Targeting tauopathy with engineered tau-degrading intrabodies

[1]  I. Tooyama,et al.  Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals , 2018, Scientific Reports.

[2]  Fei Liu,et al.  Tau passive immunization blocks seeding and spread of Alzheimer hyperphosphorylated Tau-induced pathology in 3 × Tg-AD mice , 2018, Alzheimer's Research & Therapy.

[3]  A. Fagan,et al.  ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy , 2017, Nature.

[4]  D. Holtzman,et al.  AAV-mediated expression of anti-tau scFvs decreases tau accumulation in a mouse model of tauopathy , 2017, The Journal of experimental medicine.

[5]  S. Paul,et al.  Vectored Intracerebral Immunization with the Anti-Tau Monoclonal Antibody PHF1 Markedly Reduces Tau Pathology in Mutant Tau Transgenic Mice , 2016, The Journal of Neuroscience.

[6]  P. Pereira,et al.  K63 linked ubiquitin chain formation is a signal for HIF1A degradation by Chaperone-Mediated Autophagy , 2015, Scientific Reports.

[7]  D. Holtzman,et al.  Anti-tau antibody reduces insoluble tau and decreases brain atrophy , 2015, Annals of clinical and translational neurology.

[8]  E. Mandelkow,et al.  Lost after translation: missorting of Tau protein and consequences for Alzheimer disease , 2014, Trends in Neurosciences.

[9]  D. Holtzman,et al.  Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo , 2013, Neuron.

[10]  J. Trojanowski,et al.  Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy , 2013, The Journal of Neuroscience.

[11]  U. Sengupta,et al.  Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau , 2012, Scientific Reports.

[12]  D. Butler,et al.  Bifunctional Anti-Huntingtin Proteasome-Directed Intrabodies Mediate Efficient Degradation of Mutant Huntingtin Exon 1 Protein Fragments , 2011, PloS one.

[13]  A. Ittner,et al.  Tau-Targeted Immunization Impedes Progression of Neurofibrillary Histopathology in Aged P301L Tau Transgenic Mice , 2011, PloS one.

[14]  P. Davies,et al.  Passive Immunization with Anti-Tau Antibodies in Two Transgenic Models , 2011, The Journal of Biological Chemistry.

[15]  D. Quartermain,et al.  Immunotherapy Targeting Pathological Tau Prevents Cognitive Decline in a New Tangle Mouse Model , 2010, The Journal of Neuroscience.

[16]  N. Grigoriadis,et al.  Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice , 2010, Experimental Neurology.

[17]  Martin Beibel,et al.  Transmission and spreading of tauopathy in transgenic mouse brain , 2009, Nature Cell Biology.

[18]  S. Gygi,et al.  Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases. , 2008, Human molecular genetics.

[19]  J. Olzmann,et al.  Parkin-mediated K63-linked polyubiquitination: A signal for targeting misfolded proteins to the aggresome-autophagy pathway , 2008, Autophagy.

[20]  Ayodeji A. Asuni,et al.  Immunotherapy Targeting Pathological Tau Conformers in a Tangle Mouse Model Reduces Brain Pathology with Associated Functional Improvements , 2007, The Journal of Neuroscience.

[21]  Bin Zhang,et al.  Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model , 2007, Neuron.

[22]  P. Lehner,et al.  Lysine‐63‐linked ubiquitination is required for endolysosomal degradation of class I molecules , 2006, The EMBO journal.

[23]  Jianxiong Jiang,et al.  Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling. , 2005, Molecular cell.

[24]  C. Holmes,et al.  Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report , 2003, Nature Medicine.

[25]  B. Bahr,et al.  The neuropathogenic contributions of lysosomal dysfunction , 2002, Journal of neurochemistry.

[26]  R. Haguenauer‐Tsapis,et al.  Ubiquitin Lys63 is involved in ubiquitination of a yeast plasma membrane protein , 1997, The EMBO journal.

[27]  D. Ecker,et al.  A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein. , 1989, Science.

[28]  M. L. Schmidt,et al.  Distribution of tau proteins in the normal human central and peripheral nervous system. , 1989, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[29]  D. Selkoe,et al.  Tau antisera recognize neurofibrillary tangles in a range of neurodegenerative disorders , 1987, Annals of neurology.

[30]  M. Kirschner,et al.  Tubulin requires tau for growth onto microtubule initiating sites. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[31]  M. Kirschner,et al.  A protein factor essential for microtubule assembly. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[32]  R. Nixon,et al.  Lysosomal system pathways: genes to neurodegeneration in Alzheimer's disease. , 2006, Journal of Alzheimer's disease : JAD.

[33]  Hilde van der Togt,et al.  Publisher's Note , 2003, J. Netw. Comput. Appl..

[34]  J. Trojanowski,et al.  Neurodegenerative tauopathies. , 2001, Annual review of neuroscience.