Epidermal growth factor down‐regulates the expression of neutrophil gelatinase‐associated lipocalin (NGAL) through E‐cadherin in pancreatic cancer cells

The authors previously reported that neutrophil gelatinase‐associated lipocalin (NGAL) overexpression significantly blocked invasion and angiogenesis of pancreatic ductal adenocarcinoma (PDAC). They also demonstrated a loss of NGAL expression in the advanced stages of PDAC. However, little is known regarding the mechanisms of NGAL regulation in PDAC. Because the epidermal growth factor (EGF)‐EGF receptor (EGFR) axis is up‐regulated significantly in PDAC, they examined EGF‐mediated NGAL regulation in these cells.

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