Doxorubicin-Fe(III)-Gossypol Infinite Coordination Polymer@PDA:CuO2 Composite Nanoparticles for Cost-Effective Programmed Photothermal-Chemodynamic-Coordinated Dual Drug Chemotherapy Trimodal Synergistic Tumor Therapy.

To achieve the maximum therapeutic effects and minimize adverse effects of trimodal synergistic tumor therapies, a cost-effective programmed photothermal (PTT)-chemodynamic (CDT)-coordinated dual drug chemotherapy (CT) trimodal synergistic therapy strategy in chronological order is proposed. According to the status or volumes of the tumors, the intensity and time of each therapeutic modality are optimized, and three modalities are combined programmatically and work in chronological order. The optimal synergistic therapy begins with high-intensity PTT for 10 min to ablate larger tumors, followed by medium-intensity CDT for several hours to eliminate medium-sized tumors, and then low-intensity coordinated dual drugs CT lasts over 48 h to clear smaller residual tumors. Composite nanoparticles, made of Fe-coordinated polydopamine mixed with copper peroxide as the cores and their surface dotted with lots of doxorubicin-Fe(III)-gossypol infinite coordination polymers (ICPs), have been developed to implement the strategy. These composite nanoparticles show excellent synergistic effects with the minimum dose of therapeutic agents and result in nearly 100% tumor inhibition for mice bearing PC-3 tumors and no observed recurrence within 60 days of treatment. The ratios of the different therapeutic agents in the composite nanoparticles can be adjusted to accommodate different types of tumors with this cost-effective programmed trimodal therapy strategy.

[1]  Peng Wang,et al.  Phototheranostic Agents Based on Nonionic Heptamethine Cyanine for Realizing Synergistic Cancer Phototherapy , 2023, Advanced healthcare materials.

[2]  Yu Chen,et al.  Covalent Organic Framework Nanobowls as Activatable Nanosensitizers for Tumor‐Specific and Ferroptosis‐Augmented Sonodynamic Therapy , 2023, Advanced science.

[3]  Yue Lan,et al.  Dual-stimuli responsive smart nanoprobe for precise diagnosis and synergistic multi-modalities therapy of superficial squamous cell carcinoma , 2023, Journal of Nanobiotechnology.

[4]  Da-Wei Zhang,et al.  Self-delivery biomedicine for enhanced photodynamic therapy by feedback promotion of tumor autophagy. , 2023, Acta biomaterialia.

[5]  J. Tao,et al.  When Iodine Meets Starch: On-Demand Generation of Photothermal Hydrogels for Mild-Temperature Photothermal-Chemo Disinfection. , 2022, ACS applied materials & interfaces.

[6]  Li Cheng,et al.  Titanium Sulfide Nanosheets Serve as Cascade Bioreactors for H2S‐Mediated Programmed Gas–Sonodynamic Cancer Therapy , 2022, Advanced science.

[7]  Qinfu Zhao,et al.  Tailored nanoplatforms with detachable ‘meteorolite’ for photothermal-enhanced programmed tumor therapy , 2022, Carbon.

[8]  Wanhai Xu,et al.  Bacteria-inspired transformable nanoparticle targets and covers residual tumor against bladder cancer recurrence , 2022, Nano Today.

[9]  Wei Feng,et al.  An NIR‐II Photothermally Triggered “Oxygen Bomb” for Hypoxic Tumor Programmed Cascade Therapy , 2022, Advanced materials.

[10]  Jun Zhang,et al.  Chemodynamic and Photothermal Combination Therapy Based on Dual-Modified Metal-Organic Framework for Inducing Tumor Ferroptosis/Pyroptosis. , 2022, ACS applied materials & interfaces.

[11]  Xuli Feng,et al.  Self-Assembly of Intelligent Nanoplatform for Endogenous H2S-Triggered Multimodal Cascade Therapy of Colon Cancer. , 2022, Nano letters.

