Progress in pig‐to‐non‐human primate transplantation models (1998–2013): a comprehensive review of the literature

The pig‐to‐non‐human primate model is the standard choice for in vivo studies of organ and cell xenotransplantation. In 1998, Lambrigts and his colleagues surveyed the entire world literature and reported all experimental studies in this model. With the increasing number of genetically engineered pigs that have become available during the past few years, this model is being utilized ever more frequently.

[1]  P. Gianello,et al.  Improvement of Subcutaneous Bioartificial Pancreas Vascularization and Function by Coencapsulation of Pig Islets and Mesenchymal Stem Cells in Primates , 2014, Cell transplantation.

[2]  H. Lee,et al.  Cross‐reactivity between decellularized porcine corneal lamellae for corneal xenobridging and subsequent corneal allotransplants , 2014, Xenotransplantation.

[3]  D. Ayares,et al.  One‐Year Heterotopic Cardiac Xenograft Survival in a Pig to Baboon Model , 2014, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[4]  Jung‐Sik Kim,et al.  Application of the Multiplex Cytokine Analysis to Monitor Xenogeneic Immune Responses to the Porcine Islet Graft in Non-Human Primate , 2013, Journal of Korean medical science.

[5]  S. Robson,et al.  Clinicopathological findings in non‐human primate recipients of porcine renal xenografts: quantitative and qualitative evaluation of proteinuria , 2013, Xenotransplantation.

[6]  K. Park,et al.  Outcomes of alpha 1,3-GT-knockout porcine heart transplants into a preclinical nonhuman primate model. , 2013, Transplantation proceedings.

[7]  Won-Young Jung,et al.  Porcine islet adaptation to metabolic need of monkeys in pig-to-monkey intraportal islet xenotransplantation. , 2013, Transplantation proceedings.

[8]  Limin Liu,et al.  Survival of pig-to-rhesus corneal xenografts prolonged by prior donor bone marrow transplantation. , 2013, Molecular medicine reports.

[9]  P. Simioni,et al.  Thromboelastographic evaluation of coagulative profiles in pig‐to‐monkey kidney xenotransplantation , 2013, Xenotransplantation.

[10]  R. Bottino,et al.  Clinical Islet Xenotransplantation , 2012, Diabetes.

[11]  A. Kirk,et al.  Alternative Immunomodulatory Strategies for Xenotransplantation: CD40/154 Pathway‐Sparing Regimens Promote Xenograft Survival , 2012, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[12]  M. Ezzelarab,et al.  Costimulation blockade in pig artery patch xenotransplantation – a simple model to monitor the adaptive immune response in nonhuman primates , 2012, Xenotransplantation.

[13]  I. Wamala,et al.  Up to 9‐day survival and control of thrombocytopenia following alpha1,3‐galactosyl transferase knockout swine liver xenotransplantation in baboons , 2012, Xenotransplantation.

[14]  H. Tazelaar,et al.  Human CD55 Expression Blocks Hyperacute Rejection and Restricts Complement Activation in Gal Knockout Cardiac Xenografts , 2012, Transplantation.

[15]  J. Denner,et al.  Infection Barriers to Successful Xenotransplantation Focusing on Porcine Endogenous Retroviruses , 2012, Clinical Microbiology Reviews.

[16]  Ashutosh Kumar Singh,et al.  B‐Cell Depletion Extends the Survival of GTKO.hCD46Tg Pig Heart Xenografts in Baboons for up to 8 Months , 2012, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[17]  R. Bottino,et al.  Clinical xenotransplantation: the next medical revolution? , 2012, The Lancet.

[18]  R. Colvin,et al.  Pathologic characteristics of transplanted kidney xenografts. , 2012, Journal of the American Society of Nephrology : JASN.

[19]  A. Kirk,et al.  Islet Xenotransplantation Using Gal‐Deficient Neonatal Donors Improves Engraftment and Function , 2011, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[20]  L. Scobie,et al.  Xenotransplantation of galactosyl-transferase knockout, CD55, CD59, CD39, and fucosyl-transferase transgenic pig kidneys into baboons. , 2011, Transplantation proceedings.

[21]  D. Sachs,et al.  First Experience With the Use of a Recombinant CD3 Immunotoxin as Induction Therapy in Pig-to-Primate Xenotransplantation: The Effect of T-Cell Depletion on Outcome , 2011, Transplantation.

