Toxicokinetic models and related tools in environmental risk assessment of chemicals.

[1]  V. Oliverio,et al.  Prediction of the distribution of methotrexate in the sting rays Dasyatidae sabrina and sayi by use of a model developed in mice. , 1972, Comparative biochemistry and physiology. A, Comparative physiology.

[2]  G. Blau,et al.  Bioconcentration of 2,2′,4,4′-Tetrachlorobiphenyl in Rainbow Trout as Measured by an Accelerated Test , 1975 .

[3]  B. G. Blaylock,et al.  Application of various mathematical models to data from the uptake of methyl mercury in bluegill sunfish (Lepomis macrochirus) , 1977 .

[4]  C. Cho,et al.  Elimination of Hexachlorobenzene (HCB) by Rainbow Trout (Salmo gairdneri), and an Examination of its Kinetics in Lake Ontario Salmonids , 1981 .

[5]  H. Goeden,et al.  A direct measure of the uptake efficiency of a xenobiotic chemical across the gills of brook trout (Salvelinus fontinalis) under normoxic and hypoxic conditions , 1982 .

[6]  S. Bartell,et al.  Kinetics and biotransformation of benzo(a)pyrene inChironomus riparius , 1982, Archives of environmental contamination and toxicology.

[7]  D. Scavia,et al.  Influence of sediment on anthracene uptake, depuration, and biotransformation by the amphipod Hyalella azteca. , 1983 .

[8]  A. Karara,et al.  Pharmacokinetic model for the uptake and disposition of di-2-ethylhexyl phthalate in sheepshead minnow Cyprinodon variegatus , 1984 .

[9]  G. M. Hughes.  1 General Anatomy of the Gills , 1984 .

[10]  R. Erickson,et al.  Toxicokinetic modeling of [14C] pentachlorophenol in the rainbow trout (Salmo gairdneri) , 1986 .

[11]  J. Means,et al.  Bioaccumulation of trace organic contaminants from sediment by baltic clams (Macoma balthica) and soft‐shell clams (Mya arenaria) , 1987 .

[12]  W. Hayton,et al.  Temperature-dependence of cardiac output and regional blood flow in rainbow trout, Salmo gairdneri Richardson , 1987 .

[13]  D. Mackay,et al.  Dynamics of dietary bioaccumulation and faecal elimination of hydrophobic organic chemicals in fish , 1988 .

[14]  P. Schumacker,et al.  Organ blood flow haemodynamics and metabolism of the albacore tuna Thunnus alalunga (Bonnaterre). , 1988, Experimental biology.

[15]  M. James,et al.  Pharmacokinetics of sulphadimethoxine in the lobster, Homarus americanus, following intrapericardial administration. , 1988, Xenobiotica; the fate of foreign compounds in biological systems.

[16]  P. Landrum,et al.  Toxicokinetics of Selected Xenobiotics in Hexagenia Limbata , 1988 .

[17]  J. Giesy,et al.  Maternal transfer of bioactive polychlorinated aromatic hydrocarbons in spawning chinook salmon (Oncorhynchus tschawytscha) , 1989 .

[18]  F. Gobas,et al.  Bioaccumulation of chlorinated hydrocarbons by the mayfly (Hexagenia limbata) in Lake St. Clair , 1989 .

[19]  A. J. Niimi,et al.  Dietary absorption efficiencies and elimination rates of polycyclic aromatic hydrocarbons (PAHs) in rainbow trout (salmo gairdneri) , 1989 .

[20]  I. Schultz,et al.  Presystemic branchial metabolism limits di-2-ethylhexyl phthalate accumulation in fish. , 1989, Toxicology and applied pharmacology.

[21]  W. Hayton,et al.  Disposition of pentachlorophenol in rainbow trout (Salmo gairdneri): effect of inhibition of metabolism , 1989 .

[22]  E. McLean,et al.  Chronic cannulation of the hepatic portal vein in rainbow trout, Salmo gairdneri: A prerequisite to net absorption studies , 1989 .

[23]  A. Karara,et al.  A pharmacokinetic analysis of the effect of temperature on the accumulation of di-2-ethylhexyl phthalate (DEHP) in sheepshead minnow , 1989 .

[24]  W. Hayton,et al.  Effect of pH on the accumulation kinetics of pentachlorophenol in goldfish , 1990, Archives of environmental contamination and toxicology.

[25]  R. Nagel,et al.  Kinetics and metabolism of 14C-lindane and 14C-atrazine in early life stages of zebrafish (Brachydanio Rerio) , 1990 .

[26]  P. Landrum,et al.  Toxicokinetics of PAHs in Hexagenia , 1990 .

[27]  M. Andersen,et al.  A physiologically based toxicokinetic model for the uptake and disposition of waterborne organic chemicals in fish. , 1990, Toxicology and applied pharmacology.

