Oncostatin M produced in Kupffer cells in response to PGE2: possible contributor to hepatic insulin resistance and steatosis

[1]  T. Okanoue,et al.  Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice , 2010, Laboratory Investigation.

[2]  G. Kristiansen,et al.  Expression of fatty acid synthase in nonalcoholic fatty liver disease. , 2010, International journal of clinical and experimental pathology.

[3]  M. Febbraio,et al.  IL6 as a mediator of insulin resistance: fat or fiction? , 2010, Diabetologia.

[4]  S. Klein,et al.  Obesity and nonalcoholic fatty liver disease: Biochemical, metabolic, and clinical implications , 2010, Hepatology.

[5]  Darjus F. Tschaharganeh,et al.  Lack of interleukin‐6/glycoprotein 130/signal transducers and activators of transcription‐3 signaling in hepatocytes predisposes to liver steatosis and injury in mice , 2010, Hepatology.

[6]  E. Brunt,et al.  Nonalcoholic fatty liver disease: pathology and pathogenesis. , 2010, Annual review of pathology.

[7]  J. Dubé,et al.  Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance , 2009, Diabetes.

[8]  M. White,et al.  Human IL6 enhances leptin action in mice , 2009, Diabetologia.

[9]  G. Püschel,et al.  Aggravation by prostaglandin E2 of interleukin‐6‐dependent insulin resistance in hepatocytes , 2009, Hepatology.

[10]  Patrice D Cani,et al.  Critical role of Kupffer cells in the management of diet-induced diabetes and obesity. , 2009, Biochemical and biophysical research communications.

[11]  P. Heinrich,et al.  Prostaglandin E1 inhibits IL-6-induced MCP-1 expression by interfering specifically in IL-6-dependent ERK1/2, but not STAT3, activation. , 2008, The Biochemical journal.

[12]  H. Tilg,et al.  Inflammatory Mechanisms in the Regulation of Insulin Resistance , 2008, Molecular medicine.

[13]  M. Honda,et al.  Lipid‐induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet , 2007, Hepatology.

[14]  Ting-Ting Huang,et al.  Transcriptional Activation of Hepatic ACSL3 and ACSL5 by Oncostatin M Reduces Hypertriglyceridemia Through Enhanced β-Oxidation , 2007, Arteriosclerosis, thrombosis, and vascular biology.

[15]  S. Uotani,et al.  Leptin activates AMP-activated protein kinase in hepatic cells via a JAK2-dependent pathway. , 2006, Biochemical and biophysical research communications.

[16]  P. Aspichueta,et al.  The 2-series prostaglandins suppress VLDL secretion in an inflammatory condition-dependent manner in primary rat hepatocytes. , 2006, Biochimica et biophysica acta.

[17]  R. Mooney,et al.  Interleukin-6 depletion selectively improves hepatic insulin action in obesity. , 2005, Endocrinology.

[18]  T. Maruyama,et al.  PGE2 exerts its effect on the LPS-induced release of TNF-α, ET-1, IL-lα, IL-6 and IL-10 via the EP2 and EP4 receptor in rat liver macrophages , 2004 .

[19]  T. Zimmers,et al.  Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice. , 2003, Diabetes.

[20]  P. Heinrich,et al.  Principles of interleukin (IL)-6-type cytokine signalling and its regulation. , 2003, The Biochemical journal.

[21]  E. Benveniste,et al.  Oncostatin M enhances the expression of prostaglandin E2 and cyclooxygenase‐2 in astrocytes: Synergy with interleukin‐1β, tumor necrosis factor‐α, and bacterial lipopolysaccharide , 2003, Glia.

[22]  R. Mooney,et al.  Interleukin-6 induces cellular insulin resistance in hepatocytes. , 2002, Diabetes.

[23]  E. Benveniste,et al.  Prostaglandin E2 Is a Novel Inducer of Oncostatin-M Expression in Macrophages and Microglia , 2002, The Journal of Neuroscience.

[24]  Y. Sugimoto,et al.  Contribution of the two Gs-coupled PGE2-receptors EP2-receptor and EP4-receptor to the inhibition by PGE2 of the LPS-induced TNFalpha-formation in Kupffer cells from EP2-or EP4-receptor-deficient mice. Pivotal role for the EP4-receptor in wild type Kupffer cells. , 2002, Journal of hepatology.

[25]  Z. Kmieć,et al.  Cooperation of Liver Cells in Health and Disease , 2001, Advances in Anatomy Embryology and Cell Biology.

[26]  G. Püschel,et al.  Induction by interleukin 6 of Gs‐coupled prostaglandin E2 receptors in rat hepatocytes mediating a prostaglandin E2–dependent inhibition of the hepatocyte's acute phase response , 2000, Hepatology.

[27]  K. Jungermann,et al.  Feedback‐inhibition of glucagon‐stimulated glycogenolysis in hepatocyte/kupffer cell cocultures by glucagon‐elicited prostaglandin production in kupffer cells , 1995, Hepatology.

[28]  B. Christ,et al.  Inhibition by PGE2 of glucagon‐induced increase in phosphoenolpyruvate carboxykinase mRNA and acceleration of mRNA degradation in cultured rat hepatocytes , 1994, FEBS letters.

[29]  M. W. Flye,et al.  Autoregulation by Eicosanoids of Human Kupffer Cell Secretory Products A Study of Interleukin‐1, Interleukin‐6, Tumor Necrosis Factor-α, Transforming Growth Factor-β, and Nitric Oxide , 1994, Annals of surgery.

[30]  M. W. Flye,et al.  Prostaglandin E2 downregulates Kupffer cell production of IL-1 and IL-6 during hepatic regeneration. , 1993, The American journal of physiology.

[31]  M. Meredith.  Rat hepatocytes prepared without collagenase: Prolonged retention of differentiated characteristics in culture , 1988, Cell Biology and Toxicology.

[32]  E. Brass,et al.  Inhibition of glucagon-stimulated cAMP accumulation and fatty acid oxidation by E-series prostaglandins in isolated rat hepatocytes. , 1987, Biochimica et biophysica acta.

[33]  M. M. Bradford.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.

[34]  U. K. Laemmli,et al.  Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 , 1970, Nature.

[35]  K. Frede,et al.  Stimulation der hepatischen Lipidakkumulation durch PGE2-vermittelte Hemmung von β-Oxidation und VLDL-Bildung , 2011 .

[36]  K. Jungermann,et al.  Integration of function in the hepatic acinus: intercellular communication in neural and humoral control of liver metabolism. , 1994, Progress in liver diseases.