[22]  H. Lee,et al.  Efficacy of pig-to-rhesus lamellar corneal xenotransplantation. , 2011, Investigative ophthalmology & visual science.

[23]  B. Reichart,et al.  Microcirculatory alterations after orthotopic pig‐to‐baboon heart transplantation , 2011, Xenotransplantation.

[24]  M. Talcott,et al.  Engraftment of cells from porcine islets of Langerhans following transplantation of pig pancreatic primordia in non-immunosuppressed diabetic rhesus macaques , 2011, Organogenesis.

[25]  H. Tazelaar,et al.  Comparison of Gal and Non-Gal-Mediated Cardiac Xenograft Rejection , 2011, Transplantation.

[26]  G. Korbutt,et al.  CD40‐Specific Costimulation Blockade Enhances Neonatal Porcine Islet Survival in Nonhuman Primates , 2011, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[27]  W. Wee,et al.  Xenocorneal transplantation , 2011, Current opinion in organ transplantation.

[28]  D. Cooper,et al.  Xenotransplantation-The Future of Corneal Transplantation? , 2011, Cornea.

[29]  P. Naveilhan,et al.  Intracerebral xenotransplantation: recent findings and perspectives for local immunosuppression , 2011, Current opinion in organ transplantation.

[30]  R. Elliott.  Towards xenotransplantation of pig islets in the clinic. , 2011, Current opinion in organ transplantation.

[31]  M. Plebani,et al.  Effects of Long-Term Administration of Recombinant Human Protein C in Xenografted Primates , 2011, Transplantation.

[32]  Denis Dufrane,et al.  Alginate Macroencapsulation of Pig Islets Allows Correction of Streptozotocin-Induced Diabetes in Primates up to 6 Months Without Immunosuppression , 2010, Transplantation.

[33]  W. D’hoore,et al.  Beta‐5 Score to evaluate pig islet graft function in a primate pre‐clinical model , 2010, Xenotransplantation.

[34]  P. Morel,et al.  International Human Xenotransplantation Inventory , 2010, Transplantation.

[35]  D. Cooper,et al.  The immunology of corneal xenotransplantation: a review of the literature , 2010, Xenotransplantation.

[36]  R. F. Hoyt,et al.  Surgical and nonsurgical complications of a pig to baboon heterotopic heart transplantation model. , 2010, Transplantation proceedings.

[37]  Marvin L. Thomas,et al.  Left ventricular pressure measurement by telemetry is an effective means to evaluate transplanted heart function in experimental heterotopic cardiac xenotransplantation. , 2010, Transplantation proceedings.

[38]  D. Sachs,et al.  Occurrence of specific humoral non‐responsiveness to swine antigens following administration of GalT‐KO bone marrow to baboons , 2010, Xenotransplantation.

[39]  D. Cooper,et al.  Recipient Tissue Factor Expression Is Associated With Consumptive Coagulopathy in Pig‐to‐Primate Kidney Xenotransplantation , 2010, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[40]  D. Cooper,et al.  Genetically engineered pigs as a source for clinical red blood cell transfusion. , 2010, Clinics in laboratory medicine.

[41]  B. Wintersperger,et al.  First experience with heterotopic thoracic pig‐to‐baboon cardiac xenotransplantation , 2010, Xenotransplantation.

[42]  D. Sachs,et al.  Prolonged survival of GalT‐KO swine skin on baboons , 2010, Xenotransplantation.

[43]  E. Klein,et al.  Impact of Thrombocytopenia on Survival of Baboons with Genetically Modified Pig Liver Transplants: Clinical Relevance , 2010, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[44]  R. Bottino,et al.  Long‐Term Controlled Normoglycemia in Diabetic Non‐Human Primates After Transplantation with hCD46 Transgenic Porcine Islets , 2009, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[45]  D. Sachs,et al.  Results of Gal‐Knockout Porcine Thymokidney Xenografts , 2009, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[46]  A. Nakao,et al.  Successful cross‐breeding of cloned pigs expressing endo‐β‐galactosidase C and human decay accelerating factor , 2009, Xenotransplantation.

[47]  A. Tobar,et al.  Embryonic pig pancreatic tissue for the treatment of diabetes in a nonhuman primate model , 2009, Proceedings of the National Academy of Sciences.

