论文信息 - Continuous synthesis of aminophenols from nitroaromatic compounds by combination of metal and biocatalyst. - 字舞流文

Continuous synthesis of aminophenols from nitroaromatic compounds by combination of metal and biocatalyst.

The combined action of immobilized hydroxylaminobenzene mutase and zinc in a flow-through system catalyzes the conversion of nitroaromatic compounds to the corresponding ortho-aminophenols, including a novel analog of chloramphenicol.

H. Luckarift | L. Nadeau | J. Spain | Heather R Luckarift | Jim C Spain | Lloyd J Nadeau

[1] A. R. Tatchell,et al. Vogel's Textbook of Practical Organic Chemistry , 1996 .

[2] D. Avnir,et al. One-pot sequences of reactions with sol-gel entrapped opposing reagents: an enzyme and metal-complex catalysts. , 2002, Journal of the American Chemical Society.

[3] T. Izard,et al. Structural basis for chloramphenicol tolerance in Streptomyces venezuelae by chloramphenicol phosphotransferase activity , 2001, Protein science : a publication of the Protein Society.

[4] J. Bäckvall,et al. Combined metal catalysis and biocatalysis for an efficient deracemization process. , 2003, Current opinion in biotechnology.

[5] Rajesh R Naik,et al. Enzyme immobilization in a biomimetic silica support , 2004, Nature Biotechnology.

[6] M. D. Corbett,et al. Synthesis and Antibiotic Properties of Chloramphenicol Reduction Products , 1978, Antimicrobial Agents and Chemotherapy.