Exploring Alcohol Withdrawal Syndrome

Alcohol withdrawal syndrome is characterized by hyperactivity of the nervous system. This hyperactivity represents the brain’s attempt to function normally despite the inhibitory effect of chronic alcohol consumption. The syndrome manifests when alcohol consumption ceases. Experimental, clinical, and genetic research have linked the development of withdrawal to alterations in the sensitivity of neuronal communication systems. Early treatment of the syndrome is advised, because the symptom severity may increase with each subsequent episode.

[1]  HighWire Press,et al.  The British Journal of Psychiatry , 2006, British Journal of Psychiatry.

[2]  J. Crabbe,et al.  Quantitative Trait Loci Involved in Genetic Predisposition to Acute Alcohol Withdrawal in Mice , 1997, The Journal of Neuroscience.

[3]  G. Spalletta,et al.  Marked decrease of plasma neuroactive steroids during alcohol withdrawal. , 1996, Clinical neuropharmacology.

[4]  A. Morrow,et al.  Sensitization of gamma-aminobutyric acidA receptors to neuroactive steroids in rats during ethanol withdrawal. , 1996, The Journal of pharmacology and experimental therapeutics.

[5]  Yost Da.  Alcohol withdrawal syndrome. , 1996, American family physician.

[6]  K. Buck.  Molecular genetic analysis of the role of GABAergic systems in the behavioral and cellular actions of alcohol , 1996, Behavior genetics.

[7]  K. Bucholz,et al.  The histories of withdrawal convulsions and delirium tremens in 1648 alcohol dependent subjects. , 1995, Addiction.

[8]  H. Little,et al.  Identification of distinct components, with different time courses, of the changes in response to convulsive stimuli during ethanol withdrawal. , 1995, The Journal of pharmacology and experimental therapeutics.

[9]  E. Lander,et al.  A genetic linkage map of the mouse: current applications and future prospects. , 1993, Science.

[10]  R. Hale,et al.  Repeated episodes of ethanol withdrawal potentiate the severity of subsequent withdrawal seizures: an animal model of alcohol withdrawal "kindling". , 1993, Alcoholism, clinical and experimental research.

[11]  P. Glue,et al.  Overexcitement and Disinhibition , 1990, British Journal of Psychiatry.

[12]  J. Crabbe,et al.  Genetic correlations with ethanol withdrawal severity , 1983, Pharmacology Biochemistry and Behavior.

[13]  R. Kakihana.  Alcohol intoxication and withdrawal in inbred strains of mice: behavioral and endocrine studies. , 1979, Behavioral and neural biology.

[14]  R. Post,et al.  Kindling as a Model for Alcohol Withdrawal Syndromes , 1978, British Journal of Psychiatry.

[15]  D. B. Goldstein.  Inherited Differences in Intensity of Alcohol Withdrawal Reactions in Mice , 1973, Nature.

[16]  F. Crews,et al.  Effects of ethanol on ion channels. , 1996, International review of neurobiology.

[17]  A. Morrow,et al.  Regulation of GABAA receptor function and gene expression in the central nervous system. , 1995, International review of neurobiology.

[18]  H. Little.  The role of neuronal calcium channels in dependence on ethanol and other sedatives/hypnotics. , 1991, Pharmacology & therapeutics.

[19]  I. Golovchenko,et al.  [Effect of alcohol on the nervous system]. , 1986, Fel'dsher i akusherka.

[20]  R. Deitrich,et al.  Genetics of Alcoholism and Alcohol Actions , 1984 .