neuroscience.

[12]  G A Ojemann,et al.  Brain mapping techniques to maximize resection, safety, and seizure control in children with brain tumors. , 1989, Neurosurgery.

[13]  R Llinás,et al.  Anatomical localization revealed by MEG recordings of the human somatosensory system. , 1991, Electroencephalography and clinical neurophysiology.

[14]  C. Pelizzari,et al.  Accurate Three‐Dimensional Registration of CT, PET, and/or MR Images of the Brain , 1989, Journal of computer assisted tomography.

[15]  Hong Zhou,et al.  On mesh refinement and accuracy of numerical solutions , 1993, Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Societ.

[16]  Mitchel S. Berger,et al.  Brain Mapping Techniques to Maximize Resection, Safety, and Seizure Control in Children with Brain Tumors , 1989 .

[17]  V. Mountcastle.  Modality and topographic properties of single neurons of cat's somatic sensory cortex. , 1957, Journal of neurophysiology.

[18]  M. E. Spencer,et al.  Error bounds for EEG and MEG dipole source localization. , 1993, Electroencephalography and clinical neurophysiology.

[19]  M R Schneider,et al.  A multistage process for computing virtual dipolar sources of EEG discharges from surface information. , 1972, IEEE transactions on bio-medical engineering.

[20]  C. C. Wood,et al.  Localization of human sensorimotor cortex during surgery by cortical surface recording of somatosensory evoked potentials. , 1988, Journal of neurosurgery.

[21]  K. K. Tan,et al.  Surface of the brain: three-dimensional MR images created with volume rendering. , 1989, Radiology.

[22]  K. K. Tan,et al.  The spatial location of EEG electrodes: locating the best-fitting sphere relative to cortical anatomy. , 1993, Electroencephalography and clinical neurophysiology.

[23]  J. P. Ary,et al.  Location of Sources of Evoked Scalp Potentials: Corrections for Skull and Scalp Thicknesses , 1981, IEEE Transactions on Biomedical Engineering.

[24]  M Scherg,et al.  Preoperative localization of the central sulcus by dipole source analysis of early somatosensory evoked potentials and three-dimensional magnetic resonance imaging. , 1994, Journal of neurosurgery.

[25]  G A Ojemann,et al.  Correlation of motor cortex brain mapping data with magnetic resonance imaging. , 1990, Journal of neurosurgery.

[26]  F E Bloom,et al.  Intrasubject reliability and validity of somatosensory source localization using a large array biomagnetometer. , 1994, Electroencephalography and clinical neurophysiology.

[27]  M. LeMay,et al.  Computed tomographic localization of the precentral gyrus. , 1980, Radiology.

[28]  J.C. Mosher,et al.  Multiple dipole modeling and localization from spatio-temporal MEG data , 1992, IEEE Transactions on Biomedical Engineering.

[29]  W. Eric L. Grimson,et al.  Statistical intensity correction and segmentation of MRI data , 1994, Other Conferences.

[30]  W. Penfield,et al.  SOMATIC MOTOR AND SENSORY REPRESENTATION IN THE CEREBRAL CORTEX OF MAN AS STUDIED BY ELECTRICAL STIMULATION , 1937 .

[31]  M Scherg,et al.  A new interpretation of the generators of BAEP waves I-V: results of a spatio-temporal dipole model. , 1985, Electroencephalography and clinical neurophysiology.

[32]  J. Lewine,et al.  Comparison of primary motor cortex localization using functional magnetic resonance imaging and magnetoencephalography , 1996, Human brain mapping.

[33]  P H Crandall,et al.  The magnetic and electric fields agree with intracranial localizations of somatosensory cortex , 1988, Neurology.

[34]  D. B. Smith,et al.  Experimental tests of the cortical imaging technique-applications to the response to median nerve stimulation and the localization of epileptiform discharges , 1992, IEEE Transactions on Biomedical Engineering.

[35]  R. Llinás,et al.  Somatosensory cortical plasticity in adult humans revealed by magnetoencephalography. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[36]  R. Leahy,et al.  Multiple Dipole Modeling and Localization from , 1992 .

[37]  M Scherg,et al.  Spatio-temporal modelling of early auditory evoked potentials. , 1984, Revue de laryngologie - otologie - rhinologie.