Killing of Aspergillus fumigatus spores and Candida albicans yeast phase by the iron-hydrogen peroxide-iodide cytotoxic system: comparison with the myeloperoxidase-hydrogen peroxide-halide system

A new fungicidal system composed of ferrous ion, H2O2, and iodide is described and compared with the myeloperoxidase-hydrogen peroxide-halide system. Both systems had similar activity against Aspergillus fumigatus spores and the Candida albicans yeast phase, but only the ferrous ion-hydrogen peroxide-iodide system was inhibited by hydroxyl radical scavengers.

[1]  R. Clark,et al.  Damage to Aspergillus fumigatus and Rhizopus oryzae Hyphae by Oxidative and Nonoxidative Microbicidal Products of Human Neutrophils In Vitro , 1982, Infection and immunity.

[2]  Nir Lipsman,et al.  The iron-H2O2-iodide cytotoxic system , 1982, The Journal of experimental medicine.

[3]  S. Klebanoff.  Iodination catalyzed by the xanthine oxidase system: role of hydroxyl radicals. , 1982, Biochemistry.

[4]  A. Schaffner,et al.  Selective protection against conidia by mononuclear and against mycelia by polymorphonuclear phagocytes in resistance to Aspergillus. Observations on these two lines of defense in vivo and in vitro with human and mouse phagocytes. , 1982, The Journal of clinical investigation.

[5]  C. Haudenschild,et al.  Damage to Candida albicans hyphae and pseudohyphae by the myeloperoxidase system and oxidative products of neutrophil metabolism in vitro. , 1980, The Journal of clinical investigation.

[6]  K. Imai,et al.  Expression of peroxidase-dependent iodination by macrophages ingesting neutrophil debris. , 1980, Journal of the Reticuloendothelial Society.

[7]  S. Klebanoff.  Oxygen metabolism and the toxic properties of phagocytes. , 1980, Annals of internal medicine.

[8]  T. Sorrell,et al.  Fungicidal activity of rabbit alveolar and peritoneal macrophages against Candida albicans , 1980, Infection and immunity.

[9]  Z. Cohn,et al.  Increased superoxide anion production by immunologically activated and chemically elicited macrophages , 1978, The Journal of experimental medicine.

[10]  B Poole,et al.  Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[11]  B. Babior,et al.  Oxygen-dependent microbial killing by phagocytes (second of two parts). , 1978, The New England journal of medicine.

[12]  R. Clark,et al.  Iodination by human polymorphonuclear leukocytes: a re-evaluation. , 1977, The Journal of laboratory and clinical medicine.

[13]  R. Clark,et al.  Hemolysis and iodination of erythrocyte components by a myeloperoxidase-mediated system. , 1975, Blood.

[14]  S. R. Simmons,et al.  IODINATING ABILITY OF VARIOUS LEUKOCYTES AND THEIR BACTERICIDAL ACTIVITY , 1973, The Journal of experimental medicine.

[15]  D. Bainton,et al.  TEMPORAL CHANGES IN PH WITHIN THE PHAGOCYTIC VACUOLE OF THE POLYMORPHONUCLEAR NEUTROPHILIC LEUKOCYTE , 1973, The Journal of cell biology.

[16]  S. Klebanoff,et al.  Role of myeloperoxidase-mediated antimicrobial systems in intact leukocytes. , 1972, Journal of the Reticuloendothelial Society.

[17]  R. Lehrer,et al.  Interaction of Aspergillus fumigatus Spores with Human Leukocytes and Serum , 1970, Infection and immunity.

[18]  R. Lehrer,et al.  Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infection. , 1969, The Journal of clinical investigation.

[19]  S. Klebanoff.  IODINATION OF BACTERIA: A BACTERICIDAL MECHANISM , 1967, The Journal of experimental medicine.

[20]  M. B. Goren.  Some paradoxes of macrophage function. , 1983, Advances in experimental medicine and biology.