Wide field-of-view high lateral resolution optical coherence tomography with 3D image stitching and superresolution

We report that wide field-of-view (FOV) optical coherence tomography images with high lateral resolution can be obtained by using superresolution and 3D image stitching techniques. About 3 times lateral resolution improvement from 6.20 μm to 2.19 μm using a focusing lens of 0.08 numerical aperture has been demonstrated. With such lens the FOV is generally small owing to off-axis focusing degradation. To enlarge the FOV while maintaining high lateral resolution, 3D image stitching technique is introduced to effectively reconstruct an ultra-wide FOV 3D image of 2.10x1.15 mm2 lateral area from ten C-scans of 500×500 μm2 FOV. Improved FOV with high lateral resolution should benefit various biomedical imaging applications.

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