[12]  Wei Zhang,et al.  Escherichia coli Mimetic Gold Nanorod-Mediated Photo- and Immunotherapy for Treating Cancer and Its Metastasis. , 2022, ACS nano.

[13]  Daocheng Wu,et al.  Molecular Stacking Composite Nanoparticles of Gossypolone and Thermodynamic Agent for Elimination of Large Tumor in Mice via Electrothermal‐Thermodynamic‐Chemo Trimodal Combination Therapy , 2022, Advanced Functional Materials.

[14]  G. Yin,et al.  Fe(III)-Chelated Polydopamine Nanoparticles for Synergistic Tumor Therapies of Enhanced Photothermal Ablation and Antitumor Immune Activation. , 2022, ACS applied materials & interfaces.

[15]  Wei Peng,et al.  In situ Thermal-Responsive Magnetic Hydrogel for Multidisciplinary Therapy of Hepatocellular Carcinoma. , 2022, Nano letters.

[16]  Zhuang Liu,et al.  Albumin-Based Therapeutics Capable of Glutathione Consumption and Hydrogen Peroxide Generation for Synergetic Chemodynamic and Chemotherapy of Cancer. , 2022, ACS nano.

[17]  Huijing Xiang,et al.  Engineering 2D Cu-composed metal–organic framework nanosheets for augmented nanocatalytic tumor therapy , 2022, Journal of Nanobiotechnology.

[18]  Wen-jun Wang,et al.  γ‐Fe2O3 Loading Mitoxantrone and Glucose Oxidase for pH‐Responsive Chemo/Chemodynamic/Photothermal Synergistic Cancer Therapy , 2022, Advanced healthcare materials.

[19]  Chang Xu,et al.  Multimodal Imaging-Guided Spatiotemporal Tracking of Photosensitive Stem Cells for Breast Cancer Treatment. , 2022, ACS applied materials & interfaces.

[20]  Xudong Fan,et al.  Cooperative coordination-mediated multi-component self-assembly of “all-in-one” nanospike theranostic nano-platform for MRI-guided synergistic therapy against breast cancer , 2022, Acta pharmaceutica Sinica. B.

[21]  G. Ning,et al.  Infection microenvironment-activated core-shell nanoassemblies for photothermal/chemodynamic synergistic wound therapy and multimodal imaging. , 2022, Acta biomaterialia.

[22]  T. Hyeon,et al.  Enhanced Chemodynamic Therapy by Cu-Fe Peroxide Nanoparticles: Tumor Microenvironment-Mediated Synergistic Fenton Reaction. , 2022, ACS nano.

[23]  Jun Lin,et al.  Recent advances on endogenous/exogenous stimuli-triggered nanoplatforms for enhanced chemodynamic therapy , 2022, Coordination Chemistry Reviews.

[24]  K. Cai,et al.  Flower‐Like Nanozymes with Large Accessibility of Single Atom Catalysis Sites for ROS Generation Boosted Tumor Therapy , 2021, Advanced Functional Materials.

[25]  Jun Lin,et al.  One-Step Integration of Tumor Microenvironment-Responsive Calcium and Copper Peroxides Nanocomposite for Enhanced Chemodynamic/Ion-Interference Therapy. , 2021, ACS nano.

[26]  Xiaolong Liu,et al.  Natural Killer Cell Membrane‐Cloaked Virus‐Mimicking Nanogenerator with NIR‐Triggered Shape Reversal and •C/•OH Storm for Synergistic Thermodynamic–Chemodynamic Therapy , 2021, Advanced science.

[27]  Shikai Liu,et al.  Guiding Transition Metal‐Doped Hollow Cerium Tandem Nanozymes with Elaborately Regulated Multi‐Enzymatic Activities for Intensive Chemodynamic Therapy , 2021, Advanced materials.

[28]  Michael E. Dunham,et al.  Detection of pancreatic cancer by indocyanine green‐assisted fluorescence imaging in the first and second near‐infrared windows , 2021, Cancer communications.

