Migraine in 746 patients with multiple sclerosis.

Migraine adds to the burden of patients suffering from multiple sclerosis (MS). The ID-migraine is a useful tool for screening migraine, and the Migraine Disability Assessment questionnaire can evaluate disease burden. The aim of the present study was to assess the presence and burden of migraine in patients with MS. METHODS Patients diagnosed with MS attending specialized MS units were invited to answer an online survey if they also experienced headache. RESULTS The study included 746 complete responses from patients with MS and headache. There were 625 women and 121 men, and 69% of all the patients were aged between 20 and 40 years. Migraine was identified in 404 patients (54.1%) and a moderate-to-high burden of disease was observed in 68.3% of the patients. CONCLUSION Migraine is a frequent and disabling type of primary headache reported by patients with MS.

[1]  T. Steiner,et al.  The Global Burden of Headache , 2018, Seminars in Neurology.

[2]  L. G. Velarde,et al.  ID-Migraine™ questionnaire and accurate diagnosis of migraine. , 2017, Arquivos de neuro-psiquiatria.

[3]  L. La Mantia,et al.  Headache in multiple sclerosis and autoimmune disorders , 2015, Neurological Sciences.

[4]  C. Pozzilli,et al.  The Impact of Interferon Beta and Natalizumab on Comorbid Migraine in Multiple Sclerosis , 2012, Headache.

[5]  C. Pozzilli,et al.  Determinants of the severity of comorbid migraine in multiple sclerosis , 2012, Neurological Sciences.

[6]  E. D’Amico,et al.  Frequency and severity of headache is worsened by Interferon‐β therapy in patients with multiple sclerosis , 2012, Acta Neurologica Scandinavica.

[7]  C. Pozzilli,et al.  The use of ID migraine™ questionnaire in patients with multiple sclerosis , 2011, Neurological Sciences.

[8]  R. Lipton,et al.  Migraine is comorbid with multiple sclerosis and associated with a more symptomatic MS course , 2010, The Journal of Headache and Pain.

[9]  N. Putzki,et al.  Headache in Multiple Sclerosis , 2010, Current pain and headache reports.

[10]  Y. Fragoso,et al.  Two Cases of Lesions in Brainstem in Multiple Sclerosis and Refractory Migraine , 2007, Headache.

[11]  M. Segal,et al.  Migraines linked to interferon-β treatment of multiple sclerosis , 2005 .

[12]  A. Dublin,et al.  The Association of Brainstem Lesions With Migraine‐Like Headache: An Imaging Study of Multiple Sclerosis , 2005, Headache.

[13]  R. Lipton,et al.  A self-administered screener for migraine in primary care , 2003, Neurology.

[14]  Y. Fragoso.  MIDAS (Migraine Disability Assessment): a valuable tool for work-site identification of migraine in workers in Brazil. , 2002, Sao Paulo medical journal = Revista paulista de medicina.

[15]  R. Lipton,et al.  Validity of the Migraine Disability Assessment (MIDAS) score in comparison to a diary-based measure in a population sample of migraine sufferers , 2000, Pain.

[16]  Y. Beckmann,et al.  Headache characteristics in multiple sclerosis. , 2019, Multiple sclerosis and related disorders.