[28]  R. Erickson,et al.  A model for exchange of organic chemicals at fish gills: flow and diffusion limitations , 1990 .

[29]  W. Hayton,et al.  Effect of body size on the uptake and bioconcentration of di‐2‐ethylhexyl phthalate in rainbow trout , 1990 .

[30]  W. Hayton,et al.  Pharmacokinetic modeling in aquatic animals I. Models and concepts , 1990 .

[31]  W. L. Lockhart,et al.  Dietary accumulation and sustained hepatic mixed function oxidase enzyme induction by 2,3,4,7,8‐pentachlorodibenzofuran in rainbow trout , 1990 .

[32]  M. Janssen,et al.  The effect of temperature on cadmium kinetics and oxygen consumption in soil arthropods , 1991 .

[33]  C. Kennedy,et al.  A biologically based toxicokinetic model for pyrene in rainbow trout. , 1991, Toxicology and applied pharmacology.

[34]  J. Nichols,et al.  Physiologically based toxicokinetic modeling of three waterborne chloroethanes in rainbow trout (Oncorhynchus mykiss). , 1991, Toxicology and applied pharmacology.

[35]  F. Gobas,et al.  Bioconcentration of chlorinated aromatic hydrocarbons in aquatic macrophytes , 1991 .

[36]  D. Dixon,et al.  Toxicokinetic modeling of mixtures of organic chemicals , 1992 .

[37]  M. Lydy,et al.  Toxicokinetics in aquatic systems: Model comparisons and use in hazard assessment , 1992 .

[38]  Hoffman Ad,et al.  An in vitro gas equilibration method for determination of chemical partition coefficients in fish. , 1992 .

[39]  I. Schultz,et al.  Toxicokinetics of trifluralin in rainbow trout , 1993 .

[40]  J. Mckim,et al.  Predicting branchial and cutaneous uptake of 2,2′,5,5′-tetrachlorobiphenyl in fathead minnows (Pimephales promelas) and Japanese medaka (Oryzias latipes): Rate limiting factors , 1993 .

[41]  J. Nichols,et al.  Physiologically-based toxicokinetic modeling of three waterborne chloroethanes in channel catfish, Ictalurus punctatus , 1993 .

[42]  P. Rheingans,et al.  Three-dimensional visualization of physiologically based kinetic model outputs. , 1994, Environmental health perspectives.

[43]  David H. Evans,et al.  The Physiology of Fishes , 1994 .

[44]  Sebastiaan A.L.M. Kooijman,et al.  Dynamic energy budgets affect kinetics of xenobiotics in the marine mussel Mytilus edulis , 1994 .

[45]  J. Deneer.  Bioconcentration of chlorpyrifos by the three-spined stickleback under laboratory and field conditions , 1994 .

[46]  J. Nichols,et al.  Modeling the accumulation of three waterborne chlorinated ethanes in fathead minnows (Pimephales promelas): A physiologically based approach , 1994 .

[47]  M. C. Newman,et al.  Quantitative methods in aquatic ecotoxicology , 1995 .

[48]  K Krishnan,et al.  An algorithm for predicting tissue: blood partition coefficients of organic chemicals from n-octanol: water partition coefficient data. , 1995, Journal of toxicology and environmental health.

[49]  Sebastiaan A.L.M. Kooijman,et al.  No-effect concentrations in algal growth inhibition tests , 1996 .

[50]  J. Nichols,et al.  Dermal absorption of three waterborne chloroethanes in rainbow trout (Oncorhynchus mykiss) and channel catfish (Ictalurus punctatus). , 1996 .

[51]  Colleen M. Elonen,et al.  A physiologically based toxicokinetic model for dermal absorption of organic chemicals by fish. , 1996, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[52]  A. R. Lewis,et al.  Scaling of skeletal mass to body mass in fishes , 1996, Journal of morphology.

[53]  G. Zauke,et al.  Bioaccumulation of trace metals in Greenland Sea copepod and amphipod collectives on board ship: verification of toxicokinetic model parameters , 1997 .

[54]  I. Schultz,et al.  Influence of body fat on trifluralin toxicokinetics in rainbow trout (Oncorhynchus mykiss) , 1997 .

[55]  W. Hayton,et al.  A physiologically based pharmacokinetic and pharmacodynamic model for paraoxon in rainbow trout. , 1997, Toxicology and applied pharmacology.

[56]  Robert V. Thomann,et al.  A pharmacokinetic model of cadmium in rainbow trout , 1997 .

[57]  J. Nichols,et al.  Evaluation of log KOW and tissue lipid content as predictors of chemical partitioning to fish tissues , 1998 .

