Characterization of near-wall hydrodynamic lift forces using sedimentation field-flow fractionation

Abstract In field-flow fractionation (FFF), a family of high resolution techniques for the separation of particles and polymers, the measured retention time of entrained particles eluting through a thin (50-500 μm) parallel plate channel is determined by the transverse forces acting on the particles during their migration. For particles in the size range ∼l-100μm an applied transverse driving force (in the present case sedimentation) rapidly brings the particles into balance with hydrodynamic lift forces, so that the two force vectors are equal in magnitude but opposite in direction. By subjecting latex microspheres of known size and density to a specified rotation rate in a centrifuge, the applied sedimentation force is known and thus the magnitude of the lift forces is immediately obtained. The transverse particle position can be determined from the measured particle retention time. Thus lift forces can be determined as a function of particle size, transverse position, and flowrate. This strategy has be...

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