Bronchogenic Carcinoma with Cardiac Invasion Simulating Acute Myocardial Infarction

Cardiac metastases in bronchogenic carcinoma may occur due to retrograde lymphatic spread or by hematogenous dissemination of tumour cells, but direct invasion of heart by adjacent malignant lung mass is very uncommon. Pericardium is frequently involved in direct cardiac invasion by adjacent lung cancer. Pericardial effusion, pericarditis, and tamponade are common and life threatening presentation in such cases. But direct invasion of myocardium and endocardium is very uncommon. Left atrial endocardium is most commonly involved in such cases due to anatomical contiguity with pulmonary hilum through pulmonary veins, and in most cases left atrial involvement is asymptomatic. But myocardial compression and invasion by adjacent lung mass may result in myocardial ischemia and may present with retrosternal, oppressive chest pain which clinically may simulate with the acute myocardial infarction (AMI). As a result, it leads to misdiagnosis and delayed diagnosis of lung cancer. Here we report a case of non-small-cell carcinoma of right lung which was presented with asymptomatic invasion in left atrium and retrosternal chest pain simulating AMI due to myocardial compression by adjacent lung mass, in a seventy-four-year-old male smoker.

[1]  T. D’amico,et al.  Extensive invasion of the left atrium by lung cancer. , 2013, The Annals of thoracic surgery.

[2]  N. Ishikawa,et al.  Advanced lung cancer invading the left atrium, treated with pneumonectomy combined with left atrium resection under cardiopulmonary bypass. , 2010, Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia.

[3]  Er-yong Zhang,et al.  Left ventricular metastasis from a primary lung carcinoma. , 2007, Chinese medical journal.

[4]  A. Abbate,et al.  ST segment elevation and new right bundle branch block: broadening the differential diagnosis. , 2007, International journal of cardiology.

[5]  G. Pelosi,et al.  Extended pneumonectomy with partial resection of the left atrium, without cardiopulmonary bypass, for lung cancer. , 2005, The Annals of thoracic surgery.

[6]  G. Shen,et al.  Successful resection of osteosarcoma pulmonary metastasis extending into left side of heart under cardiopulmonary bypass: a case report. , 2002, Chinese medical journal.

[7]  J. Roy [Cardiac metastases]. , 1969, L'union medicale du Canada.

[8]  J. Małolepszy,et al.  [Metastases to the heart]. , 1966, Polski tygodnik lekarski.