[58]  J. Sumpter,et al.  Endocrine disruption in wildlife: a critical review of the evidence. , 1998, Critical reviews in toxicology.

[59]  J. Tietge,et al.  Physiologically based toxicokinetic model for maternal transfer of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin in brook trout (Salvelinus fontinalis) , 1998 .

[60]  M. Barron,et al.  Tissue carboxylesterase activity of rainbow trout , 1999 .

[61]  J. Mckim,et al.  Respiratory–cardiovascular physiology and xenobiotic gill flux in the lake trout (Salvelinus namaycush) , 1999 .

[62]  M. C. Newman,et al.  Blood flow distribution and tissue allometry in channel catfish , 1999 .

[63]  J. Doull,et al.  Dose and time as variables of toxicity. , 2000, Toxicology.

[64]  Chung-Min Liao,et al.  An optimal trace zinc biomonitor (Haliotis diversicolor supertexta) control system design in aquacultural ecosystems , 2000 .

[65]  P M Schlosser,et al.  Haber's rule: a special case in a family of curves relating concentration and duration of exposure to a fixed level of response for a given endpoint. , 2000, Toxicology.

[66]  S. Ahmad,et al.  Differential inhibition of xenobiotic-metabolizing carboxylesterases by organotins in marine fish. , 2000, Ecotoxicology and environmental safety.

[67]  D. Mackay,et al.  Kenneth Mellanby Review Award. Bioaccumulation of persistent organic chemicals: mechanisms and models. , 2000, Environmental pollution.

[68]  Jacqueline Garnier-Laplace,et al.  A simple fish physiological model for radioecologists exemplified for direct transfer and rainbow trout (Oncorhynchus mykiss W.) , 2000 .

[69]  F Y Bois,et al.  Statistical issues in toxicokinetic modeling: a bayesian perspective. , 2000, Environmental health perspectives.

[70]  J. Mckim,et al.  A physiologically based toxicokinetic model for lake trout (Salvelinus namaycush). , 2001, Aquatic toxicology.

[71]  B. Mourot,et al.  In vivo and in vitro effects of prochloraz and nonylphenol ethoxylates on trout spermatogenesis. , 2001, Aquatic toxicology.

[72]  J. Nichols,et al.  Branchial elimination of superhydrophobic organic compounds by rainbow trout (Oncorhynchus mykiss). , 2001, Aquatic toxicology.

[73]  A. Hendriks,et al.  The power of size. 2. Rate constants and equilibrium ratios for accumulation of inorganic substances related to species weight , 2001, Environmental toxicology and chemistry.

[74]  T. Baussant,et al.  Bioaccumulation of polycyclic aromatic compounds: 2. Modeling bioaccumulation in marine organisms chronically exposed to dispersed oil , 2001, Environmental toxicology and chemistry.

[75]  Patrick Poulin,et al.  Prediction of pharmacokinetics prior to in vivo studies. II. Generic physiologically based pharmacokinetic models of drug disposition. , 2002, Journal of pharmaceutical sciences.

[76]  J. Zhang,et al.  Determination of Toxicokinetic Parameters for Bioconcentration of Water-Soluble Fraction of Petroleum Hydrocarbon Associated with No. 0 Diesel in Changjiang Estuary and Jiaozhou Bay: Model Versus Mesocosm Experiments , 2002, Archives of Environmental Contamination and Toxicology.

[77]  G. R. Parsons,et al.  Respiratory and hematological responses of the bonnethead shark, Sphyrna tiburo, to acute changes in dissolved oxygen , 2003 .

[78]  M. C. Barber.  A review and comparison of models for predicting dynamic chemical bioconcentration in fish , 2003, Environmental toxicology and chemistry.

[79]  H. van de Waterbeemd,et al.  ADMET in silico modelling: towards prediction paradise? , 2003, Nature reviews. Drug discovery.

[80]  M. Lydy,et al.  Toxicokinetics of Organic Contaminants in Hyalella azteca , 2003, Archives of environmental contamination and toxicology.

[81]  M. Lydy,et al.  Toxicokinetics of sediment‐sorbed benzo[a]pyrene and hexachlorobiphenyl using the freshwater invertebrates Hyalella azteca, Chironomus tentans, and Lumbriculus variegatus , 2003, Environmental toxicology and chemistry.

[82]  N. Bunce,et al.  Haber's Rule: The Search for Quantitative Relationships in Toxicology , 2003 .

[83]  John W Nichols,et al.  A physiologically based toxicokinetic model for dietary uptake of hydrophobic organic compounds by fish: I. Feeding studies with 2,2',5,5'-tetrachlorobiphenyl. , 2004, Toxicological sciences : an official journal of the Society of Toxicology.