[29]  Shuang‐Shuang Wan,et al.  Nanocatalyst‐Mediated Chemodynamic Tumor Therapy , 2021, Advanced healthcare materials.

[30]  J. Qian,et al.  NIR-II Responsive Hollow Magnetite Nanoclusters for Targeted Magnetic Resonance Imaging-Guided Photothermal/Chemo-Therapy and Chemodynamic Therapy. , 2021, Small.

[31]  Yanli Zhao,et al.  Ultrasmall Alloy Nanozyme for Ultrasound- and Near-Infrared Light-Promoted Tumor Ablation. , 2021, ACS nano.

[32]  Ya Wang,et al.  IR780‐Loaded Hyaluronic Acid@Gossypol–Fe(III)–EGCG Infinite Coordination Polymer Nanoparticles for Highly Efficient Tumor Photothermal/Coordinated Dual Drugs Synergistic Therapy , 2021, Advanced Functional Materials.

[33]  Lan Xu,et al.  A CaO2@Tannic Acid‐FeIII Nanoconjugate for Enhanced Chemodynamic Tumor Therapy , 2021, ChemMedChem.

[34]  G. Guo,et al.  Tumor Acidity and Near‐Infrared Light Responsive Dual Drug Delivery Polydopamine‐Based Nanoparticles for Chemo‐Photothermal Therapy , 2021, Advanced Functional Materials.

[35]  Youshen Wu,et al.  Highly Penetrable and On-Demand Oxygen Release with Tumor Activity Composite Nanosystem for Photothermal/Photodynamic Synergetic Therapy. , 2020, ACS nano.

[36]  Y. Gan,et al.  Photothermal Generation of Oxygen-Irrelevant Free Radicals with Simultaneous Suppression of Glutathione Synthesis for an Enhanced Photonic Thermodynamic Cancer Therapy. , 2020, ACS biomaterials science & engineering.

[37]  Zhipeng Gu,et al.  Regulating the absorption spectrum of polydopamine , 2020, Science Advances.

[38]  Xiaoyuan Chen,et al.  Clinical development and potential of photothermal and photodynamic therapies for cancer , 2020, Nature Reviews Clinical Oncology.

[39]  Jun Lin,et al.  Biocompatible CuO-decorated carbon nanoplatforms for multiplexed imaging and enhanced antitumor efficacy via combined photothermal therapy/chemodynamic therapy/chemotherapy , 2020, Science China Materials.

[40]  Jianqing Gao,et al.  Engineering bacterial outer membrane vesicles as transdermal nanoplatforms for photo-TRAIL–programmed therapy against melanoma , 2020, Science Advances.

[41]  Shige Wang,et al.  Integration of Fe3O4 with Bi2S3 for Multi-Modality Tumor Theranostics. , 2020, ACS applied materials & interfaces.

[42]  Wei Li,et al.  Bioinspired Construction of a Nanozyme-Based H2O2 Homeostasis Disruptor for Intensive Chemodynamic Therapy. , 2020, Journal of the American Chemical Society.

[43]  Yu Chen,et al.  Chemoreactive Nanotherapeutics by Metal Peroxide Based Nanomedicine , 2020, Advanced science.

[44]  Jun Lin,et al.  A Multifunctional Cascade Bioreactor Based on Hollow‐Structured Cu2MoS4 for Synergetic Cancer Chemo‐Dynamic Therapy/Starvation Therapy/Phototherapy/Immunotherapy with Remarkably Enhanced Efficacy , 2019, Advanced materials.

[45]  M. Büchler,et al.  Patterns of Recurrence After Resection of Pancreatic Ductal Adenocarcinoma: A Secondary Analysis of the ESPAC-4 Randomized Adjuvant Chemotherapy Trial. , 2019, JAMA surgery.

[46]  Peng Yang,et al.  Tailoring Synthetic Melanin Nanoparticles for Enhanced Photothermal Therapy. , 2019, ACS applied materials & interfaces.