[48]  N. Bodyak,et al.  Renal and Cardiac Endothelial Heterogeneity Impact Acute Vascular Rejection in Pig‐to‐Baboon Xenotransplantation , 2009, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[49]  R. Pierson,et al.  The Innate Immune Response and Activation of Coagulation in α1,3-Galactosyltransferase Gene-Knockout Xenograft Recipients , 2009, Transplantation.

[50]  D. Sachs,et al.  Rejection of Cardiac Xenografts Transplanted from α1,3‐Galactosyltransferase Gene‐Knockout (GalT‐KO) Pigs to Baboons , 2008, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[51]  J. Denner,et al.  Absence of transmission of potentially xenotic viruses in a prospective pig to primate islet xenotransplantation study , 2008, Journal of medical virology.

[52]  H. Tazelaar,et al.  Proteomic identification of non‐Gal antibody targets after pig‐to‐primate cardiac xenotransplantation , 2008, Xenotransplantation.

[53]  M. Talcott,et al.  Long‐term engraftment following transplantation of pig pancreatic primordia into non‐immunosuppressed diabetic rhesus macaques , 2007, Xenotransplantation.

[54]  Pan Zhiqiang,et al.  WZS‐pig is a potential donor alternative in corneal xenotransplantation , 2007, Xenotransplantation.

[55]  B. Hering,et al.  Engraftment of Adult Porcine Islet Xenografts in Diabetic Nonhuman Primates Through Targeting of Costimulation Pathways , 2007, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[56]  W. Kremers,et al.  The utility of right ventricular endomyocardial biopsy for the diagnosis of xenograft rejection after CD46 pig-to-baboon cardiac transplantation. , 2007, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[57]  B. Reichart,et al.  Comparison of propofol and isoflurane anesthesia in orthotopic pig‐to‐baboon cardiac xenotransplantation , 2007, Xenotransplantation.

[58]  R. Pierson,et al.  Life-supporting function of genetically modified swine lungs in baboons. , 2007, The Journal of thoracic and cardiovascular surgery.

[59]  B. Reichart,et al.  Transgenic animals in experimental xenotransplantation models: orthotopic heart transplantation in the pig-to-baboon model. , 2007, Transplantation proceedings.

[60]  V. Starnes,et al.  The xenoantibody response and immunoglobulin gene expression profile of cynomolgus monkeys transplanted with hDAF‐transgenic porcine hearts , 2007, Xenotransplantation.

[61]  D. Cooper,et al.  Pig-to-non-human primate heart transplantation: immunologic progress over 20 years. , 2007, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[62]  V. Zappulli,et al.  Histopathological findings in the gastrointestinal tract of primate recipients of porcine renal xenografts following different immunosuppressive regimens , 2007, Xenotransplantation.

[63]  R. Bottino,et al.  Reduction of Early Graft Loss After Intraportal Porcine Islet Transplantation in Monkeys , 2007, Transplantation.

[64]  R. Pierson,et al.  Coagulation cascade activation triggers early failure of pig hearts expressing human complement regulatory genes , 2007, Xenotransplantation.

[65]  G. Gonzalez-Stawinski,et al.  Prolonged Function of Macrophage, von Willebrand Factor‐Deficient Porcine Pulmonary Xenografts , 2007, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[66]  H. Tazelaar,et al.  Increased Immunosuppression, Not Anticoagulation, Extends Cardiac Xenograft Survival , 2006, Transplantation.

[67]  U. Christians,et al.  Prolonged survival of porcine hepatocytes in cynomolgus monkeys. , 2006, Gastroenterology.

[68]  J. Platt,et al.  Effect of an Anti-C5a Monoclonal Antibody Indicates a Prominent Role for Anaphylatoxin in Pulmonary Xenograft Dysfunction , 2006, Transplantation.

[69]  Denis Dufrane,et al.  Six-Month Survival of Microencapsulated Pig Islets and Alginate Biocompatibility in Primates: Proof of Concept , 2006, Transplantation.

[70]  U. Christians,et al.  Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates , 2006, Nature Medicine.

[71]  G. Korbutt,et al.  Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways , 2006, Nature Medicine.

[72]  B. Meiser,et al.  Combination of hDAF-transgenic pig hearts and immunoadsorption in heterotopic xenotransplantation of immunosuppressed baboons , 2006 .

