Imaging severe asthma

[1]  C. Brightling,et al.  Functional CT imaging for identification of the spatial determinants of small-airways disease in adults with asthma. , 2019, The Journal of allergy and clinical immunology.

[2]  E. Hoffman,et al.  Lumen area change (Delta Lumen) between inspiratory and expiratory multidetector computed tomography as a measure of severe outcomes in asthmatic patients , 2018, The Journal of allergy and clinical immunology.

[3]  Hans-Ulrich Kauczor,et al.  Quantitative CT detects changes in airway dimensions and air-trapping after bronchial thermoplasty for severe asthma. , 2018, European journal of radiology.

[4]  D. D. de Bruin,et al.  Bronchial Thermoplasty-Induced Acute Airway Effects Assessed with Optical Coherence Tomography in Severe Asthma , 2018, Respiration.

[5]  C. Brightling,et al.  In vivo imaging reveals increased eosinophil uptake in the lungs of obese asthmatic patients , 2018, The Journal of allergy and clinical immunology.

[6]  V. Backer,et al.  Effect of tralokinumab, an interleukin-13 neutralising monoclonal antibody, on eosinophilic airway inflammation in uncontrolled moderate-to-severe asthma (MESOS): a multicentre, double-blind, randomised, placebo-controlled phase 2 trial. , 2018, The Lancet. Respiratory medicine.

[7]  C. Brightling,et al.  Modelling the effect of gravity on inert‐gas washout outputs , 2018, Physiological reports.

[8]  Stanley J Kruger,et al.  Pulmonary ventilation imaging in asthma and cystic fibrosis using oxygen‐enhanced 3D radial ultrashort echo time MRI , 2018, Journal of magnetic resonance imaging : JMRI.

[9]  G. Parraga,et al.  Sputum Eosinophilia and Magnetic Resonance Imaging Ventilation Heterogeneity in Severe Asthma , 2018, American journal of respiratory and critical care medicine.

[10]  C. Olveira,et al.  Factors associated with bronchiectasis in patients with uncontrolled asthma; the NOPES score: a study in 398 patients , 2018, Respiratory Research.

[11]  E. Hoffman,et al.  Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction , 2018, The Journal of clinical investigation.

[12]  A. Fenster,et al.  Thoracic CT‐MRI coregistration for regional pulmonary structure–function measurements of obstructive lung disease , 2017, Medical physics.

[13]  A. Sousa,et al.  Associations in asthma between quantitative computed tomography and bronchial biopsy-derived airway remodelling , 2017, European Respiratory Journal.

[14]  Grace Parraga,et al.  Ultrashort echo time MRI biomarkers of asthma , 2017, Journal of magnetic resonance imaging : JMRI.

[15]  H. Kauczor,et al.  Reproducibility and comparison of oxygen-enhanced T1 quantification in COPD and asthma patients , 2017, PloS one.

[16]  I. Pavord,et al.  Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial. , 2016, The Lancet. Respiratory medicine.

[17]  A. Sousa,et al.  Relationship between lung function and quantitative computed tomographic parameters of airway remodeling, air trapping, and emphysema in patients with asthma and chronic obstructive pulmonary disease: A single-center study , 2016, The Journal of allergy and clinical immunology.

[18]  C. Brightling,et al.  Characterization of acinar airspace involvement in asthmatic patients by using inert gas washout and hyperpolarized (3)helium magnetic resonance. , 2016, The Journal of allergy and clinical immunology.

[19]  G. Parker,et al.  Dynamic oxygen-enhanced magnetic resonance imaging of the lung in asthma -- initial experience. , 2015, European journal of radiology.

[20]  Jim Kozlowski,et al.  Regional ventilation changes in severe asthma after bronchial thermoplasty with (3)He MR imaging and CT. , 2015, Radiology.

[21]  S. Matsumoto,et al.  Asthma: comparison of dynamic oxygen-enhanced MR imaging and quantitative thin-section CT for evaluation of clinical treatment. , 2014, Radiology.

[22]  Salman Siddiqui,et al.  Quantitative computed tomography–derived clusters: Redefining airway remodeling in asthmatic patients☆ , 2014, The Journal of allergy and clinical immunology.

