Mitochondrial dysfunction in multiple symmetrical lipomatosis

Multiple symmetrical lipomatosis is a striking clinical finding associated with a variety of peripheral and central nervous system abnormalities. We describe 4 unrelated patients with evidence of mitochondrial dysfunction in skeletal muscle. Multiple symmetrical lipomatosis is an additional, albeit unusual, manifestation of the expanding clinical spectrum of mitochondrial diseases.

[1]  C. Zancanaro,et al.  Multiple symmetric lipomatosis. Ultrastructural investigation of the tissue and preadipocytes in primary culture. , 1990, Laboratory investigation; a journal of technical methods and pathology.

[2]  E. Shoubridge,et al.  Myoclonus epilepsy and ragged-red fibres (MERRF). 1. A clinical, pathological, biochemical, magnetic resonance spectrographic and positron emission tomographic study. , 1989, Brain : a journal of neurology.

[3]  R. Kuzniecky,et al.  Myoclonus epilepsy and ragged-red fibres (MERRF). 2. Electrophysiological studies and comparison with other progressive myoclonus epilepsies. , 1989, Brain : a journal of neurology.

[4]  Charles R.scriver,et al.  The Metabolic basis of inherited disease , 1989 .

[5]  M. Pollock,et al.  NEUROPATHY IN MULTIPLE SYMMETRIC LIPOMATOSIS , 1988 .

[6]  M. Landthaler,et al.  Benign symmetric lipomatosis Launois-Bensaude. Report of ten cases and review of the literature. , 1987, Journal of the American Academy of Dermatology.

[7]  C. Angelini,et al.  Sensory, Motor, and Autonomic Neuropathy in Patients with Multiple Symmetric Lipomatosis , 1985, Medicine.

[8]  S. Carpenter,et al.  Pathology of Skeletal Muscle , 1984 .

[9]  G. Enzi.  Multiple Symmetric Lipomatosis: An Updated Clinical Report , 1984, Medicine.

[10]  R. Haller,et al.  Skeletal muscle disease in alcoholism. , 1984, The Medical clinics of North America.

[11]  M. Prosdocimi,et al.  Multiple symmetric lipomatosis: a defect in adrenergic-stimulated lipolysis. , 1977, The Journal of clinical investigation.

[12]  K. Ekbom.  HEREDITARY ATAXIA, PHOTOMYOCLONUS, SKELETAL DEFORMITIES AND LIPOMA , 1975, Acta neurologica Scandinavica.

[13]  R. N. Alsever,et al.  Benign symmetric lipomatosis: functional sympathetic denervation of adipose tissue and possible hypertrophy of brown fat. , 1974, Metabolism: clinical and experimental.

[14]  B. Troost,et al.  Hyperuricemia and neurologic deficits. A family study. , 1970, The New England journal of medicine.

[15]  C. Glueck,et al.  Benign symmetric lipomatosis (Launois-Bensaude adenolipomatosis) with gout and hyperlipoproteinemia. , 1970, The American journal of medicine.

[16]  I. Lyon.  ADIPOSIS AND LIPOMATOSIS: CONSIDERED IN REFERENCE TO THEIR CONSTITUTIONAL RELATIONS AND SYMPTOMATOLOGY , 1910 .