[73]  C. Cardella,et al.  The Role of Anti-non-Gal Antibodies in the Development of Acute Humoral Xenograft Rejection of hDAF Transgenic Porcine Kidneys in Baboons Receiving Anti-Gal Antibody Neutralization Therapy , 2006, Transplantation.

[74]  H. Tazelaar,et al.  T‐cell responses during pig‐to‐primate xenotransplantation , 2006, Xenotransplantation.

[75]  T. Starzl,et al.  Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys , 2005, Nature Medicine.

[76]  Gang Chen,et al.  The Influence of Baseline Expression of Human Decay Accelerating Factor Transgene on Graft Survival and Acute Humoral Xenograft Rejection , 2005, Transplantation.

[77]  K. Peter,et al.  hDAF porcine cardiac xenograft maintains cardiac output after orthotopic transplantation into baboon – a perioperative study , 2005, Xenotransplantation.

[78]  J. Yélamos,et al.  Prevention of hyperacute rejection in a model of orthotopic liver xenotransplantation from pig to baboon using polytransgenic pig livers (CD55, CD59, and H-transferase). , 2005, Transplantation proceedings.

[79]  D. Sachs,et al.  α1,3-Galactosyltransferase Gene-Knockout Pig Heart Transplantation in Baboons with Survival Approaching 6 Months , 2005, Transplantation.

[80]  A. Vasconcellos,et al.  Intraperitoneal alginate-encapsulated neonatal porcine islets in a placebo-controlled study with 16 diabetic cynomolgus primates. , 2005, Transplantation proceedings.

[81]  R. Colvin,et al.  Thrombotic microangiopathic glomerulopathy in human decay accelerating factor-transgenic swine-to-baboon kidney xenografts. , 2005, Journal of the American Society of Nephrology : JASN.

[82]  Eduardo Bracho-Blanchet,et al.  Xenotransplantation of porcine neonatal islets of Langerhans and Sertoli cells: a 4-year study. , 2005, European journal of endocrinology.

[83]  W. Kremers,et al.  Cardiac xenotransplantation: recent preclinical progress with 3-month median survival. , 2005, The Journal of thoracic and cardiovascular surgery.

[84]  B. Melchior,et al.  Transgenic expression of CTLA4-Ig by fetal pig neurons for xenotransplantation , 2005, Transgenic Research.

[85]  A. Badley,et al.  Rejection severity directly correlates with myocyte apoptosis in pig-to-baboon cardiac xenotransplantation. , 2005, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[86]  R. Morris,et al.  Use of echocardiography to assess function of hDAF-transgenic pig cardiac xenografts. , 2005, Transplantation proceedings.

[87]  W. Kremers,et al.  Warfarin or Low‐Molecular‐Weight Heparin Therapy does not Prolong Pig‐To‐Primate Cardiac Xenograft Function , 2005, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[88]  T. Shigehisa,et al.  Survival of adult islet grafts from transgenic pigs with N‐acetylglucosaminyltransferase‐III (GnT‐III) in cynomolgus monkeys , 2005, Xenotransplantation.

[89]  R. Pierson,et al.  Co‐stimulation blockade targeting CD154 and CD28/B7 modulates the induced antibody response after a pig‐to‐baboon cardiac xenograft , 2005, Xenotransplantation.

[90]  M. Hermida-Prieto,et al.  Lack of Cross-Species Transmission of Porcine Endogenous Retrovirus in Pig-to-Baboon Xenotransplantation with Sustained Depletion of Anti-&agr;Gal Antibodies , 2005, Transplantation.

[91]  H. Tazelaar,et al.  Prevention, detection, and management of early bacterial and fungal infections in a preclinical cardiac xenotransplantation model that achieves prolonged survival , 2005, Xenotransplantation.

[92]  B. Reichart,et al.  Administration of GAS914 in an orthotopic pig‐to‐baboon heart transplantation model , 2005, Xenotransplantation.

[93]  G. Berry,et al.  Improved assessment of graft function by echocardiography in cynomolgus monkey recipients of hDAF-transgenic pig cardiac xenografts. , 2005, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[94]  U. Christians,et al.  The effect of soluble complement receptor type 1 on acute humoral xenograft rejection in hDAF‐transgenic pig‐to‐primate life‐supporting kidney xenografts , 2005, Xenotransplantation.

[95]  H. Tazelaar,et al.  Cardiac Xenotransplantation: Progress Toward the Clinic , 2004, Transplantation.