[23]  British guideline on the management of asthma. , 2014, Thorax.

[24]  E. Bleecker,et al.  International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma , 2013, European Respiratory Journal.

[25]  A. Glanville.  Community-acquired respiratory viruses after lung transplantation: common, sometimes silent, potentially lethal , 2013, Thorax.

[26]  Ella A. Kazerooni,et al.  CT-based Biomarker Provides Unique Signature for Diagnosis of COPD Phenotypes and Disease Progression , 2012, Nature Medicine.

[27]  M. Hoshino,et al.  Effects of Adding Omalizumab, an Anti-Immunoglobulin E Antibody, on Airway Wall Thickening in Asthma , 2012, Respiration.

[28]  B. Medoff,et al.  18F-FDG Uptake Rate Is a Biomarker of Eosinophilic Inflammation and Airway Response in Asthma , 2011, The Journal of Nuclear Medicine.

[29]  I. Pavord,et al.  Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes , 2010, Thorax.

[30]  P. Burgel,et al.  Mucus hypersecretion in COPD: should we only rely on symptoms? , 2010, European Respiratory Review.

[31]  J. Seo,et al.  Xenon Ventilation Imaging Using Dual-Energy Computed Tomography in Asthmatics: Initial Experience , 2010, Investigative radiology.

[32]  Shiyuan Liu,et al.  Demonstration of pulmonary perfusion heterogeneity induced by gravity and lung inflation using arterial spin labeling. , 2010, European journal of radiology.

[33]  I. Pavord,et al.  Qualitative analysis of high-resolution CT scans in severe asthma. , 2009, Chest.

[34]  E. Nizankowska-Mogilnicka,et al.  The use of endobronchial ultrasonography in assessment of bronchial wall remodeling in patients with asthma. , 2009, Chest.

[35]  R. Rizi,et al.  Quantitative assessment of lung using hyperpolarized magnetic resonance imaging. , 2009, Proceedings of the American Thoracic Society.

[36]  P. Leander,et al.  Validity of apparent diffusion coefficient hyperpolarized 3He-MRI using MSCT and pulmonary function tests as references. , 2009, European journal of radiology.

[37]  C. Brightling,et al.  Airway wall geometry in asthma and nonasthmatic eosinophilic bronchitis , 2009, Allergy.

[38]  Ana Sousa,et al.  Mepolizumab and exacerbations of refractory eosinophilic asthma. , 2009, The New England journal of medicine.

[39]  W. Hop,et al.  Lung morphology assessment using MRI: A robust ultra‐short TR/TE 2D steady state free precession sequence used in cystic fibrosis patients , 2009, Magnetic resonance in medicine.

[40]  E. Hoffman,et al.  A multivariate analysis of risk factors for the air-trapping asthmatic phenotype as measured by quantitative CT analysis. , 2009, Chest.

[41]  Jie Zheng,et al.  Airway remodeling measured by multidetector CT is increased in severe asthma and correlates with pathology. , 2008, Chest.

[42]  K. Kurashima,et al.  Effect of early versus late intervention with inhaled corticosteroids on airway wall thickness in patients with asthma , 2008, Respirology.

[43]  K. Minard,et al.  3D 3He diffusion MRI as a local in vivo morphometric tool to evaluate emphysematous rat lungs. , 2008, Journal of applied physiology.

[44]  Chengbo Wang,et al.  Assessment of the lung microstructure in patients with asthma using hyperpolarized 3He diffusion MRI at two time scales: Comparison with healthy subjects and patients with COPD , 2008, Journal of magnetic resonance imaging : JMRI.

[45]  W. Busse,et al.  Evaluation of structure-function relationships in asthma using multidetector CT and hyperpolarized He-3 MRI. , 2008, Academic radiology.

[46]  Y. Ohno,et al.  Oxygen-enhanced magnetic resonance imaging versus computed tomography: multicenter study for clinical stage classification of smoking-related chronic obstructive pulmonary disease. , 2008, American journal of respiratory and critical care medicine.

[47]  K. Chin,et al.  Sputum levels of transforming growth factor-beta1 in asthma: relation to clinical and computed tomography findings. , 2008, Journal of investigational allergology & clinical immunology.