[84]  J. Leatherland,et al.  Temporal changes in plasma thyroid hormone, growth hormone and free fatty acid concentrations, and hepatic 5′-monodeiodinase activity, lipid and protein content during chronic fasting and re-feeding in rainbow trout (Oncorhynchus mykiss) , 1992, Fish Physiology & Biochemistry.

[85]  Joop L. M. Hermens,et al.  Peer Reviewed: Internal Exposure: Linking Bioavailability to Effects , 2004 .

[86]  Harvey J Clewell,et al.  Evaluation of the potential impact of age- and gender-specific pharmacokinetic differences on tissue dosimetry. , 2004, Toxicological sciences : an official journal of the Society of Toxicology.

[87]  Bas Kooijman,et al.  Dynamic Energy Budget Theory for Metabolic Organisation , 2005 .

[88]  Inge Werner,et al.  Individual variability in esterase activity and CYP1A levels in Chinook salmon (Oncorhynchus tshawytscha) exposed to esfenvalerate and chlorpyrifos. , 2005, Aquatic toxicology.

[89]  J. Burger,et al.  The development of a physiologically-based pharmacokinetic model using the distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the tissues of the eastern oyster (Crassostrea virginica). , 2005, Marine environmental research.

[90]  Tjalling Jager,et al.  Modeling receptor kinetics in the analysis of survival data for organophosphorus pesticides. , 2005, Environmental science & technology.

[91]  Frédéric Y Bois,et al.  Use of a Chemical Probe to Increase Safety for Human Volunteers in Toxicokinetic Studies , 2005, Risk analysis : an official publication of the Society for Risk Analysis.

[92]  C. Liao,et al.  A PBTK/TD Modeling-Based Approach Can Assess Arsenic Bioaccumulation in Farmed Tilapia (Oreochromis mossambicus) and Human Health Risks , 2005, Integrated environmental assessment and management.

[93]  M. Carvan,et al.  Accumulation, tissue distribution, and maternal transfer of dietary 2,3,7,8,-tetrachlorodibenzo-p-dioxin: impacts on reproductive success of zebrafish. , 2005, Toxicological sciences : an official journal of the Society of Toxicology.

[94]  C. Liao,et al.  Dynamical coupling of PBPK/PD and AUC-based toxicity models for arsenic in tilapia Oreochromis mossambicus from blackfoot disease area in Taiwan. , 2005, Environmental pollution.

[95]  A. Guarino,et al.  Pharmacokinetic modeling of the dogfish shark (Squalus acanthias): Distribution and urinary and biliary excretion of phenol red and its glucuronide , 1976, Journal of Pharmacokinetics and Biopharmaceutics.

[96]  Tjalling Jager,et al.  Physiological modes of action of toxic chemicals in the nematode Acrobeloides nanus , 2006, Environmental toxicology and chemistry.

[97]  Roman Ashauer,et al.  Uptake and Elimination of Chlorpyrifos and Pentachlorophenol into the Freshwater Amphipod Gammarus pulex , 2006, Archives of environmental contamination and toxicology.

[98]  I. Schultz,et al.  In vitro-in vivo extrapolation of quantitative hepatic biotransformation data for fish. I. A review of methods, and strategies for incorporating intrinsic clearance estimates into chemical kinetic models. , 2006, Aquatic toxicology.

[99]  M. Khosravi,et al.  Kinetic modeling and thermodynamic study to remove Pb(II), Cd(II), Ni(II) and Zn(II) from aqueous solution using dead and living Azolla filiculoides. , 2006, Journal of hazardous materials.

[100]  O. Richter,et al.  Guidance Document on Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in EU Registration , 2006 .

[101]  Roman Ashauer,et al.  Predicting effects on aquatic organisms from fluctuating or pulsed exposure to pesticides , 2006, Environmental toxicology and chemistry.

[102]  A. Kolok,et al.  Cd Exposures in Fathead Minnows: Effects on Adult Spawning Success and Reproductive Physiology , 2006, Archives of environmental contamination and toxicology.

[103]  I. Schultz,et al.  Oral exposure of PBDE-47 in fish: toxicokinetics and reproductive effects in Japanese Medaka (Oryzias latipes) and fathead minnows (Pimephales promelas). , 2006, Environmental science & technology.

[104]  C. Liao,et al.  A dose‐based modeling approach for accumulation and toxicity of arsenic in tilapia Oreochromis mossambicus , 2006, Environmental toxicology.

[105]  Lawrence P Burkhard,et al.  In vitro‐in vivo extrapolation of quantitative hepatic biotransformation data for fish. II. Modeled effects on chemical bioaccumulation , 2007, Environmental toxicology and chemistry.

[106]  E. Sandblom,et al.  Venous hemodynamic responses to acute temperature increase in the rainbow trout (Oncorhynchus mykiss). , 2007, American journal of physiology. Regulatory, integrative and comparative physiology.