[96]  N. Domenech,et al.  Flow cytometry complement-mediated cytotoxicity assay detects baboon xenoantibodies directed to porcine epitopes undetected by hemolytic assay. , 2004, Transplant immunology.

[97]  R. Morris,et al.  Anti‐non‐Gal porcine endothelial cell antibodies in acute humoral xenograft rejection of hDAF‐transgenic porcine hearts in cynomolgus monkeys , 2004, Xenotransplantation.

[98]  G. Berry,et al.  Hyperacute rejection of hDAF‐transgenic pig organ xenografts in cynomolgus monkeys: influence of pre‐existing anti‐pig antibodies and prevention by the αGAL glycoconjugate GAS914 , 2004, Xenotransplantation.

[99]  H. Schuurman,et al.  Transgenic expression in pig hearts of both human decay-accelerating factor and human membrane cofactor protein does not provide an additional benefit to that of human decay-accelerating factor alone in pig-to-baboon xenotransplantation. , 2004, Transplantation.

[100]  H. Tazelaar,et al.  Effective antiplatelet therapy does not prolong transgenic pig to baboon cardiac xenograft survival , 2004, Xenotransplantation.

[101]  K. Kuwaki,et al.  Thrombotic microangiopathy and graft arteriopathy in pig hearts following transplantation into baboons , 2004, Xenotransplantation.

[102]  R. Mañez,et al.  Failure to deplete anti‐Galα1‐3Gal antibodies after pig‐to‐baboon organ xenotransplantation by immunoaffinity columns containing multiple Galα1‐3Gal oligosaccharides , 2004, Xenotransplantation.

[103]  H. Schuurman,et al.  Does exposure to swine leukocyte antigens after pig‐to‐nonhuman primate xenotransplantation provoke antibodies that cross‐react with human leukocyte antigens? , 2004, Xenotransplantation.

[104]  A. Dalmasso,et al.  Reversal of diabetes in non‐immunosuppressed rhesus macaques by intraportal porcine islet xenografts precedes acute cellular rejection , 2004, Xenotransplantation.

[105]  H. Yang,et al.  Xenotransplantation of human decay accelerating factor transgenic porcine kidney to non-human primates: 4 years experience at a Canadian center. , 2004, Transplantation proceedings.

[106]  B. Meiser,et al.  MEAN XENOGRAFT SURVIVAL OF 14,6 DAYS IN A SMALL GROUP OF HDAF-TRANSGENIC PIG HEARTS TRANSPLANTED ORTHOTOPICALLY INTO BABOONS , 2004 .

[107]  S. Robson,et al.  ACUTE VASCULAR REJECTION OF XENOGRAFTS: ROLES OF NATURAL AND ELICITED XENOREACTIVE ANTIBODIES IN ACTIVATION OF VASCULAR ENDOTHELIAL CELLS AND INDUCTION OF PROCOAGULANT ACTIVITY , 2004, Transplantation.

[108]  B. Weill,et al.  Characterization of human CD55 and CD59 transgenic pigs and kidney xenotransplantation in the pig-to-baboon combination. , 2004, Transplantation.

[109]  M. Mendicino,et al.  Endothelial Induction of fgl2 Contributes to Thrombosis during Acute Vascular Xenograft Rejection1 , 2004, The Journal of Immunology.

[110]  G. Thiene,et al.  Ureteral Stenosis in HDAF Pig‐to‐Primate Renal Xenotransplantation: A Phenomenon Related to Immunological Events? , 2004, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[111]  N. Mueller,et al.  Suppression of Natural and Elicited Antibodies in Pig‐to‐Baboon Heart Transplantation Using a Human Anti‐Human CD154 mAb‐Based Regimen , 2004, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[112]  G. Thiene,et al.  Alterations in the Coagulation Profile in Renal Pig‐to‐Monkey Xenotransplantation , 2004, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[113]  B. Loveland,et al.  Characterization of a CD46 transgenic pig and protection of transgenic kidneys against hyperacute rejection in non‐immunosuppressed baboons , 2004, Xenotransplantation.

[114]  L. Tesson,et al.  The study of mitoxantrone as a potential immunosuppressor in transgenic pig renal xenotransplantation in baboons: comparison with cyclophosphamide , 2004, Xenotransplantation.

