Superparamagnetic Nanocomposites of Poly(vinyl alcohol‐graft‐acrylonitrile) as Carrier for Magnetically Assisted Release of Ciprofloxacin

In the present study also a superparamagnetic nanocomposite of Poly (vinyl- alcohol-g-acrylonitrile) has been designed by homogeneous impregnation of iron oxide nanoparticles into the graft polymer matrix. The so prepared nanocomposite was characterized by FT-IR, TEM and XRD techniques and studied for water sorption behavior and magnetization properties. The superparamagnetic nanocomposite was loaded with an antibiotic drug, ciprofloxacin (CFx), and its release behavior was investigated under varying experimental conditions such as chemical composition of the matrix, pH of the release media, applied magnetic field and percent loading of the drug. The drug transport mechanism was also analyzed using Ficks power law. The drug loaded magnetic nanocomposite was also studied for antibacterial and in-vitro blood compatible properties.

[1]  K. Shinoda,et al.  Size controlled Fe nanoparticles through polyol process and their magnetic properties , 2010 .

[2]  T. Drewa,et al.  Does ciprofloxacin have an obverse and a reverse? , 2010, Pulmonary pharmacology & therapeutics.

[3]  J. Hubbell,et al.  In vivo study of an injectable poly(acrylonitrile)-based hydrogel paste as a bulking agent for the treatment of urinary incontinence. , 2010, Biomaterials.

[4]  Raluca Muller,et al.  Manipulation of nanoparticles within a microfluidic system based on SU-8 polymer for bio-applications , 2010 .

[5]  R. Ramanujan,et al.  Doxorubicin loaded PVA coated iron oxide nanoparticles for targeted drug delivery , 2010 .

[6]  Rashmi R. Gupta,et al.  Evaluation of water sorption behavior and in vitro blood compatibility of polyvinyl alcohol based magnetic bionanocomposites , 2009 .

[7]  Sungho Jin,et al.  Magnetic nanoparticles for theragnostics. , 2009, Advanced drug delivery reviews.

[8]  Anil Kumar Bajpai,et al.  Synthesis and characterization of magnetite (Fe3O4)—Polyvinyl alcohol‐based nanocomposites and study of superparamagnetism , 2009 .

[9]  Klaus D. Jandt,et al.  Temperature-sensitive PVA/PNIPAAm semi-IPN hydrogels with enhanced responsive properties. , 2009, Acta biomaterialia.

[10]  I. Chourpa,et al.  Novel method of doxorubicin-SPION reversible association for magnetic drug targeting. , 2008, International journal of pharmaceutics.

[11]  A. Bajpai,et al.  Preparation and characterization of macroporous poly(2‐hydroxyethyl methacrylate)‐based biomaterials: Water sorption property and in vitro blood compatibility , 2007 .

[12]  A. Bajpai,et al.  Study of biomineralization of poly(vinyl alcohol)-based scaffolds using an alternate soaking approach , 2007 .

[13]  R. Misra,et al.  On the suitability of nanocrystalline ferrites as a magnetic carrier for drug delivery: functionalization, conjugation and drug release kinetics. , 2007, Acta biomaterialia.

[14]  M. Kokabi,et al.  PVA–clay nanocomposite hydrogels for wound dressing , 2007 .

[15]  V. John,et al.  Core-shell nanohydrogel structures as tunable delivery systems , 2007 .

[16]  A. Bajpai,et al.  In vitro release dynamics of an anticancer drug from swellable gelatin nanoparticles , 2006 .

[17]  Tarasankar Pal,et al.  Magnetite nanoparticles with tunable gold or silver shell. , 2005, Journal of colloid and interface science.

[18]  R. Manzo,et al.  Release kinetics and up-take studies of model fluoroquinolones from carbomer hydrogels. , 2002, International journal of pharmaceutics.

[19]  S. Shukla,et al.  Water sorption through a semi-interpenetrating polymer network (IPN) with hydrophilic and hydrophobic chains , 2002 .

[20]  I. Shim,et al.  Preparation of Iron Nanoparticles in Cellulose Acetate Polymer and Their Reaction Chemistry in the Polymer , 2001 .

[21]  K. Hu,et al.  Synthesis of 10 nanometric copper clusters in a polymer matrix by a solution‐reduction synthesis (SRS) , 2000 .

[22]  Pieter Stroeve,et al.  Synthesis and Characterization of Nanometer-Size Fe3O4 and γ-Fe2O3 Particles , 1996 .

[23]  Y. Nosé,et al.  A new method for evalution of antithrombogenicity of materials. , 1972, Journal of biomedical materials research.