[107]  Thomas J. Smith,et al.  Development of a physiologically based toxicokinetic model for butadiene and four major metabolites in humans: global sensitivity analysis for experimental design issues. , 2007, Chemico-biological interactions.

[108]  O. Pelkonen,et al.  In vitro–in vivo extrapolation of hepatic clearance: Biological tools, scaling factors, model assumptions and correct concentrations , 2007, Xenobiotica; the fate of foreign compounds in biological systems.

[109]  J. Vives i Batlle,et al.  Allometric methodology for the calculation of biokinetic parameters for marine biota. , 2007, The Science of the total environment.

[110]  R. Letcher,et al.  Debromination of polybrominated diphenyl ether-99 (BDE-99) in carp (Cyprinus carpio) microflora and microsomes. , 2007, Chemosphere.

[111]  Xing Han,et al.  Determination of xenobiotic intrinsic clearance in freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) and rat and its application in bioaccumulation assessment. , 2007, Environmental science & technology.

[112]  J. Nichols,et al.  A compilation of in vitro rate and affinity values for xenobiotic biotransformation in fish, measured under physiological conditions. , 2007, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[113]  S. Dyer,et al.  Approach for extrapolating in vitro metabolism data to refine bioconcentration factor estimates. , 2008, Chemosphere.

[114]  S. F. D’souza,et al.  Biosorption characteristics of uranium(VI) from aqueous medium onto Catenella repens, a red alga. , 2008, Journal of hazardous materials.

[115]  S. Klaine,et al.  Developmental effects of a municipal wastewater effluent on two generations of the fathead minnow, Pimephales promelas. , 2009, Aquatic toxicology.

[116]  Chartchalerm Isarankura-Na-Ayudhya,et al.  A practical overview of quantitative structure-activity relationship , 2009 .

[117]  N. Brown‐Peterson,et al.  Responses of Fathead Minnows (Pimephales promelas) During Life-Cycle Exposures to Pulp Mill Effluents at Four Long-Term Receiving Water Study Sites , 2009, Integrated environmental assessment and management.

[118]  Jon A. Arnot,et al.  Mass Balance Models for Chemical Fate, Bioaccumulation, Exposure and Risk Assessment , 2009 .

[119]  Kinetic study of the bioaccumulation of heavy metals (Cu, Pb, and Cd) in Chinese domestic oyster Ostrea plicatula , 2010, Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering.

[120]  Roman Ashauer,et al.  Advantages of toxicokinetic and toxicodynamic modelling in aquatic ecotoxicology and risk assessment. , 2010, Journal of environmental monitoring : JEM.

[121]  C. A. V. van Gestel,et al.  Influence of soil properties on molybdenum uptake and elimination kinetics in the earthworm Eisenia andrei. , 2010, Chemosphere.

[122]  S. Mabury,et al.  Biotransformation of the 8:2 fluorotelomer acrylate in rainbow trout. 2. In vitro incubations with liver and stomach S9 fractions , 2010, Environmental toxicology and chemistry.

[123]  Ben A. Smith,et al.  Uptake and Elimination of Cadmium and Zinc by Eisenia andrei During Exposure to Low Concentrations in Artificial Soil , 2010, Archives of environmental contamination and toxicology.

[124]  B. Nair,et al.  Biosorption of cadmium metal ion from simulated wastewaters using Hypnea valentiae biomass: a kinetic and thermodynamic study. , 2010, Bioresource technology.

[125]  J. Dorne,et al.  Metabolism, variability and risk assessment. , 2010, Toxicology.

[126]  E. Balsa-Canto,et al.  Generic parameterization for a pharmacokinetic model to predict Cd concentrations in several tissues of different fish species. , 2010, Chemosphere.

[127]  A. Sandbichler,et al.  Chronic reduction in cardiac output induces hypoxic signaling in larval zebrafish even at a time when convective oxygen transport is not required. , 2010, Physiological genomics.

[128]  Rémy Beaudouin,et al.  A stochastic whole-body physiologically based pharmacokinetic model to assess the impact of inter-individual variability on tissue dosimetry over the human lifespan. , 2010, Regulatory toxicology and pharmacology : RTP.

[129]  H. E. Buist,et al.  Characterization and application of physiologically based pharmacokinetic models in risk assessment , 2010 .

[130]  Oliver A.H. Jones,et al.  Systems toxicology approaches for understanding the joint effects of environmental chemical mixtures. , 2010, The Science of the total environment.

[131]  C. A. V. van Gestel,et al.  Three-phase metal kinetics in terrestrial invertebrates exposed to high metal concentrations. , 2010, The Science of the total environment.