[115]  N. Mueller,et al.  Correlation of Biochemical and Hematological Changes with Graft Failure Following Pig Heart and Kidney Transplantation in Baboons , 2003, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[116]  J. Ringers,et al.  T-Cell–specific immunosuppression results in more than 53 days survival of porcine islets of langerhans in the monkey , 2003, Transplantation.

[117]  D. Sachs,et al.  Pig kidney transplantation in baboons treated intravenously with a bovine serum albumin‐Galα1‐3Gal conjugate , 2003, Xenotransplantation.

[118]  G. Thiene,et al.  Methotrexate for immunosuppression in life‐supporting pig‐to‐cynomolgus monkey renal xenotransplantation , 2003, Xenotransplantation.

[119]  J. Ashton-Chess,et al.  The effect of immunoglobulin immunoadsorptions on delayed xenograft rejection of human CD55 transgenic pig kidneys in baboons , 2003, Xenotransplantation.

[120]  J. Ashton-Chess,et al.  Cellular participation in delayed xenograft rejection of hCD55 transgenic pig hearts by baboons , 2003, Xenotransplantation.

[121]  J. Platt,et al.  The Role of Antibodies and Von Willebrand Factor in Discordant Pulmonary Xenotransplantation , 2003, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[122]  R. Mañez,et al.  Elicited non-anti-alphaGAL antibodies may cause acute humoral rejection of hDAF pig organs transplanted in baboons. , 2003, Transplantation proceedings.

[123]  R. Mañez,et al.  Porcine endothelial cell activation in hDAF pig hearts transplanted in baboons with prolonged survival and lack of rejection. , 2003, Transplantation Proceedings.

[124]  Kenneth G. C. Smith,et al.  Maintenance triple immunosuppression with cyclosporin A, mycophenolate sodium and steroids allows prolonged survival of primate recipients of hDAF porcine renal xenografts , 2003, Xenotransplantation.

[125]  N. Mueller,et al.  Porcine cytomegalovirus and coagulopathy in pig-to-primate xenotransplantation1 , 2003, Transplantation.

[126]  R. Colvin,et al.  Xenogeneic thymokidney and thymic tissue transplantation in a pig-to-baboon model: I. evidence for pig-specific T-cell unresponsiveness1 , 2003, Transplantation.

[127]  G. Berry,et al.  Graft thrombosis in hDA-transgenic pig hearts transplanted into rhesus monkeys. , 2003, Xenotransplantation.

[128]  R. Colvin,et al.  Xenogeneic thymus transplantation in a pig-to-baboon model1 , 2003, Transplantation.

[129]  S. Chakrabarti,et al.  Improvement in human decay accelerating factor transgenic porcine kidney xenograft rejection with intravenous administration of gas914, a polymeric form of &agr;gal1 , 2003, Transplantation.

[130]  M. Araie,et al.  Antigenicity of porcine cornea as xenograft , 2003, Current eye research.

[131]  Z. Ruggeri,et al.  The role of the porcine von willebrand factor: baboon platelet interactions in pulmonary xenotransplantation , 2002, Transplantation.

[132]  H. Bazin,et al.  Characterization of baboon anti‐porcine IgG antibodies during acute vascular rejection of porcine kidney xenograft , 2002, Xenotransplantation.

[133]  R. Morris,et al.  Cyclophosphamide-induced postoperative anemia in cynomolgus monkey recipients of hDAF-transgenic pig organ xenografts. , 2002, Transplantation proceedings.

[134]  C. Cardella,et al.  Improvement in rejection of human decay accelerating factor transgenic pig-to-primate renal xenografts with administration of rabbit antithymocyte serum1 , 2002, Transplantation.

[135]  E. Salvaris,et al.  Protective Effects of Recombinant Human Antithrombin III in Pig‐to‐Primate Renal Xenotransplantation , 2002, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[136]  G. Gonzalez-Stawinski,et al.  Non-anti-Gal alpha1-3Gal antibody mechanisms are sufficient to cause hyperacute lung dysfunction in pulmonary xenotransplantation. , 2002, Journal of the American College of Surgeons.

[137]  H. Schuurman,et al.  Incidence of hyperacute rejection in pig-to-primate transplantation using organs from hDAF-transgenic donors , 2002, Transplantation.

