CRYSTALLIZATION AND MECHANICAL PROPERTIES OF (45S5-HA) BIOCOMPOSITE FOR BIOMEDICAL IMPLANTATION

Bioglass (45S5) was prepared by conventional melting process and hydroxyapatite (HA) was prepared by sol-gel method. The bioglass (45S5) and hydroxyapatite (Ca10(PO4)6(OH)2) samples were mixed in a particular proportion to prepare composite by using hydraulic pressing. Based on thermogravimetric and differential thermal analysis, the composite were sintered with a suitable heat treatment process at 1000-1050°C. The in-vitro bioactivity of samples was determined in simulated body fluid for 1, 3, 7, 14 and 21 days. The bioactivity was examined in vitro with respect to the ability of hydroxyapatite layer formation on the surface of samples when they were immersed in simulated body fluid (SBF). DTA/TGA, XRD, SEM and mechanical studies were conducted for different characteristic measurement of biocomposites. The result shows the enhancement in bioactivity and mechanical properties of (45S5-HA) biocomposites for clinical implantation.

[1]  Cuie Wen,et al.  Bioactive Materials , 2017 .

[2]  E. Liu,et al.  Mechanical, tribological and biological properties of novel 45S5 Bioglass® composites reinforced with in situ reduced graphene oxide. , 2017, Journal of the mechanical behavior of biomedical materials.

[3]  H. Kauczor,et al.  Three-dimensional polymer coated 45S5-type bioactive glass scaffolds seeded with human mesenchymal stem cells show bone formation in vivo , 2016, Journal of Materials Science: Materials in Medicine.

[4]  Nishant Shankhwar,et al.  Influence of phosphate precursors on the structure, crystallization behaviour and bioactivity of sol–gel derived 45S5 bioglass , 2015 .

[5]  G. Stan,et al.  Strong bonding between sputtered bioglass–ceramic films and Ti-substrate implants induced by atomic inter-diffusion post-deposition heat-treatments , 2013 .

[6]  Julian R Jones,et al.  Review of bioactive glass: from Hench to hybrids. , 2013, Acta biomaterialia.

[7]  M. Fathi,et al.  Preparation and characterization of hydroxyapatite–forsterite–bioactive glass nanocomposite coatings for biomedical applications , 2012 .

[8]  Delbert E Day,et al.  Bioactive glass in tissue engineering. , 2011, Acta biomaterialia.

[9]  K. Tanner.  Bioactive composites for bone tissue engineering , 2010, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[10]  G. Jell,et al.  Synthesis and characterization of hypoxia-mimicking bioactive glasses for skeletal regeneration , 2010 .

[11]  Valeria Cannillo,et al.  Different approaches to produce coatings with bioactive glasses: Enamelling vs plasma spraying , 2010 .

[12]  D. Brauer,et al.  Fluoride-containing bioactive glasses: effect of glass design and structure on degradation, pH and apatite formation in simulated body fluid. , 2010, Acta biomaterialia.

[13]  S. Datta,et al.  Cefuroxime-impregnated calcium phosphates as an implantable delivery system in experimental osteomyelitis , 2009 .

[14]  Larry L. Hench,et al.  The story of Bioglass® , 2006, Journal of materials science. Materials in medicine.

[15]  V. Rajendran,et al.  Ultrasonic Investigation on Nanocrystalline Barium Borate (BBO) Glass Ceramics , 2006 .

[16]  K. Powers,et al.  Effect of pH and ionic strength on the reactivity of Bioglass 45S5. , 2005, Biomaterials.

[17]  J. Fernández‐Pradas,et al.  In vitro bioactivity of laser ablation pseudowollastonite coating. , 2004, Biomaterials.

[18]  F. Hughes,et al.  In vitro behavior of osteoblastic cells cultured in the presence of pseudowollastonite ceramic. , 2004, Journal of biomedical materials research. Part A.

[19]  K. H. Karlsson,et al.  Bioactivity of glass and bioactive glasses for bone repair , 2004 .

[20]  Masakazu Kawashita,et al.  Novel bioactive materials with different mechanical properties. , 2003, Biomaterials.

[21]  M. Vallet‐Regí,et al.  Bioactivity of three CaO-P2O5-SiO2 sol-gel glasses. , 2002, Journal of biomedical materials research.

[22]  F. Rustichelli,et al.  Improvement in zirconia osseointegration by means of a biological glass coating: An in vitro and in vivo investigation. , 2002, Journal of biomedical materials research.

[23]  Larry L Hench,et al.  Third-Generation Biomedical Materials , 2002, Science.

[24]  L. Hench.  Science, Faith and Ethics , 2001 .

[25]  Edgar Dutra Zanotto,et al.  Relationship between short-range order and ease of nucleation in Na2Ca2Si3O9, CaSiO3 and PbSiO3 glasses , 2000 .

[26]  Martínez,et al.  Morphological and structural study of pseudowollastonite implants in bone , 2000, Journal of microscopy.

[27]  P Ducheyne,et al.  Bioactive ceramics: the effect of surface reactivity on bone formation and bone cell function. , 1999, Biomaterials.

[28]  E. Saiz,et al.  Glass-based coatings for titanium implant alloys. , 1999, Journal of biomedical materials research.

[29]  C. R. Anderegg,et al.  A bioactive glass particulate in the treatment of molar furcation invasions. , 1999, Journal of periodontology.

[30]  F. Guitián,et al.  Bioactivity of pseudowollastonite in human saliva. , 1999, Journal of dentistry.

[31]  U. Wikesjö,et al.  Effect of a calcium sulfate implant with calcium sulfate barrier on periodontal healing in 3-wall intrabony defects in dogs. , 1998, Journal of periodontology.

[32]  C. Ohtsuki,et al.  Bioactivity of titanium treated with hydrogen peroxide solutions containing metal chlorides. , 1997, Journal of biomedical materials research.

[33]  T. Yamamuro,et al.  Bioactivity of CaO·SiO2-based glasses:in vitro evaluation , 1990 .

[34]  T Kitsugi,et al.  Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramic A-W. , 1990, Journal of biomedical materials research.

[35]  Larry L. Hench,et al.  Bonding mechanisms at the interface of ceramic prosthetic materials , 1971 .