[48]  J. Wild,et al.  Single‐scan acquisition of registered hyperpolarized 3He ventilation and ADC images using a hybrid 2D gradient‐echo sequence , 2007, Magnetic resonance in medicine.

[49]  John P Mugler,et al.  The variability of regional airflow obstruction within the lungs of patients with asthma: assessment with hyperpolarized helium-3 magnetic resonance imaging. , 2007, The Journal of allergy and clinical immunology.

[50]  T. Ozis,et al.  The Impact of Bronchiectasis in Clinical Presentation of Asthma , 2007, Southern medical journal.

[51]  F. Laurent,et al.  Air trapping in mild and moderate asthma: effect of inhaled corticosteroids. , 2007, The Journal of allergy and clinical immunology.

[52]  M. Reiser,et al.  Material differentiation by dual energy CT: initial experience , 2007, European Radiology.

[53]  Dmitriy A Yablonskiy,et al.  Hyperpolarized 3He diffusion MRI and histology in pulmonary emphysema , 2006, Magnetic resonance in medicine.

[54]  S. Muro,et al.  Role of small airways in asthma: investigation using high-resolution computed tomography. , 2006, The Journal of allergy and clinical immunology.

[55]  John P Mugler,et al.  Evaluation of asthma with hyperpolarized helium-3 MRI: correlation with clinical severity and spirometry. , 2006, Chest.

[56]  M. Ekici,et al.  High-resolution computed tomography findings in elderly patients with asthma. , 2006, European journal of radiology.

[57]  Frank R. Korosec,et al.  Early Emphysematous Changes in Asymptomatic Smokers: Detection with 3He MR Imaging , 2006 .

[58]  D. Hansell,et al.  Can HRCT be used as a marker of airway remodelling in children with difficult asthma? , 2006, Respiratory research.

[59]  R. Elashoff,et al.  Montelukast improves regional air-trapping due to small airways obstruction in asthma , 2006, European Respiratory Journal.

[60]  C. Brightling.  Chronic cough due to nonasthmatic eosinophilic bronchitis: ACCP evidence-based clinical practice guidelines. , 2006, Chest.

[61]  A. Sukstanskii,et al.  3He diffusion MRI of the lung. , 2005, Academic radiology.

[62]  J. Hogg,et al.  Long-range diffusion of hyperpolarized 3He in explanted normal and emphysematous human lungs via magnetization tagging. , 2005, Journal of applied physiology.

[63]  I. Tillie‐Leblond,et al.  High-resolution computed tomography scan and airway remodeling in children with severe asthma. , 2005, The Journal of allergy and clinical immunology.

[64]  Jörg Schmiedeskamp,et al.  Diffusion‐weighted MRI of the lung with hyperpolarized helium‐3: A study of reproducibility , 2005, Journal of magnetic resonance imaging : JMRI.

[65]  Tilo Winkler,et al.  Self-organized patchiness in asthma as a prelude to catastrophic shifts , 2005, Nature.

[66]  S. Fukuhara,et al.  Relationship of airway wall thickening to an imbalance between matrix metalloproteinase-9 and its inhibitor in asthma , 2005, Thorax.

[67]  Edwin J R van Beek,et al.  Hyperpolarized 3-helium magnetic resonance imaging to probe lung function. , 2005, Proceedings of the American Thoracic Society.

[68]  S. Uh,et al.  High-resolution CT findings in patients with near-fatal asthma: comparison of patients with mild-to-severe asthma and normal control subjects and changes in airway abnormalities following steroid treatment. , 2004, Chest.

[69]  I. Pavord,et al.  Sputum and bronchial submucosal IL-13 expression in asthma and eosinophilic bronchitis. , 2004, The Journal of allergy and clinical immunology.

[70]  P. Barnes,et al.  Parameters associated with persistent airflow obstruction in chronic severe asthma , 2004, European Respiratory Journal.

[71]  P. Howarth,et al.  Endobronchial ultrasound to assess airway wall thickening: validation in vitro and in vivo , 2004, European Respiratory Journal.

[72]  Yasutaka Nakano,et al.  Effect of short-term treatment with inhaled corticosteroid on airway wall thickening in asthma. , 2004, The American journal of medicine.

