Effects of Mismodeling on Tests of Association Based on Logistic Regression Models

We consider the effects of misspecifying the covariate vector on tests of association between a particular covariate and the response variable in logistic regression models. Misspecification can include random measurement error, discretizing a continuous explanatory variable and mismodeling the functional form of an explanatory variable. The effects of misspecification are examined by deriving the asymptotic distribution of the test statistic under a sequence of models. Applications of this result are discussed.

[1]  D. Schoenfeld The asymptotic properties of nonparametric tests for comparing survival distributions , 1981 .

[2]  Ben Armstrong,et al.  Measurement error in the generalised linear model , 1985 .

[3]  L. Ryan,et al.  Statistical analysis of disease onset and lifetime data from tumorigenicity experiments. , 1985, Environmental health perspectives.

[4]  R. Tripathi,et al.  The Effect of Errors in Diagnosis and Measurement on the Estimation of the Probability of an Event , 1980 .

[5]  Raymond J. Carroll,et al.  On errors-in-variables for binary regression models , 1984 .

[6]  Wayne A. Fuller,et al.  Properties of Some Estimators for the Errors-in-Variables Model , 1980 .

[7]  Bailer Aj,et al.  Effects of treatment-induced mortality and tumor-induced mortality on tests for carcinogenicity in small samples. , 1988 .

[8]  W. G. Cochran Errors of Measurement in Statistics , 1968 .

[9]  M. Gail,et al.  Biased estimates of treatment effect in randomized experiments with nonlinear regressions and omitted covariates , 1984 .

[10]  Stephen W. Lagakos,et al.  Loss in Efficiency Caused by Omitting Covariates and Misspecifying Exposure in Logistic Regression Models , 1993 .

[11]  R. Prentice Covariate measurement errors and parameter estimation in a failure time regression model , 1982 .

[12]  Deborah Burr,et al.  On Errors-in-Variables in Binary Regression—Berkson Case , 1988 .

[13]  P. Sen,et al.  Nonparametric methods in multivariate analysis , 1974 .

[14]  M. Gail The Effect of Pooling Across Strata in Perfectly Balanced Studies , 1988 .

[15]  S W Lagakos,et al.  Properties of proportional-hazards score tests under misspecified regression models. , 1984, Biometrics.

[16]  Deconvolution-Based Score Tests in Measurement Error Models , 1991 .

[17]  B. L. S. Prakasa Rao Asymptotic theory of statistical inference , 1987 .

[18]  Anastasios A. Tsiatis,et al.  The asymptotic relative efficiency of score tests in a generalized linear model with surrogate covariates , 1988 .

[19]  Kai Lai Chung,et al.  A Course in Probability Theory , 1949 .

[20]  N E Day,et al.  The design of case-control studies: the influence of confounding and interaction effects. , 1984, International journal of epidemiology.

[21]  Leonard A. Stefanski,et al.  The effects of measurement error on parameter estimation , 1985 .

[22]  Raymond J. Carroll,et al.  Covariate Measurement Error in Logistic Regression , 1985 .

[23]  S. W. Lagakos The loss in efficiency from misspecifying covariates in proportional hazards regression models , 1988 .

[24]  M. H. Gail,et al.  Tests for no treatment e?ect in randomized clinical trials , 1988 .

[25]  Raymond J. Carroll,et al.  Score Tests in Generalized Linear Measurement Error Models , 1990 .