Enhanced prostaglandin synthesis due to phospholipid breakdown in ischemic-reperfused myocardium. Control of its production by a phospholipase inhibitor or free radical scavengers.

[1]  G. R. Bartlett.  Phosphorus assay in column chromatography. , 1959, The Journal of biological chemistry.

[2]  R. Irvine.  How is the level of free arachidonic acid controlled in mammalian cells? , 1982, The Biochemical journal.

[3]  R. Engelman,et al.  The effect of normothermic anoxic arrest and ventricular fibrillation on the coronary blood flow distribution of the pig. , 1975, The Journal of thoracic and cardiovascular surgery.

[4]  W. Weglicki,et al.  Phospholipase A activity of lysosomes of rat myocardial tissue. , 1972, Biochemistry.

[5]  P. Needleman,et al.  Sites of lipase activation and prostaglandin synthesis in isolated, perfused rabbit hearts and hydronephrotic kidneys , 1978 .

[6]  L. Daniel,et al.  Source of arachidonic acid for prostaglandin synthesis in Madin-Darby canine kidney cells. , 1981, The Journal of biological chemistry.

[7]  O. Ylikorkala,et al.  Increased prostacyclin and thromboxane production in man during cardiopulmonary bypass. , 1981, The Journal of thoracic and cardiovascular surgery.

[8]  R. Jennings,et al.  Myocardial calcium and magnesium in acute ischemic injury. , 1972, The American journal of pathology.

[9]  R. Colman,et al.  Thromboxane synthesis and platelet secretion during cardiopulmonary bypass with bubble oxygenator. , 1980, The Journal of thoracic and cardiovascular surgery.

[10]  F. Prinzen,et al.  Accumulation of nonesterified fatty acids in ischemic canine myocardium. , 1984, The American journal of physiology.

[11]  P. Cuatrecasas,et al.  Phospholipase A2 activity specific for phosphatidic acid. A possible mechanism for the production of arachidonic acid in platelets. , 1981, The Journal of biological chemistry.

[12]  P. Isakson,et al.  Lipases and prostaglandin biosynthesis. , 1978, Advances in prostaglandin and thromboxane research.

[13]  M. Schork,et al.  The Effect of Ibuprofen on Accumulation of Indium‐111‐labeled Platelets and Leukocytes in Experimental Myocardial Infarction , 1982, Circulation.

[14]  A. Marcus,et al.  Synthesis of prostacyclin from platelet-derived endoperoxides by cultured human endothelial cells. , 1980, The Journal of clinical investigation.

[15]  A. Katz,et al.  Lipid-membrane interactions and the pathogenesis of ischemic damage in the myocardium. , 1981, Circulation research.

[16]  S. Shohet,et al.  Myocardial phospholipase A of microsomal and mitochondrial fractions. , 1971, Biochimica et biophysica acta.

[17]  K. Chien,et al.  Accumulation of Unesterified Arachidonic Acid in Ischemic Canine Myocardium: Relationship to a Phosphatidylcholine Deacylation‐Reacylation Cycle and the Depletion of Membrane Phospholipids , 1984, Circulation research.

[18]  G. J. Blackwell,et al.  THE DISTRIBUTION AND METABOLISM OF ARACHIDONIC ACID IN RABBIT PLATELETS DURING AGGREGATION AND ITS MODIFICATION BY DRUGS , 1977, British journal of pharmacology.

[19]  M. Majewska,et al.  Effect of ischemic anoxia and barbiturate anesthesia on free radical oxidation of mitochondrial phospholipids , 1978, Brain Research.

[20]  D. Pfeiffer,et al.  The role of glutathione in the retention of Ca2+ by liver mitochondria. , 1984, The Journal of biological chemistry.

[21]  K. Ogawa,et al.  Roles of Endogenous Prostacyclin and Thromboxane A2 in the Ischemic Canine Heart , 1982, Journal of cardiovascular pharmacology.

[22]  P. Wong,et al.  Calmodulin stimulates human platelet phospholipase A2. , 1979, Biochemical and biophysical research communications.

[23]  K. Moriya,et al.  Effects of thromboxane A2 injection on the rabbit coronary artery. I. Physiologic effects in healthy animals. , 1982, Experimental and molecular pathology.

[24]  O. H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[25]  J. Parratt,et al.  Evidence that thromboxane contributes to ventricular fibrillation induced by reperfusion of the ischaemic myocardium. , 1982, Journal of molecular and cellular cardiology.

[26]  B. Sobel,et al.  Lysophosphatidylcholine metabolism in the rabbit heart. Characterization of metabolic pathways and partial purification of myocardial lysophospholipase-transacylase. , 1982, The Journal of biological chemistry.

[27]  E. Puré,et al.  Prostaglandins and the heart. , 1979, Federation proceedings.

[28]  R. Gross,et al.  Identification of neutral active phospholipase C which hydrolyzes choline glycerophospholipids and plasmalogen selective phospholipase A2 in canine myocardium. , 1985, The Journal of biological chemistry.

[29]  N. Shaikh.  Time Course of Changes in Porcine Myocardial Phospholipid Levels during Ischemia: A Reassessment of the Lysolipid Hypothesis , 1981, Circulation research.

[30]  R. Egan,et al.  Role of prostaglandin endoperoxide PGG2 in inflammatory processes , 1977, Nature.

[31]  D. Towle,et al.  Phospholipase A activity of highly enriched preparations of cardiac sarcolemma from hamster and dog. , 1978, Journal of molecular and cellular cardiology.

[32]  R. Egan,et al.  Inflammation: the role of peroxidase-derived products. , 1980, Advances in prostaglandin and thromboxane research.

[33]  R. Jennings,et al.  Kinetics of calcium accumulation in acute myocardial ischemic injury. , 1972, The American journal of pathology.

[34]  K. Nishiyama,et al.  Effects of thromboxane A2 injection on the rabbit coronary artery. II. The production of infarcts in cholesterol-fed animals. , 1982, Experimental and molecular pathology.

[35]  J. Folch,et al.  A simple method for the isolation and purification of total lipides from animal tissues. , 1957, The Journal of biological chemistry.

[36]  P. Grinwald,et al.  Calcium entry in the calcium paradox. , 1981, Journal of molecular and cellular cardiology.

[37]  J. Vane,et al.  Anoxia‐Induced Release of Prostaglandins in Rabbit Isolated Hearts , 1975, Circulation research.

[38]  A. A. Taylor,et al.  Prostacyclin in experimental myocardial ischemia: effects on hemodynamics, regional myocardial blood flow, infarct size and mortality. , 1981, The American journal of cardiology.