[47]  Yue Ding,et al.  NIR-Responsive Polypeptide Nanocomposite Generates NO Gas, Mild Photothermia and Chemotherapy to Reverse Multidrug Resistant Cancer. , 2019, Nano letters.

[48]  Rui Tian,et al.  Synthesis of Copper Peroxide Nanodots for H2O2 Self-Supplying Chemodynamic Therapy. , 2019, Journal of the American Chemical Society.

[49]  Minfeng Huo,et al.  Ultrasmall Cu2-xS nanodots as photothermal-enhanced Fenton nanocatalysts for synergistic tumor therapy at NIR-II biowindow. , 2019, Biomaterials.

[50]  M. Wan,et al.  IR780 loaded perfluorohexane nanodroplets for efficient sonodynamic effect induced by short-pulsed focused ultrasound. , 2019, Ultrasonics sonochemistry.

[51]  J. Chen,et al.  Core-Satellite Nanomedicines for in Vivo Real-Time Monitoring of Enzyme-Activatable Drug Release by Fluorescence and Photoacoustic Dual-Modal Imaging. , 2018, ACS nano.

[52]  W. Bu,et al.  Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reactions. , 2018, Angewandte Chemie.

[53]  Youshen Wu,et al.  Ultralong Circulating Lollipop‐Like Nanoparticles Assembled with Gossypol, Doxorubicin, and Polydopamine via π–π Stacking for Synergistic Tumor Therapy , 2018, Advanced Functional Materials.

[54]  Youshen Wu,et al.  Versatile hyaluronic acid modified AQ4N-Cu(II)-gossypol infinite coordination polymer nanoparticles: Multiple tumor targeting, highly efficient synergistic chemotherapy, and real-time self-monitoring. , 2018, Biomaterials.

[55]  Xian‐Zheng Zhang,et al.  Stimuli-Responsive "Cluster Bomb" for Programmed Tumor Therapy. , 2017, ACS nano.

[56]  Zhiping Zhang,et al.  Nanotechnology based therapeutic modality to boost anti‐tumor immunity and collapse tumor defense , 2017, Journal of controlled release : official journal of the Controlled Release Society.

[57]  T. Ishizawa,et al.  Liver transection using indocyanine green fluorescence imaging and hepatic vein clamping , 2017, The British journal of surgery.

[58]  Dalong Ni,et al.  Magnesium silicide nanoparticles as a deoxygenation agent for cancer starvation therapy. , 2017, Nature nanotechnology.

[59]  Ligeng Xu,et al.  Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy , 2016, Nature Communications.

[60]  Hao Zhang,et al.  Fe3O4@polydopamine Composite Theranostic Superparticles Employing Preassembled Fe3O4 Nanoparticles as the Core. , 2016, ACS applied materials & interfaces.

[61]  Zhuang Liu,et al.  Albumin-NIR dye self-assembled nanoparticles for photoacoustic pH imaging and pH-responsive photothermal therapy effective for large tumors. , 2016, Biomaterials.

[62]  Lehui Lu,et al.  Dopamine‐Melanin Colloidal Nanospheres: An Efficient Near‐Infrared Photothermal Therapeutic Agent for In Vivo Cancer Therapy , 2013, Advanced materials.

[63]  Suwarna Datar,et al.  Reversible Aggregation Control of Polyvinylpyrrolidone Capped Gold Nanoparticles as a Function of pH , 2012 .

[64]  R. Chun.  Lymphoma: which chemotherapy protocol and why? , 2009, Topics in companion animal medicine.

[65]  Irfan Rahman,et al.  Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method , 2006, Nature Protocols.

[66]  Y. Liu,et al.  Thermochromism-induced temperature self-regulation and alternating photothermal nanohelix clusters for synergistic tumor chemo/photothermal therapy. , 2019, Biomaterials.

[67]  Jiajun Liu,et al.  Mulberry-like dual-drug complicated nanocarriers assembled with apogossypolone amphiphilic starch micelles and doxorubicin hyaluronic acid nanoparticles for tumor combination and targeted therapy. , 2015, Biomaterials.