[132]  Zhenhong Li,et al.  A computational model of the hypothalamic - pituitary - gonadal axis in female fathead minnows (Pimephales promelas) exposed to 17α-ethynylestradiol and 17β-trenbolone , 2011, BMC Systems Biology.

[133]  P. Bjerregaard,et al.  Bezafibrate, a lipid-lowering pharmaceutical, as a potential endocrine disruptor in male zebrafish (Danio rerio). , 2011, Aquatic toxicology.

[134]  Thomas Jaki,et al.  Estimation of pharmacokinetic parameters with the R package PK , 2011 .

[135]  A. Farrell,et al.  Effects of body mass on physiological and anatomical parameters of mature salmon: evidence against a universal heart rate scaling exponent , 2011, Journal of Experimental Biology.

[136]  Walter Schmitt,et al.  Toxicokinetic‐toxicodynamic modeling of quantal and graded sublethal endpoints: A brief discussion of concepts , 2011, Environmental toxicology and chemistry.

[137]  Roman Ashauer,et al.  General unified threshold model of survival--a toxicokinetic-toxicodynamic framework for ecotoxicology. , 2011, Environmental science & technology.

[138]  E. Ullerås,et al.  Retention and maternal transfer of brominated dioxins in zebrafish (Danio rerio) and effects on reproduction, aryl hydrocarbon receptor-regulated genes, and ethoxyresorufin-O-deethylase (EROD) activity. , 2011, Aquatic toxicology.

[139]  M. Reinhard,et al.  Novel perspectives on the bioaccumulation of PFCs--the concentration dependency. , 2011, Environmental science & technology.

[140]  Xiaowei Zhang,et al.  Effects of β‐endosulfan on the growth and reproduction of zebrafish (Danio rerio) , 2011, Environmental toxicology and chemistry.

[141]  Roman Ashauer,et al.  Toxicokinetic model describing bioconcentration and biotransformation of diazinon in Daphnia magna. , 2011, Environmental Science and Technology.

[142]  Hannu Raunio,et al.  In Silico Toxicology – Non-Testing Methods , 2011, Front. Pharmacol..

[143]  S. Dyer,et al.  Protein and lipid binding parameters in rainbow trout (Oncorhynchus mykiss) blood and liver fractions to extrapolate from an in vitro metabolic degradation assay to in vivo bioaccumulation potential of hydrophobic organic chemicals. , 2011, Chemical research in toxicology.

[144]  D. Spurgeon,et al.  Modelling the joint effects of a metal and a pesticide on reproduction and toxicokinetics in Lumbricid earthworms. , 2011, Environment international.

[145]  L. H. Petersen,et al.  The interactive effects of a gradual temperature decrease and long-term food deprivation on cardiac and hepatic blood flows in rainbow trout (Oncorhynchus mykiss). , 2011, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.

[146]  Byron Hall.  Bayesian Inference , 2011 .

[147]  A. Péry,et al.  Biology-based modeling to analyze uranium toxicity data on Daphnia magna in a multigeneration study. , 2011, Environmental science & technology.

[148]  Roman Ashauer,et al.  Predicting Concentrations of Organic Chemicals in Fish by Using Toxicokinetic Models , 2012, Environmental science & technology.

[149]  Roman Ashauer,et al.  Toxicokinetic-toxicodynamic modelling of survival of Gammarus pulex in multiple pulse exposures to propiconazole: model assumptions, calibration data requirements and predictive power , 2012, Ecotoxicology.

[150]  François Bouzom,et al.  Physiologically based pharmacokinetic (PBPK) modelling tools: how to fit with our needs? , 2012, Biopharmaceutics & drug disposition.

[151]  Jon A Arnot,et al.  Iterative fragment selection: a group contribution approach to predicting fish biotransformation half-lives. , 2012, Environmental science & technology.

[152]  Assessing the impact of thermal acclimation on physiological condition in the zebrafish model , 2012, Journal of Comparative Physiology B.

[153]  S. Kooijman,et al.  Effects of uranium on the metabolism of zebrafish, Danio rerio. , 2012, Aquatic toxicology.

[154]  Wen-Xiong Wang,et al.  Two-compartment toxicokinetic-toxicodynamic model to predict metal toxicity in Daphnia magna. , 2012, Environmental science & technology.

[155]  A. K. Gamperl,et al.  Blood oxygenation and cardiorespiratory function in steelhead trout (Oncorhynchus mykiss) challenged with an acute temperature increase and zatebradine-induced bradycardia , 2012 .

[156]  Roman Ashauer,et al.  Significance of Xenobiotic Metabolism for Bioaccumulation Kinetics of Organic Chemicals in Gammarus pulex , 2012, Environmental science & technology.

