The future is here: ventricular assist devices for the failing heart

Mechanical circulatory support is an important adjunct to the management of patients with advanced heart failure. Technological advances in this area have improved overall survival and decreased the incidence of complications. In addition, they have expanded the population suitable for this therapy. The challenge for clinicians is to translate the clinical evidence into the selection of the most appropriate device that will benefit an individual patient. This paper will review ventricular assist devices currently available and their clinical indications.

[1]  D. Burkhoff,et al.  Impact of left ventricular assist device (LVAD) support on the cardiac reverse remodeling process. , 2008, Progress in biophysics and molecular biology.

[2]  Karen Ulisney,et al.  INTERMACS database for durable devices for circulatory support: first annual report. , 2008, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[3]  Roland Hetzer,et al.  Does total implantability reduce infection with the use of a left ventricular assist device? The LionHeart experience in Europe. , 2007, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[4]  Mark S. Slaughter,et al.  Outcomes of Left Ventricular Assist Device Implantation as Destination Therapy in the Post-REMATCH Era: Implications for Patient Selection , 2007, Circulation.

[5]  James Fang,et al.  Development of circulatory-renal limitations to angiotensin-converting enzyme inhibitors identifies patients with severe heart failure and early mortality. , 2003, Journal of the American College of Cardiology.

[6]  Takeshi Nakatani,et al.  517: Japanese Clinical Trial Results of an Implantable Centrifugal Blood Pump “EVAHEART” , 2008 .

[7]  Andrew Boyle,et al.  Gastrointestinal bleeding rates in recipients of nonpulsatile and pulsatile left ventricular assist devices. , 2009, The Journal of thoracic and cardiovascular surgery.

[8]  H. Rodríguez-Abella,et al.  [Ventricular assist devices as a bridge to transplantation]. , 2007, Revista espanola de cardiologia.

[9]  F Beyersdorf,et al.  The Jarvik 2000 is associated with less infections than the HeartMate left ventricular assist device. , 2003, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[10]  P. McCarthy,et al.  One hundred patients with the HeartMate left ventricular assist device: evolving concepts and technology. , 1998, The Journal of thoracic and cardiovascular surgery.

[11]  R. Hetzer,et al.  Long-Term Results in Patients With Idiopathic Dilated Cardiomyopathy After Weaning From Left Ventricular Assist Devices , 2005, Circulation.

[12]  Kenji Yamazaki,et al.  Preclinical biocompatibility assessment of the EVAHEART ventricular assist device: coating comparison and platelet activation. , 2007, Journal of biomedical materials research. Part A.

[13]  M C Oz,et al.  Long-term use of a left ventricular assist device for end-stage heart failure. , 2001, The New England journal of medicine.

[14]  D. Goldstein,et al.  Worldwide Experience With the MicroMed DeBakey Ventricular Assist Device® as a Bridge to Transplantation , 2003, Circulation.

[15]  Andrew Boyle,et al.  Improved survival and decreasing incidence of adverse events with the HeartMate II left ventricular assist device as bridge-to-transplant therapy. , 2008, The Annals of thoracic surgery.

[16]  R. Patten,et al.  The effect of ventricular assist devices on post-transplant mortality an analysis of the United network for organ sharing thoracic registry. , 2009, Journal of the American College of Cardiology.

[17]  Heather J Ross,et al.  Usefulness of the INTERMACS scale to predict outcomes after mechanical assist device implantation. , 2009, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[18]  O H Frazier,et al.  Cardiac Improvement During Mechanical Circulatory Support: A Prospective Multicenter Study of the LVAD Working Group , 2007, Circulation.

[19]  O H Frazier,et al.  Use of a continuous-flow device in patients awaiting heart transplantation. , 2007, The New England journal of medicine.

[20]  S. Drakos,et al.  Intermittent Inotropic Infusions Combined With Prophylactic Oral Amiodarone for Patients With Decompensated End-stage Heart Failure , 2009, Journal of cardiovascular pharmacology.

[21]  M. Oz,et al.  A new off-pump technique for thoratec right ventricular assist device insertion. , 2001, The Annals of thoracic surgery.

[22]  C. Nojiri,et al.  514: Long-Term Circulatory Support with the DuraHeart™ Mag-Lev Centrifugal Left Ventricular Assist System for Advanced Heart Failure Patients Eligible to Transplantation: European Experiences , 2008 .

[23]  J. Pepper,et al.  Advanced heart failure: feasibility study of long-term continuous axial flow pump support. , 2005, European Heart Journal.

