Neuroanatomical substrate of noise sensitivity

&NA; Recent functional studies suggest that noise sensitivity, a trait describing attitudes towards noise and predicting noise annoyance, is associated with altered processing in the central auditory system. In the present work, we examined whether noise sensitivity could be related to the structural anatomy of auditory and limbic brain areas. Anatomical MR brain images of 80 subjects were parcellated with FreeSurfer to measure grey matter volume, cortical thickness, cortical area and folding index of anatomical structures in the temporal lobe and insular cortex. The grey matter volume of amygdala and hippocampus was measured as well. According to our findings, noise sensitivity is associated with the grey matter volume in the selected structures. Among those, we propose and discuss particular areas, previously linked to auditory perceptual, emotional and interoceptive processing, in which larger grey matter volume seems to be related to higher noise sensitivity. HighlightsNoise sensitivity is related enlarged primary auditory areas in the left hemisphere.The bilateral hippocampus and temporal pole are enlarged in noise sensitivity.The volume of the right anterior insula is increased in noise sensitivity.Noise sensitivity is related to the morphology of auditory‐limbic brain areas.

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