[157]  Daniel L Villeneuve,et al.  Effects of a glucocorticoid receptor agonist, dexamethasone, on fathead minnow reproduction, growth, and development , 2012, Environmental toxicology and chemistry.

[158]  C. Cowan-Ellsberry,et al.  Toward improved models for predicting bioconcentration of well‐metabolized compounds by rainbow trout using measured rates of in vitro intrinsic clearance , 2013, Environmental toxicology and chemistry.

[159]  Z. Zeng,et al.  A physiologically based pharmacokinetics model for florfenicol in crucian carp and oral-to-intramuscular extrapolation. , 2013, Journal of veterinary pharmacology and therapeutics.

[160]  Carla A. Ng,et al.  Bioconcentration of perfluorinated alkyl acids: how important is specific binding? , 2013, Environmental science & technology.

[161]  Juhua Chang,et al.  Effects of butachlor on reproduction and hormone levels in adult zebrafish (Danio rerio). , 2013, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

[162]  C. A. V. van Gestel,et al.  Toxicokinetics and toxicodynamics of nickel in Enchytraeus crypticus , 2013, Environmental toxicology and chemistry.

[163]  Kyungho Choi,et al.  Effects of bisphenol s exposure on endocrine functions and reproduction of zebrafish. , 2013, Environmental science & technology.

[164]  A. Lloyd,et al.  Developing predictive approaches to characterize adaptive responses of the reproductive endocrine axis to aromatase inhibition: II. Computational modeling. , 2013, Toxicological sciences : an official journal of the Society of Toxicology.

[165]  C. A. V. van Gestel,et al.  Using a toxicokinetics approach to explain the effect of soil pH on cadmium bioavailability to Folsomia candida. , 2013, Environmental pollution.

[166]  Shiaulou Yuan,et al.  Polycystin-2 mutations lead to impaired calcium cycling in the heart and predispose to dilated cardiomyopathy. , 2013, Journal of molecular and cellular cardiology.

[167]  Roman Ashauer,et al.  A METHOD TO PREDICT AND UNDERSTAND FISH SURVIVAL UNDER DYNAMIC CHEMICAL STRESS USING STANDARD ECOTOXICITY DATA , 2013, Environmental toxicology and chemistry.

[168]  F. Brion,et al.  Effect of in vivo chronic exposure to clotrimazole on zebrafish testis function , 2013, Environmental Science and Pollution Research.

[169]  M F Wilks,et al.  Perspectives for integrating human and environmental risk assessment and synergies with socio-economic analysis. , 2013, The Science of the total environment.

[170]  K. Drouillard,et al.  Spatial and temporal variability of PCBs in Detroit River water assessed using a long term biomonitoring program. , 2013, Chemosphere.

[171]  C. Kennedy,et al.  Induction and Recovery of Estrogenic Effects After Short-Term 17β-Estradiol Exposure in Juvenile Rainbow Trout (Oncorhynchus mykiss) , 2013, Archives of Environmental Contamination and Toxicology.

[172]  Trevor N Brown,et al.  General model for estimating partition coefficients to organisms and their tissues using the biological compositions and polyparameter linear free energy relationships. , 2013, Environmental science & technology.

[173]  D. Schlenk,et al.  The effects of the pyrethroid insecticide, bifenthrin, on steroid hormone levels and gonadal development of steelhead (Oncorhynchus mykiss) under hypersaline conditions. , 2013, General and comparative endocrinology.

[174]  Jianying Hu,et al.  Distribution is a major factor affecting bioaccumulation of decabrominated diphenyl ether: Chinese sturgeon (Acipenser sinensis) as an example. , 2013, Environmental science & technology.

[175]  Roman Ashauer,et al.  Measured and Modeled Toxicokinetics in Cultured Fish Cells and Application to In Vitro - In Vivo Toxicity Extrapolation , 2014, PloS one.

[176]  S. Unniappan,et al.  Clinically Approved Iron Chelators Influence Zebrafish Mortality, Hatching Morphology and Cardiac Function , 2014, PloS one.

[177]  James Li,et al.  A physiologically‐based pharmacokinetic model for disposition of 2,3,7,8‐TCDD in fathead minnow and medaka , 2014, Environmental toxicology and chemistry.

[178]  Nina Cedergreen,et al.  Dynamic modeling of sublethal mixture toxicity in the nematode Caenorhabditis elegans. , 2014, Environmental science & technology.

[179]  Fathead Minnow and Bluegill Sunfish Life‐Stage Responses to 17β‐Estradiol Exposure in Outdoor Mesocosms , 2014 .

[180]  L. Pan,et al.  A physiologically based toxicokinetic and toxicodynamic model links the tissue distribution of benzo[a]pyrene and toxic effects in the scallop Chlamys farreri. , 2014, Environmental toxicology and pharmacology.