[73]  Dmitriy A Yablonskiy,et al.  Magnetization tagging decay to measure long‐range 3He diffusion in healthy and emphysematous canine lungs , 2004, Magnetic resonance in medicine.

[74]  M. Mishima,et al.  Bronchial dilatation in asthma: relation to clinical and sputum indices. , 2004, Chest.

[75]  B. Mazoyer,et al.  Abnormalities of the airways and lung parenchyma in asthmatics: CT observations in 50 patients and inter- and intraobserver variability , 2004, European Radiology.

[76]  S. Kawakami,et al.  Evaluation of airway wall thickness and air trapping by HRCT in asymptomatic asthma , 2003, European Respiratory Journal.

[77]  M. Mishima,et al.  Relationship of airway wall thickness to airway sensitivity and airway reactivity in asthma. , 2003, American journal of respiratory and critical care medicine.

[78]  D. Karras,et al.  Guidelines reduce x-ray and blood gas utilization in acute asthma. , 2003, The American journal of emergency medicine.

[79]  M. Okamoto,et al.  Decreased computed tomographic lung density during exacerbation of asthma , 2003, European Respiratory Journal.

[80]  Katsuhiko Ueda,et al.  Air trapping at CT: high prevalence in asymptomatic subjects with normal pulmonary function. , 2003, Radiology.

[81]  I. Pavord,et al.  Comparison of airway immunopathology of eosinophilic bronchitis and asthma , 2003, Thorax.

[82]  John P Mugler,et al.  Rapid hyperpolarized 3He diffusion MRI of healthy and emphysematous human lungs using an optimized interleaved‐spiral pulse sequence , 2003, Journal of magnetic resonance imaging : JMRI.

[83]  Tadashi Yokoi,et al.  Complexity of terminal airspace geometry assessed by computed tomography in asthma. , 2003, American journal of respiratory and critical care medicine.

[84]  Hideki Shima,et al.  Bronchoarterial ratio and bronchial wall thickness on high-resolution CT in asymptomatic subjects: correlation with age and smoking. , 2003, AJR. American journal of roentgenology.

[85]  A. Yamasaki,et al.  Measuring Subepithelial Thickness Using Endobronchial Ultrasonography in a Patient with Asthma: A Case Report , 2003, Lung.

[86]  F. Brunelle,et al.  Thoracic CT in pediatric patients with difficult-to-treat asthma. , 2002, AJR. American journal of roentgenology.

[87]  M. Metintaş,et al.  High-Resolution Computed Tomography Findings Are Correlated with Disease Severity in Asthma , 2002, Respiration.

[88]  I. Pavord,et al.  Mast-cell infiltration of airway smooth muscle in asthma. , 2002, The New England journal of medicine.

[89]  P. Grenier,et al.  Mild intermittent asthma: CT assessment of bronchial cross-sectional area and lung attenuation at controlled lung volume. , 2002, Radiology.

[90]  Catherine Beigelman-Aubry,et al.  New frontiers in CT imaging of airway disease , 2002, European Radiology.

[91]  M. Adachi,et al.  Correlation between the bronchial subepithelial layer and whole airway wall thickness in patients with asthma , 2002, Thorax.

[92]  K. J. Macleod,et al.  High resolution computed tomographic assessment of airway wall thickness in chronic asthma: reproducibility and relationship with lung function and severity , 2002, Thorax.

[93]  Dmitriy A Yablonskiy,et al.  Quantitative in vivo assessment of lung microstructure at the alveolar level with hyperpolarized 3He diffusion MRI , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[94]  M. Okamoto,et al.  Influence of age and disease severity on high resolution CT lung densitometry in asthma , 2001, Thorax.

[95]  T A Wilson,et al.  Airway stability and heterogeneity in the constricted lung. , 2001, Journal of applied physiology.

[96]  T A Altes,et al.  Hyperpolarized 3He MR lung ventilation imaging in asthmatics: Preliminary findings , 2001, Journal of magnetic resonance imaging : JMRI.

[97]  H Itoh,et al.  Airway wall thickness in asthma assessed by computed tomography. Relation to clinical indices. , 2000, American journal of respiratory and critical care medicine.