[138]  H. Schuurman,et al.  Serum anti-pig antibodies as potential indicators of acute humoral xenograft rejection in pig-to-cynomolgus monkey kidney transplantation , 2002, Transplantation.

[139]  J. Platt,et al.  C1 inhibitor for prophylaxis of xenograft rejection after pig to cynomolgus monkey kidney transplantation. , 2002, Transplantation.

[140]  Yifan Dai,et al.  Targeted disruption of the α1,3-galactosyltransferase gene in cloned pigs , 2002, Nature Biotechnology.

[141]  M. Goddard,et al.  POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDER ASSOCIATED WITH PRIMATE GAMMA‐HERPESVIRUS IN CYNOMOLGUS MONKEYS USED IN PIG‐TO‐PRIMATE RENAL XENOTRANSPLANTATION AND PRIMATE RENAL ALLOTRANSPLANTATION , 2002, Transplantation.

[142]  B. N. Day,et al.  Production of α-1,3-Galactosyltransferase Knockout Pigs by Nuclear Transfer Cloning , 2002, Science.

[143]  J. Squifflet,et al.  Adult porcine islet transplantation in baboons treated with conventional immunosuppression or a non‐myeloablative regimen and CD154 blockade , 2002, Xenotransplantation.

[144]  C. Chagneau,et al.  Rapid failure of pig islet transplantation in non human primates , 2002, Xenotransplantation.

[145]  R. Colvin,et al.  Pig kidney transplantation in baboons: anti-Gal(alpha)1-3Gal IgM alone is associated with acute humoral xenograft rejection and disseminated intravascular coagulation. , 2001, Transplantation.

[146]  M. Przemeck,et al.  C1‐Inhibitor for treatment of acute vascular xenograft rejection in cynomolgus recipients of h‐DAF transgenic porcine kidneys , 2001, Xenotransplantation.

[147]  J. Klempnauer,et al.  HEMODYNAMIC CONSEQUENCES OF PORCINE KIDNEY XENOGRAFT REPERFUSION IN CYNOMOLGUS MONKEYS1,2 , 2001, Transplantation.

[148]  J. Ringers,et al.  T-cell-directed immunosuppression allows prolonged survival of xenogeneic pig islets in monkeys. , 2001, Transplantation Proceedings.

[149]  J. Wain,et al.  Effects of xenogeneic thymic transplantation in baboons. , 2001, Transplantation proceedings.

[150]  Prof. Dr. med. Gustav Steinhoff,et al.  Analysis of potential porcine endogenous retrovirus (PERV) transmission in a whole-organ xenotransplantation model without interfering microchimerism , 2001, Transplant international : official journal of the European Society for Organ Transplantation.

[151]  J. Platt,et al.  The role of anti-Galalpha1-3Gal antibodies in acute vascular rejection and accommodation of xenografts. , 2000, Transplantation.

[152]  D. Sachs,et al.  COAGULATION AND THROMBOTIC DISORDERS ASSOCIATED WITH PIG ORGAN AND HEMATOPOIETIC CELL TRANSPLANTATION IN NONHUMAN PRIMATES , 2000, Transplantation.

[153]  J. Yélamos,et al.  LIFE-SUPPORTING HUMAN COMPLEMENT REGULATOR DECAY ACCELERATING FACTOR TRANSGENIC PIG LIVER XENOGRAFT MAINTAINS THE METABOLIC FUNCTION AND COAGULATION IN THE NONHUMAN PRIMATE FOR UP TO 8 DAYS1 , 2000, Transplantation.

[154]  H. Bazin,et al.  SPECIFIC DEPLETION OF PREFORMED IgM NATURAL ANTIBODIES BY ADMINISTRATION OF ANTI-&mgr; MONOCLONAL ANTIBODY SUPPRESSES HYPERACUTE REJECTION OF PIG TO BABOON RENAL XENOGRAFTS1 , 2000, Transplantation.

[155]  D. Sachs,et al.  Coagulation/thrombotic disorders associated with organ and cell xenotransplantation. , 2000, Transplantation Proceedings.

[156]  B. Meiser,et al.  Technique of immunoapheresis in heterotopic and orthotopic xenotransplantation of pig hearts into cynomolgus and rhesus monkeys. , 2000, Transplantation proceedings.

[157]  J. Ringers,et al.  Xenografting of pig islets in monkeys does not result in hyperacute rejection. , 2000, Transplantation Proceedings.

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