L‐Carnitine. Novel Synthesis and Determination of the Optical Purity

A new route to L-carnitine (1) based on the resolution of th trimethylammonium derivative 5 is described. The enantiomeric purity of 1 is determined by 1H-NMR of its O-acetyl hydrochloride 11 using [Eu(hfc)3] as chiral shift reagent. The optical rotation of 1 with an enantiomeric purity ≥99% is [α] =−31.3° (c = 10, H2O).

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