[98]  F. Laurent,et al.  Functional significance of air trapping detected in moderate asthma , 2000, European Radiology.

[99]  D. Aberle,et al.  Comparative effects of hydrofluoroalkane and chlorofluorocarbon beclomethasone dipropionate inhalation on small airways: assessment with functional helical thin-section computed tomography. , 1999, The Journal of allergy and clinical immunology.

[100]  M. Kraft.  The distal airways: are they important in asthma? , 1999, The European respiratory journal.

[101]  J G Goldin,et al.  Airway hyperreactivity: assessment with helical thin-section CT. , 1998, Radiology.

[102]  N L Müller,et al.  Airway wall thickness in patients with near fatal asthma and control groups: assessment with high resolution computed tomographic scanning , 1998, Thorax.

[103]  G. Ripandelli,et al.  Optical coherence tomography. , 1998, Seminars in ophthalmology.

[104]  J. Fujimoto,et al.  In vivo endoscopic optical biopsy with optical coherence tomography. , 1997, Science.

[105]  C. W. Kim,et al.  High-resolution computed tomography in patients with bronchial asthma: correlation with clinical features, pulmonary functions and bronchial hyperresponsiveness. , 1997, Journal of investigational allergology & clinical immunology.

[106]  N L Müller,et al.  Airway obstruction in asthmatic and healthy individuals: inspiratory and expiratory thin-section CT findings. , 1997, Radiology.

[107]  D A Lynch,et al.  Bronchoarterial ratio on thin section CT: comparison between high altitude and sea level. , 1997, Journal of computer assisted tomography.

[108]  P. Paré,et al.  Human airway narrowing measured using high resolution computed tomography. , 1996, American journal of respiratory and critical care medicine.

[109]  R. Pauwels,et al.  GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION , 1996 .

[110]  J. Bousquet,et al.  Computed tomography of the lungs in asthma: influence of disease severity and etiology. , 1996, American journal of respiratory and critical care medicine.

[111]  L. Boulet,et al.  Airway responsiveness and bronchial-wall thickness in asthma with or without fixed airflow obstruction. , 1995, American journal of respiratory and critical care medicine.

[112]  J. Fujimoto,et al.  Optical biopsy and imaging using optical coherence tomography , 1995, Nature Medicine.

[113]  W. Happer,et al.  Biological magnetic resonance imaging using laser-polarized 129Xe , 1994, Nature.

[114]  D. Lynch,et al.  Quantitative computed tomography detects air trapping due to asthma. , 1994, Chest.

[115]  W. Webb.  High-resolution computed tomography of obstructive lung disease. , 1994, Radiologic clinics of North America.

[116]  E. Gallagher,et al.  Guidelines for the selective ordering of admission chest radiography in adult obstructive airway disease. , 1993, Annals of emergency medicine.

[117]  J D Newell,et al.  Uncomplicated asthma in adults: comparison of CT appearance of the lungs in asthmatic and healthy subjects. , 1993, Radiology.

[118]  J. Bousquet,et al.  Chest radiography and high resolution computed tomography of the lungs in asthma. , 1992, The American review of respiratory disease.

[119]  T Takishima,et al.  Site of airway obstruction in pulmonary disease: direct measurement of intrabronchial pressure. , 1992, Journal of applied physiology.

[120]  J. Fujimoto,et al.  Optical Coherence Tomography , 1991, LEOS '92 Conference Proceedings.

[121]  J. Austin,et al.  Acute asthma. Admission chest radiography in hospitalized adult patients. , 1991, Chest.

[122]  P. Paré,et al.  The mechanics of airway narrowing in asthma. , 1989, The American review of respiratory disease.

[123]  N. Müller,et al.  "Density mask". An objective method to quantitate emphysema using computed tomography. , 1988, Chest.

[124]  M. Dunnill.  THE PATHOLOGY OF ASTHMA, WITH SPECIAL REFERENCE TO CHANGES IN THE BRONCHIAL MUCOSA , 1960, Journal of clinical pathology.

[125]  K. Koessler,et al.  THE PATHOLOGY OF BRONCHIAL ASTHMA , 1922 .