[181]  T. Jager,et al.  Considerations for test design to accommodate energy‐budget models in ecotoxicology: A case study for acetone in the pond snail Lymnaea stagnalis , 2014, Environmental toxicology and chemistry.

[182]  G. Edris,et al.  Biosorption of Cadmium and Lead from Aqueous Solutions by Chlorella vulgaris Biomass: Equilibrium and Kinetic Study , 2014 .

[183]  Tissue-Specific Metabolism of Benzo[a]pyrene in Rainbow Trout (Oncorhynchus mykiss): A Comparison between the Liver and Immune Organs , 2014, Drug Metabolism and Disposition.

[184]  A. Bednarska,et al.  Toxicokinetics of Metals in Terrestrial Invertebrates: Making Things Straight with the One-Compartment Principle , 2014, PloS one.

[185]  Danny H.Y. Lee,et al.  In vitro biotransformation rates in fish liver S9: Effect of dosing techniques , 2014, Environmental toxicology and chemistry.

[186]  C. Liao,et al.  Interpreting copper bioaccumulation dynamics in tilapia using systems-level explorations of pulsed acute/chronic exposures , 2014, Ecotoxicology.

[187]  J. Devillers,et al.  A physiologically based toxicokinetic model for the zebrafish Danio rerio. , 2014, Environmental science & technology.

[188]  Paola Gramatica,et al.  Metabolic biotransformation half-lives in fish: QSAR modeling and consensus analysis. , 2014, The Science of the total environment.

[189]  G. Reifferscheid,et al.  Understanding receptor-mediated effects in rainbow trout: in vitro-in vivo extrapolation using physiologically based toxicokinetic models. , 2014, Environmental science & technology.

[190]  James Devillers,et al.  An Individual-Based Model of Zebrafish Population Dynamics Accounting for Energy Dynamics , 2015, PloS one.

[191]  Jianfeng Feng,et al.  Prediction of acute toxicity of cadmium and lead to zebrafish larvae by using a refined toxicokinetic-toxicodynamic model. , 2015, Aquatic toxicology.

[192]  S. Loureiro,et al.  Endocrine disruption effects of p,p′‐DDE on juvenile zebrafish , 2015, Journal of applied toxicology : JAT.

[193]  Wen-Xiong Wang,et al.  Physiologically Based Pharmacokinetic Model for Inorganic and Methylmercury in a Marine Fish. , 2015, Environmental science & technology.

[194]  P. Kille,et al.  Uptake routes and toxicokinetics of silver nanoparticles and silver ions in the earthworm Lumbricus rubellus , 2015, Environmental toxicology and chemistry.

[195]  M. Johansen,et al.  Dietary ingestion of fine sediments and microalgae represent the dominant route of exposure and metal accumulation for Sydney rock oyster (Saccostrea glomerata): A biokinetic model for zinc. , 2015, Aquatic toxicology.

[196]  S. H. Bennekou,et al.  EFSA's 21st Scientific Colloquium on Harmonisation of human and ecological risk assessment of combined exposure to multiple chemicals , 2015 .

[197]  G. Reifferscheid,et al.  A physiologically based toxicokinetic (PBTK) model for moderately hydrophobic organic chemicals in the European eel (Anguilla anguilla). , 2015, The Science of the total environment.

[198]  G. Reifferscheid,et al.  Cross-Species Extrapolation of Uptake and Disposition of Neutral Organic Chemicals in Fish Using a Multispecies Physiologically-Based Toxicokinetic Model Framework. , 2016, Environmental science & technology.

[199]  Rodolphe Gilbin,et al.  Dynamic energy-based modeling of uranium and cadmium joint toxicity to Caenorhabditis elegans. , 2016, Chemosphere.

[200]  J. M. Navas,et al.  Tissue distribution of zinc and subtle oxidative stress effects after dietary administration of ZnO nanoparticles to rainbow trout. , 2016, The Science of the total environment.

[201]  W. Karasov,et al.  Impacts of 2,4‐dichlorophenoxyacetic acid aquatic herbicide formulations on reproduction and development of the fathead minnow (Pimephales promelas) , 2015, Environmental toxicology and chemistry.

[202]  E. Salmina,et al.  Variation in predicted internal concentrations in relation to PBPK model complexity for rainbow trout. , 2016, The Science of the total environment.

[203]  J. Dalsgaard,et al.  Increasing levels of dietary crystalline methionine affect plasma methionine profiles, ammonia excretion, and the expression of genes related to the hepatic intermediary metabolism in rainbow trout (Oncorhynchus mykiss). , 2016, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

[204]  M. Vijver,et al.  Comparison and evaluation of pesticide monitoring programs using a process‐based mixture model , 2016, Environmental toxicology and chemistry.