[24]  J. Pepper,et al.  Mechanical reliability of the Jarvik 2000 Heart. , 2006, The Annals of thoracic surgery.

[25]  M. Oz,et al.  Multicenter clinical evaluation of the heartmate; vented electric left ventricular assist system in patients awaiting heart transplantation. , 2001, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[26]  M. Firstenberg,et al.  Placement of long-term implantable ventricular assist devices without the use of cardiopulmonary bypass. , 2008, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[27]  V. Rao,et al.  Predictors of acute renal dysfunction after ventricular assist device placement. , 2009, Journal of cardiac failure.

[28]  L. Miller,et al.  Low thromboembolic risk for patients with the Heartmate II left ventricular assist device. , 2008, The Journal of thoracic and cardiovascular surgery.

[29]  K. Mather,et al.  Obesity, Insulin Resistance, and the Metabolic Syndrome: Determinants of Endothelial Dysfunction in Whites and Blacks , 2005, Circulation.

[30]  F. Pagani Continuous-flow rotary left ventricular assist devices with "3rd generation" design. , 2008, Seminars in thoracic and cardiovascular surgery.

[31]  H. Haddad,et al.  Cardiac transplantation in HIV-positive patients: are we there yet? , 2007, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[32]  First successful bridge to myocardial recovery with a HeartWare HVAD. , 2008, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[33]  Stephen Westaby,et al.  Six years of continuous mechanical circulatory support. , 2006, The New England journal of medicine.

[34]  G. Breithardt,et al.  Selection and management of ventricular assist device patients: the Muenster experience. , 2000, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[35]  M. Oz,et al.  Bridging to transplant with the HeartMate left ventricular assist device: The Columbia Presbyterian 12-year experience. , 2004, The Journal of thoracic and cardiovascular surgery.

[36]  L. Miller,et al.  Destination therapy: current results and future promise. , 2008, Seminars in thoracic and cardiovascular surgery.

[37]  R. Robbins,et al.  The Novacor Left Ventricular Assist System: Clinical Experience from the Novacor Registry , 2001, Journal of cardiac surgery.

[38]  A. Khaghani,et al.  515: Experience with the Novel Heartware HVAD with Hydromagnetically Levitated Rotor in a Multiinstitutional Trial , 2008 .

[39]  Allison R. Schulman,et al.  Effect of clenbuterol on cardiac and skeletal muscle function during left ventricular assist device support. , 2006, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[40]  N. Smedira,et al.  Mechanical circulatory assistance: state of art. , 2002, Circulation.

[41]  L. Stevenson,et al.  Ventricular assist devices for durable support. , 2005, Circulation.

[42]  J. Cleveland,et al.  Left ventricular assist device as bridge to transplantation does not adversely affect one-year heart transplantation survival. , 2008, The Journal of thoracic and cardiovascular surgery.

[43]  J. Shinn Implantable Left Ventricular Assist Devices , 2005, The Journal of cardiovascular nursing.

[44]  Jason D. Christie,et al.  Registry of the International Society for Heart and Lung Transplantation: twenty-fifth official adult heart transplant report--2008. , 2008, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[45]  S. Raj,et al.  Letter regarding article by Adamson et al, "Continuous autonomic assessment in patients with symptomatic heart failure: prognostic value of heart rate variability measured by an implanted cardiac resynchronization device". , 2005, Circulation.

[46]  Marc A Simon,et al.  Myocardial Recovery Using Ventricular Assist Devices: Prevalence, Clinical Characteristics, and Outcomes , 2005, Circulation.

[47]  R. Hershberger,et al.  Care processes and clinical outcomes of continuous outpatient support with inotropes (COSI) in patients with refractory endstage heart failure. , 2003, Journal of cardiac failure.

[48]  L. Miller,et al.  Improved survival of patients with end-stage heart failure listed for heart transplantation: analysis of organ procurement and transplantation network/U.S. United Network of Organ Sharing data, 1990 to 2005. , 2007, Journal of the American College of Cardiology.

[49]  Stephen Westaby,et al.  Use of the Jarvik 2000 Left Ventricular Assist System as a Bridge to Heart Transplantation or as Destination Therapy for Patients With Chronic Heart Failure , 2003, Annals of surgery.

[50]  Javed Butler,et al.  Chronic mechanical circulatory support for inotrope-dependent heart failure patients who are not transplant candidates: results of the INTrEPID Trial. , 2007, Journal of the American College of Cardiology.

[51]  David Kaye,et al.  A prospective, multicenter trial of the VentrAssist left ventricular assist device for bridge to transplant: safety and efficacy. , 2008, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.